Click here to switch to the map view.

The map label for this gene is msrA2 [H]

Identifier: 197103787

GI number: 197103787

Start: 314153

End: 314722

Strand: Direct

Name: msrA2 [H]

Synonym: PHZ_c0321

Alternate gene names: 197103787

Gene position: 314153-314722 (Clockwise)

Preceding gene: 197103786

Following gene: 197103789

Centisome position: 7.86

GC content: 71.23

Gene sequence:

>570_bases
ATGAGACCCCGCATCCTCCTCCTTACCGGAGCCGCGGCGTTCATCGCCGCCGCCCCGGCCGGCGCGGCCACCAAGACCGC
GGTCTTCGCCGGCGGCTGCTTCTGGTCGGTCGAGAAGTTCTTCGAGGCCAAACCCGGCGTCGTCTCGGCCGTCTCGGGCT
ATTCGGGCGGGACCCTGCGCCAGCCCACCTACCGCAACCACCCCGGCCACCTGGAGGCCGTGCGGGTCACCTACGATCCG
GCCAAGGTCTCCTACGCCCAGCTGGTGGACCACTTCTTCCACAACATCGACCCGACCGATCCCAAGGGCCAGATCTGCGA
CAAGGGGCCGAGCTACCGGACGGCGGTGTTCGTCGCCACGCCCGAGGAGCGCCGCATCGCCCAGCAGGCGAAGGCGGGGG
TGGCGAAGGAGCTGCGGGCCAAGGTCGCCACCGAGATCCGCGCCGCCGCGCCATTCTGGCCCGCCGAGGCCTACCATCAG
GACTACGCGAAGAAGAACCCGGCCGCCTACGAGCGCTACCGCGTGGGCTGCGGCCGCGACCGGTGGCTGGGGGTCGTCTG
GGGGCGGTGA

Upstream 100 bases:

>100_bases
GGTCGCCGCGTAGGGGGCTCAGGCGGCCGGCTGCATCCGCCAGGCGGCGGGGCGCGTACCTCACGTGACCCCTGCCTCCG
GGAGTGGCATCCTGCCGACC

Downstream 100 bases:

>100_bases
GCCCGCCTCACATCGCCGGCAGGCCGGTCGCCGGATCGCGCGGGCGGGGGGCGTAGTCCTCGGCGACGAACATCTCGATC
CGCCGCTTGCGCTTGCGGTC

Product: peptide methionine sulfoxide reductase MsrA

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MRPRILLLTGAAAFIAAAPAGAATKTAVFAGGCFWSVEKFFEAKPGVVSAVSGYSGGTLRQPTYRNHPGHLEAVRVTYDP
AKVSYAQLVDHFFHNIDPTDPKGQICDKGPSYRTAVFVATPEERRIAQQAKAGVAKELRAKVATEIRAAAPFWPAEAYHQ
DYAKKNPAAYERYRVGCGRDRWLGVVWGR

Sequences:

>Translated_189_residues
MRPRILLLTGAAAFIAAAPAGAATKTAVFAGGCFWSVEKFFEAKPGVVSAVSGYSGGTLRQPTYRNHPGHLEAVRVTYDP
AKVSYAQLVDHFFHNIDPTDPKGQICDKGPSYRTAVFVATPEERRIAQQAKAGVAKELRAKVATEIRAAAPFWPAEAYHQ
DYAKKNPAAYERYRVGCGRDRWLGVVWGR
>Mature_189_residues
MRPRILLLTGAAAFIAAAPAGAATKTAVFAGGCFWSVEKFFEAKPGVVSAVSGYSGGTLRQPTYRNHPGHLEAVRVTYDP
AKVSYAQLVDHFFHNIDPTDPKGQICDKGPSYRTAVFVATPEERRIAQQAKAGVAKELRAKVATEIRAAAPFWPAEAYHQ
DYAKKNPAAYERYRVGCGRDRWLGVVWGR

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=160, Percent_Identity=36.875, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI6912516, Length=160, Percent_Identity=36.875, Blast_Score=104, Evalue=4e-23,
Organism=Homo sapiens, GI208609993, Length=106, Percent_Identity=36.7924528301887, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1790665, Length=152, Percent_Identity=42.7631578947368, Blast_Score=117, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17533973, Length=141, Percent_Identity=29.7872340425532, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6320881, Length=164, Percent_Identity=28.6585365853659, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24664627, Length=139, Percent_Identity=35.2517985611511, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45553131, Length=133, Percent_Identity=34.5864661654135, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24664631, Length=139, Percent_Identity=33.8129496402878, Blast_Score=80, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 20668; Mature: 20668

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPRILLLTGAAAFIAAAPAGAATKTAVFAGGCFWSVEKFFEAKPGVVSAVSGYSGGTLR
CCCEEEEEECHHHHHHCCCCCCCHHHEEEECCHHHHHHHHHCCCCCEEEEECCCCCCCCC
QPTYRNHPGHLEAVRVTYDPAKVSYAQLVDHFFHNIDPTDPKGQICDKGPSYRTAVFVAT
CCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEC
PEERRIAQQAKAGVAKELRAKVATEIRAAAPFWPAEAYHQDYAKKNPAAYERYRVGCGRD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCCC
RWLGVVWGR
CEEEEEECC
>Mature Secondary Structure
MRPRILLLTGAAAFIAAAPAGAATKTAVFAGGCFWSVEKFFEAKPGVVSAVSGYSGGTLR
CCCEEEEEECHHHHHHCCCCCCCHHHEEEECCHHHHHHHHHCCCCCEEEEECCCCCCCCC
QPTYRNHPGHLEAVRVTYDPAKVSYAQLVDHFFHNIDPTDPKGQICDKGPSYRTAVFVAT
CCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEC
PEERRIAQQAKAGVAKELRAKVATEIRAAAPFWPAEAYHQDYAKKNPAAYERYRVGCGRD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHCCCCCC
RWLGVVWGR
CEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]