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The map label for this gene is fadH [H]

Identifier: 197103750

GI number: 197103750

Start: 277210

End: 278001

Strand: Reverse

Name: fadH [H]

Synonym: PHZ_c0284

Alternate gene names: 197103750

Gene position: 278001-277210 (Counterclockwise)

Preceding gene: 197103751

Following gene: 197103749

Centisome position: 6.96

GC content: 73.48

Gene sequence:

>792_bases
ATGAGCGCCTTCAAGGACGGCCTGCTGGCCGGCAAGACGGCCTTCGTCGCCGGCGGCACCAGCGGCATCAACCTGGGCAT
CGCCAAGCGCTTCGCCGAGCTGGGCGCCCGCGTGGCGGTGGCCGGCCGCGACCCGGACAAGGCCCGCCGGGCGGCGGAAT
CCATCGGGCCGGACGCCCTCGGCCTCTCGGCCGACGTGCGCGACTACGCGGCCATCCGCGCGGCCATGGAGCAGGTGACC
GAGGCCTTCGGGGCCATGGACATCGTGGTCTCGGGCGCGGCCGGCAACTTCCTGGCGCCCGCCGCGGCGATGTCGGCCAA
CGCCTTCAAGACCGTGGTGGACATCGACCTGAACGGCACCTTCAACGTCTTCCGCGGCTGCTACGACCTCCTGAACAAGC
CGGGCGCCTCGCTGATCGCCATCACCGCCGGCCAGGCGGTGAACGCCATGCCGCTGCAGATCCACGCCTGCGCCGCCAAG
GCCGGGGTGAACCAGGTGGTGCGGGTGCTGGCCATGGAGTGGGGCCCCGAGGTGCGGGTCAACGGCATCTCCCCCGGCCC
GATCGAGGACACCGAGGGCATGGCGCGGCTCGCGCCCGACCCCACCACCCGCGCCAGGCACCACGAGCGGATCCCCATGC
GCCGCTGGGGCCGGATCGCCGAGGTGGCCGAGGCGGCGGTGTTCCTGTGCAGCCCGTCGGCCGAGTACGTCACCGGCACG
ATCCTGGACTGCGACGGCGGCTCGCAGCTGGGCGACGCCACCCGCCGCGACGTCGGCAAGGGCCTGGCCTAG

Upstream 100 bases:

>100_bases
TCTCGCCCGCGTCCGACGCGGTCACCGGAACCTGCATCAAGGTGGACGACGGCCAGGGCCGCCGCTGATCCGCCGCAACC
CCAACGAGGAGGAAGACCCC

Downstream 100 bases:

>100_bases
GGGAGGCGGCGATGACGGCCTACGAGACCATCCAGATCGAGAAGCGCGGCCAGGTGGACTGGCTGACGCTGAACCGTCCC
GAGGCGCTGAACGCCATCTC

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MSAFKDGLLAGKTAFVAGGTSGINLGIAKRFAELGARVAVAGRDPDKARRAAESIGPDALGLSADVRDYAAIRAAMEQVT
EAFGAMDIVVSGAAGNFLAPAAAMSANAFKTVVDIDLNGTFNVFRGCYDLLNKPGASLIAITAGQAVNAMPLQIHACAAK
AGVNQVVRVLAMEWGPEVRVNGISPGPIEDTEGMARLAPDPTTRARHHERIPMRRWGRIAEVAEAAVFLCSPSAEYVTGT
ILDCDGGSQLGDATRRDVGKGLA

Sequences:

>Translated_263_residues
MSAFKDGLLAGKTAFVAGGTSGINLGIAKRFAELGARVAVAGRDPDKARRAAESIGPDALGLSADVRDYAAIRAAMEQVT
EAFGAMDIVVSGAAGNFLAPAAAMSANAFKTVVDIDLNGTFNVFRGCYDLLNKPGASLIAITAGQAVNAMPLQIHACAAK
AGVNQVVRVLAMEWGPEVRVNGISPGPIEDTEGMARLAPDPTTRARHHERIPMRRWGRIAEVAEAAVFLCSPSAEYVTGT
ILDCDGGSQLGDATRRDVGKGLA
>Mature_262_residues
SAFKDGLLAGKTAFVAGGTSGINLGIAKRFAELGARVAVAGRDPDKARRAAESIGPDALGLSADVRDYAAIRAAMEQVTE
AFGAMDIVVSGAAGNFLAPAAAMSANAFKTVVDIDLNGTFNVFRGCYDLLNKPGASLIAITAGQAVNAMPLQIHACAAKA
GVNQVVRVLAMEWGPEVRVNGISPGPIEDTEGMARLAPDPTTRARHHERIPMRRWGRIAEVAEAAVFLCSPSAEYVTGTI
LDCDGGSQLGDATRRDVGKGLA

Specific function: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI10190704, Length=253, Percent_Identity=43.4782608695652, Blast_Score=187, Evalue=6e-48,
Organism=Homo sapiens, GI4503301, Length=249, Percent_Identity=34.9397590361446, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI19923817, Length=260, Percent_Identity=28.8461538461538, Blast_Score=128, Evalue=5e-30,
Organism=Homo sapiens, GI59889578, Length=236, Percent_Identity=33.8983050847458, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI7705925, Length=247, Percent_Identity=27.1255060728745, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI40254992, Length=242, Percent_Identity=28.099173553719, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI32483357, Length=246, Percent_Identity=26.8292682926829, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI40254986, Length=205, Percent_Identity=28.780487804878, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI5031737, Length=241, Percent_Identity=24.896265560166, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI15277342, Length=255, Percent_Identity=30.5882352941176, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=32.5490196078431, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787905, Length=244, Percent_Identity=30.327868852459, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1789208, Length=251, Percent_Identity=28.2868525896414, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1787335, Length=240, Percent_Identity=30.8333333333333, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1789378, Length=256, Percent_Identity=28.90625, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1790717, Length=244, Percent_Identity=26.6393442622951, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87082160, Length=249, Percent_Identity=28.1124497991968, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI2367365, Length=245, Percent_Identity=28.9795918367347, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787545, Length=253, Percent_Identity=30.4347826086957, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788459, Length=246, Percent_Identity=26.8292682926829, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17536025, Length=256, Percent_Identity=36.328125, Blast_Score=137, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17536651, Length=256, Percent_Identity=35.15625, Blast_Score=134, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17561272, Length=259, Percent_Identity=35.1351351351351, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI25147288, Length=251, Percent_Identity=31.4741035856574, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562910, Length=269, Percent_Identity=27.5092936802974, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17555706, Length=253, Percent_Identity=30.0395256916996, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=267, Percent_Identity=27.3408239700375, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=246, Percent_Identity=26.0162601626016, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994600, Length=258, Percent_Identity=25.968992248062, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193204405, Length=265, Percent_Identity=26.0377358490566, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=266, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=261, Percent_Identity=24.904214559387, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI72000259, Length=267, Percent_Identity=25.8426966292135, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562990, Length=270, Percent_Identity=28.5185185185185, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=263, Percent_Identity=23.574144486692, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=263, Percent_Identity=26.2357414448669, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=245, Percent_Identity=23.6734693877551, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17560220, Length=262, Percent_Identity=24.8091603053435, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=248, Percent_Identity=39.9193548387097, Blast_Score=176, Evalue=2e-45,
Organism=Drosophila melanogaster, GI21357041, Length=256, Percent_Identity=28.515625, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28571526, Length=258, Percent_Identity=28.2945736434109, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24643142, Length=240, Percent_Identity=25.8333333333333, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI23397609, Length=256, Percent_Identity=27.34375, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21355319, Length=248, Percent_Identity=27.8225806451613, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24639444, Length=253, Percent_Identity=29.2490118577075, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24644339, Length=248, Percent_Identity=25.8064516129032, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24644337, Length=263, Percent_Identity=28.1368821292776, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21357673, Length=218, Percent_Identity=29.3577981651376, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.34 [H]

Molecular weight: Translated: 27235; Mature: 27104

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAFKDGLLAGKTAFVAGGTSGINLGIAKRFAELGARVAVAGRDPDKARRAAESIGPDAL
CCCCHHCHHCCCEEEEECCCCCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCCC
GLSADVRDYAAIRAAMEQVTEAFGAMDIVVSGAAGNFLAPAAAMSANAFKTVVDIDLNGT
CCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHCCCCEEEEEEEECCCC
FNVFRGCYDLLNKPGASLIAITAGQAVNAMPLQIHACAAKAGVNQVVRVLAMEWGPEVRV
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEE
NGISPGPIEDTEGMARLAPDPTTRARHHERIPMRRWGRIAEVAEAAVFLCSPSAEYVTGT
CCCCCCCCCCCCCCEECCCCCCHHHHHHCCCCHHHHHHHHHHHHHHEEEECCCCCCEEEE
ILDCDGGSQLGDATRRDVGKGLA
EEECCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
SAFKDGLLAGKTAFVAGGTSGINLGIAKRFAELGARVAVAGRDPDKARRAAESIGPDAL
CCCHHCHHCCCEEEEECCCCCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCCC
GLSADVRDYAAIRAAMEQVTEAFGAMDIVVSGAAGNFLAPAAAMSANAFKTVVDIDLNGT
CCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHCCCCEEEEEEEECCCC
FNVFRGCYDLLNKPGASLIAITAGQAVNAMPLQIHACAAKAGVNQVVRVLAMEWGPEVRV
HHHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCEEE
NGISPGPIEDTEGMARLAPDPTTRARHHERIPMRRWGRIAEVAEAAVFLCSPSAEYVTGT
CCCCCCCCCCCCCCEECCCCCCHHHHHHCCCCHHHHHHHHHHHHHHEEEECCCCCCEEEE
ILDCDGGSQLGDATRRDVGKGLA
EEECCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]