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The map label for this gene is echA12 [H]

Identifier: 197103749

GI number: 197103749

Start: 276401

End: 277198

Strand: Reverse

Name: echA12 [H]

Synonym: PHZ_c0283

Alternate gene names: 197103749

Gene position: 277198-276401 (Counterclockwise)

Preceding gene: 197103750

Following gene: 197103746

Centisome position: 6.94

GC content: 70.68

Gene sequence:

>798_bases
ATGACGGCCTACGAGACCATCCAGATCGAGAAGCGCGGCCAGGTGGACTGGCTGACGCTGAACCGTCCCGAGGCGCTGAA
CGCCATCTCGCTGAAGATGGTGGACGAGCTCGGCGACTATTTCGGCGGCCTCTACAACGACCCCTCGACCCGGATCGTGG
TCATGCGCGGGGCGGGCCGGGCGTTCTGCGCCGGGCTGGACATCAAGGAGGCGGACGCCGGCCAAAACGCCCCCTTCGGC
GGCGGCTTCGGCTTCCAGGGACATCTGGCGGACGTCTACATCCGCATGCGCCGATGCCCGCAGCCGATCGTGGCCCTGGT
GCAGGGGGCGGCCTGCGGCGGCGGCTTCGCCTTCGCCCTGGCCGCCGACATCCGCATCGCCGGCGAGAGCGCGCGGATGA
ACGCCGCCTTCATCCGCCTGGGCCTGTCGGCCTGCGACATGGGGGTCAGCTACTTCCTGCCGCGCCTGGTGGGGACCTCG
GTCGCCGCCGAGCTGATGCTGACCGGCCGCTTCATCGGCGCCCAACGGGCGCTGGCGACCGGCCTCGTCTCGGAGGTCGT
GCCCGACGATCGGCTGGAGGCCGCGGCCGAGCCCTATGTGGACGAAATGCTGACCACCTCGCCCATGGGCCTTCGGCTCA
CCAAGGAGGGGCTGAACCTGGCGGTGGACGCGCCCAGCCTGGAGGCGGCCATGGCCATCGAGAACCGCAACCAGGTGCTC
TGCGCCCGCACCCGCGACTTCGCCGAGGGCCGGCGGGCGTTCATCGAGAAGCGCCGGCCGGTCTACACCGACAGCTGA

Upstream 100 bases:

>100_bases
AGTACGTCACCGGCACGATCCTGGACTGCGACGGCGGCTCGCAGCTGGGCGACGCCACCCGCCGCGACGTCGGCAAGGGC
CTGGCCTAGGGGAGGCGGCG

Downstream 100 bases:

>100_bases
AGCCTCAGCCGCGGCGGTCGATGGGGATCGTCGCGGCCTGAAGCTGCTCGGGACTGTCGGCGTCCGAGACGCCCACGTGG
TGCTTGTAGACCAGCTCCCA

Product: enoyl-CoA hydratase/carnithine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MTAYETIQIEKRGQVDWLTLNRPEALNAISLKMVDELGDYFGGLYNDPSTRIVVMRGAGRAFCAGLDIKEADAGQNAPFG
GGFGFQGHLADVYIRMRRCPQPIVALVQGAACGGGFAFALAADIRIAGESARMNAAFIRLGLSACDMGVSYFLPRLVGTS
VAAELMLTGRFIGAQRALATGLVSEVVPDDRLEAAAEPYVDEMLTTSPMGLRLTKEGLNLAVDAPSLEAAMAIENRNQVL
CARTRDFAEGRRAFIEKRRPVYTDS

Sequences:

>Translated_265_residues
MTAYETIQIEKRGQVDWLTLNRPEALNAISLKMVDELGDYFGGLYNDPSTRIVVMRGAGRAFCAGLDIKEADAGQNAPFG
GGFGFQGHLADVYIRMRRCPQPIVALVQGAACGGGFAFALAADIRIAGESARMNAAFIRLGLSACDMGVSYFLPRLVGTS
VAAELMLTGRFIGAQRALATGLVSEVVPDDRLEAAAEPYVDEMLTTSPMGLRLTKEGLNLAVDAPSLEAAMAIENRNQVL
CARTRDFAEGRRAFIEKRRPVYTDS
>Mature_264_residues
TAYETIQIEKRGQVDWLTLNRPEALNAISLKMVDELGDYFGGLYNDPSTRIVVMRGAGRAFCAGLDIKEADAGQNAPFGG
GFGFQGHLADVYIRMRRCPQPIVALVQGAACGGGFAFALAADIRIAGESARMNAAFIRLGLSACDMGVSYFLPRLVGTSV
AAELMLTGRFIGAQRALATGLVSEVVPDDRLEAAAEPYVDEMLTTSPMGLRLTKEGLNLAVDAPSLEAAMAIENRNQVLC
ARTRDFAEGRRAFIEKRRPVYTDS

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=267, Percent_Identity=34.0823970037453, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI70995211, Length=267, Percent_Identity=29.9625468164794, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI37594469, Length=204, Percent_Identity=30.8823529411765, Blast_Score=92, Evalue=6e-19,
Organism=Homo sapiens, GI37594471, Length=199, Percent_Identity=31.1557788944724, Blast_Score=91, Evalue=7e-19,
Organism=Homo sapiens, GI31542718, Length=249, Percent_Identity=28.1124497991968, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4502327, Length=261, Percent_Identity=31.8007662835249, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI68989263, Length=174, Percent_Identity=34.4827586206897, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI45643119, Length=221, Percent_Identity=27.1493212669683, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI260275230, Length=221, Percent_Identity=27.1493212669683, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI260274832, Length=221, Percent_Identity=27.1493212669683, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI221142681, Length=264, Percent_Identity=32.9545454545455, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1787660, Length=247, Percent_Identity=34.0080971659919, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788597, Length=263, Percent_Identity=31.9391634980989, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1787659, Length=254, Percent_Identity=32.2834645669291, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI87082183, Length=268, Percent_Identity=26.1194029850746, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1790281, Length=190, Percent_Identity=29.4736842105263, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788682, Length=217, Percent_Identity=29.0322580645161, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17554946, Length=263, Percent_Identity=34.6007604562738, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI25145438, Length=248, Percent_Identity=35.0806451612903, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17536985, Length=272, Percent_Identity=30.5147058823529, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17534483, Length=221, Percent_Identity=30.316742081448, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17540714, Length=223, Percent_Identity=29.1479820627803, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17549921, Length=217, Percent_Identity=31.3364055299539, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17535521, Length=224, Percent_Identity=29.9107142857143, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17560910, Length=190, Percent_Identity=28.9473684210526, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI25144157, Length=208, Percent_Identity=30.2884615384615, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI25144160, Length=208, Percent_Identity=30.2884615384615, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17558304, Length=192, Percent_Identity=29.6875, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17540306, Length=237, Percent_Identity=27.4261603375527, Blast_Score=71, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6320241, Length=185, Percent_Identity=27.5675675675676, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI20129971, Length=266, Percent_Identity=35.3383458646617, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24653477, Length=266, Percent_Identity=35.3383458646617, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24653139, Length=256, Percent_Identity=32.8125, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI19920382, Length=255, Percent_Identity=31.3725490196078, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21357171, Length=192, Percent_Identity=30.2083333333333, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI19922422, Length=258, Percent_Identity=25.1937984496124, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24654903, Length=221, Percent_Identity=27.1493212669683, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24650670, Length=182, Percent_Identity=30.7692307692308, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571730, Length=159, Percent_Identity=32.0754716981132, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28571729, Length=159, Percent_Identity=32.0754716981132, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 28533; Mature: 28402

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAYETIQIEKRGQVDWLTLNRPEALNAISLKMVDELGDYFGGLYNDPSTRIVVMRGAGR
CCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
AFCAGLDIKEADAGQNAPFGGGFGFQGHLADVYIRMRRCPQPIVALVQGAACGGGFAFAL
EEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEE
AADIRIAGESARMNAAFIRLGLSACDMGVSYFLPRLVGTSVAAELMLTGRFIGAQRALAT
EEEEEEECCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLVSEVVPDDRLEAAAEPYVDEMLTTSPMGLRLTKEGLNLAVDAPSLEAAMAIENRNQVL
HHHHHHCCCHHHHHHHCHHHHHHHCCCCCCEEEECCCCEEEEECCCCCEEEEECCCCCEE
CARTRDFAEGRRAFIEKRRPVYTDS
EECCHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TAYETIQIEKRGQVDWLTLNRPEALNAISLKMVDELGDYFGGLYNDPSTRIVVMRGAGR
CCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCC
AFCAGLDIKEADAGQNAPFGGGFGFQGHLADVYIRMRRCPQPIVALVQGAACGGGFAFAL
EEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHCCCCCCCEEEEE
AADIRIAGESARMNAAFIRLGLSACDMGVSYFLPRLVGTSVAAELMLTGRFIGAQRALAT
EEEEEEECCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLVSEVVPDDRLEAAAEPYVDEMLTTSPMGLRLTKEGLNLAVDAPSLEAAMAIENRNQVL
HHHHHHCCCHHHHHHHCHHHHHHHCCCCCCEEEECCCCEEEEECCCCCEEEEECCCCCEE
CARTRDFAEGRRAFIEKRRPVYTDS
EECCHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]