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The map label for this gene is moaA [H]

Identifier: 197103746

GI number: 197103746

Start: 274156

End: 275181

Strand: Reverse

Name: moaA [H]

Synonym: PHZ_c0280

Alternate gene names: 197103746

Gene position: 275181-274156 (Counterclockwise)

Preceding gene: 197103749

Following gene: 197103745

Centisome position: 6.89

GC content: 72.81

Gene sequence:

>1026_bases
ATGACGCACACGCCTGACCTTTCGCCGCAAGGCCCCGCGCTCGTGGACGGCTTCGGCCGCGGGGTGACCTACCTGCGCCT
GTCGGTGACCGACCGCTGCGACCTGCGGTGCGTCTACTGCATGGCCGAGCACATGACCTTCCTGCCGAAGGCGCAGGTGC
TGACCCTGGAGGAGCTGGACCGCATCGCCTCGGCCTTCGTGGCCCTGGGCGTCAGGAAGCTGCGGCTCACCGGCGGCGAG
CCCCTGGTTCGCAAGGGCGTGATGGAGCTGATCGAGGCCCTGTCGCGGCACCTGGCGTCCGGCGCGCTCTCCGAGCTGAC
CCTGACCACCAACGGCACCCAGCTCGCCGGGTTCGCCCCGCGCCTGGCGGCGGCCGGCGTGCGGCGGGTGAACGTCTCGC
TGGACACCCTGAAGCCCGACCTCTTCCGTCGGCTCACCCGGGGGGGCGACCTTTCCAAGGTGCTGGCCGGGATCGAGGCG
GCGCAGGCGGCGGGGCTGTCGGTGAAGATCAACGCCGTGGCCCTGAAGGACGACAACGCCGCCGAGCTGCCCGAGCTGAT
CGCCTGGGCCCACGGCCGCGGCTGCGACGTGACCCTCATCGAGACCATGCCGATGGGCGAGGTCGAGGCCGACCGCACCG
ACCAGTTCCTGTCGCTGAGGGACGTGCGGCGCGAGCTGGAGAGCTACTGGCGGCTGGAGGACCTGCCGCTCGACACCGGC
GGCCCCGCCCGCTACGTCCGCGTCGCCGAGACCGGCGGGCGGCTGGGGTTCATCACCCCGCTCAGCCACAATTTCTGCGA
GGGCTGCAATCGCGTGCGGCTGACCTGCACCGGGACCCTGCACACCTGCCTGGGGCAGGACGATTCCGCCGACCTGCGCG
CGGTCCTGCGGGCCGGCGGCGGCGAGGCCGAGCTGATCGCGGCGATCCGTGGGGCGGTGGACGCCAAGCCCAGAGGCCAC
GACTTCCAGATCGCCCGCGCCGCGGCCCCGGCCGTCGCCCGGCACATGTCCACGACCGGGGGCTGA

Upstream 100 bases:

>100_bases
GGTCAGCAGCTTGCCGCCCCCGAACCGGGAGCCCGCACCCGCCGCCAGGACAACCGCCTCTGTCGCCACGACCGGTTCGC
CTCTATCTTGGTCCGAGCCT

Downstream 100 bases:

>100_bases
GCATGGCGCGCGTGCTGCTGTTCGGGCCCCTGCGCGACCTCGCCGGCTGGCGCGAGCGGACCCTGGACGCGGCCTCGCTG
TCGGCCCTGAAGGCCCTGAT

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MTHTPDLSPQGPALVDGFGRGVTYLRLSVTDRCDLRCVYCMAEHMTFLPKAQVLTLEELDRIASAFVALGVRKLRLTGGE
PLVRKGVMELIEALSRHLASGALSELTLTTNGTQLAGFAPRLAAAGVRRVNVSLDTLKPDLFRRLTRGGDLSKVLAGIEA
AQAAGLSVKINAVALKDDNAAELPELIAWAHGRGCDVTLIETMPMGEVEADRTDQFLSLRDVRRELESYWRLEDLPLDTG
GPARYVRVAETGGRLGFITPLSHNFCEGCNRVRLTCTGTLHTCLGQDDSADLRAVLRAGGGEAELIAAIRGAVDAKPRGH
DFQIARAAAPAVARHMSTTGG

Sequences:

>Translated_341_residues
MTHTPDLSPQGPALVDGFGRGVTYLRLSVTDRCDLRCVYCMAEHMTFLPKAQVLTLEELDRIASAFVALGVRKLRLTGGE
PLVRKGVMELIEALSRHLASGALSELTLTTNGTQLAGFAPRLAAAGVRRVNVSLDTLKPDLFRRLTRGGDLSKVLAGIEA
AQAAGLSVKINAVALKDDNAAELPELIAWAHGRGCDVTLIETMPMGEVEADRTDQFLSLRDVRRELESYWRLEDLPLDTG
GPARYVRVAETGGRLGFITPLSHNFCEGCNRVRLTCTGTLHTCLGQDDSADLRAVLRAGGGEAELIAAIRGAVDAKPRGH
DFQIARAAAPAVARHMSTTGG
>Mature_340_residues
THTPDLSPQGPALVDGFGRGVTYLRLSVTDRCDLRCVYCMAEHMTFLPKAQVLTLEELDRIASAFVALGVRKLRLTGGEP
LVRKGVMELIEALSRHLASGALSELTLTTNGTQLAGFAPRLAAAGVRRVNVSLDTLKPDLFRRLTRGGDLSKVLAGIEAA
QAAGLSVKINAVALKDDNAAELPELIAWAHGRGCDVTLIETMPMGEVEADRTDQFLSLRDVRRELESYWRLEDLPLDTGG
PARYVRVAETGGRLGFITPLSHNFCEGCNRVRLTCTGTLHTCLGQDDSADLRAVLRAGGGEAELIAAIRGAVDAKPRGHD
FQIARAAAPAVARHMSTTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=316, Percent_Identity=38.2911392405063, Blast_Score=207, Evalue=1e-53,
Organism=Homo sapiens, GI22027536, Length=316, Percent_Identity=38.2911392405063, Blast_Score=207, Evalue=1e-53,
Organism=Escherichia coli, GI1786999, Length=331, Percent_Identity=32.3262839879154, Blast_Score=173, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17561210, Length=313, Percent_Identity=37.6996805111821, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI32566331, Length=336, Percent_Identity=36.0119047619048, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI32566329, Length=315, Percent_Identity=36.8253968253968, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI28574490, Length=330, Percent_Identity=36.969696969697, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI28574488, Length=314, Percent_Identity=37.5796178343949, Blast_Score=202, Evalue=4e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 36560; Mature: 36429

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHTPDLSPQGPALVDGFGRGVTYLRLSVTDRCDLRCVYCMAEHMTFLPKAQVLTLEELD
CCCCCCCCCCCCHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCHHEEEHHHHH
RIASAFVALGVRKLRLTGGEPLVRKGVMELIEALSRHLASGALSELTLTTNGTQLAGFAP
HHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCEECCCCH
RLAAAGVRRVNVSLDTLKPDLFRRLTRGGDLSKVLAGIEAAQAAGLSVKINAVALKDDNA
HHHHCCCEEEEEEHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCH
AELPELIAWAHGRGCDVTLIETMPMGEVEADRTDQFLSLRDVRRELESYWRLEDLPLDTG
HHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHCCCCCCC
GPARYVRVAETGGRLGFITPLSHNFCEGCNRVRLTCTGTLHTCLGQDDSADLRAVLRAGG
CCCEEEEEEECCCCEEEECCCCCHHHCCCCEEEEEEECHHHHHCCCCCCHHHHHHHHCCC
GEAELIAAIRGAVDAKPRGHDFQIARAAAPAVARHMSTTGG
CCHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
THTPDLSPQGPALVDGFGRGVTYLRLSVTDRCDLRCVYCMAEHMTFLPKAQVLTLEELD
CCCCCCCCCCCHHHHHCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCHHEEEHHHHH
RIASAFVALGVRKLRLTGGEPLVRKGVMELIEALSRHLASGALSELTLTTNGTQLAGFAP
HHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCEECCCCH
RLAAAGVRRVNVSLDTLKPDLFRRLTRGGDLSKVLAGIEAAQAAGLSVKINAVALKDDNA
HHHHCCCEEEEEEHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCH
AELPELIAWAHGRGCDVTLIETMPMGEVEADRTDQFLSLRDVRRELESYWRLEDLPLDTG
HHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHCCCCCCC
GPARYVRVAETGGRLGFITPLSHNFCEGCNRVRLTCTGTLHTCLGQDDSADLRAVLRAGG
CCCEEEEEEECCCCEEEECCCCCHHHCCCCEEEEEEECHHHHHCCCCCCHHHHHHHHCCC
GEAELIAAIRGAVDAKPRGHDFQIARAAAPAVARHMSTTGG
CCHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11259647 [H]