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The map label for this gene is trpF [H]

Identifier: 197103660

GI number: 197103660

Start: 187276

End: 187911

Strand: Direct

Name: trpF [H]

Synonym: PHZ_c0194

Alternate gene names: 197103660

Gene position: 187276-187911 (Clockwise)

Preceding gene: 197103658

Following gene: 197103661

Centisome position: 4.69

GC content: 73.9

Gene sequence:

>636_bases
ATGGCCAAGATCTGCGGGGTCTCGACGCCCGAGGCGGTGAGCGCCGCCCTCGACGGCGGGGCGGCCTTCCTGGGCTTCAT
GTTCTTCCCGAAGAGCCCGCGGAACGTCAGCCCCGAGGCGGCGGCCCGGCTGACGCCGCCGGCCCGGGCGCGCGGGGCGA
AGGTCGTGGCGGTGGTGGTGGATCCCTCCGACACCGAGCTGGACGCCATCGTGGCCGGCCTGTCCCCCGACCTGATCCAG
CTCCACGGCAAGGAGAGCCCGGCGCGGGTGCGCGAGATCGCCGGGCGGACGGGGTGCGGGATCATCAAGGTGACGCCGGT
GTCCGAGCCCTCGGACGTGGCCGCCGCCCGCGCCTACGAGCCCCTGGTCGAGCACCTGATGTTCGAGACCAAGCCGCCGA
AGGACGCCGACCGGCCCGGCGGCCTCGGCGTTCCGTTCGACTGGACCCTGCTGGAGGGCGCCCGGTTCGCGCGGCCCTGG
TTCCTGGCCGGCGGGCTCGATCCCTGGAACGTGGGCGAGGCGATCGCCGCCTCGGGCGCGCCGCTGGTGGACGTTTCCTC
TGGCGTGGAGCGCGGCCCCGGACTAAAGGACCCCACCTTGATCCGGGCGTTCCTCGACGCCGTCAGACGCGCCTAA

Upstream 100 bases:

>100_bases
CCCGGGTTCGCCAGGGAAAACCCGGCACGGGCGGGGCCGTTCCGGCGCTTAGCACTTGCAGGGGAGCTCACGAGCCTCCT
AATCCCGCCGCATGACGGCG

Downstream 100 bases:

>100_bases
GAGCCTCGTTTTGAACGCGCCTTCCCGTCCGAACGACTACGCGGCCTATCCCGACCTCAAGGGGCGGTTCGGCGACTACG
GCGGCCAGTACGTGCCGGAA

Product: N-(5'-phosphoribosyl)anthranilate isomerase

Products: NA

Alternate protein names: PRAI [H]

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MAKICGVSTPEAVSAALDGGAAFLGFMFFPKSPRNVSPEAAARLTPPARARGAKVVAVVVDPSDTELDAIVAGLSPDLIQ
LHGKESPARVREIAGRTGCGIIKVTPVSEPSDVAAARAYEPLVEHLMFETKPPKDADRPGGLGVPFDWTLLEGARFARPW
FLAGGLDPWNVGEAIAASGAPLVDVSSGVERGPGLKDPTLIRAFLDAVRRA

Sequences:

>Translated_211_residues
MAKICGVSTPEAVSAALDGGAAFLGFMFFPKSPRNVSPEAAARLTPPARARGAKVVAVVVDPSDTELDAIVAGLSPDLIQ
LHGKESPARVREIAGRTGCGIIKVTPVSEPSDVAAARAYEPLVEHLMFETKPPKDADRPGGLGVPFDWTLLEGARFARPW
FLAGGLDPWNVGEAIAASGAPLVDVSSGVERGPGLKDPTLIRAFLDAVRRA
>Mature_210_residues
AKICGVSTPEAVSAALDGGAAFLGFMFFPKSPRNVSPEAAARLTPPARARGAKVVAVVVDPSDTELDAIVAGLSPDLIQL
HGKESPARVREIAGRTGCGIIKVTPVSEPSDVAAARAYEPLVEHLMFETKPPKDADRPGGLGVPFDWTLLEGARFARPWF
LAGGLDPWNVGEAIAASGAPLVDVSSGVERGPGLKDPTLIRAFLDAVRRA

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=214, Percent_Identity=30.3738317757009, Blast_Score=72, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320210, Length=231, Percent_Identity=27.7056277056277, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00697 PRAI [H]

EC number: =5.3.1.24 [H]

Molecular weight: Translated: 21999; Mature: 21868

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKICGVSTPEAVSAALDGGAAFLGFMFFPKSPRNVSPEAAARLTPPARARGAKVVAVVV
CCCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHCCCCEEEEEEE
DPSDTELDAIVAGLSPDLIQLHGKESPARVREIAGRTGCGIIKVTPVSEPSDVAAARAYE
CCCCCCHHHHHHCCCCCEEEECCCCCHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHH
PLVEHLMFETKPPKDADRPGGLGVPFDWTLLEGARFARPWFLAGGLDPWNVGEAIAASGA
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCEEEECCCCCCCCCHHHHCCCC
PLVDVSSGVERGPGLKDPTLIRAFLDAVRRA
CEEECCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AKICGVSTPEAVSAALDGGAAFLGFMFFPKSPRNVSPEAAARLTPPARARGAKVVAVVV
CCCCCCCCHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHCCCCEEEEEEE
DPSDTELDAIVAGLSPDLIQLHGKESPARVREIAGRTGCGIIKVTPVSEPSDVAAARAYE
CCCCCCHHHHHHCCCCCEEEECCCCCHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHH
PLVEHLMFETKPPKDADRPGGLGVPFDWTLLEGARFARPWFLAGGLDPWNVGEAIAASGA
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCEEEECCCCCCCCCHHHHCCCC
PLVDVSSGVERGPGLKDPTLIRAFLDAVRRA
CEEECCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2828322; 11259647 [H]