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The map label for this gene is tesB [H]

Identifier: 197103579

GI number: 197103579

Start: 103547

End: 104419

Strand: Direct

Name: tesB [H]

Synonym: PHZ_c0113

Alternate gene names: 197103579

Gene position: 103547-104419 (Clockwise)

Preceding gene: 197103575

Following gene: 197103580

Centisome position: 2.59

GC content: 68.73

Gene sequence:

>873_bases
ATGAGCGAGACCGACGCCCAAGACGAGACCCTGGTCGAGACTCTCCAGCTGGAGCGGATCGAGGAGAACCTGTTCCGCGG
GACCTCGCCCGACAACGCGCCGGGCCGCATCTTCGGCGGGCAGGTGATCGCCCAGTCGCTGCTGGCGGCCTACGAGACGG
TGGAGTCGCGGGTCTGCCACTCGCTGCACTGCTATTTCATCCGGCCGGGCGATCCGACCGTGCCGATCGTCTTCGAGGTG
GACCGGTCCCGCGACGGCGGCAGCTTCACCACCCGCCGGGTCGTGGCGGTCCAGCACGGCAAGCAGATCTTCAATCTCGC
CGCCTCGTTCAAGGACCCGGAGGAGGGCTTCCGCCACCAGGCCCCGATGCCGGAAGGCCCGCACTGGTCCGAGCTGAAGG
ACCAGATGGAGGTCCTGCGCGAGCTGATGAAGGACGCGCCCGAACAGGCCAAGCGCTGGCTCTCGCGGCCGATGCCGATC
GAGATGCGCTCGAAGGACGCCCGGACCTACTGGCTGGACGGGCCCAAGGAGCCGGTGTCGCAGAACTGGTTCCGGTGCCG
CACGCCGATCGGGGGCGATGCGCGCATGCACCAGGTGATCCTGGCCTACGCGTCGGACATGAACCTGCTCTCGACGGCCA
TGCGTCCGCACCAGGTCCACTGGCAGACGCCGGGCTTCCAGTCGGCGAGCCTGGACCACGCCATGTGGTTCCACGCCCCG
ACCGACTTCAACACCTGGCACCTCTACGTCCACGACAGCCCCTCGGCGTCGGACGGGCGCGGACTGATCCGGGGCGCGAT
CTACGCCGAGGACGGCACGCTGGTCGCCTCGGTCGCCCAGGAAGGCCTGATGCGGATGAAGGCCGCGAAGTAG

Upstream 100 bases:

>100_bases
AGTACGGCGCAGTCGAAGGACATGGCGGTCGTAAGGCGGGCGCCGACGCCGCCACGTCAAGCCTTGCCGGGCGCGGCGCC
CCCGCGTATCGCCGCTGGTC

Downstream 100 bases:

>100_bases
ACGGCCTCGCCGCGGCGGCGTAATGCACGCGCCTTCGCACTTGCAGCATCCGCGGACGCCATGGACACCCAGACGCTGGT
CGAAACGCTCGGGCTGGAGC

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MSETDAQDETLVETLQLERIEENLFRGTSPDNAPGRIFGGQVIAQSLLAAYETVESRVCHSLHCYFIRPGDPTVPIVFEV
DRSRDGGSFTTRRVVAVQHGKQIFNLAASFKDPEEGFRHQAPMPEGPHWSELKDQMEVLRELMKDAPEQAKRWLSRPMPI
EMRSKDARTYWLDGPKEPVSQNWFRCRTPIGGDARMHQVILAYASDMNLLSTAMRPHQVHWQTPGFQSASLDHAMWFHAP
TDFNTWHLYVHDSPSASDGRGLIRGAIYAEDGTLVASVAQEGLMRMKAAK

Sequences:

>Translated_290_residues
MSETDAQDETLVETLQLERIEENLFRGTSPDNAPGRIFGGQVIAQSLLAAYETVESRVCHSLHCYFIRPGDPTVPIVFEV
DRSRDGGSFTTRRVVAVQHGKQIFNLAASFKDPEEGFRHQAPMPEGPHWSELKDQMEVLRELMKDAPEQAKRWLSRPMPI
EMRSKDARTYWLDGPKEPVSQNWFRCRTPIGGDARMHQVILAYASDMNLLSTAMRPHQVHWQTPGFQSASLDHAMWFHAP
TDFNTWHLYVHDSPSASDGRGLIRGAIYAEDGTLVASVAQEGLMRMKAAK
>Mature_289_residues
SETDAQDETLVETLQLERIEENLFRGTSPDNAPGRIFGGQVIAQSLLAAYETVESRVCHSLHCYFIRPGDPTVPIVFEVD
RSRDGGSFTTRRVVAVQHGKQIFNLAASFKDPEEGFRHQAPMPEGPHWSELKDQMEVLRELMKDAPEQAKRWLSRPMPIE
MRSKDARTYWLDGPKEPVSQNWFRCRTPIGGDARMHQVILAYASDMNLLSTAMRPHQVHWQTPGFQSASLDHAMWFHAPT
DFNTWHLYVHDSPSASDGRGLIRGAIYAEDGTLVASVAQEGLMRMKAAK

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=292, Percent_Identity=40.0684931506849, Blast_Score=206, Evalue=3e-53,
Organism=Escherichia coli, GI1786657, Length=269, Percent_Identity=45.724907063197, Blast_Score=246, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI71988741, Length=302, Percent_Identity=37.0860927152318, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17558508, Length=313, Percent_Identity=35.7827476038339, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI115532456, Length=277, Percent_Identity=36.101083032491, Blast_Score=140, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17531889, Length=277, Percent_Identity=36.101083032491, Blast_Score=140, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17531885, Length=277, Percent_Identity=36.101083032491, Blast_Score=140, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI212645202, Length=289, Percent_Identity=33.9100346020761, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71982224, Length=300, Percent_Identity=31.3333333333333, Blast_Score=115, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 32788; Mature: 32657

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETDAQDETLVETLQLERIEENLFRGTSPDNAPGRIFGGQVIAQSLLAAYETVESRVCH
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHC
SLHCYFIRPGDPTVPIVFEVDRSRDGGSFTTRRVVAVQHGKQIFNLAASFKDPEEGFRHQ
CEEEEEECCCCCCEEEEEEECCCCCCCCCHHEEEEHHHHHHHHHHHHHCCCCHHHHHHCC
APMPEGPHWSELKDQMEVLRELMKDAPEQAKRWLSRPMPIEMRSKDARTYWLDGPKEPVS
CCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEECCCCCCEEECCCCCCCCC
QNWFRCRTPIGGDARMHQVILAYASDMNLLSTAMRPHQVHWQTPGFQSASLDHAMWFHAP
CCCEEECCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCEEEECCCCCCCCCCCCEEEEECC
TDFNTWHLYVHDSPSASDGRGLIRGAIYAEDGTLVASVAQEGLMRMKAAK
CCCCEEEEEEECCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SETDAQDETLVETLQLERIEENLFRGTSPDNAPGRIFGGQVIAQSLLAAYETVESRVCH
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHC
SLHCYFIRPGDPTVPIVFEVDRSRDGGSFTTRRVVAVQHGKQIFNLAASFKDPEEGFRHQ
CEEEEEECCCCCCEEEEEEECCCCCCCCCHHEEEEHHHHHHHHHHHHHCCCCHHHHHHCC
APMPEGPHWSELKDQMEVLRELMKDAPEQAKRWLSRPMPIEMRSKDARTYWLDGPKEPVS
CCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEECCCCCCEEECCCCCCCCC
QNWFRCRTPIGGDARMHQVILAYASDMNLLSTAMRPHQVHWQTPGFQSASLDHAMWFHAP
CCCEEECCCCCCCHHHHHHHHHHHCCHHHHHHHCCCCEEEECCCCCCCCCCCCEEEEECC
TDFNTWHLYVHDSPSASDGRGLIRGAIYAEDGTLVASVAQEGLMRMKAAK
CCCCEEEEEEECCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]