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The map label for this gene is tesB [H]

Identifier: 197103580

GI number: 197103580

Start: 104480

End: 105349

Strand: Direct

Name: tesB [H]

Synonym: PHZ_c0114

Alternate gene names: 197103580

Gene position: 104480-105349 (Clockwise)

Preceding gene: 197103579

Following gene: 197103584

Centisome position: 2.61

GC content: 69.77

Gene sequence:

>870_bases
ATGGACACCCAGACGCTGGTCGAAACGCTCGGGCTGGAGCAGCTCGAGGTGAACCTCTTCCGGGGGACCACTCCCGACAA
GGAGCAGCGCCAGCGCATCTACGGCGGCCAGGTGATCGCCCAGTCCCTGCTGGCGGCCTACGAGACGGTCGAGGGCCGGA
TCTGCCACTCGCTGCACTGCTACTTCATCCGGCCGGGCGACCCGACCGTGCCGATCATCTTCGAGGTGGACCGGGCGCGC
GACGGGGGCAGCTTCACCACCCGTCGGGTGGTGGCCATCCAGCACGGTCAGCAGATCTTCAACCTGGCGGCCTCGTTCCA
GACCGAGGAGCAGGGCTTCGAGCACCAGGCCGACATGCCCGCCGCGCCCTCGCCCGACGAGGTGGAGGACGACGCCGTCG
TGCGCCGCCGGCTCAATCCGAACCCGCCGCCGCAGGACGTCGACTGGATCGACCGCGTGCAGCCGATCGAGATGCGAACC
GTCGGCGGCCGCTTCGACACCGCCAGTCCCGAGCCGCGCGACCCGCACCAGCAGGTCTGGTTCCGCGCCCGCCATCCGAT
CGGCGATGATCCGCACATGCACCAGGTGATCCTGGCCTACGCCTCGGACATGAGCCTCCTGGGCACCGCGATCCGCCCGC
ACGGGGTGAGCTGGCGCACGCCGGGCTTCCAGTCGGCGAGCCTGGACCACGCCATGTGGTTCCACCGCCCGACCGACTTC
AACGAATGGCACCTGTACGTCCAGGAGAGCCCCAGCGCCTCGGGCGGGCGGGGCTTCAACCTGGGCTACATCTACCGGGC
CTCGGACGGGGTGCTGGTGGCGTCCTGCGCCCAGGAAGGCCTGATGCGAATGCGCAAGCCGAAGGCCTGA

Upstream 100 bases:

>100_bases
CGCCCAGGAAGGCCTGATGCGGATGAAGGCCGCGAAGTAGACGGCCTCGCCGCGGCGGCGTAATGCACGCGCCTTCGCAC
TTGCAGCATCCGCGGACGCC

Downstream 100 bases:

>100_bases
CCTACTCGGTTTCCTCGGGGCGCACGGCCACGACCTTGCCCTCGGCGAGGCGCACCTCGGGCACGGCCTCCTTCGTGAAC
GGCAGGTACCAGGCGGCGCC

Product: acyl-CoA thiolesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MDTQTLVETLGLEQLEVNLFRGTTPDKEQRQRIYGGQVIAQSLLAAYETVEGRICHSLHCYFIRPGDPTVPIIFEVDRAR
DGGSFTTRRVVAIQHGQQIFNLAASFQTEEQGFEHQADMPAAPSPDEVEDDAVVRRRLNPNPPPQDVDWIDRVQPIEMRT
VGGRFDTASPEPRDPHQQVWFRARHPIGDDPHMHQVILAYASDMSLLGTAIRPHGVSWRTPGFQSASLDHAMWFHRPTDF
NEWHLYVQESPSASGGRGFNLGYIYRASDGVLVASCAQEGLMRMRKPKA

Sequences:

>Translated_289_residues
MDTQTLVETLGLEQLEVNLFRGTTPDKEQRQRIYGGQVIAQSLLAAYETVEGRICHSLHCYFIRPGDPTVPIIFEVDRAR
DGGSFTTRRVVAIQHGQQIFNLAASFQTEEQGFEHQADMPAAPSPDEVEDDAVVRRRLNPNPPPQDVDWIDRVQPIEMRT
VGGRFDTASPEPRDPHQQVWFRARHPIGDDPHMHQVILAYASDMSLLGTAIRPHGVSWRTPGFQSASLDHAMWFHRPTDF
NEWHLYVQESPSASGGRGFNLGYIYRASDGVLVASCAQEGLMRMRKPKA
>Mature_289_residues
MDTQTLVETLGLEQLEVNLFRGTTPDKEQRQRIYGGQVIAQSLLAAYETVEGRICHSLHCYFIRPGDPTVPIIFEVDRAR
DGGSFTTRRVVAIQHGQQIFNLAASFQTEEQGFEHQADMPAAPSPDEVEDDAVVRRRLNPNPPPQDVDWIDRVQPIEMRT
VGGRFDTASPEPRDPHQQVWFRARHPIGDDPHMHQVILAYASDMSLLGTAIRPHGVSWRTPGFQSASLDHAMWFHRPTDF
NEWHLYVQESPSASGGRGFNLGYIYRASDGVLVASCAQEGLMRMRKPKA

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=294, Percent_Identity=41.156462585034, Blast_Score=197, Evalue=1e-50,
Organism=Escherichia coli, GI1786657, Length=272, Percent_Identity=48.8970588235294, Blast_Score=251, Evalue=3e-68,
Organism=Caenorhabditis elegans, GI17558508, Length=312, Percent_Identity=37.1794871794872, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71988741, Length=303, Percent_Identity=35.6435643564356, Blast_Score=159, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI115532456, Length=276, Percent_Identity=38.768115942029, Blast_Score=151, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17531889, Length=276, Percent_Identity=38.768115942029, Blast_Score=151, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17531885, Length=276, Percent_Identity=38.768115942029, Blast_Score=150, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI212645202, Length=288, Percent_Identity=28.4722222222222, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71982224, Length=274, Percent_Identity=31.3868613138686, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6322480, Length=299, Percent_Identity=26.7558528428094, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 32583; Mature: 32583

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTQTLVETLGLEQLEVNLFRGTTPDKEQRQRIYGGQVIAQSLLAAYETVEGRICHSLHC
CCHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
YFIRPGDPTVPIIFEVDRARDGGSFTTRRVVAIQHGQQIFNLAASFQTEEQGFEHQADMP
EEECCCCCCEEEEEEEECCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCHHHCCCCCCCCC
AAPSPDEVEDDAVVRRRLNPNPPPQDVDWIDRVQPIEMRTVGGRFDTASPEPRDPHQQVW
CCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHH
FRARHPIGDDPHMHQVILAYASDMSLLGTAIRPHGVSWRTPGFQSASLDHAMWFHRPTDF
HHCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHEECCCCCC
NEWHLYVQESPSASGGRGFNLGYIYRASDGVLVASCAQEGLMRMRKPKA
CCEEEEEECCCCCCCCCCCCEEEEEECCCCEEEEHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDTQTLVETLGLEQLEVNLFRGTTPDKEQRQRIYGGQVIAQSLLAAYETVEGRICHSLHC
CCHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
YFIRPGDPTVPIIFEVDRARDGGSFTTRRVVAIQHGQQIFNLAASFQTEEQGFEHQADMP
EEECCCCCCEEEEEEEECCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCHHHCCCCCCCCC
AAPSPDEVEDDAVVRRRLNPNPPPQDVDWIDRVQPIEMRTVGGRFDTASPEPRDPHQQVW
CCCCCCCCCHHHHHHHCCCCCCCCCCCCHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHH
FRARHPIGDDPHMHQVILAYASDMSLLGTAIRPHGVSWRTPGFQSASLDHAMWFHRPTDF
HHCCCCCCCCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHEECCCCCC
NEWHLYVQESPSASGGRGFNLGYIYRASDGVLVASCAQEGLMRMRKPKA
CCEEEEEECCCCCCCCCCCCEEEEEECCCCEEEEHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]