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The map label for this gene is fhuB [H]

Identifier: 195978720

GI number: 195978720

Start: 1666882

End: 1667934

Strand: Direct

Name: fhuB [H]

Synonym: Sez_1620

Alternate gene names: 195978720

Gene position: 1666882-1667934 (Clockwise)

Preceding gene: 195978719

Following gene: 195978721

Centisome position: 82.35

GC content: 45.68

Gene sequence:

>1053_bases
ATGGGGCAAATCACTAAAAAGCTTAAGATGACAGCTCAACATCATACTAAGCCTAAACTAACTAAAGCAGCTCCTCCTTG
GCTGATCTTAACCTTTATCAGCTTAACTCTAGTGCTTGCCATTTACTGCAGTCTGAGGTTTGGGGCTGTGTCACTATCAC
ATCAGGAGCTCTTTCATATTCTGCTTGGAAAGCATGGTCTGGGGCAAAAGGCCAGCATTATTTGGGATATTCGCCTGCCC
CGCTTGATTTTAGCGGCTCTAGTTGGTGCTGCACTTGCTGTTTCAGGAGCTATCATGCAGGGCATTACGAGAAATCCCAT
TGCTGAGCCTGGCTTACTGGGAATCAACTCTGGTGCTGGTCTGGCATTAGTTATCGGCTATGCTTTTTTCCCTCACCTTC
ATTATTCGATAATTATCTTGCTTTCCTTGTTAGGGTCACTCTTAGCAACCCTATTAATTCTTAGTCTAGCCTATCAAACT
CGCAAGGGCTACACTCAAATGAGGCTGATTTTAGCAGGAGCAATGATTTCTATGTTGCTATCAGCTATCGGACAAGGAAT
AACAACTTATTGTCACCTAGCCAATGCCATTATCGGCTGGCAGGCGGGAGGTTTGATTGGAGTCAATTGGCAGATGGTTA
GCTATGTTGCTCCGCTCATCATCTGTGGCTTAGTCCTATCTTATCTGCTAGCCTATCATTTGACCATTTTAAGCTTAAGT
CAAGAGCAGGCCAAGGCCCTAGGGCAACGCACCTTCTTGATTAGCCTTATCTTTATTGGACTTGTGCTGCTTCTGTCTTC
TGCTGCTGTAGCAGTAGCCGGCAGCATTTCCTTTGTCGGCTTGATTATCCCTCATGCCATCACATTAGTCACTGCTAAGG
ATTACCGCTGGATCCTGCCGCTAGCTACTCTTCTTGGAGCCAGCTTTATGCTTTGGGTAGACTTTGCCTGTCGGAATATC
AATCCCCCCTATGAAACACCGCTATCTGCTTTGATCAGCTTTATTGGGCTGCCCTGCTTTTTATGGCTAGTTAGAAAAGG
AGGTCGCTTTTGA

Upstream 100 bases:

>100_bases
AACAATCATGTCATCAAGGTCAATGCTAATGTCTTTTACTTCACAGACCCACTGTCACTAGAGCACCAGCTTGAGGTTCT
GAAAAAGGCTATTCTCTCAA

Downstream 100 bases:

>100_bases
CAGCTACTAAAAGACACGTCCCATTATTTCTAGGGCTAAGCGCTGGACTGGTCTGCTTGATGATCATTTCCTTATCTATT
GGGGATTCTAGCATGTCACC

Product: ferrichrome transport system permease protein FhuB

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 350; Mature: 349

Protein sequence:

>350_residues
MGQITKKLKMTAQHHTKPKLTKAAPPWLILTFISLTLVLAIYCSLRFGAVSLSHQELFHILLGKHGLGQKASIIWDIRLP
RLILAALVGAALAVSGAIMQGITRNPIAEPGLLGINSGAGLALVIGYAFFPHLHYSIIILLSLLGSLLATLLILSLAYQT
RKGYTQMRLILAGAMISMLLSAIGQGITTYCHLANAIIGWQAGGLIGVNWQMVSYVAPLIICGLVLSYLLAYHLTILSLS
QEQAKALGQRTFLISLIFIGLVLLLSSAAVAVAGSISFVGLIIPHAITLVTAKDYRWILPLATLLGASFMLWVDFACRNI
NPPYETPLSALISFIGLPCFLWLVRKGGRF

Sequences:

>Translated_350_residues
MGQITKKLKMTAQHHTKPKLTKAAPPWLILTFISLTLVLAIYCSLRFGAVSLSHQELFHILLGKHGLGQKASIIWDIRLP
RLILAALVGAALAVSGAIMQGITRNPIAEPGLLGINSGAGLALVIGYAFFPHLHYSIIILLSLLGSLLATLLILSLAYQT
RKGYTQMRLILAGAMISMLLSAIGQGITTYCHLANAIIGWQAGGLIGVNWQMVSYVAPLIICGLVLSYLLAYHLTILSLS
QEQAKALGQRTFLISLIFIGLVLLLSSAAVAVAGSISFVGLIIPHAITLVTAKDYRWILPLATLLGASFMLWVDFACRNI
NPPYETPLSALISFIGLPCFLWLVRKGGRF
>Mature_349_residues
GQITKKLKMTAQHHTKPKLTKAAPPWLILTFISLTLVLAIYCSLRFGAVSLSHQELFHILLGKHGLGQKASIIWDIRLPR
LILAALVGAALAVSGAIMQGITRNPIAEPGLLGINSGAGLALVIGYAFFPHLHYSIIILLSLLGSLLATLLILSLAYQTR
KGYTQMRLILAGAMISMLLSAIGQGITTYCHLANAIIGWQAGGLIGVNWQMVSYVAPLIICGLVLSYLLAYHLTILSLSQ
EQAKALGQRTFLISLIFIGLVLLLSSAAVAVAGSISFVGLIIPHAITLVTAKDYRWILPLATLLGASFMLWVDFACRNIN
PPYETPLSALISFIGLPCFLWLVRKGGRF

Specific function: Part of the ABC transporter complex fhuBGCD involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790741, Length=317, Percent_Identity=35.9621451104101, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1790740, Length=323, Percent_Identity=34.0557275541796, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1786805, Length=308, Percent_Identity=34.4155844155844, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI1788004, Length=285, Percent_Identity=33.6842105263158, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI1786804, Length=258, Percent_Identity=33.7209302325581, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1786347, Length=282, Percent_Identity=30.1418439716312, Blast_Score=92, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 37729; Mature: 37598

Theoretical pI: Translated: 10.33; Mature: 10.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQITKKLKMTAQHHTKPKLTKAAPPWLILTFISLTLVLAIYCSLRFGAVSLSHQELFHI
CCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LLGKHGLGQKASIIWDIRLPRLILAALVGAALAVSGAIMQGITRNPIAEPGLLGINSGAG
HHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCC
LALVIGYAFFPHLHYSIIILLSLLGSLLATLLILSLAYQTRKGYTQMRLILAGAMISMLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
SAIGQGITTYCHLANAIIGWQAGGLIGVNWQMVSYVAPLIICGLVLSYLLAYHLTILSLS
HHHCCHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QEQAKALGQRTFLISLIFIGLVLLLSSAAVAVAGSISFVGLIIPHAITLVTAKDYRWILP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHH
LATLLGASFMLWVDFACRNINPPYETPLSALISFIGLPCFLWLVRKGGRF
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GQITKKLKMTAQHHTKPKLTKAAPPWLILTFISLTLVLAIYCSLRFGAVSLSHQELFHI
CCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LLGKHGLGQKASIIWDIRLPRLILAALVGAALAVSGAIMQGITRNPIAEPGLLGINSGAG
HHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCC
LALVIGYAFFPHLHYSIIILLSLLGSLLATLLILSLAYQTRKGYTQMRLILAGAMISMLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
SAIGQGITTYCHLANAIIGWQAGGLIGVNWQMVSYVAPLIICGLVLSYLLAYHLTILSLS
HHHCCHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QEQAKALGQRTFLISLIFIGLVLLLSSAAVAVAGSISFVGLIIPHAITLVTAKDYRWILP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHH
LATLLGASFMLWVDFACRNINPPYETPLSALISFIGLPCFLWLVRKGGRF
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377; 8388528 [H]