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The map label for this gene is fhuD [H]

Identifier: 195978719

GI number: 195978719

Start: 1665960

End: 1666898

Strand: Direct

Name: fhuD [H]

Synonym: Sez_1619

Alternate gene names: 195978719

Gene position: 1665960-1666898 (Clockwise)

Preceding gene: 195978718

Following gene: 195978720

Centisome position: 82.3

GC content: 43.02

Gene sequence:

>939_bases
ATGAAAAAACTACTGCTTATTTTAACTGTTTTTGTGACAGCTTTTACATTAGTCGCCTGCTCAAGTCAAAGCAAGCAACA
AGAAAGCACCAGCAAAGCAAGCCTATCCCACAAGCCAAAAATCGCCGGAGTGACCTATTATGGTGACATTCCCGCCAAGC
CAAAGCGCGTGGTTAGCTTAGCAGCTACATATACTGGTTACTTAGCAAAATTAGACCTTCATCTGGTGGGTGTCACCTCC
TACGACAAAAAGAACCCTGTTTTAACAAAAAGCATTACTCAAGCCAAGCAGGTGGCAGCTACTGACCTAGAGGCTATTAC
AGCACTAGAGCCTGATCTCATTGTTGTTGGCTCAACAGAAGAAAACATTGACCAGCTAGCAAAAATCGCACCGCTAATTT
CCATTGAATACCGCAAGCGTGATTATTTGCAGGTATTTTCTGATTTTGGTCGTATCTTTAACAAGGAAAAGGAAACCAAC
CAATGGTTGGCCGACTGGAAGCAAAAAACAAGTGACTATGAAAAAGAAGTAAAACAAGCCACCGGCTCAGCTGCTACCTT
TACAATCATGGGACTCTATGAGAAGGAAATTTACCTTTTTGGTAAGGACTGGGGAAGAGGTGGTGAAATTATCCATCAGG
CCTTCCATTATGATGCTCCTGAAAAGGTGACAAAAGAGGTATTTAAGCAAGGCTATCTGTCCTTATCACAGGAGGTTCTA
CCAGATTATATTGGTGATTATGTGGTGGTTGCTGCTGAGGATGATCAAACCGGCTCAGCCTTATATGAAAGCGACCTTTG
GCAGCAGATCCCTGCTGTGACCAACAATCATGTCATCAAGGTCAATGCTAATGTCTTTTACTTCACAGACCCACTGTCAC
TAGAGCACCAGCTTGAGGTTCTGAAAAAGGCTATTCTCTCAAATGGGGCAAATCACTAA

Upstream 100 bases:

>100_bases
TTTTCAAGTAAAGGCTCAGCTCGTCACTGATCCTCTCTATCATTGCCCTACATTGCTGACCTATCAGCTGATATAAATTT
ATTCTAGGAGAATAGAATAC

Downstream 100 bases:

>100_bases
AAAGCTTAAGATGACAGCTCAACATCATACTAAGCCTAAACTAACTAAAGCAGCTCCTCCTTGGCTGATCTTAACCTTTA
TCAGCTTAACTCTAGTGCTT

Product: ferrichrome-binding lipoprotein precursor FhuD

Products: ADP; phosphate; ferric enterobactin [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein D; Ferrichrome-binding protein; Iron(III)-hydroxamate-binding protein fhuD [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MKKLLLILTVFVTAFTLVACSSQSKQQESTSKASLSHKPKIAGVTYYGDIPAKPKRVVSLAATYTGYLAKLDLHLVGVTS
YDKKNPVLTKSITQAKQVAATDLEAITALEPDLIVVGSTEENIDQLAKIAPLISIEYRKRDYLQVFSDFGRIFNKEKETN
QWLADWKQKTSDYEKEVKQATGSAATFTIMGLYEKEIYLFGKDWGRGGEIIHQAFHYDAPEKVTKEVFKQGYLSLSQEVL
PDYIGDYVVVAAEDDQTGSALYESDLWQQIPAVTNNHVIKVNANVFYFTDPLSLEHQLEVLKKAILSNGANH

Sequences:

>Translated_312_residues
MKKLLLILTVFVTAFTLVACSSQSKQQESTSKASLSHKPKIAGVTYYGDIPAKPKRVVSLAATYTGYLAKLDLHLVGVTS
YDKKNPVLTKSITQAKQVAATDLEAITALEPDLIVVGSTEENIDQLAKIAPLISIEYRKRDYLQVFSDFGRIFNKEKETN
QWLADWKQKTSDYEKEVKQATGSAATFTIMGLYEKEIYLFGKDWGRGGEIIHQAFHYDAPEKVTKEVFKQGYLSLSQEVL
PDYIGDYVVVAAEDDQTGSALYESDLWQQIPAVTNNHVIKVNANVFYFTDPLSLEHQLEVLKKAILSNGANH
>Mature_312_residues
MKKLLLILTVFVTAFTLVACSSQSKQQESTSKASLSHKPKIAGVTYYGDIPAKPKRVVSLAATYTGYLAKLDLHLVGVTS
YDKKNPVLTKSITQAKQVAATDLEAITALEPDLIVVGSTEENIDQLAKIAPLISIEYRKRDYLQVFSDFGRIFNKEKETN
QWLADWKQKTSDYEKEVKQATGSAATFTIMGLYEKEIYLFGKDWGRGGEIIHQAFHYDAPEKVTKEVFKQGYLSLSQEVL
PDYIGDYVVVAAEDDQTGSALYESDLWQQIPAVTNNHVIKVNANVFYFTDPLSLEHQLEVLKKAILSNGANH

Specific function: Part of the ABC transporter complex fhuCBGD involved in iron(3+)-hydroxamate import. Binds the iron(3+)-hydroxamate complex and transfers it to the membrane-bound permease. Required for the transport of ferrichrome and coprogen [H]

COG id: COG0614

COG function: function code P; ABC-type Fe3+-hydroxamate transport system, periplasmic component

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Fe/B12 periplasmic-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002491 [H]

Pfam domain/function: PF01497 Peripla_BP_2 [H]

EC number: NA

Molecular weight: Translated: 34853; Mature: 34853

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50983 FE_B12_PBP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLLLILTVFVTAFTLVACSSQSKQQESTSKASLSHKPKIAGVTYYGDIPAKPKRVVSL
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHH
AATYTGYLAKLDLHLVGVTSYDKKNPVLTKSITQAKQVAATDLEAITALEPDLIVVGSTE
HHHHHHHHEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCH
ENIDQLAKIAPLISIEYRKRDYLQVFSDFGRIFNKEKETNQWLADWKQKTSDYEKEVKQA
HHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
TGSAATFTIMGLYEKEIYLFGKDWGRGGEIIHQAFHYDAPEKVTKEVFKQGYLSLSQEVL
CCCCEEEEEEEEEEEEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
PDYIGDYVVVAAEDDQTGSALYESDLWQQIPAVTNNHVIKVNANVFYFTDPLSLEHQLEV
HHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEECEEEEEECCCCHHHHHHH
LKKAILSNGANH
HHHHHHHCCCCC
>Mature Secondary Structure
MKKLLLILTVFVTAFTLVACSSQSKQQESTSKASLSHKPKIAGVTYYGDIPAKPKRVVSL
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHH
AATYTGYLAKLDLHLVGVTSYDKKNPVLTKSITQAKQVAATDLEAITALEPDLIVVGSTE
HHHHHHHHEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCH
ENIDQLAKIAPLISIEYRKRDYLQVFSDFGRIFNKEKETNQWLADWKQKTSDYEKEVKQA
HHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
TGSAATFTIMGLYEKEIYLFGKDWGRGGEIIHQAFHYDAPEKVTKEVFKQGYLSLSQEVL
CCCCEEEEEEEEEEEEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
PDYIGDYVVVAAEDDQTGSALYESDLWQQIPAVTNNHVIKVNANVFYFTDPLSLEHQLEV
HHHCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEEEEECEEEEEECCCCHHHHHHH
LKKAILSNGANH
HHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; ferric enterobactin [Periplasm]; H2O [C]

Specific reaction: ATP + ferric enterobactin [Periplasm] + H2O = ADP + phosphate + ferric enterobactin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8388528; 9639930; 9384377 [H]