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The map label for this gene is manD [H]

Identifier: 195977618

GI number: 195977618

Start: 498183

End: 499331

Strand: Direct

Name: manD [H]

Synonym: Sez_0477

Alternate gene names: 195977618

Gene position: 498183-499331 (Clockwise)

Preceding gene: 195977617

Following gene: 195977619

Centisome position: 24.61

GC content: 45.52

Gene sequence:

>1149_bases
ATGACAAGCTATATTAAAGCAGATTGCTTTTATTACCCCAACGAGGTAAAGCCAGCAGGCTATTTGGAGCTAAATAATGG
CACATTTGGTCATTGGACGGCTACTGTTGATGATCAGGCAGAGGTTATTGATTATACAGGCTATCAAATAGCACCAGGAC
TTGTAGATACTCATATTCATGGCTATGCTGGTGCTGATGTGATGGATAATTCAGCAGAAGGTCTCCATGCCATCAGTGAG
GGTCTCTTATCAACAGGAGTGACCTCCTTCTTGCCGACTACCCTAACCTCAACCTTTGAGCATCTAGAGCAGGTGTCTGC
AACCGTTGCTTCTGTTGCCGATCAGGTCAAAGGAGCAAAGATTCAGGGGATTTATTTTGAAGGGCCTTACTTCACTGAAG
AATACAAGGGAGCCCAAAACCCGATATATATGAAAAATCCTCGCTTAGACGAATTTGCAGCTTGGCAAAAAGCAGCTAAG
GGCTTGATCAAAAAAATAGCTTTGGCTCCTGAGCGTGATGGCGTAGAAGCATTTGTCTCTGAGGTGACCAAGCAGGGTGT
CACAGTAGCTTTAGGTCACTCAAATGGTACCTATGCTGAGGCTAAAAAGGCAGTAGCAGCAGGAGCTAGTGTTTGGGTTC
ATGCCTACAATGGGATGCGTGGCTTGACTCATCGTGAGCCTGGTATGGTTGGAGCTGTTTATAATATTCCTGGAACGGTT
GCAGAGCTGATCTGCGACGGACATCATGTCTCACCTGTTGCTTGCGATATTTTGATGCAGCAAAAGGGGCATGAGCATGT
GGCTTTGATTACGGACTGTATGCGTGCAGGCGGTTCACCAGATGGTGATTACATGCTTGGAGAGTTTCCGGTTATTGTGG
AAAATGGCACAGCTCGCTTGAAGGATAGTGGTAATCTAGCAGGCTCTATCTTAAAATTAAAGGACGGCATTAAAAATGTT
GTTGCTTGGGGAATTGCAAGTCCAGCAGAAGCAATTCACATGTCCTCTTACGTCCCAGCTGCTTCGGTTGGTATTGATGA
TGTCTGTGGCCAAATCAAGGCAGGGCATGCCGCTGACTTTATTGTTCTTGATAAGGACTTAGAATTAGTAGCAACCTACC
TAAATGGTCAAAAGGCCTTTGAGGCTTGA

Upstream 100 bases:

>100_bases
AAATAGTATTCAGGTTTTTCTTTTTAACAGAAGGACTGGTATATACCATTTACAAAATAAGAATTAAGGCGTATAATAAA
CGAAAAAGGGAGGAAAAAAG

Downstream 100 bases:

>100_bases
TACGGTAAAGGAATTGGGCTAGTGATCAGCTCAATTCTTTTTGCTTTGCTTATCATTGTGCTACAATAAAAAAGGAGGTT
TTAGATATGATTAAAACAGT

Product: N-acetylglucosamine-6-phosphate deacetylase

Products: NA

Alternate protein names: GlcNAc 6-P deacetylase [H]

Number of amino acids: Translated: 382; Mature: 381

Protein sequence:

>382_residues
MTSYIKADCFYYPNEVKPAGYLELNNGTFGHWTATVDDQAEVIDYTGYQIAPGLVDTHIHGYAGADVMDNSAEGLHAISE
GLLSTGVTSFLPTTLTSTFEHLEQVSATVASVADQVKGAKIQGIYFEGPYFTEEYKGAQNPIYMKNPRLDEFAAWQKAAK
GLIKKIALAPERDGVEAFVSEVTKQGVTVALGHSNGTYAEAKKAVAAGASVWVHAYNGMRGLTHREPGMVGAVYNIPGTV
AELICDGHHVSPVACDILMQQKGHEHVALITDCMRAGGSPDGDYMLGEFPVIVENGTARLKDSGNLAGSILKLKDGIKNV
VAWGIASPAEAIHMSSYVPAASVGIDDVCGQIKAGHAADFIVLDKDLELVATYLNGQKAFEA

Sequences:

>Translated_382_residues
MTSYIKADCFYYPNEVKPAGYLELNNGTFGHWTATVDDQAEVIDYTGYQIAPGLVDTHIHGYAGADVMDNSAEGLHAISE
GLLSTGVTSFLPTTLTSTFEHLEQVSATVASVADQVKGAKIQGIYFEGPYFTEEYKGAQNPIYMKNPRLDEFAAWQKAAK
GLIKKIALAPERDGVEAFVSEVTKQGVTVALGHSNGTYAEAKKAVAAGASVWVHAYNGMRGLTHREPGMVGAVYNIPGTV
AELICDGHHVSPVACDILMQQKGHEHVALITDCMRAGGSPDGDYMLGEFPVIVENGTARLKDSGNLAGSILKLKDGIKNV
VAWGIASPAEAIHMSSYVPAASVGIDDVCGQIKAGHAADFIVLDKDLELVATYLNGQKAFEA
>Mature_381_residues
TSYIKADCFYYPNEVKPAGYLELNNGTFGHWTATVDDQAEVIDYTGYQIAPGLVDTHIHGYAGADVMDNSAEGLHAISEG
LLSTGVTSFLPTTLTSTFEHLEQVSATVASVADQVKGAKIQGIYFEGPYFTEEYKGAQNPIYMKNPRLDEFAAWQKAAKG
LIKKIALAPERDGVEAFVSEVTKQGVTVALGHSNGTYAEAKKAVAAGASVWVHAYNGMRGLTHREPGMVGAVYNIPGTVA
ELICDGHHVSPVACDILMQQKGHEHVALITDCMRAGGSPDGDYMLGEFPVIVENGTARLKDSGNLAGSILKLKDGIKNVV
AWGIASPAEAIHMSSYVPAASVGIDDVCGQIKAGHAADFIVLDKDLELVATYLNGQKAFEA

Specific function: N-acetylglucosamine utilization. [C]

COG id: COG1820

COG function: function code G; N-acetylglucosamine-6-phosphate deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nagA family [H]

Homologues:

Organism=Homo sapiens, GI21361513, Length=383, Percent_Identity=27.9373368146214, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI224922791, Length=377, Percent_Identity=28.1167108753316, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1786892, Length=352, Percent_Identity=28.125, Blast_Score=140, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17553768, Length=355, Percent_Identity=28.169014084507, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI281361140, Length=357, Percent_Identity=30.812324929972, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI19920392, Length=345, Percent_Identity=31.5942028985507, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR003764
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.1.25 [H]

Molecular weight: Translated: 40656; Mature: 40525

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSYIKADCFYYPNEVKPAGYLELNNGTFGHWTATVDDQAEVIDYTGYQIAPGLVDTHIH
CCCEEEECEEECCCCCCCCCEEEECCCCCEEEEEECCCCCCEEECCCCEECCCHHHHCCC
GYAGADVMDNSAEGLHAISEGLLSTGVTSFLPTTLTSTFEHLEQVSATVASVADQVKGAK
CCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
IQGIYFEGPYFTEEYKGAQNPIYMKNPRLDEFAAWQKAAKGLIKKIALAPERDGVEAFVS
EEEEEECCCEECHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
EVTKQGVTVALGHSNGTYAEAKKAVAAGASVWVHAYNGMRGLTHREPGMVGAVYNIPGTV
HHHHCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEEECCCHHH
AELICDGHHVSPVACDILMQQKGHEHVALITDCMRAGGSPDGDYMLGEFPVIVENGTARL
HHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEECCCCEEEECCCEEE
KDSGNLAGSILKLKDGIKNVVAWGIASPAEAIHMSSYVPAASVGIDDVCGQIKAGHAADF
CCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHCCHHHHHHHCCCCCCEEE
IVLDKDLELVATYLNGQKAFEA
EEECCCHHHHHHHHCCCHHCCC
>Mature Secondary Structure 
TSYIKADCFYYPNEVKPAGYLELNNGTFGHWTATVDDQAEVIDYTGYQIAPGLVDTHIH
CCEEEECEEECCCCCCCCCEEEECCCCCEEEEEECCCCCCEEECCCCEECCCHHHHCCC
GYAGADVMDNSAEGLHAISEGLLSTGVTSFLPTTLTSTFEHLEQVSATVASVADQVKGAK
CCCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
IQGIYFEGPYFTEEYKGAQNPIYMKNPRLDEFAAWQKAAKGLIKKIALAPERDGVEAFVS
EEEEEECCCEECHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
EVTKQGVTVALGHSNGTYAEAKKAVAAGASVWVHAYNGMRGLTHREPGMVGAVYNIPGTV
HHHHCCCEEEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEEECCCHHH
AELICDGHHVSPVACDILMQQKGHEHVALITDCMRAGGSPDGDYMLGEFPVIVENGTARL
HHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEECCCCEEEECCCEEE
KDSGNLAGSILKLKDGIKNVVAWGIASPAEAIHMSSYVPAASVGIDDVCGQIKAGHAADF
CCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHCCHHHHHHHCCCCCCEEE
IVLDKDLELVATYLNGQKAFEA
EEECCCHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969210 [H]