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The map label for this gene is guaA [H]

Identifier: 195953020

GI number: 195953020

Start: 579066

End: 580589

Strand: Direct

Name: guaA [H]

Synonym: HY04AAS1_0645

Alternate gene names: 195953020

Gene position: 579066-580589 (Clockwise)

Preceding gene: 195953019

Following gene: 195953021

Centisome position: 37.13

GC content: 36.55

Gene sequence:

>1524_bases
TTGGAAGGTCACGTACTAATAGTTAGTTTTGGGTCTCAATATGTACAGCTTATAGCTAGAAAAGTAAGAGAATTAGGAGT
TTATAGCGAGATAGTTTTACCAGATATAGACATTGAGGAGATAATTACAAAAAAACCATGCGCATTGATATTTTCTGGAG
GTCCATACTCGGTATACGAGAAAAATGCACCAAAGCTTGACAAGAAGATTTATGAGCTTGGAATACCCGTATTGGGAATA
TGCTACGGGCATCAGCTAATAGCCTATGAGTTTGGTGGAATAGTGGAAAAATCAGATAAACATGAGTACGGTAAGGCATA
CTTAGACTTTAAACCTAACATTTTTTTCAAAAATATACCACAGCATACCGTAGTTTGGATGAGTCATGCGGATAAGGTAT
CCACATTGCCAAAGGATTTTGAGTCTATAGGCTTTTCGGATAACTCGGAAAATGCAGTTATAAAACATAATCATTTTCCA
ATATACGGTGTACAGTTTCATTTGGAGGTTTATCATACCGAATACGGTAAAGAGATGTTGTCAAATTTCTTGTTCGATAT
AGCAAAATGCCACCAAAACTGGAATATGAAAAGCTTCAAAGAGCATAAAATAGAAGAGATAAGAGTGACAGTTGGGAATA
AAAAGGTAATATGCGCTATTTCTGGTGGTGTAGATTCTGCCGTAGCTGCTGTTTTAACCCACAAAGCTATAGGTGATAAA
CTAACGTGTATTTTTGTAGATCATGGGCTTCTTAGAAAAAACGAGTCAAAGGAAGTAATATCAAATCTTACCAAACTTGG
TCTTAATATAGTGGCGCTTGATAGAAGCAATTTATTTTTAGAAAAGCTTAAAAATGTTGAAGATCCAGAACAAAAAAGAA
AAATCATAGGAAACACTTTTATAGAGATTTTTGAAGAAGAAGCCAAAAAATACAACGCAGAGTTTTTGCTTCAGGGCACA
CTTTATCCAGATCTTGTTGAAAGCGCCGGCATTCATGGGTCAGCCAAGATAAAGTCTCATCACAACGTTGGAGGGCTCCC
AGAAAAAATGAATCTAAAACTTTTGGAACCGTTAAGAGAGCTTTTCAAAGACGAAGTAAGAGCCTTAGGCTTAGAGCTTG
ATCTTCCAAAAGACATGGTATATAGACATCCGTTTCCTGGCCCAGGACTCGCGATAAGAATAATAGGAGATGTAAAAGAA
GAAGATTTAAATATACTAAGAGAAGCCGATGCCATTTTTATAGAAGAGTTGAAAAAATGGAATTTATACGATAAGACATG
GCAAGCTTCTGCTGTGCTTTTACCAATAAAATCTGTGGGTGTAATGGGAGACAATAGAACATACGGCAAGGTTTTAGCTT
TAAGAGCGGTAGACAGTCAAGATGGAATGACCGCAGAACCATCGAAGCTTCCTTATGAATTTTTAGAGCATGTGATGAGG
AGAATAATACAAGAAGTAAAAGGTATTAATAGAGTGGTTTACGATATATCTTCAAAACCACCAGCCACAATAGAGTGGGA
ATAG

Upstream 100 bases:

>100_bases
AGAAGGCATAATACATACGGAAAGAGGCTATATAGAGATACTTAAGAAAAGAGAATTAGAAAGGCTCATGATATAAGCTA
AATATTATAAGGGTAAAACA

Downstream 100 bases:

>100_bases
TGTTATGAGACTGGGCGTAAATATAGATCATGTTGCTACCATCAGAGAAGCGAGAAAAACCTTCGAACCATCTGTATTAG
AAGCTGCTTTTATAGCAAAA

Product: GMP synthase, large subunit

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MEGHVLIVSFGSQYVQLIARKVRELGVYSEIVLPDIDIEEIITKKPCALIFSGGPYSVYEKNAPKLDKKIYELGIPVLGI
CYGHQLIAYEFGGIVEKSDKHEYGKAYLDFKPNIFFKNIPQHTVVWMSHADKVSTLPKDFESIGFSDNSENAVIKHNHFP
IYGVQFHLEVYHTEYGKEMLSNFLFDIAKCHQNWNMKSFKEHKIEEIRVTVGNKKVICAISGGVDSAVAAVLTHKAIGDK
LTCIFVDHGLLRKNESKEVISNLTKLGLNIVALDRSNLFLEKLKNVEDPEQKRKIIGNTFIEIFEEEAKKYNAEFLLQGT
LYPDLVESAGIHGSAKIKSHHNVGGLPEKMNLKLLEPLRELFKDEVRALGLELDLPKDMVYRHPFPGPGLAIRIIGDVKE
EDLNILREADAIFIEELKKWNLYDKTWQASAVLLPIKSVGVMGDNRTYGKVLALRAVDSQDGMTAEPSKLPYEFLEHVMR
RIIQEVKGINRVVYDISSKPPATIEWE

Sequences:

>Translated_507_residues
MEGHVLIVSFGSQYVQLIARKVRELGVYSEIVLPDIDIEEIITKKPCALIFSGGPYSVYEKNAPKLDKKIYELGIPVLGI
CYGHQLIAYEFGGIVEKSDKHEYGKAYLDFKPNIFFKNIPQHTVVWMSHADKVSTLPKDFESIGFSDNSENAVIKHNHFP
IYGVQFHLEVYHTEYGKEMLSNFLFDIAKCHQNWNMKSFKEHKIEEIRVTVGNKKVICAISGGVDSAVAAVLTHKAIGDK
LTCIFVDHGLLRKNESKEVISNLTKLGLNIVALDRSNLFLEKLKNVEDPEQKRKIIGNTFIEIFEEEAKKYNAEFLLQGT
LYPDLVESAGIHGSAKIKSHHNVGGLPEKMNLKLLEPLRELFKDEVRALGLELDLPKDMVYRHPFPGPGLAIRIIGDVKE
EDLNILREADAIFIEELKKWNLYDKTWQASAVLLPIKSVGVMGDNRTYGKVLALRAVDSQDGMTAEPSKLPYEFLEHVMR
RIIQEVKGINRVVYDISSKPPATIEWE
>Mature_507_residues
MEGHVLIVSFGSQYVQLIARKVRELGVYSEIVLPDIDIEEIITKKPCALIFSGGPYSVYEKNAPKLDKKIYELGIPVLGI
CYGHQLIAYEFGGIVEKSDKHEYGKAYLDFKPNIFFKNIPQHTVVWMSHADKVSTLPKDFESIGFSDNSENAVIKHNHFP
IYGVQFHLEVYHTEYGKEMLSNFLFDIAKCHQNWNMKSFKEHKIEEIRVTVGNKKVICAISGGVDSAVAAVLTHKAIGDK
LTCIFVDHGLLRKNESKEVISNLTKLGLNIVALDRSNLFLEKLKNVEDPEQKRKIIGNTFIEIFEEEAKKYNAEFLLQGT
LYPDLVESAGIHGSAKIKSHHNVGGLPEKMNLKLLEPLRELFKDEVRALGLELDLPKDMVYRHPFPGPGLAIRIIGDVKE
EDLNILREADAIFIEELKKWNLYDKTWQASAVLLPIKSVGVMGDNRTYGKVLALRAVDSQDGMTAEPSKLPYEFLEHVMR
RIIQEVKGINRVVYDISSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=549, Percent_Identity=36.4298724954463, Blast_Score=297, Evalue=1e-80,
Organism=Escherichia coli, GI1788854, Length=517, Percent_Identity=51.063829787234, Blast_Score=519, Evalue=1e-148,
Organism=Escherichia coli, GI1789760, Length=157, Percent_Identity=31.2101910828025, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI133901714, Length=565, Percent_Identity=36.4601769911504, Blast_Score=298, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI71992710, Length=565, Percent_Identity=36.283185840708, Blast_Score=298, Evalue=5e-81,
Organism=Caenorhabditis elegans, GI71992717, Length=565, Percent_Identity=36.283185840708, Blast_Score=298, Evalue=5e-81,
Organism=Saccharomyces cerevisiae, GI6323873, Length=514, Percent_Identity=52.3346303501946, Blast_Score=516, Evalue=1e-147,
Organism=Saccharomyces cerevisiae, GI6322638, Length=159, Percent_Identity=33.9622641509434, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281365319, Length=543, Percent_Identity=36.8324125230203, Blast_Score=293, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001962
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 57447; Mature: 57447

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGHVLIVSFGSQYVQLIARKVRELGVYSEIVLPDIDIEEIITKKPCALIFSGGPYSVYE
CCCCEEEEECCHHHHHHHHHHHHHCCCHHHEECCCCCHHHHHCCCCCEEEECCCCCEECC
KNAPKLDKKIYELGIPVLGICYGHQLIAYEFGGIVEKSDKHEYGKAYLDFKPNIFFKNIP
CCCCHHHHHHHHHCCCCEEHHHCCEEEEEHHCCCCCCCCCCCCCCEEEECCCCEEECCCC
QHTVVWMSHADKVSTLPKDFESIGFSDNSENAVIKHNHFPIYGVQFHLEVYHTEYGKEML
CCEEEEEECCCHHHCCCHHHHHCCCCCCCCCEEEEECCCEEEEEEEEEEEEECHHHHHHH
SNFLFDIAKCHQNWNMKSFKEHKIEEIRVTVGNKKVICAISGGVDSAVAAVLTHKAIGDK
HHHHHHHHHHHCCCCCCHHHHHCCEEEEEEECCCEEEEEECCCHHHHHHHHHHHHHCCCC
LTCIFVDHGLLRKNESKEVISNLTKLGLNIVALDRSNLFLEKLKNVEDPEQKRKIIGNTF
EEEEEECCCHHCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHH
IEIFEEEAKKYNAEFLLQGTLYPDLVESAGIHGSAKIKSHHNVGGLPEKMNLKLLEPLRE
HHHHHHHHHHCCCEEEEECCCCHHHHHHCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHH
LFKDEVRALGLELDLPKDMVYRHPFPGPGLAIRIIGDVKEEDLNILREADAIFIEELKKW
HHHHHHHHCCCEECCCHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHC
NLYDKTWQASAVLLPIKSVGVMGDNRTYGKVLALRAVDSQDGMTAEPSKLPYEFLEHVMR
CCCCCCCCCCEEEEEHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHH
RIIQEVKGINRVVYDISSKPPATIEWE
HHHHHHHHHCEEEEECCCCCCCEEECC
>Mature Secondary Structure
MEGHVLIVSFGSQYVQLIARKVRELGVYSEIVLPDIDIEEIITKKPCALIFSGGPYSVYE
CCCCEEEEECCHHHHHHHHHHHHHCCCHHHEECCCCCHHHHHCCCCCEEEECCCCCEECC
KNAPKLDKKIYELGIPVLGICYGHQLIAYEFGGIVEKSDKHEYGKAYLDFKPNIFFKNIP
CCCCHHHHHHHHHCCCCEEHHHCCEEEEEHHCCCCCCCCCCCCCCEEEECCCCEEECCCC
QHTVVWMSHADKVSTLPKDFESIGFSDNSENAVIKHNHFPIYGVQFHLEVYHTEYGKEML
CCEEEEEECCCHHHCCCHHHHHCCCCCCCCCEEEEECCCEEEEEEEEEEEEECHHHHHHH
SNFLFDIAKCHQNWNMKSFKEHKIEEIRVTVGNKKVICAISGGVDSAVAAVLTHKAIGDK
HHHHHHHHHHHCCCCCCHHHHHCCEEEEEEECCCEEEEEECCCHHHHHHHHHHHHHCCCC
LTCIFVDHGLLRKNESKEVISNLTKLGLNIVALDRSNLFLEKLKNVEDPEQKRKIIGNTF
EEEEEECCCHHCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCCCHHHHHHHHHHHH
IEIFEEEAKKYNAEFLLQGTLYPDLVESAGIHGSAKIKSHHNVGGLPEKMNLKLLEPLRE
HHHHHHHHHHCCCEEEEECCCCHHHHHHCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHH
LFKDEVRALGLELDLPKDMVYRHPFPGPGLAIRIIGDVKEEDLNILREADAIFIEELKKW
HHHHHHHHCCCEECCCHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHC
NLYDKTWQASAVLLPIKSVGVMGDNRTYGKVLALRAVDSQDGMTAEPSKLPYEFLEHVMR
CCCCCCCCCCEEEEEHHHHCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHH
RIIQEVKGINRVVYDISSKPPATIEWE
HHHHHHHHHCEEEEECCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]