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The map label for this gene is sdhA [H]

Identifier: 195953010

GI number: 195953010

Start: 567557

End: 569257

Strand: Direct

Name: sdhA [H]

Synonym: HY04AAS1_0635

Alternate gene names: 195953010

Gene position: 567557-569257 (Clockwise)

Preceding gene: 195953009

Following gene: 195953011

Centisome position: 36.39

GC content: 36.92

Gene sequence:

>1701_bases
ATGCTAAAGTACGATATAGTTATAATAGGCGGTGGCGGTGCTGGATTAATGGCTGCCATAGAAGCTTCTAAAGATAAAAA
CATAAAAATAGCAATTGTTTCTAAAGTTTTTCCAACAAGATCTCATACCGGTGCTGCTCAAGGTGGTATGAACGCCAGCA
TAGGAGTAGCTGATCCAAACGATTCACCAGAAAAACATGCTTTTGATACCACAAAAGGTGCCGATTTTTTAGCAGACCAG
CAAGCTGTCTTGTTTATGTGCAAGAATGCCCCAGACATGATATACGAGTTAGATAGAATGGGTGTTCCATTTTCAAGGAC
AATCGACGGTAAAATAGCACAAAGACCTTTTGGGGGAGCATCTTTTCCAAGAACTGTTTATTCCGCAGATAGAACAGGTC
ACGTACTTCTACATACACTATTTGAACAGGCAATGTCAAAAGAAAATATAGACTTTTTCAACGAGTATTTTTTGCTCGAT
TTAGATATAGAAAATGAAAAAATAGAGGGTGTTGAGCTTTTAAACATAAAAGATTCAAGTGTATTGTATATAAAGACGAA
GGTTTTAATATTAGCAGGTGGTGGCTTTGCAAGAATATATTGGCATAGAAGCACAAATGCCTCAGGCAACACAGGAGATC
TGCAAGCTATAGCGCTTAGAAAAGGTATAGCTTTAAAAGATATAGAGTTTATCCAATTTCACCCAACGGGTCTTGCCAAA
ACTGGTATACTGCTTTCAGAAGCTTCAAGAGGAGAAGGTGGATACCTTTTAAATGTTAAAGGCGAAAGGTTTATGGAGAA
ATATTCTCCAAATAAAATGGAACTAGCTCCGAGAGATATAGTATCAAGATCGATAGAGCTTGAAATAAAGAGCGGGCTTG
GTGTAGGAGAAGGAACATCTGCGTATGTGTATTTAGATTTAAGACATTTGGGAGAAGAAAAAATAAATGAACGATTACCT
CAGGTAAGGCAATTAGCCATCGATTTTGAAGGCGTAGACCCTGTAAAAGCTCCTATACCTATAAGACCCACAGCTCATTA
TTGCATGGGTGGTATAGATGTTGTTGATTTTAAAAGCTCCCAAACCAGCGTAAAAGGACTTTTAGCTATAGGAGAGTGTG
CTTGCGTATCAGTACATGGTGCAAACAGGTTAGGAGGTAATTCCCTTACTGAGCTTGTGGTGTTTGGCAAATATGCTGGT
GAATATGCACGTGAATATGCAAAAGATTTCGATTTTTCAAATAGAAACCCTACAACAAAAGCTGAAGCTTATGTAAACTC
TTTGATGCAAAGAGAAGGAAATGTTAAATTGTATGAGGTAAGAAATAAAATGGGGGAAATAACATGGTTTAACATGGGTA
TATTTAGGACAGAAAGCTCTTTGAAAGAAGCTTATAAAGAACTCACAAAACTATTGGATATGTGGCATTATATACCAGTC
TCAGACAAATCGAGAATATTTAATACAAATCTTATTGAGCTTTTAGAGTTAAGAAATATGCTTGAATTATCAAGAGCGGT
AGCTTTATGCGCTTTAAACAGAAGAGAATCAAGAGGTGGGCATTGGAGAGAAGATTACAAAGAAAGAGACGATGAGAATT
TTTTAAAACATTCGCTGGTACAATATAAAAATGGTGAGCTTAGCTTAAGCTACAAAGAGGTAGATACAAGCATTTATAAA
CTGGAGGAGAGAAAGTACTGA

Upstream 100 bases:

>100_bases
AATGGGAGCAAATAGAAAGAAAATGGGGTATCATCCCAAATGCTCAAAATCCCAATAACCAATCTCAGTAAATTTTTGGT
TTTTCATATATAATATTTAT

Downstream 100 bases:

>100_bases
TGAAGAAAGTATTTTTATTTATATTGCTGTTAGTATCGCTTGGTTTTTCCCAAACTATATCAAAAATAGAAGTTGTTGGA
AATAAGTATATACAGTCGGG

Product: succinate dehydrogenase or fumarate reductase, flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 566; Mature: 566

Protein sequence:

>566_residues
MLKYDIVIIGGGGAGLMAAIEASKDKNIKIAIVSKVFPTRSHTGAAQGGMNASIGVADPNDSPEKHAFDTTKGADFLADQ
QAVLFMCKNAPDMIYELDRMGVPFSRTIDGKIAQRPFGGASFPRTVYSADRTGHVLLHTLFEQAMSKENIDFFNEYFLLD
LDIENEKIEGVELLNIKDSSVLYIKTKVLILAGGGFARIYWHRSTNASGNTGDLQAIALRKGIALKDIEFIQFHPTGLAK
TGILLSEASRGEGGYLLNVKGERFMEKYSPNKMELAPRDIVSRSIELEIKSGLGVGEGTSAYVYLDLRHLGEEKINERLP
QVRQLAIDFEGVDPVKAPIPIRPTAHYCMGGIDVVDFKSSQTSVKGLLAIGECACVSVHGANRLGGNSLTELVVFGKYAG
EYAREYAKDFDFSNRNPTTKAEAYVNSLMQREGNVKLYEVRNKMGEITWFNMGIFRTESSLKEAYKELTKLLDMWHYIPV
SDKSRIFNTNLIELLELRNMLELSRAVALCALNRRESRGGHWREDYKERDDENFLKHSLVQYKNGELSLSYKEVDTSIYK
LEERKY

Sequences:

>Translated_566_residues
MLKYDIVIIGGGGAGLMAAIEASKDKNIKIAIVSKVFPTRSHTGAAQGGMNASIGVADPNDSPEKHAFDTTKGADFLADQ
QAVLFMCKNAPDMIYELDRMGVPFSRTIDGKIAQRPFGGASFPRTVYSADRTGHVLLHTLFEQAMSKENIDFFNEYFLLD
LDIENEKIEGVELLNIKDSSVLYIKTKVLILAGGGFARIYWHRSTNASGNTGDLQAIALRKGIALKDIEFIQFHPTGLAK
TGILLSEASRGEGGYLLNVKGERFMEKYSPNKMELAPRDIVSRSIELEIKSGLGVGEGTSAYVYLDLRHLGEEKINERLP
QVRQLAIDFEGVDPVKAPIPIRPTAHYCMGGIDVVDFKSSQTSVKGLLAIGECACVSVHGANRLGGNSLTELVVFGKYAG
EYAREYAKDFDFSNRNPTTKAEAYVNSLMQREGNVKLYEVRNKMGEITWFNMGIFRTESSLKEAYKELTKLLDMWHYIPV
SDKSRIFNTNLIELLELRNMLELSRAVALCALNRRESRGGHWREDYKERDDENFLKHSLVQYKNGELSLSYKEVDTSIYK
LEERKY
>Mature_566_residues
MLKYDIVIIGGGGAGLMAAIEASKDKNIKIAIVSKVFPTRSHTGAAQGGMNASIGVADPNDSPEKHAFDTTKGADFLADQ
QAVLFMCKNAPDMIYELDRMGVPFSRTIDGKIAQRPFGGASFPRTVYSADRTGHVLLHTLFEQAMSKENIDFFNEYFLLD
LDIENEKIEGVELLNIKDSSVLYIKTKVLILAGGGFARIYWHRSTNASGNTGDLQAIALRKGIALKDIEFIQFHPTGLAK
TGILLSEASRGEGGYLLNVKGERFMEKYSPNKMELAPRDIVSRSIELEIKSGLGVGEGTSAYVYLDLRHLGEEKINERLP
QVRQLAIDFEGVDPVKAPIPIRPTAHYCMGGIDVVDFKSSQTSVKGLLAIGECACVSVHGANRLGGNSLTELVVFGKYAG
EYAREYAKDFDFSNRNPTTKAEAYVNSLMQREGNVKLYEVRNKMGEITWFNMGIFRTESSLKEAYKELTKLLDMWHYIPV
SDKSRIFNTNLIELLELRNMLELSRAVALCALNRRESRGGHWREDYKERDDENFLKHSLVQYKNGELSLSYKEVDTSIYK
LEERKY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=570, Percent_Identity=41.5789473684211, Blast_Score=409, Evalue=1e-114,
Organism=Escherichia coli, GI1786942, Length=557, Percent_Identity=44.3447037701975, Blast_Score=414, Evalue=1e-117,
Organism=Escherichia coli, GI1790597, Length=556, Percent_Identity=40.6474820143885, Blast_Score=411, Evalue=1e-116,
Organism=Escherichia coli, GI1788928, Length=552, Percent_Identity=33.1521739130435, Blast_Score=234, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17550100, Length=574, Percent_Identity=41.6376306620209, Blast_Score=419, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17505833, Length=575, Percent_Identity=41.0434782608696, Blast_Score=409, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71986328, Length=437, Percent_Identity=27.0022883295195, Blast_Score=92, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6322701, Length=548, Percent_Identity=43.6131386861314, Blast_Score=438, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6322416, Length=555, Percent_Identity=42.7027027027027, Blast_Score=435, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6320788, Length=476, Percent_Identity=27.1008403361345, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI17137288, Length=575, Percent_Identity=40.3478260869565, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24655642, Length=575, Percent_Identity=40.3478260869565, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24655647, Length=575, Percent_Identity=40.3478260869565, Blast_Score=409, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24663005, Length=531, Percent_Identity=39.5480225988701, Blast_Score=381, Evalue=1e-106,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 63260; Mature: 63260

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00504 FRD_SDH_FAD_BINDING ; PS00436 PEROXIDASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKYDIVIIGGGGAGLMAAIEASKDKNIKIAIVSKVFPTRSHTGAAQGGMNASIGVADPN
CEEEEEEEEECCCCCEEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEEECCCC
DSPEKHAFDTTKGADFLADQQAVLFMCKNAPDMIYELDRMGVPFSRTIDGKIAQRPFGGA
CCCCCCCCCCCCCCHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCHHCCCCCCC
SFPRTVYSADRTGHVLLHTLFEQAMSKENIDFFNEYFLLDLDIENEKIEGVELLNIKDSS
CCCCHHHCCCCCCHHHHHHHHHHHHCCCCCCEECCEEEEEEECCCCCCCCEEEEEECCCC
VLYIKTKVLILAGGGFARIYWHRSTNASGNTGDLQAIALRKGIALKDIEFIQFHPTGLAK
EEEEEEEEEEEECCCEEEEEEEECCCCCCCCCCEEEEEECCCCEEECEEEEEECCCCCCC
TGILLSEASRGEGGYLLNVKGERFMEKYSPNKMELAPRDIVSRSIELEIKSGLGVGEGTS
CCEEEECCCCCCCCEEEEECHHHHHHHCCCCCEEECHHHHHCCEEEEEEECCCCCCCCCC
AYVYLDLRHLGEEKINERLPQVRQLAIDFEGVDPVKAPIPIRPTAHYCMGGIDVVDFKSS
EEEEEEHHHCCHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCHHHHCCCCEEEEECCC
QTSVKGLLAIGECACVSVHGANRLGGNSLTELVVFGKYAGEYAREYAKDFDFSNRNPTTK
CHHHHHHEEECCEEEEEECCCCCCCCCCHHHHEEEHHHHHHHHHHHHHHCCCCCCCCCHH
AEAYVNSLMQREGNVKLYEVRNKMGEITWFNMGIFRTESSLKEAYKELTKLLDMWHYIPV
HHHHHHHHHHCCCCEEEEEEHHHCCCEEEEEEEEEECHHHHHHHHHHHHHHHHHHHCCCC
SDKSRIFNTNLIELLELRNMLELSRAVALCALNRRESRGGHWREDYKERDDENFLKHSLV
CCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHH
QYKNGELSLSYKEVDTSIYKLEERKY
HCCCCCEEEEHHHHCCHHHHHHCCCC
>Mature Secondary Structure
MLKYDIVIIGGGGAGLMAAIEASKDKNIKIAIVSKVFPTRSHTGAAQGGMNASIGVADPN
CEEEEEEEEECCCCCEEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEEECCCC
DSPEKHAFDTTKGADFLADQQAVLFMCKNAPDMIYELDRMGVPFSRTIDGKIAQRPFGGA
CCCCCCCCCCCCCCHHHCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCHHCCCCCCC
SFPRTVYSADRTGHVLLHTLFEQAMSKENIDFFNEYFLLDLDIENEKIEGVELLNIKDSS
CCCCHHHCCCCCCHHHHHHHHHHHHCCCCCCEECCEEEEEEECCCCCCCCEEEEEECCCC
VLYIKTKVLILAGGGFARIYWHRSTNASGNTGDLQAIALRKGIALKDIEFIQFHPTGLAK
EEEEEEEEEEEECCCEEEEEEEECCCCCCCCCCEEEEEECCCCEEECEEEEEECCCCCCC
TGILLSEASRGEGGYLLNVKGERFMEKYSPNKMELAPRDIVSRSIELEIKSGLGVGEGTS
CCEEEECCCCCCCCEEEEECHHHHHHHCCCCCEEECHHHHHCCEEEEEEECCCCCCCCCC
AYVYLDLRHLGEEKINERLPQVRQLAIDFEGVDPVKAPIPIRPTAHYCMGGIDVVDFKSS
EEEEEEHHHCCHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCHHHHCCCCEEEEECCC
QTSVKGLLAIGECACVSVHGANRLGGNSLTELVVFGKYAGEYAREYAKDFDFSNRNPTTK
CHHHHHHEEECCEEEEEECCCCCCCCCCHHHHEEEHHHHHHHHHHHHHHCCCCCCCCCHH
AEAYVNSLMQREGNVKLYEVRNKMGEITWFNMGIFRTESSLKEAYKELTKLLDMWHYIPV
HHHHHHHHHHCCCCEEEEEEHHHCCCEEEEEEEEEECHHHHHHHHHHHHHHHHHHHCCCC
SDKSRIFNTNLIELLELRNMLELSRAVALCALNRRESRGGHWREDYKERDDENFLKHSLV
CCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCHHHHHHHHHH
QYKNGELSLSYKEVDTSIYKLEERKY
HCCCCCEEEEHHHHCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA