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The map label for this gene is murC

Identifier: 195952962

GI number: 195952962

Start: 523551

End: 524900

Strand: Direct

Name: murC

Synonym: HY04AAS1_0587

Alternate gene names: 195952962

Gene position: 523551-524900 (Clockwise)

Preceding gene: 195952956

Following gene: 195952963

Centisome position: 33.57

GC content: 34.52

Gene sequence:

>1350_bases
ATGTTTAGAGAAAAATTTAGAAAGTTTCATTTTATAGGTATTGGTGGTATAGGTATGAGCGGTATCGCTAAGATACTGCT
TGATATGGGTTATGAGGTATCTGGCTCTGATGTTAGACAAAACGATGTTATAAAGGAACTAAAAGAAAAAGGAGCCACCA
TCTATATAGGACATGATGCTAAAAATGTGATAGGCAAAGAAGTAGTAGTGTATTCGTCTGCTATATCAAATGTAAACGAA
GAGCTTTTAAAAGCCAAAGAGCTTGGTCTTCAAGTGATATCAAGAGGGGATATGTTGGCAGATTTGTTTAGGATGAAAGA
GGGTATAGCCATATCAGGCTCTCACGGCAAAACTACCACCACATCTATGATTTCTCATATATCACATATAGCTGGACTAG
ATCCTACTGTTTTAATAGGTGGTATCTTACAGACCTTTGGTTCAAACGCAGTGCTTGGAAAAAGCGAGCTTTTGATATCT
GAAGCCGATGAGTCTGATGGATCTTTTTTAAAACTAAACTCTGTTATAAACGTAGTTACAAATATAGACAAAGAGCATAT
TGGATACTACAAAGATTATGAAGATATAAAAGAAGCCTTTGTAAAGTTTATAAACAACGTACCTTTTTACGGAGCATCGG
TGGTAAATATAGACGATACCGGTGTTAGGTCTATATTATCAAAAATACATAAAAAGATAATCACTTACGGGATAGAATCT
GGGGATTTTCAAGCTAAAAATATAGTTTTTAACAGCGACAACACCCGTTTTGATGTATTTTACAAAGGTATAAAACTAAA
CACAATAGAGCTTCAAATCCCAGGTATCCACAACGTTTACAACGCACTTGCTTCAATAGCCGTTTCAACACTTATGGAAA
TAGAACAACCTGTTATAAGAGACGCTCTTAAAAGCTTTAAAAACGCCAAAAGAAGGATCGAATTTGTCGGTGAAAAAAAC
ACAAACCTCATCTACGATGATTACGGACATCATCCAACGGAGATAAAAAGCGTTTACGAAGCCCTAAAATCAAAATATAA
AGACAAAAATATAGTAGTGGTGTTCCAACCTCATAGATATTCAAGAACTTACTATCTTATAGATGATTTTGTAGATCTTT
TTAAAAGCTTAGATAAGGTATTCTTACTTGATATATATGGGGCTTCTGAGGAAAATACGTTTGGTATTTCTTCTTTAGAT
ATGATAAACAAAGTATCAAAAGAAGAGTGTGTTTATATACCATCAAAAGAAGAGCTTTTTGATAGACTTGATGAGCTAAA
AGATAGCGTTATTGTGTTTATGGGGGCTGGTTCTATAGGCCAATGGTCTCATGAATATGCAAAGACGTAA

Upstream 100 bases:

>100_bases
ATAACAAAACATCTAAATGCTTTCTATGATAGGTATCATTATATATAAAAAATTTTTTATACAAAATTGTTTATTTTGTG
TTGGTGCTATAATATAACAA

Downstream 100 bases:

>100_bases
AATATCTTTTGTAATTCTTACAAAAAACGAAGAAAAAAACATAAAAAGAGCCATAGATAGCATAAAAGATGTAGCAGATG
AGATACTTGTAATAGATTCA

Product: UDP-N-acetylmuramate/alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MFREKFRKFHFIGIGGIGMSGIAKILLDMGYEVSGSDVRQNDVIKELKEKGATIYIGHDAKNVIGKEVVVYSSAISNVNE
ELLKAKELGLQVISRGDMLADLFRMKEGIAISGSHGKTTTTSMISHISHIAGLDPTVLIGGILQTFGSNAVLGKSELLIS
EADESDGSFLKLNSVINVVTNIDKEHIGYYKDYEDIKEAFVKFINNVPFYGASVVNIDDTGVRSILSKIHKKIITYGIES
GDFQAKNIVFNSDNTRFDVFYKGIKLNTIELQIPGIHNVYNALASIAVSTLMEIEQPVIRDALKSFKNAKRRIEFVGEKN
TNLIYDDYGHHPTEIKSVYEALKSKYKDKNIVVVFQPHRYSRTYYLIDDFVDLFKSLDKVFLLDIYGASEENTFGISSLD
MINKVSKEECVYIPSKEELFDRLDELKDSVIVFMGAGSIGQWSHEYAKT

Sequences:

>Translated_449_residues
MFREKFRKFHFIGIGGIGMSGIAKILLDMGYEVSGSDVRQNDVIKELKEKGATIYIGHDAKNVIGKEVVVYSSAISNVNE
ELLKAKELGLQVISRGDMLADLFRMKEGIAISGSHGKTTTTSMISHISHIAGLDPTVLIGGILQTFGSNAVLGKSELLIS
EADESDGSFLKLNSVINVVTNIDKEHIGYYKDYEDIKEAFVKFINNVPFYGASVVNIDDTGVRSILSKIHKKIITYGIES
GDFQAKNIVFNSDNTRFDVFYKGIKLNTIELQIPGIHNVYNALASIAVSTLMEIEQPVIRDALKSFKNAKRRIEFVGEKN
TNLIYDDYGHHPTEIKSVYEALKSKYKDKNIVVVFQPHRYSRTYYLIDDFVDLFKSLDKVFLLDIYGASEENTFGISSLD
MINKVSKEECVYIPSKEELFDRLDELKDSVIVFMGAGSIGQWSHEYAKT
>Mature_449_residues
MFREKFRKFHFIGIGGIGMSGIAKILLDMGYEVSGSDVRQNDVIKELKEKGATIYIGHDAKNVIGKEVVVYSSAISNVNE
ELLKAKELGLQVISRGDMLADLFRMKEGIAISGSHGKTTTTSMISHISHIAGLDPTVLIGGILQTFGSNAVLGKSELLIS
EADESDGSFLKLNSVINVVTNIDKEHIGYYKDYEDIKEAFVKFINNVPFYGASVVNIDDTGVRSILSKIHKKIITYGIES
GDFQAKNIVFNSDNTRFDVFYKGIKLNTIELQIPGIHNVYNALASIAVSTLMEIEQPVIRDALKSFKNAKRRIEFVGEKN
TNLIYDDYGHHPTEIKSVYEALKSKYKDKNIVVVFQPHRYSRTYYLIDDFVDLFKSLDKVFLLDIYGASEENTFGISSLD
MINKVSKEECVYIPSKEELFDRLDELKDSVIVFMGAGSIGQWSHEYAKT

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=460, Percent_Identity=39.3478260869565, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI1790680, Length=388, Percent_Identity=29.1237113402062, Blast_Score=165, Evalue=6e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_HYDS0 (B4U813)

Other databases:

- EMBL:   CP001130
- RefSeq:   YP_002121252.1
- ProteinModelPortal:   B4U813
- SMR:   B4U813
- GeneID:   6743383
- GenomeReviews:   CP001130_GR
- KEGG:   hya:HY04AAS1_0587
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   CLSK2299677
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 50276; Mature: 50276

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFREKFRKFHFIGIGGIGMSGIAKILLDMGYEVSGSDVRQNDVIKELKEKGATIYIGHDA
CCHHHHCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCH
KNVIGKEVVVYSSAISNVNEELLKAKELGLQVISRGDMLADLFRMKEGIAISGSHGKTTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEECCCCCHHH
TSMISHISHIAGLDPTVLIGGILQTFGSNAVLGKSELLISEADESDGSFLKLNSVINVVT
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEECCHHEEEEECCCCCCCEEEHHHHHHHHH
NIDKEHIGYYKDYEDIKEAFVKFINNVPFYGASVVNIDDTGVRSILSKIHKKIITYGIES
CCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCC
GDFQAKNIVFNSDNTRFDVFYKGIKLNTIELQIPGIHNVYNALASIAVSTLMEIEQPVIR
CCCEECEEEECCCCCEEEEEEECEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
DALKSFKNAKRRIEFVGEKNTNLIYDDYGHHPTEIKSVYEALKSKYKDKNIVVVFQPHRY
HHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCC
SRTYYLIDDFVDLFKSLDKVFLLDIYGASEENTFGISSLDMINKVSKEECVYIPSKEELF
CCEEEEHHHHHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHCCCCCEEECCCHHHHH
DRLDELKDSVIVFMGAGSIGQWSHEYAKT
HHHHHHCCCEEEEEECCCCCCCCHHHCCC
>Mature Secondary Structure
MFREKFRKFHFIGIGGIGMSGIAKILLDMGYEVSGSDVRQNDVIKELKEKGATIYIGHDA
CCHHHHCCEEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCH
KNVIGKEVVVYSSAISNVNEELLKAKELGLQVISRGDMLADLFRMKEGIAISGSHGKTTT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCEEECCCCCHHH
TSMISHISHIAGLDPTVLIGGILQTFGSNAVLGKSELLISEADESDGSFLKLNSVINVVT
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEECCHHEEEEECCCCCCCEEEHHHHHHHHH
NIDKEHIGYYKDYEDIKEAFVKFINNVPFYGASVVNIDDTGVRSILSKIHKKIITYGIES
CCCHHHCCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCC
GDFQAKNIVFNSDNTRFDVFYKGIKLNTIELQIPGIHNVYNALASIAVSTLMEIEQPVIR
CCCEECEEEECCCCCEEEEEEECEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
DALKSFKNAKRRIEFVGEKNTNLIYDDYGHHPTEIKSVYEALKSKYKDKNIVVVFQPHRY
HHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCC
SRTYYLIDDFVDLFKSLDKVFLLDIYGASEENTFGISSLDMINKVSKEECVYIPSKEELF
CCEEEEHHHHHHHHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHCCCCCEEECCCHHHHH
DRLDELKDSVIVFMGAGSIGQWSHEYAKT
HHHHHHCCCEEEEEECCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA