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The map label for this gene is nuoF [H]

Identifier: 195952596

GI number: 195952596

Start: 195546

End: 196823

Strand: Direct

Name: nuoF [H]

Synonym: HY04AAS1_0216

Alternate gene names: 195952596

Gene position: 195546-196823 (Clockwise)

Preceding gene: 195952595

Following gene: 195952597

Centisome position: 12.54

GC content: 39.91

Gene sequence:

>1278_bases
ATGAAATACTTGCCAAATATAGCTAATATACACGCTGAAACGGAGCTAAACCTTCTTCTTAAAAGAGCCAAACGCAAGCG
AACCGCCGATATAAAAGAATACTTAAAAGACAATGGATATCTTGCGTTAGAGAAAGCCCTAAGCATGAAGCCTGAAGACA
TAGTAGAAGAAGTAGACAACAGCAATTTAAGAGGAAGAGGCGGAGCAGGTTTTCCTACTGGTAGAAAGTGGAAATTTTGT
CTTCAAAACAAAGCTCCTAGATACTTGGTGTGCAACGCCGATGAATCAGAGCCAGGCACTTTTAAAGACAGGCTTATTAT
AGAAAGGGATCCTCATCTACTTTTGGAGGGTATGATTATATCCGCTTACGCTCTTGGGGTCAACAGAGCTTACATATACA
TAAGAGGCGAGTATCCAGCCGGTTATTATATATTAAGAAACGCCATAGAAGAAGCAAAAAAAGAAGGTTTTTTGGGTAAA
AATATACTAAACTCTGGTTTTGATCTTGAAATACTTGTTTCAAGAGGAGCCGGTGCTTATATCTGCGGTGAAGAGACGGC
TCTTCTTAACTCTATAGAAGGTAAAAGAGGGCATCCAAGGCTAAAACCACCTTTTCCAGTCCAGGTGGGCTTATGGGGTA
GGCCTACAGTTGTAAACAATGTAGAAACGTTGTCAAATATTCCTATTATTATAAATTTAGGTTCTGAAGGCTATAAAGAG
ATAGGCCCTATGGATTATCCTGGTCCTAAGCTTTTTCCAGTGAGCGGGAAGGTGAAAAAGCCAGGTGTTTATGAACTCCC
CATGAATACAACCCTAAGAGAGGTTATATTTAAATACGCTGGTGGGACTATTAGAAACGTTCCTATAAAGGCTGTATTTT
CTGGAGCTCTTGATTGTCTTAGCGTGAGTGAACTAGATACTCCTATGGATTACTCACAGTTTGGCTTTGGTGGTACTGGT
ACTGTGATAGTGCTAACTGAAGAAGATGATATAGTGAATGCTTGTTATAAGATAGCTGAGTTTTATGAACATGAGACTTG
TGGCTTTTGTACACCGTGCCGTATAGGTTGCCACGAGCAAGCTTATCTTCTTGACAAGATAGAAAAAGACGAAGCCACAC
CAAAGACTTGGGAAGGTCTTAGGTTTGTGACAAAGTATATTCAACCCACTTCTGTTTGTGGTCTTGGCGCTGTGGCTAGT
AGACTTATCAAACAAGCTATGGAAAAGTTCCCAGAGGATTTTGCCAAGAAAGAACAAAAATCCTTTGTAAATATTTAA

Upstream 100 bases:

>100_bases
TTTAAGCTTGTGGAAGTCCAATGCCTTGGTGCTTGCTCAGAAGCACCGGTTTTCATGGTAGACAACGATACGTATAGGTA
TGAATCAAAGGAGAAGCTTC

Downstream 100 bases:

>100_bases
AGTTTGGAGGTTTTTATGAGAAGCGATATAATACAAAAAGGCTATGACAAAGCCCCGCATAGATCTTTATTGAGGGCTTG
TGGTTTTAAAGATGAGGATT

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F; NDH-1 subunit F [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MKYLPNIANIHAETELNLLLKRAKRKRTADIKEYLKDNGYLALEKALSMKPEDIVEEVDNSNLRGRGGAGFPTGRKWKFC
LQNKAPRYLVCNADESEPGTFKDRLIIERDPHLLLEGMIISAYALGVNRAYIYIRGEYPAGYYILRNAIEEAKKEGFLGK
NILNSGFDLEILVSRGAGAYICGEETALLNSIEGKRGHPRLKPPFPVQVGLWGRPTVVNNVETLSNIPIIINLGSEGYKE
IGPMDYPGPKLFPVSGKVKKPGVYELPMNTTLREVIFKYAGGTIRNVPIKAVFSGALDCLSVSELDTPMDYSQFGFGGTG
TVIVLTEEDDIVNACYKIAEFYEHETCGFCTPCRIGCHEQAYLLDKIEKDEATPKTWEGLRFVTKYIQPTSVCGLGAVAS
RLIKQAMEKFPEDFAKKEQKSFVNI

Sequences:

>Translated_425_residues
MKYLPNIANIHAETELNLLLKRAKRKRTADIKEYLKDNGYLALEKALSMKPEDIVEEVDNSNLRGRGGAGFPTGRKWKFC
LQNKAPRYLVCNADESEPGTFKDRLIIERDPHLLLEGMIISAYALGVNRAYIYIRGEYPAGYYILRNAIEEAKKEGFLGK
NILNSGFDLEILVSRGAGAYICGEETALLNSIEGKRGHPRLKPPFPVQVGLWGRPTVVNNVETLSNIPIIINLGSEGYKE
IGPMDYPGPKLFPVSGKVKKPGVYELPMNTTLREVIFKYAGGTIRNVPIKAVFSGALDCLSVSELDTPMDYSQFGFGGTG
TVIVLTEEDDIVNACYKIAEFYEHETCGFCTPCRIGCHEQAYLLDKIEKDEATPKTWEGLRFVTKYIQPTSVCGLGAVAS
RLIKQAMEKFPEDFAKKEQKSFVNI
>Mature_425_residues
MKYLPNIANIHAETELNLLLKRAKRKRTADIKEYLKDNGYLALEKALSMKPEDIVEEVDNSNLRGRGGAGFPTGRKWKFC
LQNKAPRYLVCNADESEPGTFKDRLIIERDPHLLLEGMIISAYALGVNRAYIYIRGEYPAGYYILRNAIEEAKKEGFLGK
NILNSGFDLEILVSRGAGAYICGEETALLNSIEGKRGHPRLKPPFPVQVGLWGRPTVVNNVETLSNIPIIINLGSEGYKE
IGPMDYPGPKLFPVSGKVKKPGVYELPMNTTLREVIFKYAGGTIRNVPIKAVFSGALDCLSVSELDTPMDYSQFGFGGTG
TVIVLTEEDDIVNACYKIAEFYEHETCGFCTPCRIGCHEQAYLLDKIEKDEATPKTWEGLRFVTKYIQPTSVCGLGAVAS
RLIKQAMEKFPEDFAKKEQKSFVNI

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=402, Percent_Identity=42.5373134328358, Blast_Score=292, Evalue=4e-79,
Organism=Homo sapiens, GI260656005, Length=402, Percent_Identity=42.5373134328358, Blast_Score=292, Evalue=4e-79,
Organism=Escherichia coli, GI1788620, Length=409, Percent_Identity=44.2542787286064, Blast_Score=344, Evalue=6e-96,
Organism=Caenorhabditis elegans, GI17531727, Length=385, Percent_Identity=41.8181818181818, Blast_Score=291, Evalue=6e-79,
Organism=Drosophila melanogaster, GI19920794, Length=399, Percent_Identity=39.0977443609023, Blast_Score=282, Evalue=4e-76,
Organism=Drosophila melanogaster, GI45550452, Length=380, Percent_Identity=40.7894736842105, Blast_Score=278, Evalue=3e-75,
Organism=Drosophila melanogaster, GI24653819, Length=396, Percent_Identity=34.3434343434343, Blast_Score=211, Evalue=8e-55,
Organism=Drosophila melanogaster, GI24653817, Length=368, Percent_Identity=32.3369565217391, Blast_Score=182, Evalue=5e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47386; Mature: 47386

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYLPNIANIHAETELNLLLKRAKRKRTADIKEYLKDNGYLALEKALSMKPEDIVEEVDN
CCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHCCCHHHHHHHHCC
SNLRGRGGAGFPTGRKWKFCLQNKAPRYLVCNADESEPGTFKDRLIIERDPHLLLEGMII
CCCCCCCCCCCCCCCCCCEEECCCCCCEEEEECCCCCCCCCCCCEEEECCCCHHHHHHHH
SAYALGVNRAYIYIRGEYPAGYYILRNAIEEAKKEGFLGKNILNSGFDLEILVSRGAGAY
HHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCCEEEEEECCCCEE
ICGEETALLNSIEGKRGHPRLKPPFPVQVGLWGRPTVVNNVETLSNIPIIINLGSEGYKE
EECCHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCHHCCHHHHCCCCEEEECCCCCHHH
IGPMDYPGPKLFPVSGKVKKPGVYELPMNTTLREVIFKYAGGTIRNVPIKAVFSGALDCL
CCCCCCCCCEEEECCCCCCCCCEEECCCCHHHHHHHHHHCCCCEECCCHHHHHHHHHHHH
SVSELDTPMDYSQFGFGGTGTVIVLTEEDDIVNACYKIAEFYEHETCGFCTPCRIGCHEQ
HHHHCCCCCCHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCH
AYLLDKIEKDEATPKTWEGLRFVTKYIQPTSVCGLGAVASRLIKQAMEKFPEDFAKKEQK
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFVNI
HCCCC
>Mature Secondary Structure
MKYLPNIANIHAETELNLLLKRAKRKRTADIKEYLKDNGYLALEKALSMKPEDIVEEVDN
CCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHCCCHHHHHHHHCC
SNLRGRGGAGFPTGRKWKFCLQNKAPRYLVCNADESEPGTFKDRLIIERDPHLLLEGMII
CCCCCCCCCCCCCCCCCCEEECCCCCCEEEEECCCCCCCCCCCCEEEECCCCHHHHHHHH
SAYALGVNRAYIYIRGEYPAGYYILRNAIEEAKKEGFLGKNILNSGFDLEILVSRGAGAY
HHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCCEEEEEECCCCEE
ICGEETALLNSIEGKRGHPRLKPPFPVQVGLWGRPTVVNNVETLSNIPIIINLGSEGYKE
EECCHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCHHCCHHHHCCCCEEEECCCCCHHH
IGPMDYPGPKLFPVSGKVKKPGVYELPMNTTLREVIFKYAGGTIRNVPIKAVFSGALDCL
CCCCCCCCCEEEECCCCCCCCCEEECCCCHHHHHHHHHHCCCCEECCCHHHHHHHHHHHH
SVSELDTPMDYSQFGFGGTGTVIVLTEEDDIVNACYKIAEFYEHETCGFCTPCRIGCHEQ
HHHHCCCCCCHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCH
AYLLDKIEKDEATPKTWEGLRFVTKYIQPTSVCGLGAVASRLIKQAMEKFPEDFAKKEQK
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFVNI
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]