Click here to switch to the map view.

The map label for this gene is wzb [H]

Identifier: 194737610

GI number: 194737610

Start: 2222600

End: 2223049

Strand: Reverse

Name: wzb [H]

Synonym: SeSA_A2350

Alternate gene names: 194737610

Gene position: 2223049-2222600 (Counterclockwise)

Preceding gene: 194736033

Following gene: 194736839

Centisome position: 47.21

GC content: 57.56

Gene sequence:

>450_bases
ATGTTTAACAAAATCTTAGTGGTCTGTGTGGGGAATGTTTGCCGTTCCCCGACGGCGGAACGTTTGCTAAAACGCTTTCA
TCCCTCGCTGACGGTTGCGTCCGCAGGATTAGGCGCGCTGGTCGGCAAAGGCGCCGATCCTGCGGCGGCGAGCGTGGCGA
GCGCCCACGATCTGTCTTTGGAAAATCACTGCGCAAGGCAAATTTCCGCGCGTCTGTGCCGGGAATATGACCTGATTCTG
ACGATGGAGAAACGCCACATCGCCGCCCTGTGCGACATTGCGCCGGAAATGCGCGGCAAGGTAATGCTGTTTGGTCACTG
GGACAGCGAGCGTGAAATACCGGACCCGTATCGCAAAAGCCGCGATGCGTTTGAGGCGGTGTACACATTACTGGAAAGGT
CTGCCCGCCAGTGGGCGCAGGCACTGAATGCAGAGCAGGGAAAACCATGA

Upstream 100 bases:

>100_bases
TTGCTCGCTGGAACCGTCTGATCAATCAGTTGCTGCCAACCATTAGCGGTGTCCGTTATATGACGGATACGGCCAGCGAC
ATTCATTCCTGGTAATCGTT

Downstream 100 bases:

>100_bases
CAGAAAAAGTAAAACAATCTGCGGCGGTTACGGGTAGCGATGAAATCGATATCGGGCGCCTGGTCGGAACGGTGATTGAA
GCGCGTTGGTGGGTGTTGGG

Product: tyrosine phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MFNKILVVCVGNVCRSPTAERLLKRFHPSLTVASAGLGALVGKGADPAAASVASAHDLSLENHCARQISARLCREYDLIL
TMEKRHIAALCDIAPEMRGKVMLFGHWDSEREIPDPYRKSRDAFEAVYTLLERSARQWAQALNAEQGKP

Sequences:

>Translated_149_residues
MFNKILVVCVGNVCRSPTAERLLKRFHPSLTVASAGLGALVGKGADPAAASVASAHDLSLENHCARQISARLCREYDLIL
TMEKRHIAALCDIAPEMRGKVMLFGHWDSEREIPDPYRKSRDAFEAVYTLLERSARQWAQALNAEQGKP
>Mature_149_residues
MFNKILVVCVGNVCRSPTAERLLKRFHPSLTVASAGLGALVGKGADPAAASVASAHDLSLENHCARQISARLCREYDLIL
TMEKRHIAALCDIAPEMRGKVMLFGHWDSEREIPDPYRKSRDAFEAVYTLLERSARQWAQALNAEQGKP

Specific function: Dephosphorylates wzc. Required for the extracellular polysaccharide colanic acid synthesis. Probably involved in the export of colanic acid from the cell to medium [H]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Escherichia coli, GI1788375, Length=146, Percent_Identity=83.5616438356164, Blast_Score=259, Evalue=7e-71,
Organism=Escherichia coli, GI87081812, Length=142, Percent_Identity=57.0422535211268, Blast_Score=164, Evalue=2e-42,
Organism=Drosophila melanogaster, GI78706766, Length=139, Percent_Identity=33.0935251798561, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI78706768, Length=139, Percent_Identity=33.0935251798561, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI78706764, Length=127, Percent_Identity=33.8582677165354, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 16474; Mature: 16474

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNKILVVCVGNVCRSPTAERLLKRFHPSLTVASAGLGALVGKGADPAAASVASAHDLSL
CCCCEEHEECCHHHCCCHHHHHHHHHCCCCEEHHCCHHHHHCCCCCCHHHHHHHHHHCCH
ENHCARQISARLCREYDLILTMEKRHIAALCDIAPEMRGKVMLFGHWDSEREIPDPYRKS
HHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHCHHHCCCEEEEECCCCCCCCCCHHHHH
RDAFEAVYTLLERSARQWAQALNAEQGKP
HHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFNKILVVCVGNVCRSPTAERLLKRFHPSLTVASAGLGALVGKGADPAAASVASAHDLSL
CCCCEEHEECCHHHCCCHHHHHHHHHCCCCEEHHCCHHHHHCCCCCCHHHHHHHHHHCCH
ENHCARQISARLCREYDLILTMEKRHIAALCDIAPEMRGKVMLFGHWDSEREIPDPYRKS
HHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHCHHHCCCEEEEECCCCCCCCCCHHHHH
RDAFEAVYTLLERSARQWAQALNAEQGKP
HHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]