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The map label for this gene is wzc [H]

Identifier: 194736839

GI number: 194736839

Start: 2220444

End: 2222603

Strand: Reverse

Name: wzc [H]

Synonym: SeSA_A2349

Alternate gene names: 194736839

Gene position: 2222603-2220444 (Counterclockwise)

Preceding gene: 194737610

Following gene: 194737530

Centisome position: 47.2

GC content: 53.89

Gene sequence:

>2160_bases
ATGACAGAAAAAGTAAAACAATCTGCGGCGGTTACGGGTAGCGATGAAATCGATATCGGGCGCCTGGTCGGAACGGTGAT
TGAAGCGCGTTGGTGGGTGTTGGGGACGACGGCCATATTTGCGCTGTGCGCGGTAATTTATACGTTCTTCGCCACGCCCA
TCTATAGCGCCGATGCGCTGGTGCAGATTGAACAAAACGCCGGTAATTCGCTGGTACAGGATATCAACAGCGCATTAGCG
AATAAGCCGCCGGCTTCCGATGCGGAAATTCAGCTCATTCGATCGCGTCTGGTGCTGGGGAAGACCGTTGACGATCTGGA
TCTGGATATTGCCGTCACCAAAAACACCTTTCCGCTGTTCGGCGCCGGGTGGGAGCGGCTGATGGGACGTCACAATGAAA
GGGTGAAAGTCACGACATTCACCCGACCAGAGACGATGAGCGGACAGATCTTCACCCTCAAAGTGCTGGGCGACAAACGT
TATCAGTTGGTCAGCGACGGCGGATTTAGCGCGCAGGGCGTTGTGGGCCAGCCACTCAATAAAGACGGCGTGACGATGTG
GGTAGAGGCAATTGACGCCCGTCCTGATACGGAATTTACGGTGAGTAAATTCTCAACGCTTGGCATGATTAATAACCTGC
AAAATAACCTCACCGTAACGGAAACCGGCAAAGATACAGGCGTTCTGAGCCTGACGTTCACGGGAGAGGATCGCGACCAG
ATCCGCGAAATTCTCAACAGTATTACCCGTAACTATCTGCAACAGGATATTGCGCGGAAATCTGAAGAGGCGGGGAAGAG
CCTGGCGTTTCTGGCAAAACAACTGCCGGAAGTCCGCAGCCGTCTGGATGTGGCGGAAAACAAGCTAAACGCTTTCCGCC
AGGATAAAGACTCGGTGGATTTACCGCTGGAGGCGAAGGCGGTGCTCGATTCGATGGTTAATATCGACGCCCAGTTGAAT
GAGTTGACGTTTAAAGAGGCGGAAATTTCCAAGCTCTTTACCAAAGCGCATCCGGCTTACCGCACCCTGCTGGAAAAACG
TAAAGCGCTGGAAGATGAAAAAGCCAAACTGAACGGGCGGGTGACGGCAATGCCGAAAACCCAGCAGGAGATTGTGCGTT
TGACCCGCGATGTGGAGTCCGGCCAGCAGGTCTATATGCAACTGCTTAATAAACAGCAGGAGCTGAAAATCACCGAAGCC
AGCACCGTTGGCGACGTACGCATCGTTGACCCGGCGATTACCCAGCCGGGCGTGCTGAAGCCGAAAAAGGCGTTGATTAT
TCTCGGCAGCATTATTCTGGGATTAATGTTATCGATTGTCGGCGTGCTGCTGCGCTCGCTGTTTAATCGTGGTATCGAAA
GCCCACAGGTGCTGGAGGAGCACGGGATCAGCGTCTATGCCAGTATTCCGCTGTCGGAATGGCAAAAAGCGCGCGATAGC
GTCAAAACCATTAAAGGGATTAAGCGTTACAAGCAGAGCCAACTGCTGGCGGTGGGCAATCCGACCGATCTGGCGATTGA
GGCGATTCGCAGCCTGCGCACCAGCCTGCATTTCGCCATGATGCAGGCGCAAAATAATGTACTCATGCTCACAGGCGTCA
GCCCCTCTATCGGCAAAACCTTTGTTTGCGCCAACCTGGCGGCCGTCATCAGCCAGACGCATAAACGGGTATTACTGATC
GACTGCGATATGCGCAAGGGCTACACCCATGAACTGCTCGGCACCAATAACGTGGACGGCTTATCTGACATTCTGGCGGG
CAAAGGCGAGATAGCCTCCTGCGCGAAACCTACGGCGATCGCTAATTTTGATCTTATTCCGCGCGGTCAGGTACCTCCTA
ATCCATCGGAACTGCTGATGAGCGAGCGCTTCGGCGAGCTGATCACCTGGGCAAGCAGCCGCTACGACCTGGTATTAATC
GACACGCCGCCGATTCTGGCCGTGACGGACGCCGCGATTGTGGGTCGCCACGTCGGGACGACGCTGATGGTGGCGCGTTA
TGCCGTCAACACTTTAAAAGAGGTGGAAACCAGTCTGAGCCGTTTTGACCAGAATGGCATTCAGGTCAAAGGCGTCATTC
TCAACTCCATTTTCCGCCGGGCGACGGGCTACCAGGATTATGGCTATTACGAGTATGAATACCAGTCAGATTCCAAATAA

Upstream 100 bases:

>100_bases
CGTATCGCAAAAGCCGCGATGCGTTTGAGGCGGTGTACACATTACTGGAAAGGTCTGCCCGCCAGTGGGCGCAGGCACTG
AATGCAGAGCAGGGAAAACC

Downstream 100 bases:

>100_bases
AAAATAAGGCGTGCCGGATGGCGCGGCCTGTGACTGTAGGCCGGACAAGCGTAGCGCCATGCGGCAAAACTATCTGGGGA
ATAAGCATGACAACAGACAA

Product: tyrosine kinase

Products: ADP; protein tyrosine phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 719; Mature: 718

Protein sequence:

>719_residues
MTEKVKQSAAVTGSDEIDIGRLVGTVIEARWWVLGTTAIFALCAVIYTFFATPIYSADALVQIEQNAGNSLVQDINSALA
NKPPASDAEIQLIRSRLVLGKTVDDLDLDIAVTKNTFPLFGAGWERLMGRHNERVKVTTFTRPETMSGQIFTLKVLGDKR
YQLVSDGGFSAQGVVGQPLNKDGVTMWVEAIDARPDTEFTVSKFSTLGMINNLQNNLTVTETGKDTGVLSLTFTGEDRDQ
IREILNSITRNYLQQDIARKSEEAGKSLAFLAKQLPEVRSRLDVAENKLNAFRQDKDSVDLPLEAKAVLDSMVNIDAQLN
ELTFKEAEISKLFTKAHPAYRTLLEKRKALEDEKAKLNGRVTAMPKTQQEIVRLTRDVESGQQVYMQLLNKQQELKITEA
STVGDVRIVDPAITQPGVLKPKKALIILGSIILGLMLSIVGVLLRSLFNRGIESPQVLEEHGISVYASIPLSEWQKARDS
VKTIKGIKRYKQSQLLAVGNPTDLAIEAIRSLRTSLHFAMMQAQNNVLMLTGVSPSIGKTFVCANLAAVISQTHKRVLLI
DCDMRKGYTHELLGTNNVDGLSDILAGKGEIASCAKPTAIANFDLIPRGQVPPNPSELLMSERFGELITWASSRYDLVLI
DTPPILAVTDAAIVGRHVGTTLMVARYAVNTLKEVETSLSRFDQNGIQVKGVILNSIFRRATGYQDYGYYEYEYQSDSK

Sequences:

>Translated_719_residues
MTEKVKQSAAVTGSDEIDIGRLVGTVIEARWWVLGTTAIFALCAVIYTFFATPIYSADALVQIEQNAGNSLVQDINSALA
NKPPASDAEIQLIRSRLVLGKTVDDLDLDIAVTKNTFPLFGAGWERLMGRHNERVKVTTFTRPETMSGQIFTLKVLGDKR
YQLVSDGGFSAQGVVGQPLNKDGVTMWVEAIDARPDTEFTVSKFSTLGMINNLQNNLTVTETGKDTGVLSLTFTGEDRDQ
IREILNSITRNYLQQDIARKSEEAGKSLAFLAKQLPEVRSRLDVAENKLNAFRQDKDSVDLPLEAKAVLDSMVNIDAQLN
ELTFKEAEISKLFTKAHPAYRTLLEKRKALEDEKAKLNGRVTAMPKTQQEIVRLTRDVESGQQVYMQLLNKQQELKITEA
STVGDVRIVDPAITQPGVLKPKKALIILGSIILGLMLSIVGVLLRSLFNRGIESPQVLEEHGISVYASIPLSEWQKARDS
VKTIKGIKRYKQSQLLAVGNPTDLAIEAIRSLRTSLHFAMMQAQNNVLMLTGVSPSIGKTFVCANLAAVISQTHKRVLLI
DCDMRKGYTHELLGTNNVDGLSDILAGKGEIASCAKPTAIANFDLIPRGQVPPNPSELLMSERFGELITWASSRYDLVLI
DTPPILAVTDAAIVGRHVGTTLMVARYAVNTLKEVETSLSRFDQNGIQVKGVILNSIFRRATGYQDYGYYEYEYQSDSK
>Mature_718_residues
TEKVKQSAAVTGSDEIDIGRLVGTVIEARWWVLGTTAIFALCAVIYTFFATPIYSADALVQIEQNAGNSLVQDINSALAN
KPPASDAEIQLIRSRLVLGKTVDDLDLDIAVTKNTFPLFGAGWERLMGRHNERVKVTTFTRPETMSGQIFTLKVLGDKRY
QLVSDGGFSAQGVVGQPLNKDGVTMWVEAIDARPDTEFTVSKFSTLGMINNLQNNLTVTETGKDTGVLSLTFTGEDRDQI
REILNSITRNYLQQDIARKSEEAGKSLAFLAKQLPEVRSRLDVAENKLNAFRQDKDSVDLPLEAKAVLDSMVNIDAQLNE
LTFKEAEISKLFTKAHPAYRTLLEKRKALEDEKAKLNGRVTAMPKTQQEIVRLTRDVESGQQVYMQLLNKQQELKITEAS
TVGDVRIVDPAITQPGVLKPKKALIILGSIILGLMLSIVGVLLRSLFNRGIESPQVLEEHGISVYASIPLSEWQKARDSV
KTIKGIKRYKQSQLLAVGNPTDLAIEAIRSLRTSLHFAMMQAQNNVLMLTGVSPSIGKTFVCANLAAVISQTHKRVLLID
CDMRKGYTHELLGTNNVDGLSDILAGKGEIASCAKPTAIANFDLIPRGQVPPNPSELLMSERFGELITWASSRYDLVLID
TPPILAVTDAAIVGRHVGTTLMVARYAVNTLKEVETSLSRFDQNGIQVKGVILNSIFRRATGYQDYGYYEYEYQSDSK

Specific function: Required for the extracellular polysaccharide colanic acid synthesis. The autophosphorylated form is inactive. Probably involved in the export of colanic acid from the cell to medium [H]

COG id: COG3206

COG function: function code M; Uncharacterized protein involved in exopolysaccharide biosynthesis

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the etk/wzc family [H]

Homologues:

Organism=Escherichia coli, GI87082032, Length=720, Percent_Identity=88.3333333333333, Blast_Score=1312, Evalue=0.0,
Organism=Escherichia coli, GI1787216, Length=708, Percent_Identity=50.9887005649718, Blast_Score=736, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR005702
- InterPro:   IPR003856 [H]

Pfam domain/function: PF01656 CbiA; PF02706 Wzz [H]

EC number: 2.7.1.112 [C]

Molecular weight: Translated: 79284; Mature: 79153

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKVKQSAAVTGSDEIDIGRLVGTVIEARWWVLGTTAIFALCAVIYTFFATPIYSADAL
CCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
VQIEQNAGNSLVQDINSALANKPPASDAEIQLIRSRLVLGKTVDDLDLDIAVTKNTFPLF
EEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCC
GAGWERLMGRHNERVKVTTFTRPETMSGQIFTLKVLGDKRYQLVSDGGFSAQGVVGQPLN
CCCHHHHHCCCCCEEEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCCC
KDGVTMWVEAIDARPDTEFTVSKFSTLGMINNLQNNLTVTETGKDTGVLSLTFTGEDRDQ
CCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCHHH
IREILNSITRNYLQQDIARKSEEAGKSLAFLAKQLPEVRSRLDVAENKLNAFRQDKDSVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LPLEAKAVLDSMVNIDAQLNELTFKEAEISKLFTKAHPAYRTLLEKRKALEDEKAKLNGR
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHCCE
VTAMPKTQQEIVRLTRDVESGQQVYMQLLNKQQELKITEASTVGDVRIVDPAITQPGVLK
EEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEECCCCCCEEEECCCCCCCCCCC
PKKALIILGSIILGLMLSIVGVLLRSLFNRGIESPQVLEEHGISVYASIPLSEWQKARDS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEECCHHHHHHHHHH
VKTIKGIKRYKQSQLLAVGNPTDLAIEAIRSLRTSLHFAMMQAQNNVLMLTGVSPSIGKT
HHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHH
FVCANLAAVISQTHKRVLLIDCDMRKGYTHELLGTNNVDGLSDILAGKGEIASCAKPTAI
HHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHCCCCCCCCHHHHHCCCCCCCCCCCCCEE
ANFDLIPRGQVPPNPSELLMSERFGELITWASSRYDLVLIDTPPILAVTDAAIVGRHVGT
ECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEECHHHHHHHHHHH
TLMVARYAVNTLKEVETSLSRFDQNGIQVKGVILNSIFRRATGYQDYGYYEYEYQSDSK
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCCEEEEEECCCCC
>Mature Secondary Structure 
TEKVKQSAAVTGSDEIDIGRLVGTVIEARWWVLGTTAIFALCAVIYTFFATPIYSADAL
CCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
VQIEQNAGNSLVQDINSALANKPPASDAEIQLIRSRLVLGKTVDDLDLDIAVTKNTFPLF
EEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCC
GAGWERLMGRHNERVKVTTFTRPETMSGQIFTLKVLGDKRYQLVSDGGFSAQGVVGQPLN
CCCHHHHHCCCCCEEEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCCCCC
KDGVTMWVEAIDARPDTEFTVSKFSTLGMINNLQNNLTVTETGKDTGVLSLTFTGEDRDQ
CCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCHHH
IREILNSITRNYLQQDIARKSEEAGKSLAFLAKQLPEVRSRLDVAENKLNAFRQDKDSVD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LPLEAKAVLDSMVNIDAQLNELTFKEAEISKLFTKAHPAYRTLLEKRKALEDEKAKLNGR
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHCCE
VTAMPKTQQEIVRLTRDVESGQQVYMQLLNKQQELKITEASTVGDVRIVDPAITQPGVLK
EEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEECCCCCCEEEECCCCCCCCCCC
PKKALIILGSIILGLMLSIVGVLLRSLFNRGIESPQVLEEHGISVYASIPLSEWQKARDS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEECCHHHHHHHHHH
VKTIKGIKRYKQSQLLAVGNPTDLAIEAIRSLRTSLHFAMMQAQNNVLMLTGVSPSIGKT
HHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHH
FVCANLAAVISQTHKRVLLIDCDMRKGYTHELLGTNNVDGLSDILAGKGEIASCAKPTAI
HHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHCCCCCCCCHHHHHCCCCCCCCCCCCCEE
ANFDLIPRGQVPPNPSELLMSERFGELITWASSRYDLVLIDTPPILAVTDAAIVGRHVGT
ECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEECHHHHHHHHHHH
TLMVARYAVNTLKEVETSLSRFDQNGIQVKGVILNSIFRRATGYQDYGYYEYEYQSDSK
HHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; a protein tyrosine [C]

Specific reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]