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The map label for this gene is gabT [H]

Identifier: 194736886

GI number: 194736886

Start: 2848722

End: 2850005

Strand: Direct

Name: gabT [H]

Synonym: SeSA_A2937

Alternate gene names: 194736886

Gene position: 2848722-2850005 (Clockwise)

Preceding gene: 194737869

Following gene: 194736084

Centisome position: 60.49

GC content: 57.87

Gene sequence:

>1284_bases
ATGAATACCAATCACGCTTTAATGCAGCGCCGTCATAACGCCGTTCCTCGCGGCGTGGGCCAGATTCACCCGATTTTCGC
CGAGCGGGCGGAAAATTGTCGGGTCTGGGATGTCGAAGGCCGTGAGTATCTCGATTTCGCGGGCGGCATTGCCGTCCTGA
ACACCGGTCATTTACATCCGGGCATTGTTTCAGCGGTCGAAGCGCAGCTGAAGAAATTGTCGCATACCTGTTTTCAGGTG
CTGGCCTATGAACCGTATCTGGCGTTGTGCGAACGCATGAACCAGAAGGTACCGGGCGATTTCGCCAAAAAAACGTTGCT
GGTCACGACCGGTTCAGAAGCGGTTGAAAACGCCGTGAAAATCGCCCGCGCGGCGACAAAACGCAGCGGCGCTATCGCGT
TTAGCGGCGCTTACCACGGTCGTACCCACTACACGCTCTCTCTGACCGGGAAAGTACACCCGTACTCTGCTGGTATGGGA
TTGATGCCAGGCCATGTCTACCGCGCACTTTATCCTTGCCCGCTACACAACATCAGCGACGACGACGCGATCGCCAGCAT
TGAACGCATCTTTAAAAATGATGCCGCGCCGGAAGATATCGCCGCCATTATTATTGAGCCGGTACAGGGCGAAGGCGGAT
TTTACGCTGCCTCTCCCGCGTTTATGCAGCGACTGCGCGCGCTATGCGACCAACACGGCATTATGTTGATTGCCGACGAA
GTGCAAAGCGGCGCGGGCCGGACCGGTACGCTGTTCGCCATGGAACAGATGGGCGTTGCGGCAGATATTACCACGTTTGC
GAAATCGATCGCCGGCGGCTTTCCGCTGGCAGGCGTTACCGGCCGGGCAGACGTGATGGACGCTATCGCGCCGGGCGGTC
TGGGCGGCACCTATGCCGGAAACCCGATTGCCTGCGCCGCCGCGCTGGCGGTACTGGACATTTTCGAGCAGGAAAATCTA
CTGCAAAAGGCAAATACGCTTGGCAAAACGCTGCGCGATGGCCTGATGGAGATAGCGGAAACGCACCGTGAGATTGGCGA
CGTGCGCGGACTGGGCGCCATGATCGCCATTGAGTTGTTCGAAAATGGCGACCCCGGCAAACCGAACGCGGCTCTGACCG
CCGACATTGTGGCCCGCGCCCGCGAGAAAGGGTTAATTCTGCTCTCCTGCGGTCCTTACTACAACATCTTGCGCATCCTC
GTTCCACTCACTATTGAGGCCTCGCAGATTCGGCAAGGCCTGGAGATTATCGCCCAGTGCTTTGATGAGGCGAAACAAGC
GTAA

Upstream 100 bases:

>100_bases
TTAAGGCCTCCGGATTAGGCCGTGAAGGTTCCAAATACGGCATCGAAGATTATTTAGAAATCAAATATATGTGCATCGGC
CTTTAACAGGAGAGTCGCTA

Downstream 100 bases:

>100_bases
TGTCCAATAAGCAGCGTCGGATGGCGACGTAACTGTCTTATCCGGCCTACAAAAACCGTTTCGATTGTAGGCCGAATTAA
GCCAGGCGCCATCCGGTAAA

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MNTNHALMQRRHNAVPRGVGQIHPIFAERAENCRVWDVEGREYLDFAGGIAVLNTGHLHPGIVSAVEAQLKKLSHTCFQV
LAYEPYLALCERMNQKVPGDFAKKTLLVTTGSEAVENAVKIARAATKRSGAIAFSGAYHGRTHYTLSLTGKVHPYSAGMG
LMPGHVYRALYPCPLHNISDDDAIASIERIFKNDAAPEDIAAIIIEPVQGEGGFYAASPAFMQRLRALCDQHGIMLIADE
VQSGAGRTGTLFAMEQMGVAADITTFAKSIAGGFPLAGVTGRADVMDAIAPGGLGGTYAGNPIACAAALAVLDIFEQENL
LQKANTLGKTLRDGLMEIAETHREIGDVRGLGAMIAIELFENGDPGKPNAALTADIVARAREKGLILLSCGPYYNILRIL
VPLTIEASQIRQGLEIIAQCFDEAKQA

Sequences:

>Translated_427_residues
MNTNHALMQRRHNAVPRGVGQIHPIFAERAENCRVWDVEGREYLDFAGGIAVLNTGHLHPGIVSAVEAQLKKLSHTCFQV
LAYEPYLALCERMNQKVPGDFAKKTLLVTTGSEAVENAVKIARAATKRSGAIAFSGAYHGRTHYTLSLTGKVHPYSAGMG
LMPGHVYRALYPCPLHNISDDDAIASIERIFKNDAAPEDIAAIIIEPVQGEGGFYAASPAFMQRLRALCDQHGIMLIADE
VQSGAGRTGTLFAMEQMGVAADITTFAKSIAGGFPLAGVTGRADVMDAIAPGGLGGTYAGNPIACAAALAVLDIFEQENL
LQKANTLGKTLRDGLMEIAETHREIGDVRGLGAMIAIELFENGDPGKPNAALTADIVARAREKGLILLSCGPYYNILRIL
VPLTIEASQIRQGLEIIAQCFDEAKQA
>Mature_427_residues
MNTNHALMQRRHNAVPRGVGQIHPIFAERAENCRVWDVEGREYLDFAGGIAVLNTGHLHPGIVSAVEAQLKKLSHTCFQV
LAYEPYLALCERMNQKVPGDFAKKTLLVTTGSEAVENAVKIARAATKRSGAIAFSGAYHGRTHYTLSLTGKVHPYSAGMG
LMPGHVYRALYPCPLHNISDDDAIASIERIFKNDAAPEDIAAIIIEPVQGEGGFYAASPAFMQRLRALCDQHGIMLIADE
VQSGAGRTGTLFAMEQMGVAADITTFAKSIAGGFPLAGVTGRADVMDAIAPGGLGGTYAGNPIACAAALAVLDIFEQENL
LQKANTLGKTLRDGLMEIAETHREIGDVRGLGAMIAIELFENGDPGKPNAALTADIVARAREKGLILLSCGPYYNILRIL
VPLTIEASQIRQGLEIIAQCFDEAKQA

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=410, Percent_Identity=32.6829268292683, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI13994255, Length=421, Percent_Identity=29.6912114014252, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI37574042, Length=395, Percent_Identity=30.6329113924051, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI284507298, Length=321, Percent_Identity=32.398753894081, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI226442709, Length=363, Percent_Identity=30.5785123966942, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI226442705, Length=395, Percent_Identity=29.873417721519, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI24119277, Length=426, Percent_Identity=27.2300469483568, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI188536080, Length=397, Percent_Identity=25.9445843828715, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI38679950, Length=397, Percent_Identity=25.9445843828715, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI38679946, Length=397, Percent_Identity=25.9445843828715, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI1789016, Length=426, Percent_Identity=88.7323943661972, Blast_Score=788, Evalue=0.0,
Organism=Escherichia coli, GI1787560, Length=421, Percent_Identity=53.2066508313539, Blast_Score=437, Evalue=1e-124,
Organism=Escherichia coli, GI1789759, Length=411, Percent_Identity=35.5231143552311, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI1788044, Length=401, Percent_Identity=34.1645885286783, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI145693181, Length=334, Percent_Identity=35.3293413173653, Blast_Score=185, Evalue=6e-48,
Organism=Escherichia coli, GI1786349, Length=420, Percent_Identity=32.1428571428571, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI1786991, Length=353, Percent_Identity=32.0113314447592, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI25144271, Length=418, Percent_Identity=30.1435406698565, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI32564660, Length=427, Percent_Identity=31.615925058548, Blast_Score=181, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI71992977, Length=423, Percent_Identity=29.5508274231678, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI25144274, Length=231, Percent_Identity=34.1991341991342, Blast_Score=134, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17541228, Length=404, Percent_Identity=25.7425742574257, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6323470, Length=422, Percent_Identity=30.8056872037915, Blast_Score=194, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6324432, Length=408, Percent_Identity=30.3921568627451, Blast_Score=178, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6324386, Length=435, Percent_Identity=20.6896551724138, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6321456, Length=383, Percent_Identity=25.065274151436, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI28574759, Length=445, Percent_Identity=31.685393258427, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI161085790, Length=442, Percent_Identity=31.9004524886878, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI21357415, Length=405, Percent_Identity=30.6172839506173, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI21356575, Length=424, Percent_Identity=30.4245283018868, Blast_Score=151, Evalue=9e-37,
Organism=Drosophila melanogaster, GI281366494, Length=371, Percent_Identity=25.8760107816712, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24667139, Length=371, Percent_Identity=25.8760107816712, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24667143, Length=371, Percent_Identity=25.8760107816712, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 45630; Mature: 45630

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTNHALMQRRHNAVPRGVGQIHPIFAERAENCRVWDVEGREYLDFAGGIAVLNTGHLHP
CCCHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCEEEECCCCHHHHHCCCEEEEECCCCCC
GIVSAVEAQLKKLSHTCFQVLAYEPYLALCERMNQKVPGDFAKKTLLVTTGSEAVENAVK
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHCCEEEEECCHHHHHHHHH
IARAATKRSGAIAFSGAYHGRTHYTLSLTGKVHPYSAGMGLMPGHVYRALYPCPLHNISD
HHHHHHHCCCCEEEECCCCCCEEEEEEEECEECCCCCCCCCCCHHHHHHHCCCCCCCCCC
DDAIASIERIFKNDAAPEDIAAIIIEPVQGEGGFYAASPAFMQRLRALCDQHGIMLIADE
HHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEECCHHHHHHHHHHHCCCCEEEEEEC
VQSGAGRTGTLFAMEQMGVAADITTFAKSIAGGFPLAGVTGRADVMDAIAPGGLGGTYAG
HHCCCCCCCEEEEHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCC
NPIACAAALAVLDIFEQENLLQKANTLGKTLRDGLMEIAETHREIGDVRGLGAMIAIELF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEE
ENGDPGKPNAALTADIVARAREKGLILLSCGPYYNILRILVPLTIEASQIRQGLEIIAQC
CCCCCCCCCCHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
FDEAKQA
HHHHHCC
>Mature Secondary Structure
MNTNHALMQRRHNAVPRGVGQIHPIFAERAENCRVWDVEGREYLDFAGGIAVLNTGHLHP
CCCHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCEEEECCCCHHHHHCCCEEEEECCCCCC
GIVSAVEAQLKKLSHTCFQVLAYEPYLALCERMNQKVPGDFAKKTLLVTTGSEAVENAVK
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHCCEEEEECCHHHHHHHHH
IARAATKRSGAIAFSGAYHGRTHYTLSLTGKVHPYSAGMGLMPGHVYRALYPCPLHNISD
HHHHHHHCCCCEEEECCCCCCEEEEEEEECEECCCCCCCCCCCHHHHHHHCCCCCCCCCC
DDAIASIERIFKNDAAPEDIAAIIIEPVQGEGGFYAASPAFMQRLRALCDQHGIMLIADE
HHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEECCHHHHHHHHHHHCCCCEEEEEEC
VQSGAGRTGTLFAMEQMGVAADITTFAKSIAGGFPLAGVTGRADVMDAIAPGGLGGTYAG
HHCCCCCCCEEEEHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCC
NPIACAAALAVLDIFEQENLLQKANTLGKTLRDGLMEIAETHREIGDVRGLGAMIAIELF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEE
ENGDPGKPNAALTADIVARAREKGLILLSCGPYYNILRILVPLTIEASQIRQGLEIIAQC
CCCCCCCCCCHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
FDEAKQA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254272; 9205837; 9278503; 2178550 [H]