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The map label for this gene is gabP [H]

Identifier: 194736084

GI number: 194736084

Start: 2850136

End: 2851536

Strand: Direct

Name: gabP [H]

Synonym: SeSA_A2938

Alternate gene names: 194736084

Gene position: 2850136-2851536 (Clockwise)

Preceding gene: 194736886

Following gene: 194736700

Centisome position: 60.52

GC content: 51.61

Gene sequence:

>1401_bases
ATGGGGCAATTGTCAGAATCACATGCATTAGGGGGCGGGCTGAAATCACGCCACGTCACCATGTTATCGATCGCCGGCGT
CATCGGCGCCAGCCTGTTTGTCGGCTCCAGCGTGGCGATTGCGGAGGCCGGCCCTGCGGTACTGCTGGCCTATCTGTTCG
CAGGACTTTTAGTCGTCATGATTATGCGAATGCTGGCTGAAATGGCCGTCGCCACGCCGGATACCGGTTCTTTTTCCACC
TATGCGGATAAAGCGATCGGCCCCTGGGCCGGGTATACCATCGGCTGGTTATACTGGTGGTTTTGGGTGCTGGTTATTCC
GCTGGAGGCCAATATTGCCGCCATTATTCTGAATTCATGGATACCGGGTATTCCGGTGTGGCTATTTTCATTAGTGATTA
CGCTTGCCTTAACCGGAAGCAATTTATTGAGCGTCAAAAATTACGGCGAATTCGAATTCTGGCTGGCGCTATGTAAAGTG
ATTGCTATCCTGGCGTTTATCGCGCTGGGCGCGACGGCGATTAGCGGTTTTTATCCATATGCCGAGGTAAGCGGTATCTC
CCGGCTATGGGATCACGGCGGTTTTATGCCTAACGGCTTCGGCGCGGTGTTAAGCGCCATGTTGATCACCATGTTCTCTT
TTATGGGCGCGGAAATCGTCACTATTGCTGCCGCGGAATCCGATACGCCGGATAAACATATCGTACGCGCCACCAATTCT
GTTATCTGGCGAATTTCCATCTTTTACCTGTGTTCCATTTTTGTGGTGGTGGCGCTGATCCCGTGGAATATGCCGGGTCT
GAAAAGTGTAGGTTCGTACCGTTCGGTACTGGAGCTGCTTCATATTCCGCACGCAAAATTCATTATGGACTGCGTGATTT
TGTTGTCGGTGACCAGTTGTCTGAACTCCGCATTATATACCGCCTCCCGGATGCTCTATTCCCTTAGTCGCCGCGGCGAT
GCGCCTGCGATAATGGGAAAAACTAACCGTAGCAAAACGCCCTGGGTGGCGGTTCTCCTCTCTACCGGCGCGGCCTTTTT
AACCGTTGTCGTCAATTATTACGCCCCGGCAAAAGTGTTTAAATTTCTTATCGACAGTTCTGGCGCCATCGCGCTGCTGG
TCTATCTGGTGATTGCGATTTCGCAATTGCAGATGCGTAAAATTCTGCTGGCGCAGGGCGGAGAAATTAAGTTGAAAATG
TGGCTTTATCCGTGGCTCACCTGGCTGGTTATCGGCTTTATCTGCTTTGTCCTGGTGGTGATGCTGTTTCGACCGGCACA
ACAACTAGAAGTCATTTCGACGGGGCTGTTAGGGCTGGGCATAATAGGTACTGTACCCATTATGTCTCGCTGGAAAAAAC
TGATAAGGTGGCAAAAAGCCCCCCTGCAAAACCTACGTTAG

Upstream 100 bases:

>100_bases
AACTGTCTTATCCGGCCTACAAAAACCGTTTCGATTGTAGGCCGAATTAAGCCAGGCGCCATCCGGTAAACGAGCGCAAT
AACAATAAAGAGGTTTTAGG

Downstream 100 bases:

>100_bases
TTATTCCCGGCGTCAGCCGGGAAGCTTCTCAGGAGTAAAAGATGACCGCCCTTTCCCAACCGACGGCCATAGATGGCTAT
CGCTGGCTTAAAAATGACAT

Product: gamma-aminobutyrate transporter

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: 4-amino butyrate transport carrier; Gamma-aminobutyrate permease [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MGQLSESHALGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVMIMRMLAEMAVATPDTGSFST
YADKAIGPWAGYTIGWLYWWFWVLVIPLEANIAAIILNSWIPGIPVWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKV
IAILAFIALGATAISGFYPYAEVSGISRLWDHGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPDKHIVRATNS
VIWRISIFYLCSIFVVVALIPWNMPGLKSVGSYRSVLELLHIPHAKFIMDCVILLSVTSCLNSALYTASRMLYSLSRRGD
APAIMGKTNRSKTPWVAVLLSTGAAFLTVVVNYYAPAKVFKFLIDSSGAIALLVYLVIAISQLQMRKILLAQGGEIKLKM
WLYPWLTWLVIGFICFVLVVMLFRPAQQLEVISTGLLGLGIIGTVPIMSRWKKLIRWQKAPLQNLR

Sequences:

>Translated_466_residues
MGQLSESHALGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVMIMRMLAEMAVATPDTGSFST
YADKAIGPWAGYTIGWLYWWFWVLVIPLEANIAAIILNSWIPGIPVWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKV
IAILAFIALGATAISGFYPYAEVSGISRLWDHGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPDKHIVRATNS
VIWRISIFYLCSIFVVVALIPWNMPGLKSVGSYRSVLELLHIPHAKFIMDCVILLSVTSCLNSALYTASRMLYSLSRRGD
APAIMGKTNRSKTPWVAVLLSTGAAFLTVVVNYYAPAKVFKFLIDSSGAIALLVYLVIAISQLQMRKILLAQGGEIKLKM
WLYPWLTWLVIGFICFVLVVMLFRPAQQLEVISTGLLGLGIIGTVPIMSRWKKLIRWQKAPLQNLR
>Mature_465_residues
GQLSESHALGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVMIMRMLAEMAVATPDTGSFSTY
ADKAIGPWAGYTIGWLYWWFWVLVIPLEANIAAIILNSWIPGIPVWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKVI
AILAFIALGATAISGFYPYAEVSGISRLWDHGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPDKHIVRATNSV
IWRISIFYLCSIFVVVALIPWNMPGLKSVGSYRSVLELLHIPHAKFIMDCVILLSVTSCLNSALYTASRMLYSLSRRGDA
PAIMGKTNRSKTPWVAVLLSTGAAFLTVVVNYYAPAKVFKFLIDSSGAIALLVYLVIAISQLQMRKILLAQGGEIKLKMW
LYPWLTWLVIGFICFVLVVMLFRPAQQLEVISTGLLGLGIIGTVPIMSRWKKLIRWQKAPLQNLR

Specific function: Transporter for GABA [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789017, Length=466, Percent_Identity=92.0600858369099, Blast_Score=860, Evalue=0.0,
Organism=Escherichia coli, GI1786302, Length=437, Percent_Identity=35.9267734553776, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1786789, Length=429, Percent_Identity=36.5967365967366, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI87081708, Length=436, Percent_Identity=36.4678899082569, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI48994972, Length=423, Percent_Identity=34.51536643026, Blast_Score=241, Evalue=8e-65,
Organism=Escherichia coli, GI1786602, Length=433, Percent_Identity=34.6420323325635, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1788480, Length=403, Percent_Identity=34.4913151364764, Blast_Score=237, Evalue=9e-64,
Organism=Escherichia coli, GI1790653, Length=448, Percent_Identity=30.5803571428571, Blast_Score=225, Evalue=6e-60,
Organism=Escherichia coli, GI87081915, Length=399, Percent_Identity=31.8295739348371, Blast_Score=223, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17532491, Length=364, Percent_Identity=22.8021978021978, Blast_Score=72, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320772, Length=436, Percent_Identity=30.9633027522936, Blast_Score=204, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6324061, Length=439, Percent_Identity=28.4738041002278, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6324990, Length=422, Percent_Identity=31.9905213270142, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6324059, Length=439, Percent_Identity=29.6127562642369, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6324553, Length=394, Percent_Identity=31.9796954314721, Blast_Score=180, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6322892, Length=395, Percent_Identity=32.9113924050633, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6324924, Length=459, Percent_Identity=27.6688453159041, Blast_Score=166, Evalue=8e-42,
Organism=Saccharomyces cerevisiae, GI6320717, Length=429, Percent_Identity=28.2051282051282, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6321053, Length=401, Percent_Identity=27.431421446384, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319824, Length=441, Percent_Identity=27.2108843537415, Blast_Score=152, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6319543, Length=440, Percent_Identity=26.3636363636364, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6321629, Length=399, Percent_Identity=28.0701754385965, Blast_Score=149, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6322967, Length=394, Percent_Identity=26.1421319796954, Blast_Score=142, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320251, Length=417, Percent_Identity=26.8585131894484, Blast_Score=140, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6319542, Length=406, Percent_Identity=27.0935960591133, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324981, Length=395, Percent_Identity=28.8607594936709, Blast_Score=130, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6319608, Length=421, Percent_Identity=26.1282660332542, Blast_Score=112, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6320364, Length=468, Percent_Identity=22.6495726495727, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24667468, Length=400, Percent_Identity=22.75, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840
- InterPro:   IPR011265 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50857; Mature: 50726

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQLSESHALGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVM
CCCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHH
IMRMLAEMAVATPDTGSFSTYADKAIGPWAGYTIGWLYWWFWVLVIPLEANIAAIILNSW
HHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
IPGIPVWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKVIAILAFIALGATAISGFYPY
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
AEVSGISRLWDHGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPDKHIVRATNS
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHH
VIWRISIFYLCSIFVVVALIPWNMPGLKSVGSYRSVLELLHIPHAKFIMDCVILLSVTSC
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LNSALYTASRMLYSLSRRGDAPAIMGKTNRSKTPWVAVLLSTGAAFLTVVVNYYAPAKVF
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHCCHHHHHHHHHHCCHHHHH
KFLIDSSGAIALLVYLVIAISQLQMRKILLAQGGEIKLKMWLYPWLTWLVIGFICFVLVV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
MLFRPAQQLEVISTGLLGLGIIGTVPIMSRWKKLIRWQKAPLQNLR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCC
>Mature Secondary Structure 
GQLSESHALGGGLKSRHVTMLSIAGVIGASLFVGSSVAIAEAGPAVLLAYLFAGLLVVM
CCCCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHH
IMRMLAEMAVATPDTGSFSTYADKAIGPWAGYTIGWLYWWFWVLVIPLEANIAAIILNSW
HHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
IPGIPVWLFSLVITLALTGSNLLSVKNYGEFEFWLALCKVIAILAFIALGATAISGFYPY
CCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
AEVSGISRLWDHGGFMPNGFGAVLSAMLITMFSFMGAEIVTIAAAESDTPDKHIVRATNS
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHH
VIWRISIFYLCSIFVVVALIPWNMPGLKSVGSYRSVLELLHIPHAKFIMDCVILLSVTSC
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LNSALYTASRMLYSLSRRGDAPAIMGKTNRSKTPWVAVLLSTGAAFLTVVVNYYAPAKVF
HHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHCCHHHHHHHHHHCCHHHHH
KFLIDSSGAIALLVYLVIAISQLQMRKILLAQGGEIKLKMWLYPWLTWLVIGFICFVLVV
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHH
MLFRPAQQLEVISTGLLGLGIIGTVPIMSRWKKLIRWQKAPLQNLR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8297211; 9205837; 9278503 [H]