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The map label for this gene is uvrB [H]

Identifier: 194735904

GI number: 194735904

Start: 920564

End: 922585

Strand: Direct

Name: uvrB [H]

Synonym: SeSA_A0948

Alternate gene names: 194735904

Gene position: 920564-922585 (Clockwise)

Preceding gene: 194736665

Following gene: 194735238

Centisome position: 19.55

GC content: 55.04

Gene sequence:

>2022_bases
ATGAGTAAACCGTTCAAACTGAATTCCGCTTTTAAACCTTCTGGCGATCAGCCGGACGCTATACGTCGTCTGGAAGAAGG
GCTGGAGGACGGGCTGGCGCATCAGACGTTATTGGGCGTGACCGGTTCCGGGAAGACATTCACCATTGCCAACGTCATTG
CGGACTTGCAGCGGCCAACGATGGTGCTTGCGCCCAATAAAACCCTGGCGGCGCAGCTCTACGGCGAAATGAAAGAGTTT
TTCCCGGAAAACGCGGTGGAGTATTTCGTCTCCTACTATGACTACTATCAGCCGGAAGCGTATGTGCCAAGTTCGGATAC
GTTTATCGAAAAAGACGCTTCGGTAAACGAACATATTGAGCAAATGCGGTTGTCGGCAACGAAAGCGTTGCTTGAGCGAC
GCGATGTCGTGGTGGTGGCTTCCGTGTCCGCGATTTACGGTCTGGGCGATCCGGATCTCTACCTGAAAATGATGCTGCAT
CTGACGGTGGGAATGCTGATTGACCAGCGCGCGATTTTGCGTCGGCTGGCGGAATTGCAATACACCCGTAACGATCAAGC
TTTTCAGCGTGGTACCTTTCGCGTGCGCGGCGAAGTGATCGACATCTTCCCGGCTGAATCTGACGATATCGCGCTACGCG
TTGAGCTGTTTGATGAAGAAGTGGAACGCCTGTCGCTGTTCGACCCGTTAACCGGGCAGGTAGAGTCAACGGTGCCACGT
TATACTATCTATCCCAAAACGCACTACGTGACGCCGCGCGAGCGTATTCTGCAGGCGATGGAAGAGATAAAAGATGAGCT
GGCGGACAGGCGTAAGGTCTTGCTGGCGAATAATAAGCTGCTTGAAGAGCAGCGATTAAGCCAGCGCACGCAGTTCGATT
TAGAGATGATGAACGAGCTGGGCTACTGCTCAGGCATTGAAAACTATTCCCGCTTTCTGTCGGGCCGCGGGCCGGGCGAA
CCGCCGCCAACCTTGTTCGATTATCTGCCCGCCGACGGACTGCTGGTGGTGGATGAGTCTCATGTCACCATCCCGCAGAT
AGGCGGCATGTACCGCGGCGACCGGGCGCGCAAAGAGACGCTGGTCGAGTATGGCTTCCGTCTGCCTTCGGCGCTGGATA
ACCGTCCGCTGAAGTTTGAGGAGTTTGAAGCCTTAGCGCCGCAAACTATCTATGTTTCCGCCACGCCCGGCAACTATGAG
CTGGAAAAATCTGGTGATGAGGTGGTGGATCAGGTCGTGCGACCGACCGGGCTGCTGGACCCGATTATTGAAGTGCGTCC
GGTGGCGACCCAGGTGGACGATCTGCTGTCCGAAATTCGTCAGCGTGCGGCCATTAATGAGCGTGTCCTTGTCACTACGC
TTACCAAACGGATGGCGGAAGATTTGACCGAATATCTGGAAGAACACGGCGAGCGCGTGCGTTACCTGCACTCAGATATT
GATACCGTGGAGCGCATGGAAATCATCCGCGATTTGCGTCTGGGCGAGTTTGACGTTCTGGTGGGGATTAACCTGCTGCG
CGAAGGGCTGGATATGCCGGAAGTCTCGCTGGTGGCGATTCTGGACGCCGATAAAGAGGGCTTCCTGCGCTCCGAGCGCT
CCCTGATTCAGACCATAGGACGCGCGGCGCGTAACGTTAATGGTAAAGCGATTCTGTATGGCGATAAAATCACGCCGTCG
ATGGCGAAGGCGATTGGCGAAACCGAGCGACGTCGCGAGAAGCAGCAGAAGTACAACGAAGAGCACGGTATCACTCCGCA
GGGGCTGAATAAAAAAGTGGTCGACATCCTGGCGCTGGGGCAGAACATTGCGAAAACCAAAGCGAAGGGGAAAGGCAAGG
GCCGTTCTACGGCAAAAGCCGGAATTGTCGAACTGGATATGACGCCGAAAGCGTTGCAGCAGAAAATTCATGAACTGGAA
GGGCAAATGATGCAGCACGCGCAAAATCTGGAGTTTGAAGAAGCCGCGCAAATTCGCGACCAGTTGCACCAGTTACGCGA
GTTGTTTATCGCGGCGTCCTGA

Upstream 100 bases:

>100_bases
GGAGTGTTACTGTTTTTTCATCCAGTATTTTTTATTGGCAATATTCACCGTCGAGAGTAAAATTACACCCCTGCCCGCTC
ACTCCTTCAGGTAGCCGCTC

Downstream 100 bases:

>100_bases
CAATGTGTCGATCGGCAGCGAGTCATCGTTACCATGGCTCGCTTTTGAGAATTTCAGTGCAATAGTAAGGGCTAAGTCAG
TCAGGAATGAAAAACAGTGA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 673; Mature: 672

Protein sequence:

>673_residues
MSKPFKLNSAFKPSGDQPDAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLQRPTMVLAPNKTLAAQLYGEMKEF
FPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIEQMRLSATKALLERRDVVVVASVSAIYGLGDPDLYLKMMLH
LTVGMLIDQRAILRRLAELQYTRNDQAFQRGTFRVRGEVIDIFPAESDDIALRVELFDEEVERLSLFDPLTGQVESTVPR
YTIYPKTHYVTPRERILQAMEEIKDELADRRKVLLANNKLLEEQRLSQRTQFDLEMMNELGYCSGIENYSRFLSGRGPGE
PPPTLFDYLPADGLLVVDESHVTIPQIGGMYRGDRARKETLVEYGFRLPSALDNRPLKFEEFEALAPQTIYVSATPGNYE
LEKSGDEVVDQVVRPTGLLDPIIEVRPVATQVDDLLSEIRQRAAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDI
DTVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNVNGKAILYGDKITPS
MAKAIGETERRREKQQKYNEEHGITPQGLNKKVVDILALGQNIAKTKAKGKGKGRSTAKAGIVELDMTPKALQQKIHELE
GQMMQHAQNLEFEEAAQIRDQLHQLRELFIAAS

Sequences:

>Translated_673_residues
MSKPFKLNSAFKPSGDQPDAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLQRPTMVLAPNKTLAAQLYGEMKEF
FPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIEQMRLSATKALLERRDVVVVASVSAIYGLGDPDLYLKMMLH
LTVGMLIDQRAILRRLAELQYTRNDQAFQRGTFRVRGEVIDIFPAESDDIALRVELFDEEVERLSLFDPLTGQVESTVPR
YTIYPKTHYVTPRERILQAMEEIKDELADRRKVLLANNKLLEEQRLSQRTQFDLEMMNELGYCSGIENYSRFLSGRGPGE
PPPTLFDYLPADGLLVVDESHVTIPQIGGMYRGDRARKETLVEYGFRLPSALDNRPLKFEEFEALAPQTIYVSATPGNYE
LEKSGDEVVDQVVRPTGLLDPIIEVRPVATQVDDLLSEIRQRAAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDI
DTVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNVNGKAILYGDKITPS
MAKAIGETERRREKQQKYNEEHGITPQGLNKKVVDILALGQNIAKTKAKGKGKGRSTAKAGIVELDMTPKALQQKIHELE
GQMMQHAQNLEFEEAAQIRDQLHQLRELFIAAS
>Mature_672_residues
SKPFKLNSAFKPSGDQPDAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLQRPTMVLAPNKTLAAQLYGEMKEFF
PENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIEQMRLSATKALLERRDVVVVASVSAIYGLGDPDLYLKMMLHL
TVGMLIDQRAILRRLAELQYTRNDQAFQRGTFRVRGEVIDIFPAESDDIALRVELFDEEVERLSLFDPLTGQVESTVPRY
TIYPKTHYVTPRERILQAMEEIKDELADRRKVLLANNKLLEEQRLSQRTQFDLEMMNELGYCSGIENYSRFLSGRGPGEP
PPTLFDYLPADGLLVVDESHVTIPQIGGMYRGDRARKETLVEYGFRLPSALDNRPLKFEEFEALAPQTIYVSATPGNYEL
EKSGDEVVDQVVRPTGLLDPIIEVRPVATQVDDLLSEIRQRAAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDID
TVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIGRAARNVNGKAILYGDKITPSM
AKAIGETERRREKQQKYNEEHGITPQGLNKKVVDILALGQNIAKTKAKGKGKGRSTAKAGIVELDMTPKALQQKIHELEG
QMMQHAQNLEFEEAAQIRDQLHQLRELFIAAS

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=673, Percent_Identity=95.8395245170877, Blast_Score=1295, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=307, Percent_Identity=23.7785016286645, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 76136; Mature: 76005

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPFKLNSAFKPSGDQPDAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLQRPT
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHEEECCCCCEEEHHHHHHHHCCCE
MVLAPNKTLAAQLYGEMKEFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIE
EEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
QMRLSATKALLERRDVVVVASVSAIYGLGDPDLYLKMMLHLTVGMLIDQRAILRRLAELQ
HHHHHHHHHHHHHCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YTRNDQAFQRGTFRVRGEVIDIFPAESDDIALRVELFDEEVERLSLFDPLTGQVESTVPR
HCCCCHHHHCCCEEEECEEEEEECCCCCCEEEEEEHHHHHHHHHHHCCCCCCCHHHCCCC
YTIYPKTHYVTPRERILQAMEEIKDELADRRKVLLANNKLLEEQRLSQRTQFDLEMMNEL
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEHHCCHHHHHHHHHHHHHHHHHHHHHC
GYCSGIENYSRFLSGRGPGEPPPTLFDYLPADGLLVVDESHVTIPQIGGMYRGDRARKET
CCCCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHH
LVEYGFRLPSALDNRPLKFEEFEALAPQTIYVSATPGNYELEKSGDEVVDQVVRPTGLLD
HHHHHCCCCHHHCCCCCCHHHHHHCCCCEEEEEECCCCCEECCCHHHHHHHHHCCCCCCC
PIIEVRPVATQVDDLLSEIRQRAAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIG
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHH
RAARNVNGKAILYGDKITPSMAKAIGETERRREKQQKYNEEHGITPQGLNKKVVDILALG
HHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHC
QNIAKTKAKGKGKGRSTAKAGIVELDMTPKALQQKIHELEGQMMQHAQNLEFEEAAQIRD
CHHHHHHHCCCCCCCCHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
QLHQLRELFIAAS
HHHHHHHHHHCCC
>Mature Secondary Structure 
SKPFKLNSAFKPSGDQPDAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLQRPT
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHEEECCCCCEEEHHHHHHHHCCCE
MVLAPNKTLAAQLYGEMKEFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIE
EEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHH
QMRLSATKALLERRDVVVVASVSAIYGLGDPDLYLKMMLHLTVGMLIDQRAILRRLAELQ
HHHHHHHHHHHHHCCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YTRNDQAFQRGTFRVRGEVIDIFPAESDDIALRVELFDEEVERLSLFDPLTGQVESTVPR
HCCCCHHHHCCCEEEECEEEEEECCCCCCEEEEEEHHHHHHHHHHHCCCCCCCHHHCCCC
YTIYPKTHYVTPRERILQAMEEIKDELADRRKVLLANNKLLEEQRLSQRTQFDLEMMNEL
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEHHCCHHHHHHHHHHHHHHHHHHHHHC
GYCSGIENYSRFLSGRGPGEPPPTLFDYLPADGLLVVDESHVTIPQIGGMYRGDRARKET
CCCCCHHHHHHHHCCCCCCCCCCHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHH
LVEYGFRLPSALDNRPLKFEEFEALAPQTIYVSATPGNYELEKSGDEVVDQVVRPTGLLD
HHHHHCCCCHHHCCCCCCHHHHHHCCCCEEEEEECCCCCEECCCHHHHHHHHHCCCCCCC
PIIEVRPVATQVDDLLSEIRQRAAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DTVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIG
HHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHHH
RAARNVNGKAILYGDKITPSMAKAIGETERRREKQQKYNEEHGITPQGLNKKVVDILALG
HHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHC
QNIAKTKAKGKGKGRSTAKAGIVELDMTPKALQQKIHELEGQMMQHAQNLEFEEAAQIRD
CHHHHHHHCCCCCCCCHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
QLHQLRELFIAAS
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA