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The map label for this gene is slrP [H]

Identifier: 194735238

GI number: 194735238

Start: 923074

End: 925341

Strand: Direct

Name: slrP [H]

Synonym: SeSA_A0949

Alternate gene names: 194735238

Gene position: 923074-925341 (Clockwise)

Preceding gene: 194735904

Following gene: 194734733

Centisome position: 19.6

GC content: 46.52

Gene sequence:

>2268_bases
ATGTTTAATATTACTAATATACAATCTACGGCAAGGCATCAAAGTATTAGCAATGAGGCATCAACAGAGGTGCCTTTAAA
AGAAGAGATATGGAATAAAATAAGTGCCTTTTTCTCTTCAGAACATCAGGTTGAAGCACAAAGCTGCATCGCTTATCTTT
GTCATCCACCTGAAACCGCCTCGCCAGAAGAGATCAAAAGCAAGTTTGAATGTTTGAGGGAGTTAGCCTTCCCGGCGTAT
GCGGATAATATTCAGAGTAATAGAGGGGGGACAGACCAATACTGTATTTTGAATGAAAATAGTCAGGAAATTCTGTCTAT
AATTTTTAATACAGAGGGCTATACCGTTGAGGGAGGGGGAAAGTCAGTCACCTATACCCGTGTAACAGAAAGCGAGCAGG
CGAGTAGCGCTTCCGGCTCCAAAGTTGCTGTGAATTATGAGTTAATCTGGTCTGAGTGGGTAAAAGAGGCACCAGCGGAA
GAGGCAGCAAATCGTGAAGAAGCCGTACAACGGATGCGTGACTGCCTGAAAAATAATAAGACGGAACTCCGTCTGAAAAT
ATTAGGACTTACCACTATACCCGCCTGTATTCCTGAGCAGATAACTACTCTGACACTCGATAACAATGAACTGAAAAGTT
TGCCGGAAAATTTACAGGGAAATATAAAGACCCTGTATGCCAGCAGTAATCGGCTAACCAGTATCCCTGCCACGTTACCG
GATACCATACAGAAAATGGAGCTGAGCATTAACCGTATTACTGAATTACCGGAACGTTTGCCTTCAGCGCTTCAATCGCT
GGATCTTTTCCATAATAAAATTAGTTCTTTACCTGAAAATCTACCTGAGGAACTTCGGTACCTGAGCGTTTATGATAACC
GCATAAGGACACTGCCAGAACATCTTCCGTCAGGGATTACCCATTTGAATGTGCAGAGTAATTCGTTAACCGCTCTGCCT
GAAACATTGCCGCCGGGCCTGAAGAATCTGGAGGCCGGCGAAAATGCCTTAACCAGTCTGCCCGCATCGTTACCACCAGA
ATTACAGTTCCTGGATGTAAGTAAAAATCAGATTACTGTTCTGCCTGAAACACTACCTCCCACGATAACAACGCTGGACG
TTTCCCGTAACGCATTGAGTAATCTACCGGAAAACCTCCCGGCGGCATTACAAATAATGCAGGCCTCTCGCAATCGCCTG
GTCCGTCTCCCGGAGTCGTTACCCCATTTTCGTGGTGAAGGACCTCAACCTACAAGAATAATCGTAGAACGTAATCCTTT
TTCAGAACGAACAATACAGAATATGCAGCGGCTAATGTCCTCTGCGGGTTATCAGGGACCCCGGGTATTGTTTGCCATGG
GCGACTTTTCAACTGTTCGGGTAACTCGACCACTGCATCAAGCTGTCCGGGGGTGGCTAACCAATCTCGAGGAGGAAGAC
GTCAACCAATGGCGGGCGTTTGAGACGGAAGTAAACGCGGCAGCCTTCAGCATGTTTCTGGATCGTCTTGGCGATACGCA
GAACACCCGACATTCGGATTTTAAGGAGCAAGTCTCCGCCTGGCTAATGCGCCTGGCTGATGATAGCACACTAAGAGAAA
CCGCATTTATTATAGCGATGGATGCAACGATAAGCTGTGAAGATCGGGTCACACTGGCATACCACCAAATGCAGGAAGCG
ACGTTGGTTCATGATGCTGAAAGAGGCGTCTTTGATAGCCACTTAGCGGAACTGATTATGGCGGGGCGTGAAATCTTTCG
GCTGGAGCAAATAGAATCGCTCGCGAGAGAAAAGGTAAAACGGCTGTTTTTTATTGACGAAATCGAAGTATTTCTGGGTT
TTCAGAATCAGTTACGAGAGTCGCTGTCGCTGACAACAATGACCCAGGATATGCGATTTTATAACGTTTCGGGTATCACT
GAGTCTGACCTTGACGAGGCGGAATTAAGGATAAAAATTGCTGAAAATAGGGATTTTCACAAATGGTTTGCGCTGTGGGG
GCCGTGGCATAAAGTGCTGGAGCGTATAGCGCCAGAAGAGTGGCGTGAAATGATGGCTAAAAGGGCTGAGTATATTGAAA
CGGATGAGTATCAGAGCCGGGTCAATGCTGAACTGGAAGCGTTAGGAATAGCGGGTGATCCTGACGCAGAGCGCATGGCT
GGGATGCGGATAATGGAAGAGATCAATCAGACCCACTTTACTGGGATCATGGAGAATATATTGCTGAAAAAAGAGGTGAG
CTCGCTCATGAGCGCCTACTGGCGATAG

Upstream 100 bases:

>100_bases
AATGATTTGTCCGAAATAATGATGACTATGACCTCTTGTTTAAAGTTGAGAATATCCTTATCTGTTACTTTAGGTTACGT
TCAGATCAGGTAGGGAAAAT

Downstream 100 bases:

>100_bases
CTGAACGCAGTTTATCAGAAGGGGGAGAGAGCCTGTTTACCCTTCGGTGTAAACAGGCATCTGATAAGCGCAGCGTCGTC
GGTAAACGGGCTTAACCCAA

Product: leucine-rich repeat protein

Products: NA

Alternate protein names: Secreted effector protein slrP [H]

Number of amino acids: Translated: 755; Mature: 755

Protein sequence:

>755_residues
MFNITNIQSTARHQSISNEASTEVPLKEEIWNKISAFFSSEHQVEAQSCIAYLCHPPETASPEEIKSKFECLRELAFPAY
ADNIQSNRGGTDQYCILNENSQEILSIIFNTEGYTVEGGGKSVTYTRVTESEQASSASGSKVAVNYELIWSEWVKEAPAE
EAANREEAVQRMRDCLKNNKTELRLKILGLTTIPACIPEQITTLTLDNNELKSLPENLQGNIKTLYASSNRLTSIPATLP
DTIQKMELSINRITELPERLPSALQSLDLFHNKISSLPENLPEELRYLSVYDNRIRTLPEHLPSGITHLNVQSNSLTALP
ETLPPGLKNLEAGENALTSLPASLPPELQFLDVSKNQITVLPETLPPTITTLDVSRNALSNLPENLPAALQIMQASRNRL
VRLPESLPHFRGEGPQPTRIIVERNPFSERTIQNMQRLMSSAGYQGPRVLFAMGDFSTVRVTRPLHQAVRGWLTNLEEED
VNQWRAFETEVNAAAFSMFLDRLGDTQNTRHSDFKEQVSAWLMRLADDSTLRETAFIIAMDATISCEDRVTLAYHQMQEA
TLVHDAERGVFDSHLAELIMAGREIFRLEQIESLAREKVKRLFFIDEIEVFLGFQNQLRESLSLTTMTQDMRFYNVSGIT
ESDLDEAELRIKIAENRDFHKWFALWGPWHKVLERIAPEEWREMMAKRAEYIETDEYQSRVNAELEALGIAGDPDAERMA
GMRIMEEINQTHFTGIMENILLKKEVSSLMSAYWR

Sequences:

>Translated_755_residues
MFNITNIQSTARHQSISNEASTEVPLKEEIWNKISAFFSSEHQVEAQSCIAYLCHPPETASPEEIKSKFECLRELAFPAY
ADNIQSNRGGTDQYCILNENSQEILSIIFNTEGYTVEGGGKSVTYTRVTESEQASSASGSKVAVNYELIWSEWVKEAPAE
EAANREEAVQRMRDCLKNNKTELRLKILGLTTIPACIPEQITTLTLDNNELKSLPENLQGNIKTLYASSNRLTSIPATLP
DTIQKMELSINRITELPERLPSALQSLDLFHNKISSLPENLPEELRYLSVYDNRIRTLPEHLPSGITHLNVQSNSLTALP
ETLPPGLKNLEAGENALTSLPASLPPELQFLDVSKNQITVLPETLPPTITTLDVSRNALSNLPENLPAALQIMQASRNRL
VRLPESLPHFRGEGPQPTRIIVERNPFSERTIQNMQRLMSSAGYQGPRVLFAMGDFSTVRVTRPLHQAVRGWLTNLEEED
VNQWRAFETEVNAAAFSMFLDRLGDTQNTRHSDFKEQVSAWLMRLADDSTLRETAFIIAMDATISCEDRVTLAYHQMQEA
TLVHDAERGVFDSHLAELIMAGREIFRLEQIESLAREKVKRLFFIDEIEVFLGFQNQLRESLSLTTMTQDMRFYNVSGIT
ESDLDEAELRIKIAENRDFHKWFALWGPWHKVLERIAPEEWREMMAKRAEYIETDEYQSRVNAELEALGIAGDPDAERMA
GMRIMEEINQTHFTGIMENILLKKEVSSLMSAYWR
>Mature_755_residues
MFNITNIQSTARHQSISNEASTEVPLKEEIWNKISAFFSSEHQVEAQSCIAYLCHPPETASPEEIKSKFECLRELAFPAY
ADNIQSNRGGTDQYCILNENSQEILSIIFNTEGYTVEGGGKSVTYTRVTESEQASSASGSKVAVNYELIWSEWVKEAPAE
EAANREEAVQRMRDCLKNNKTELRLKILGLTTIPACIPEQITTLTLDNNELKSLPENLQGNIKTLYASSNRLTSIPATLP
DTIQKMELSINRITELPERLPSALQSLDLFHNKISSLPENLPEELRYLSVYDNRIRTLPEHLPSGITHLNVQSNSLTALP
ETLPPGLKNLEAGENALTSLPASLPPELQFLDVSKNQITVLPETLPPTITTLDVSRNALSNLPENLPAALQIMQASRNRL
VRLPESLPHFRGEGPQPTRIIVERNPFSERTIQNMQRLMSSAGYQGPRVLFAMGDFSTVRVTRPLHQAVRGWLTNLEEED
VNQWRAFETEVNAAAFSMFLDRLGDTQNTRHSDFKEQVSAWLMRLADDSTLRETAFIIAMDATISCEDRVTLAYHQMQEA
TLVHDAERGVFDSHLAELIMAGREIFRLEQIESLAREKVKRLFFIDEIEVFLGFQNQLRESLSLTTMTQDMRFYNVSGIT
ESDLDEAELRIKIAENRDFHKWFALWGPWHKVLERIAPEEWREMMAKRAEYIETDEYQSRVNAELEALGIAGDPDAERMA
GMRIMEEINQTHFTGIMENILLKKEVSSLMSAYWR

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host TXN (Thioredoxin).

COG id: COG4886

COG function: function code S; Leucine-rich repeat (LRR) protein

Gene ontology:

Cell location: Secreted. Host cytoplasm. Note=Secreted via type III secretion systems 1 and 2 (SPI-1 and SPI-2 TTSS), and delivered into the host cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 10 LRR (leucine-rich) repeats [H]

Homologues:

Organism=Homo sapiens, GI95113664, Length=263, Percent_Identity=31.5589353612167, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI45505137, Length=274, Percent_Identity=27.3722627737226, Blast_Score=72, Evalue=3e-12,
Organism=Homo sapiens, GI226342931, Length=255, Percent_Identity=30.9803921568627, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI226342933, Length=255, Percent_Identity=30.9803921568627, Blast_Score=70, Evalue=7e-12,
Organism=Homo sapiens, GI291219891, Length=251, Percent_Identity=30.6772908366534, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI45827731, Length=230, Percent_Identity=33.0434782608696, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI45827729, Length=230, Percent_Identity=33.0434782608696, Blast_Score=68, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71991525, Length=279, Percent_Identity=30.1075268817204, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71991531, Length=279, Percent_Identity=30.1075268817204, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221379725, Length=242, Percent_Identity=30.9917355371901, Blast_Score=70, Evalue=6e-12,
Organism=Drosophila melanogaster, GI221379722, Length=242, Percent_Identity=30.9917355371901, Blast_Score=70, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17933612, Length=233, Percent_Identity=31.7596566523605, Blast_Score=70, Evalue=7e-12,
Organism=Drosophila melanogaster, GI281362653, Length=245, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=3e-11,
Organism=Drosophila melanogaster, GI281362651, Length=245, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24650334, Length=245, Percent_Identity=28.9795918367347, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24650332, Length=245, Percent_Identity=28.9795918367347, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281362657, Length=245, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281362655, Length=245, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI116007092, Length=245, Percent_Identity=28.9795918367347, Blast_Score=67, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24650330, Length=245, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001611 [H]

Pfam domain/function: PF00560 LRR_1 [H]

EC number: NA

Molecular weight: Translated: 85709; Mature: 85709

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNITNIQSTARHQSISNEASTEVPLKEEIWNKISAFFSSEHQVEAQSCIAYLCHPPETA
CCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCC
SPEEIKSKFECLRELAFPAYADNIQSNRGGTDQYCILNENSQEILSIIFNTEGYTVEGGG
CHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHCCCCCEEEECCC
KSVTYTRVTESEQASSASGSKVAVNYELIWSEWVKEAPAEEAANREEAVQRMRDCLKNNK
CEEEEEEECCCHHCCCCCCCEEEEEEEHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHCCC
TELRLKILGLTTIPACIPEQITTLTLDNNELKSLPENLQGNIKTLYASSNRLTSIPATLP
CEEEEEEEECHHCCHHCCCCCEEEEECCHHHHHCCHHHCCCEEEEEECCCCCEECCCCCH
DTIQKMELSINRITELPERLPSALQSLDLFHNKISSLPENLPEELRYLSVYDNRIRTLPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLPSGITHLNVQSNSLTALPETLPPGLKNLEAGENALTSLPASLPPELQFLDVSKNQITV
HCCCCCEEEEECCCCCCCCCCCCCCCCHHCCCCCHHHHHCCCCCCCCCEEEECCCCEEEE
LPETLPPTITTLDVSRNALSNLPENLPAALQIMQASRNRLVRLPESLPHFRGEGPQPTRI
ECCCCCCCEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHEECCHHCCCCCCCCCCCCEE
IVERNPFSERTIQNMQRLMSSAGYQGPRVLFAMGDFSTVRVTRPLHQAVRGWLTNLEEED
EEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECHHHHHHHHHHHCCCCHHH
VNQWRAFETEVNAAAFSMFLDRLGDTQNTRHSDFKEQVSAWLMRLADDSTLRETAFIIAM
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHEEEEEEE
DATISCEDRVTLAYHQMQEATLVHDAERGVFDSHLAELIMAGREIFRLEQIESLAREKVK
CCEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLFFIDEIEVFLGFQNQLRESLSLTTMTQDMRFYNVSGITESDLDEAELRIKIAENRDFH
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEEECCCCHH
KWFALWGPWHKVLERIAPEEWREMMAKRAEYIETDEYQSRVNAELEALGIAGDPDAERMA
HHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHEEECCCCCCHHHHH
GMRIMEEINQTHFTGIMENILLKKEVSSLMSAYWR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFNITNIQSTARHQSISNEASTEVPLKEEIWNKISAFFSSEHQVEAQSCIAYLCHPPETA
CCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCC
SPEEIKSKFECLRELAFPAYADNIQSNRGGTDQYCILNENSQEILSIIFNTEGYTVEGGG
CHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCEEEECCCHHHHHHHHCCCCCEEEECCC
KSVTYTRVTESEQASSASGSKVAVNYELIWSEWVKEAPAEEAANREEAVQRMRDCLKNNK
CEEEEEEECCCHHCCCCCCCEEEEEEEHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHCCC
TELRLKILGLTTIPACIPEQITTLTLDNNELKSLPENLQGNIKTLYASSNRLTSIPATLP
CEEEEEEEECHHCCHHCCCCCEEEEECCHHHHHCCHHHCCCEEEEEECCCCCEECCCCCH
DTIQKMELSINRITELPERLPSALQSLDLFHNKISSLPENLPEELRYLSVYDNRIRTLPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HLPSGITHLNVQSNSLTALPETLPPGLKNLEAGENALTSLPASLPPELQFLDVSKNQITV
HCCCCCEEEEECCCCCCCCCCCCCCCCHHCCCCCHHHHHCCCCCCCCCEEEECCCCEEEE
LPETLPPTITTLDVSRNALSNLPENLPAALQIMQASRNRLVRLPESLPHFRGEGPQPTRI
ECCCCCCCEEEEECCHHHHHCCCCCCHHHHHHHHHHHHHHEECCHHCCCCCCCCCCCCEE
IVERNPFSERTIQNMQRLMSSAGYQGPRVLFAMGDFSTVRVTRPLHQAVRGWLTNLEEED
EEECCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEEECHHHHHHHHHHHCCCCHHH
VNQWRAFETEVNAAAFSMFLDRLGDTQNTRHSDFKEQVSAWLMRLADDSTLRETAFIIAM
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHEEEEEEE
DATISCEDRVTLAYHQMQEATLVHDAERGVFDSHLAELIMAGREIFRLEQIESLAREKVK
CCEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLFFIDEIEVFLGFQNQLRESLSLTTMTQDMRFYNVSGITESDLDEAELRIKIAENRDFH
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCEEEEEEECCCCHH
KWFALWGPWHKVLERIAPEEWREMMAKRAEYIETDEYQSRVNAELEALGIAGDPDAERMA
HHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHCCCHHEEECCCCCCHHHHH
GMRIMEEINQTHFTGIMENILLKKEVSSLMSAYWR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10861017 [H]