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The map label for this gene is creC [H]

Identifier: 194735190

GI number: 194735190

Start: 4696564

End: 4697988

Strand: Direct

Name: creC [H]

Synonym: SeSA_A4840

Alternate gene names: 194735190

Gene position: 4696564-4697988 (Clockwise)

Preceding gene: 194737123

Following gene: 194735853

Centisome position: 99.73

GC content: 58.11

Gene sequence:

>1425_bases
ATGCGCATCGGAATGCGTTTGCTACTGGGCTACTTTCTTATTGTCGCCGTCGCCGCCGTGTTTGTGCTGTCTATCTTCGT
TCAGGAGATAAAGCCGGGCGTCCGCCGCGCGACGGAAGGGACGCTGATTGACACCGCGACGCTGCTGGCGGCGCTGGCCC
GCGACGATCTCCTTTCCGGCAACCCGACTGACGGCCAGTTGGCGAAAGCATTCGCCCAACTGCAACATCGCCCGTTTCGC
GCCAATATCAGCGGGATCGTCAAAGTGCGTAATGAATACCATGTCTACATGACGGATGCGCAGGGGAAGGTATTGTTTGA
TTCGGAAAACAAAGCGGTGGGGCAGGATTATTCTCGCTGGAATGACGTCTGGCTTACGCTGCGCGGACAGTATGGCGCCC
GCAGCACGGCAAAAGATGCTGCCGATCCCAATAGCACGGTGATGTACGTAGCCGCGCCGATAATCAGCGATGGGCGGATT
ATCGGCGTCCTGTCTGTAGGTAAACCGAATGCGGCAATGGCGCCGGTGATTAAGCGCAGCGAACGGCGCATTCTGTGGGC
CAGCGCCGTTTTACTGGGGATTGCGCTGGCGATTGGCGCGGGGATGGTCTGGTGGATTAACCGCTCCATCGCCCGGTTGA
CGCGCTATGCGGATTCCGTCGCCGAAAACCGCCCGCTTGCGTTACCTGCATTAGGCAGCAGCGAGCTGCGTAAACTGGCG
CAGGCGCTGGAGAGTATGCGCATTAAGCTGGAAGGCAAGAATGACATTGAGCAGTACGTGTATGCGTTGACTCATGAGCT
GAAAAGTCCACTGGCGGCGATACGCGGCGCGGCGGAGATTCTGCGTGAAGGACCGCCCGCGGAAGTGGTTACCCGCTTTA
CAGAGAATATACTGGCGCAAAATATGCGAATGCAGGCGCTGGTAGAGACCCTGCTGCGCCAGGCGCGGCTGGAAAACCGA
CAGGATATCCCTCTCGCGCCGGTTGCTGTTGATGAGCTATTTACGCAGCTTAGCGAGGCGCGCAGTATTCAGTTGGCGGC
AAAAAAGATCACGCTTACTCTACGGCCTTCCTCGCTGGTTGTCGTCGCCGACGCGGAGCTTCTGGCGCAGGCGCTGGGCA
ATGTATTGGACAATGCCATCGACTTTACGCCTGAAAATGGCGTTATCACATTAAGCGCTCAGCCGATGGGGGAGAAAGCG
ATCCTGCAGGTGACGGATTCCGGCTGTGGTATTCCTGATTTTGCGCTGCCGCGCATTTTCGACCGATTCTATTCGTTGCC
CCGTGAAAACGGGCGTAAAAGCAGCGGGCTTGGGCTGGCGTTTGTCAGCGAGGCGGCGCGACTCCTCAACGGTGAGGTGA
CGTTGTGCAATCGTCCCGAAGGCGGCGTGCTGGCCTCGTTGACACTTCACCGTCACTTCACATAA

Upstream 100 bases:

>100_bases
CACACATCAAAACCCTGCGCGCTAAACTACGCGCGATCAACCCGGATCTCTCGCCAATTAACACGCATCGTGGAATGGGA
TACAGCCTGAGGAGCGTCTG

Downstream 100 bases:

>100_bases
CTTCAAATTCTCCCCACATCGCGTTCTTACACTGCTGGCATTGCAAAGGAGAACGCTATGTTGAAATCCCCCCTGTTGTG
GAAAATGATTACGTTAGGCG

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MRIGMRLLLGYFLIVAVAAVFVLSIFVQEIKPGVRRATEGTLIDTATLLAALARDDLLSGNPTDGQLAKAFAQLQHRPFR
ANISGIVKVRNEYHVYMTDAQGKVLFDSENKAVGQDYSRWNDVWLTLRGQYGARSTAKDAADPNSTVMYVAAPIISDGRI
IGVLSVGKPNAAMAPVIKRSERRILWASAVLLGIALAIGAGMVWWINRSIARLTRYADSVAENRPLALPALGSSELRKLA
QALESMRIKLEGKNDIEQYVYALTHELKSPLAAIRGAAEILREGPPAEVVTRFTENILAQNMRMQALVETLLRQARLENR
QDIPLAPVAVDELFTQLSEARSIQLAAKKITLTLRPSSLVVVADAELLAQALGNVLDNAIDFTPENGVITLSAQPMGEKA
ILQVTDSGCGIPDFALPRIFDRFYSLPRENGRKSSGLGLAFVSEAARLLNGEVTLCNRPEGGVLASLTLHRHFT

Sequences:

>Translated_474_residues
MRIGMRLLLGYFLIVAVAAVFVLSIFVQEIKPGVRRATEGTLIDTATLLAALARDDLLSGNPTDGQLAKAFAQLQHRPFR
ANISGIVKVRNEYHVYMTDAQGKVLFDSENKAVGQDYSRWNDVWLTLRGQYGARSTAKDAADPNSTVMYVAAPIISDGRI
IGVLSVGKPNAAMAPVIKRSERRILWASAVLLGIALAIGAGMVWWINRSIARLTRYADSVAENRPLALPALGSSELRKLA
QALESMRIKLEGKNDIEQYVYALTHELKSPLAAIRGAAEILREGPPAEVVTRFTENILAQNMRMQALVETLLRQARLENR
QDIPLAPVAVDELFTQLSEARSIQLAAKKITLTLRPSSLVVVADAELLAQALGNVLDNAIDFTPENGVITLSAQPMGEKA
ILQVTDSGCGIPDFALPRIFDRFYSLPRENGRKSSGLGLAFVSEAARLLNGEVTLCNRPEGGVLASLTLHRHFT
>Mature_474_residues
MRIGMRLLLGYFLIVAVAAVFVLSIFVQEIKPGVRRATEGTLIDTATLLAALARDDLLSGNPTDGQLAKAFAQLQHRPFR
ANISGIVKVRNEYHVYMTDAQGKVLFDSENKAVGQDYSRWNDVWLTLRGQYGARSTAKDAADPNSTVMYVAAPIISDGRI
IGVLSVGKPNAAMAPVIKRSERRILWASAVLLGIALAIGAGMVWWINRSIARLTRYADSVAENRPLALPALGSSELRKLA
QALESMRIKLEGKNDIEQYVYALTHELKSPLAAIRGAAEILREGPPAEVVTRFTENILAQNMRMQALVETLLRQARLENR
QDIPLAPVAVDELFTQLSEARSIQLAAKKITLTLRPSSLVVVADAELLAQALGNVLDNAIDFTPENGVITLSAQPMGEKA
ILQVTDSGCGIPDFALPRIFDRFYSLPRENGRKSSGLGLAFVSEAARLLNGEVTLCNRPEGGVLASLTLHRHFT

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=474, Percent_Identity=80.8016877637131, Blast_Score=771, Evalue=0.0,
Organism=Escherichia coli, GI1788393, Length=248, Percent_Identity=29.8387096774194, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87082128, Length=280, Percent_Identity=26.7857142857143, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1786600, Length=209, Percent_Identity=30.622009569378, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI48994928, Length=266, Percent_Identity=24.4360902255639, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1786912, Length=237, Percent_Identity=28.6919831223629, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081816, Length=217, Percent_Identity=27.6497695852535, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI145693157, Length=234, Percent_Identity=24.3589743589744, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788713, Length=250, Percent_Identity=26, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1786783, Length=293, Percent_Identity=26.2798634812287, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1787374, Length=272, Percent_Identity=28.3088235294118, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1790436, Length=218, Percent_Identity=28.8990825688073, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788549, Length=210, Percent_Identity=27.1428571428571, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1790551, Length=285, Percent_Identity=27.719298245614, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51656; Mature: 51656

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGMRLLLGYFLIVAVAAVFVLSIFVQEIKPGVRRATEGTLIDTATLLAALARDDLLSG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
NPTDGQLAKAFAQLQHRPFRANISGIVKVRNEYHVYMTDAQGKVLFDSENKAVGQDYSRW
CCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEEEECCCCEEEECCCCCCCCCCHHCC
NDVWLTLRGQYGARSTAKDAADPNSTVMYVAAPIISDGRIIGVLSVGKPNAAMAPVIKRS
CCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECEECCCCEEEEEECCCCCCHHHHHHHHC
ERRILWASAVLLGIALAIGAGMVWWINRSIARLTRYADSVAENRPLALPALGSSELRKLA
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHH
QALESMRIKLEGKNDIEQYVYALTHELKSPLAAIRGAAEILREGPPAEVVTRFTENILAQ
HHHHHCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
NMRMQALVETLLRQARLENRQDIPLAPVAVDELFTQLSEARSIQLAAKKITLTLRPSSLV
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCEE
VVADAELLAQALGNVLDNAIDFTPENGVITLSAQPMGEKAILQVTDSGCGIPDFALPRIF
EEECHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHH
DRFYSLPRENGRKSSGLGLAFVSEAARLLNGEVTLCNRPEGGVLASLTLHRHFT
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCC
>Mature Secondary Structure
MRIGMRLLLGYFLIVAVAAVFVLSIFVQEIKPGVRRATEGTLIDTATLLAALARDDLLSG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHHHHCCCC
NPTDGQLAKAFAQLQHRPFRANISGIVKVRNEYHVYMTDAQGKVLFDSENKAVGQDYSRW
CCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEEEECCCCEEEECCCCCCCCCCHHCC
NDVWLTLRGQYGARSTAKDAADPNSTVMYVAAPIISDGRIIGVLSVGKPNAAMAPVIKRS
CCEEEEEECCCCCCCCCCCCCCCCCEEEEEEECEECCCCEEEEEECCCCCCHHHHHHHHC
ERRILWASAVLLGIALAIGAGMVWWINRSIARLTRYADSVAENRPLALPALGSSELRKLA
CCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHH
QALESMRIKLEGKNDIEQYVYALTHELKSPLAAIRGAAEILREGPPAEVVTRFTENILAQ
HHHHHCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
NMRMQALVETLLRQARLENRQDIPLAPVAVDELFTQLSEARSIQLAAKKITLTLRPSSLV
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEEEEECCCCEE
VVADAELLAQALGNVLDNAIDFTPENGVITLSAQPMGEKAILQVTDSGCGIPDFALPRIF
EEECHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHH
DRFYSLPRENGRKSSGLGLAFVSEAARLLNGEVTLCNRPEGGVLASLTLHRHFT
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]