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The map label for this gene is hutU

Identifier: 194735125

GI number: 194735125

Start: 911099

End: 912784

Strand: Direct

Name: hutU

Synonym: SeSA_A0940

Alternate gene names: 194735125

Gene position: 911099-912784 (Clockwise)

Preceding gene: 194734858

Following gene: 194736063

Centisome position: 19.35

GC content: 59.61

Gene sequence:

>1686_bases
ATGCCTGAAAGCAAGTATCGTCAGCAGACTATCCGCGCGCCCAGAGGCACGGTATTAACGGCGAAAAGCTGGCTGACAGA
AGCCCCGCTGCGGATGTTAATGAATAATCTCGATCCTGACGTGGCGGAAAATCCGCATGAGCTGGTGGTCTACGGCGGGA
TTGGTCGCGCCGCGCGCAACTGGGAATGCTATGACGCTATTGTTGATGCGCTCACCCGGCTGGAGGCGGACGAAACGTTG
CTTATTCAGTCTGGCAAACCGGTCGGCGTATTTAAAACGCACGACAACGCGCCGCGGGTATTAATCGCCAACTCCAACCT
GGTTCCCCACTGGGCGACATGGGAACATTTTAACGAACTGGATGCGAAAGGGCTGGCGATGTACGGTCAGATGACGGCCG
GAAGCTGGATCTATATCGGCAGCCAGGGAATCGTGCAGGGAACATACGAAACCTTTGTCGAGGCGGGGCGTCAGCACTAT
AACGGCACGCTGGCGGGACGCTGGGTGCTGACCGCCGGGCTGGGCGGCATGGGCGGCGCGCAACCGCTAGCCGCGACGCT
GGCCGGAGCGTGTTCGCTGACGATTGAATGCCAGCAAAGCCGTATCGATTTTCGTCTGCGTACTCGCTACGTGGATGAGC
AGGCCGCCACGCTGGATGACGCGTTGGCCCGCATTACGCGCTACACCCGCGAGGGGAAAGCCGTGTCCGTCGCCCTGTGC
GCGAACGCGGCGGATATCCTGCCGGAACTGGTTAATCGCGGCGTGCGCCCGGACCTGGTGACCGATCAGACCAGCGCCCA
CGATCCGCTACATGGCTATTTACCCTCCGGCTGGCGCTGGGAGGAGTATCAGAAAAACGCGCAATCCGATCCCCACGGGA
CGATGCAGGCAGCGAAACGTTCCATGGCGGCGCATGTTCGGGCGATGCTGGCGTTCAGTCAAATGGGCGTGCCGACCTTT
GACTATGGCAACAATATTCGCCAGATGGCGAAAGAGATGGGGGTGGAAAACGCCTTTGATTTTCCGGGATTTGTGCCAGC
CTATATTCGTCCGCTGTTCTGTCGTGGCATCGGGCCGTTTCGCTGGGTGGCGCTGTCCGGCGATCCGCAGGATATCTATA
AAACCGATGCCAAAGTCAAAGAGATAGTGGCTGAGGATAAACATCTGCATCACTGGCTGGATATGGCGCGCGAGCGCATT
CATTTTCAGGGGCTACCGGCGCGTATCTGCTGGGTAGGTCTGGAGTGGCGGCAAAAACTGGGGCTGGCGTTCAACGAAAT
GGTGCGTTGCGGTGAGGTATCCGCGCCTATTGTGATTGGCCGCGATCACCTGGATTCCGGTTCTGTCGCCAGCCCTAACC
GTGAAACCGAAGCGATGCGCGACGGTTCCGACGCGGTTTCCGACTGGCCGCTGTTAAATGCGTTGCTGAATACCGCCAGC
GGGGCGACATGGGTATCGCTCCATCATGGCGGCGGGGTGGGGATGGGGTTTTCGCAACACGCCGGTATGGTGATTGTCTG
TGATGGCACTGACGAGGCCGCCGCGCGTATTCGCCGCGTGTTACACAACGATCCGGCGACGGGCGTCATGCGCCATGCCG
ATGCCGGATATGATCTCGCGGTGGAATGCGCTGTTGAGCAAGGTCTGAATTTACCGATGGTTGCGGCGACGCAGGGGAAA
GGCTGA

Upstream 100 bases:

>100_bases
ATATGTCTGATTCTTATCTGTGGGTCTGCGGCGGTGCCTGATAGTGGCGTTTTAGCGTTATTTGGCGATGGCAGATCGAT
AATAATGAGGAGTCATTGCT

Downstream 100 bases:

>100_bases
TATGAACACCATAACACTCACTCCGGGGCAGTTAAGCCTCTCTCAACTGTACGATGTCTGGCGTCATCCGGTACAGCTTC
GGCTGGACGCCAGCGCCATT

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase

Number of amino acids: Translated: 561; Mature: 560

Protein sequence:

>561_residues
MPESKYRQQTIRAPRGTVLTAKSWLTEAPLRMLMNNLDPDVAENPHELVVYGGIGRAARNWECYDAIVDALTRLEADETL
LIQSGKPVGVFKTHDNAPRVLIANSNLVPHWATWEHFNELDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHY
NGTLAGRWVLTAGLGGMGGAQPLAATLAGACSLTIECQQSRIDFRLRTRYVDEQAATLDDALARITRYTREGKAVSVALC
ANAADILPELVNRGVRPDLVTDQTSAHDPLHGYLPSGWRWEEYQKNAQSDPHGTMQAAKRSMAAHVRAMLAFSQMGVPTF
DYGNNIRQMAKEMGVENAFDFPGFVPAYIRPLFCRGIGPFRWVALSGDPQDIYKTDAKVKEIVAEDKHLHHWLDMARERI
HFQGLPARICWVGLEWRQKLGLAFNEMVRCGEVSAPIVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTAS
GATWVSLHHGGGVGMGFSQHAGMVIVCDGTDEAAARIRRVLHNDPATGVMRHADAGYDLAVECAVEQGLNLPMVAATQGK
G

Sequences:

>Translated_561_residues
MPESKYRQQTIRAPRGTVLTAKSWLTEAPLRMLMNNLDPDVAENPHELVVYGGIGRAARNWECYDAIVDALTRLEADETL
LIQSGKPVGVFKTHDNAPRVLIANSNLVPHWATWEHFNELDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHY
NGTLAGRWVLTAGLGGMGGAQPLAATLAGACSLTIECQQSRIDFRLRTRYVDEQAATLDDALARITRYTREGKAVSVALC
ANAADILPELVNRGVRPDLVTDQTSAHDPLHGYLPSGWRWEEYQKNAQSDPHGTMQAAKRSMAAHVRAMLAFSQMGVPTF
DYGNNIRQMAKEMGVENAFDFPGFVPAYIRPLFCRGIGPFRWVALSGDPQDIYKTDAKVKEIVAEDKHLHHWLDMARERI
HFQGLPARICWVGLEWRQKLGLAFNEMVRCGEVSAPIVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTAS
GATWVSLHHGGGVGMGFSQHAGMVIVCDGTDEAAARIRRVLHNDPATGVMRHADAGYDLAVECAVEQGLNLPMVAATQGK
G
>Mature_560_residues
PESKYRQQTIRAPRGTVLTAKSWLTEAPLRMLMNNLDPDVAENPHELVVYGGIGRAARNWECYDAIVDALTRLEADETLL
IQSGKPVGVFKTHDNAPRVLIANSNLVPHWATWEHFNELDAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHYN
GTLAGRWVLTAGLGGMGGAQPLAATLAGACSLTIECQQSRIDFRLRTRYVDEQAATLDDALARITRYTREGKAVSVALCA
NAADILPELVNRGVRPDLVTDQTSAHDPLHGYLPSGWRWEEYQKNAQSDPHGTMQAAKRSMAAHVRAMLAFSQMGVPTFD
YGNNIRQMAKEMGVENAFDFPGFVPAYIRPLFCRGIGPFRWVALSGDPQDIYKTDAKVKEIVAEDKHLHHWLDMARERIH
FQGLPARICWVGLEWRQKLGLAFNEMVRCGEVSAPIVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTASG
ATWVSLHHGGGVGMGFSQHAGMVIVCDGTDEAAARIRRVLHNDPATGVMRHADAGYDLAVECAVEQGLNLPMVAATQGKG

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family

Homologues:

Organism=Homo sapiens, GI21389467, Length=544, Percent_Identity=34.5588235294118, Blast_Score=305, Evalue=1e-82,
Organism=Homo sapiens, GI260306182, Length=308, Percent_Identity=33.7662337662338, Blast_Score=157, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI71997891, Length=548, Percent_Identity=34.6715328467153, Blast_Score=314, Evalue=8e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTU_SALA4 (B5F068)

Other databases:

- EMBL:   CP001138
- RefSeq:   YP_002145746.1
- ProteinModelPortal:   B5F068
- SMR:   B5F068
- GeneID:   6794376
- GenomeReviews:   CP001138_GR
- KEGG:   sea:SeAg_B0826
- HOGENOM:   HBG305285
- OMA:   IRQMAFE
- ProtClustDB:   PRK05414
- GO:   GO:0005737
- HAMAP:   MF_00577
- InterPro:   IPR000193
- PIRSF:   PIRSF001423
- TIGRFAMs:   TIGR01228

Pfam domain/function: PF01175 Urocanase; SSF111326 Urocanase

EC number: =4.2.1.49

Molecular weight: Translated: 61466; Mature: 61335

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS01233 UROCANASE

Important sites: ACT_SITE 410-410

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPESKYRQQTIRAPRGTVLTAKSWLTEAPLRMLMNNLDPDVAENPHELVVYGGIGRAARN
CCCHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCC
WECYDAIVDALTRLEADETLLIQSGKPVGVFKTHDNAPRVLIANSNLVPHWATWEHFNEL
CHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCHHHHHHC
DAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHYNGTLAGRWVLTAGLGGMGGA
CCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCC
QPLAATLAGACSLTIECQQSRIDFRLRTRYVDEQAATLDDALARITRYTREGKAVSVALC
HHHHHHHHHHEEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
ANAADILPELVNRGVRPDLVTDQTSAHDPLHGYLPSGWRWEEYQKNAQSDPHGTMQAAKR
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHH
SMAAHVRAMLAFSQMGVPTFDYGNNIRQMAKEMGVENAFDFPGFVPAYIRPLFCRGIGPF
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCE
RWVALSGDPQDIYKTDAKVKEIVAEDKHLHHWLDMARERIHFQGLPARICWVGLEWRQKL
EEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHH
GLAFNEMVRCGEVSAPIVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTAS
CHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCC
GATWVSLHHGGGVGMGFSQHAGMVIVCDGTDEAAARIRRVLHNDPATGVMRHADAGYDLA
CCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCEE
VECAVEQGLNLPMVAATQGKG
EEEEHHCCCCCCEEECCCCCC
>Mature Secondary Structure 
PESKYRQQTIRAPRGTVLTAKSWLTEAPLRMLMNNLDPDVAENPHELVVYGGIGRAARN
CCHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCC
WECYDAIVDALTRLEADETLLIQSGKPVGVFKTHDNAPRVLIANSNLVPHWATWEHFNEL
CHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCHHHHHHC
DAKGLAMYGQMTAGSWIYIGSQGIVQGTYETFVEAGRQHYNGTLAGRWVLTAGLGGMGGA
CCCCEEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCC
QPLAATLAGACSLTIECQQSRIDFRLRTRYVDEQAATLDDALARITRYTREGKAVSVALC
HHHHHHHHHHEEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEC
ANAADILPELVNRGVRPDLVTDQTSAHDPLHGYLPSGWRWEEYQKNAQSDPHGTMQAAKR
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHH
SMAAHVRAMLAFSQMGVPTFDYGNNIRQMAKEMGVENAFDFPGFVPAYIRPLFCRGIGPF
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCE
RWVALSGDPQDIYKTDAKVKEIVAEDKHLHHWLDMARERIHFQGLPARICWVGLEWRQKL
EEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHH
GLAFNEMVRCGEVSAPIVIGRDHLDSGSVASPNRETEAMRDGSDAVSDWPLLNALLNTAS
CHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCC
GATWVSLHHGGGVGMGFSQHAGMVIVCDGTDEAAARIRRVLHNDPATGVMRHADAGYDLA
CCEEEEEECCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCEE
VECAVEQGLNLPMVAATQGKG
EEEEHHCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA