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The map label for this gene is hutH [H]

Identifier: 194736063

GI number: 194736063

Start: 912786

End: 914306

Strand: Direct

Name: hutH [H]

Synonym: SeSA_A0941

Alternate gene names: 194736063

Gene position: 912786-914306 (Clockwise)

Preceding gene: 194735125

Following gene: 194737665

Centisome position: 19.38

GC content: 60.09

Gene sequence:

>1521_bases
ATGAACACCATAACACTCACTCCGGGGCAGTTAAGCCTCTCTCAACTGTACGATGTCTGGCGTCATCCGGTACAGCTTCG
GCTGGACGCCAGCGCCATTGACGGCATTAACGCCAGCGTCGCGTGCGTCAATGATATCGTTGCCGAAGGGCGTACCGCCT
ACGGCATCAACACCGGTTTCGGCCTGCTGGCGCAGACGCGCATCGCTGATGAAGACTTGCAAAATCTACAGCGATCGTTG
GTGCTGTCTCACGCCGCGGGCGTAGGCGACCCACTGGATGACGCGATGGTGCGTCTGATCATGGTATTGAAAATCAATAG
TCTGGCGCGCGGGTTTTCCGGGATTCGGTTGAGCGTGATAGAAGCGCTCATCGCTCTGGTGAATGCCGGCGTGTATCCGC
TGATTCCGGCAAAAGGGTCGGTTGGCGCGTCGGGCGACTTAGCGCCGCTGGCGCATCTGTCGCTGACGCTGCTTGGCGAA
GGAAAAGCGCGCTGGCAGGGCGAATGGCTTCCGGCGCAGACGGCGCTAAAAAAGGCCGGACTGGAGCCTGTCGCGCTGGC
GGCCAAAGAGGGGCTGGCGCTGCTTAACGGCACCCAGGCGTCGACGGCCTTCGCGCTGCGTGGTTTGTTTGAGGCACAGG
AGTTATTTGCCTCCGCCGTTGTCTGCGGCGCGCTGACTACCGAAGCCGTACTAGGATCGCGCCGTCCTTTTGATGCGCGC
ATTCATGCCGCGCGCGGACAACAGGGGCAAATTGACGTCGCGCGGTTGTTCCGGCATCTGCTGACCGATACCAGCGCCAT
TGCTGAATCACATCACCACTGTCATAAAGTTCAGGACCCGTATTCCCTTCGCTGCCAGCCGCAGGTAATGGGCGCTTGTC
TGACCCAGTTACGTCAGACGAAAGAGGTACTGCTGGCTGAGGCCAACGCGGTGTCCGATAATCCGCTGGTCTTTGCCGAT
GCGGGGGAGGTGATCTCCGGCGGTAACTTCCATGCTGAACCGGTTGCCATGGCGGCGGATAATCTGGCGCTGGCGATAGC
GGAAATCGGCGCGCTATCGGAGCGGCGCATTGCGCTGATGATGGATAAACATATGTCGCAGTTACCGCCGTTTCTGGTGA
AAAATGGCGGCGTTAATTCCGGTTTTATGATTGCCCAGGTCACCGCCGCAGCGCTCGCCAGCGAGAATAAAGCGCTGGCG
CACCCGCACAGCGTGGATAGCCTGCCGACCTCGGCGAATCAGGAAGATCATGTCTCAATGGCCCCGGCGGCAGGACGGCG
ACTCTGGGAAATGGCGGCGAATACCCGCGGCATCATTGCCGTGGAGTGGCTGGCTGCCTGTCAGGGGATAGATTTACGGG
AAGGGTTAACCTCCAGCCCGTTACTGGAACAGGCGCGGCAGACACTACGCGAGCGGGTGGCGCACTATACGCAGGATCGT
TTTTTCGCACCCGATATTGAGTGTGCGACGGCGCTGCTGGCGCAAGGCGCGTTACAGCGTCTGGTGCCGGACTTTATGTG
A

Upstream 100 bases:

>100_bases
ATGCGCCATGCCGATGCCGGATATGATCTCGCGGTGGAATGCGCTGTTGAGCAAGGTCTGAATTTACCGATGGTTGCGGC
GACGCAGGGGAAAGGCTGAT

Downstream 100 bases:

>100_bases
ATGCTGCCGGATGGCGAGGCGCGTATTCGGCTTACCCAACCCGTTGGCAGGATAAGACGTTTACGCCGCCATCCGGCACA
GCGTTTAACTGAACATCGCC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MNTITLTPGQLSLSQLYDVWRHPVQLRLDASAIDGINASVACVNDIVAEGRTAYGINTGFGLLAQTRIADEDLQNLQRSL
VLSHAAGVGDPLDDAMVRLIMVLKINSLARGFSGIRLSVIEALIALVNAGVYPLIPAKGSVGASGDLAPLAHLSLTLLGE
GKARWQGEWLPAQTALKKAGLEPVALAAKEGLALLNGTQASTAFALRGLFEAQELFASAVVCGALTTEAVLGSRRPFDAR
IHAARGQQGQIDVARLFRHLLTDTSAIAESHHHCHKVQDPYSLRCQPQVMGACLTQLRQTKEVLLAEANAVSDNPLVFAD
AGEVISGGNFHAEPVAMAADNLALAIAEIGALSERRIALMMDKHMSQLPPFLVKNGGVNSGFMIAQVTAAALASENKALA
HPHSVDSLPTSANQEDHVSMAPAAGRRLWEMAANTRGIIAVEWLAACQGIDLREGLTSSPLLEQARQTLRERVAHYTQDR
FFAPDIECATALLAQGALQRLVPDFM

Sequences:

>Translated_506_residues
MNTITLTPGQLSLSQLYDVWRHPVQLRLDASAIDGINASVACVNDIVAEGRTAYGINTGFGLLAQTRIADEDLQNLQRSL
VLSHAAGVGDPLDDAMVRLIMVLKINSLARGFSGIRLSVIEALIALVNAGVYPLIPAKGSVGASGDLAPLAHLSLTLLGE
GKARWQGEWLPAQTALKKAGLEPVALAAKEGLALLNGTQASTAFALRGLFEAQELFASAVVCGALTTEAVLGSRRPFDAR
IHAARGQQGQIDVARLFRHLLTDTSAIAESHHHCHKVQDPYSLRCQPQVMGACLTQLRQTKEVLLAEANAVSDNPLVFAD
AGEVISGGNFHAEPVAMAADNLALAIAEIGALSERRIALMMDKHMSQLPPFLVKNGGVNSGFMIAQVTAAALASENKALA
HPHSVDSLPTSANQEDHVSMAPAAGRRLWEMAANTRGIIAVEWLAACQGIDLREGLTSSPLLEQARQTLRERVAHYTQDR
FFAPDIECATALLAQGALQRLVPDFM
>Mature_506_residues
MNTITLTPGQLSLSQLYDVWRHPVQLRLDASAIDGINASVACVNDIVAEGRTAYGINTGFGLLAQTRIADEDLQNLQRSL
VLSHAAGVGDPLDDAMVRLIMVLKINSLARGFSGIRLSVIEALIALVNAGVYPLIPAKGSVGASGDLAPLAHLSLTLLGE
GKARWQGEWLPAQTALKKAGLEPVALAAKEGLALLNGTQASTAFALRGLFEAQELFASAVVCGALTTEAVLGSRRPFDAR
IHAARGQQGQIDVARLFRHLLTDTSAIAESHHHCHKVQDPYSLRCQPQVMGACLTQLRQTKEVLLAEANAVSDNPLVFAD
AGEVISGGNFHAEPVAMAADNLALAIAEIGALSERRIALMMDKHMSQLPPFLVKNGGVNSGFMIAQVTAAALASENKALA
HPHSVDSLPTSANQEDHVSMAPAAGRRLWEMAANTRGIIAVEWLAACQGIDLREGLTSSPLLEQARQTLRERVAHYTQDR
FFAPDIECATALLAQGALQRLVPDFM

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=497, Percent_Identity=45.8752515090543, Blast_Score=419, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17567831, Length=480, Percent_Identity=43.75, Blast_Score=373, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 53837; Mature: 53837

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTITLTPGQLSLSQLYDVWRHPVQLRLDASAIDGINASVACVNDIVAEGRTAYGINTGF
CCEEECCCCCCCHHHHHHHHCCCEEEEECHHHHCCCCCHHHHHHHHHHCCCEEEECCCCH
GLLAQTRIADEDLQNLQRSLVLSHAAGVGDPLDDAMVRLIMVLKINSLARGFSGIRLSVI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
EALIALVNAGVYPLIPAKGSVGASGDLAPLAHLSLTLLGEGKARWQGEWLPAQTALKKAG
HHHHHHHCCCCCEEECCCCCCCCCCCCCHHHHEEEEEEECCCCCCCCCCCCHHHHHHHCC
LEPVALAAKEGLALLNGTQASTAFALRGLFEAQELFASAVVCGALTTEAVLGSRRPFDAR
CCHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
IHAARGQQGQIDVARLFRHLLTDTSAIAESHHHCHKVQDPYSLRCQPQVMGACLTQLRQT
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
KEVLLAEANAVSDNPLVFADAGEVISGGNFHAEPVAMAADNLALAIAEIGALSERRIALM
HHHHHHHCCCCCCCCEEEECCCCEECCCCCCCCCHHHHHCHHHHHHHHHCCCCCCHHHHH
MDKHMSQLPPFLVKNGGVNSGFMIAQVTAAALASENKALAHPHSVDSLPTSANQEDHVSM
HHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEE
APAAGRRLWEMAANTRGIIAVEWLAACQGIDLREGLTSSPLLEQARQTLRERVAHYTQDR
CCHHHHHHHHHHCCCCCEEEEHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
FFAPDIECATALLAQGALQRLVPDFM
CCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNTITLTPGQLSLSQLYDVWRHPVQLRLDASAIDGINASVACVNDIVAEGRTAYGINTGF
CCEEECCCCCCCHHHHHHHHCCCEEEEECHHHHCCCCCHHHHHHHHHHCCCEEEECCCCH
GLLAQTRIADEDLQNLQRSLVLSHAAGVGDPLDDAMVRLIMVLKINSLARGFSGIRLSVI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
EALIALVNAGVYPLIPAKGSVGASGDLAPLAHLSLTLLGEGKARWQGEWLPAQTALKKAG
HHHHHHHCCCCCEEECCCCCCCCCCCCCHHHHEEEEEEECCCCCCCCCCCCHHHHHHHCC
LEPVALAAKEGLALLNGTQASTAFALRGLFEAQELFASAVVCGALTTEAVLGSRRPFDAR
CCHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
IHAARGQQGQIDVARLFRHLLTDTSAIAESHHHCHKVQDPYSLRCQPQVMGACLTQLRQT
EEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHH
KEVLLAEANAVSDNPLVFADAGEVISGGNFHAEPVAMAADNLALAIAEIGALSERRIALM
HHHHHHHCCCCCCCCEEEECCCCEECCCCCCCCCHHHHHCHHHHHHHHHCCCCCCHHHHH
MDKHMSQLPPFLVKNGGVNSGFMIAQVTAAALASENKALAHPHSVDSLPTSANQEDHVSM
HHHHHHHCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEE
APAAGRRLWEMAANTRGIIAVEWLAACQGIDLREGLTSSPLLEQARQTLRERVAHYTQDR
CCHHHHHHHHHHCCCCCEEEEHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHCC
FFAPDIECATALLAQGALQRLVPDFM
CCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA