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The map label for this gene is hutC [H]

Identifier: 194734858

GI number: 194734858

Start: 910177

End: 910902

Strand: Direct

Name: hutC [H]

Synonym: SeSA_A0939

Alternate gene names: 194734858

Gene position: 910177-910902 (Clockwise)

Preceding gene: 194734214

Following gene: 194735125

Centisome position: 19.33

GC content: 56.89

Gene sequence:

>726_bases
ATGTATTCATCCCGCTCCCGTTCTGCGCCTGCGCCTTTTTACGAAACGGTGAAACAGGACATCTGTAAAAAAATAGCCGA
CGGCGTCTGGCAGCCGCACGATCGCATTCCGTCGGAAGCTGAACTGGTCGCGCAGTATGGCTTTAGCCGAATGACCATCA
ACCGGGCGCTGCGTGAGCTGACGGATGAAGGGTGGCTGGTGCGTTTACAGGGCGTGGGGACGTTTGTCGCCGAACCAAAA
GGCCAGTCCGCGCTGTTTGAAGTCCGCAGTATCGCCGAGGAGATTGCCGCCCGCCGTCATCAGCATCGTTGTGAGGTGCT
CACGCTGGAGCGCGTGCGGGCAAACGCCATCCAGGCCAGCGCTCTCAACGTCAATGAGAGCGATGTCATTTTCCATTCCA
TCATGGTGCATTATGAAAACGATCTGCCGGTACAAATTGAAGATCGCTGCGTGAATGCGGATATTGCCGTGGATTATCTG
ACGCAGGATTACCGTCAGACCACGCCGCACGCTTATTTGTCGCGGATCGCGCCGCTAACGGAAGGGGAACATATTGTGGA
GGCGGTGCGCGCCACGGCGCAAGAGTGCGCGTGGTTAACTATCAAAGAGCATGAGCCTTGTCTGCTCATTCGTCGTACAA
CCTGGTCCGCGTCGCGGATTGTTTCTCACGCCCGCTTACTTTTCCCCGGGTCGCGCTACCGGCTACAGGGACGATTTATC
TCCTGA

Upstream 100 bases:

>100_bases
CAGCGGCGCGCGTGGCGGCGCGGCTTGGCTGGCAAATCGCGCACTGGTGGCGTTAATCTGTCATCCGGAAAACACTATCC
GCATAAGGAAGGCTTCACGC

Downstream 100 bases:

>100_bases
GCGGACTGCTGCCGGAAAACGTGATTGCTGACACAATATAACAAAATTGTATTATTTTTGTTAATTCTATTCTTGTGCTT
ACTTGTATAGACAAGTATAT

Product: histidine utilization repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MYSSRSRSAPAPFYETVKQDICKKIADGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPK
GQSALFEVRSIAEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDYL
TQDYRQTTPHAYLSRIAPLTEGEHIVEAVRATAQECAWLTIKEHEPCLLIRRTTWSASRIVSHARLLFPGSRYRLQGRFI
S

Sequences:

>Translated_241_residues
MYSSRSRSAPAPFYETVKQDICKKIADGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPK
GQSALFEVRSIAEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDYL
TQDYRQTTPHAYLSRIAPLTEGEHIVEAVRATAQECAWLTIKEHEPCLLIRRTTWSASRIVSHARLLFPGSRYRLQGRFI
S
>Mature_241_residues
MYSSRSRSAPAPFYETVKQDICKKIADGVWQPHDRIPSEAELVAQYGFSRMTINRALRELTDEGWLVRLQGVGTFVAEPK
GQSALFEVRSIAEEIAARRHQHRCEVLTLERVRANAIQASALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDYL
TQDYRQTTPHAYLSRIAPLTEGEHIVEAVRATAQECAWLTIKEHEPCLLIRRTTWSASRIVSHARLLFPGSRYRLQGRFI
S

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=229, Percent_Identity=28.3842794759825, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1786950, Length=227, Percent_Identity=24.6696035242291, Blast_Score=84, Evalue=6e-18,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 27502; Mature: 27502

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSSRSRSAPAPFYETVKQDICKKIADGVWQPHDRIPSEAELVAQYGFSRMTINRALREL
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHH
TDEGWLVRLQGVGTFVAEPKGQSALFEVRSIAEEIAARRHQHRCEVLTLERVRANAIQAS
CCCCCEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHH
ALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDYLTQDYRQTTPHAYLSRIAPLT
CCCCCCHHHHHHHHHEEECCCCCEEEECEECCCHHHHHHHHHHHHHCCHHHHHHHHCCCC
EGEHIVEAVRATAQECAWLTIKEHEPCLLIRRTTWSASRIVSHARLLFPGSRYRLQGRFI
CCHHHHHHHHHHHHHCEEEEEECCCCEEEEEECCCCHHHHHHHHHHCCCCCCEEEECEEC
S
C
>Mature Secondary Structure
MYSSRSRSAPAPFYETVKQDICKKIADGVWQPHDRIPSEAELVAQYGFSRMTINRALREL
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHH
TDEGWLVRLQGVGTFVAEPKGQSALFEVRSIAEEIAARRHQHRCEVLTLERVRANAIQAS
CCCCCEEEEECCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHH
ALNVNESDVIFHSIMVHYENDLPVQIEDRCVNADIAVDYLTQDYRQTTPHAYLSRIAPLT
CCCCCCHHHHHHHHHEEECCCCCEEEECEECCCHHHHHHHHHHHHHCCHHHHHHHHCCCC
EGEHIVEAVRATAQECAWLTIKEHEPCLLIRRTTWSASRIVSHARLLFPGSRYRLQGRFI
CCHHHHHHHHHHHHHCEEEEEECCCCEEEEEECCCCHHHHHHHHHHCCCCCCEEEECEEC
S
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2203754; 2834335 [H]