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The map label for this gene is murC

Identifier: 194335050

GI number: 194335050

Start: 2439526

End: 2440920

Strand: Reverse

Name: murC

Synonym: Paes_2262

Alternate gene names: 194335050

Gene position: 2440920-2439526 (Counterclockwise)

Preceding gene: 194335051

Following gene: 194335049

Centisome position: 97.13

GC content: 54.19

Gene sequence:

>1395_bases
GTGGAATTAGGAAAAACAAAATGTGTGCATATCGTCGGAATCGGCGGGGCTGGAATGAGCGCAATTGCTGAACTGCTCTT
GAAATCGGGGTTTACCGTCACCGGTTCGGATTTGAGCTCCGGAGAGGTGACTGATAAACTGTCGGAGCTCGGCGCCGAGG
TCTATAAGGGGCATAGTGAAGGGAATGTAGGTGCTTGTGATGTTGTTGTCTACTCCTCTGCCGTCAGGCCGGAGAGCAAT
GTCGAGATTCTGGCAGCCGAGAAAAAAGGGATCCCGGTTATCAAGCGCGACGAGATGCTTGGGGAGCTCATGCGTTTCAG
AAGCGGGGTCTGCGTTGCCGGTACACATGGCAAGACCACAACGACGGCCATGATTGCCACCATGCTGATCGAGGCGGGCG
AATCACCGACGGTGATGATCGGAGGGATTTCCGATTACCTTAAAGGCAGCACGGTTGTCGGCAATGGTAAATATATGGTG
ATCGAAGCTGATGAGTATGACCGGGCTTTTCTGAAGCTGACACCTTCCATTGCGGTCATCAACAGCCTCGAAGCCGAACA
TGCCGACACCTACGCCACGCTTGACGAGCTGCGCGATGCCTTTATCGATTTCGCCAACAGCGTGCCTTTCTACGGCAAGG
TGATCTGCTGTGTCGACTGGCCGGAGGTGCGGCGGATCGTATCGGGCTTCAACCGTCGTTATTCCACCTATGGCATCGAC
GAAACCGCCGATCTTATGGCCAGGGATATTCGTATTGAAAAAAACGAGACATTTTTTTCAGTCGACTATATGAGAAGCCA
TCTGGCCGATTTCCGTATTGCCGTTCCCGGGCGCCATAACGTTCATAACGCGCTTGCTGCCATTGCGGTAGGGCTTGAAA
TGGGCCTGCCGGTAGAGCGTCTTGTTTCGGGTCTGGCGGCTTTCAGCGGCATGCGTCGCCGGTTTCAGATCCGTTATACA
TCTCCGGACGGACCGATCATTGTCGATGACTATGCTCATCATCCTTCAGAGGTGAAAGCCGCTGTCAAAGCGGCAAAGGC
CGGTTGGCCGGAGCGGGAGGTCATTGCGGTTTTTCAGCCCCACCTCTATTCCAGAACGGCTGATTTTGCCGGTGAGTTCG
GATGGGCGCTTTCCGGTGCCGACAGGGTTTGCATTGCGGGGATCTACCCTGCACGAGAAGATCCGAGAAATTTTCCCGGG
ATCTCAGGGGAGCTCGTTGCCGAGGCGGCAAGGGTTGCCGGGGCATCCAACGTCTCGTTTTTTGAAGACGGGAAGGAACT
CTCCGCGCATCTTGCAGGTTACTGTGTTCCTGGAATGCTGATGCTTTTTATGGGGGCTGGTGATATTACAGGCATATCTG
TCAGTATGGCGGATTTCTGCACGAAACGATCTTGA

Upstream 100 bases:

>100_bases
GCGCATGAGGGAAGCCTGCCGCAAGGAGGGACGGCCGGAGGCCGCTTTGGATCTTGCAGGAAGAATTGCCGGGCTGGCTA
ACATTAAGTGAGGAAACAGG

Downstream 100 bases:

>100_bases
AAGGAATGGAATGCTGAGTACTGAAGAGCTGTTACGGACCATACGGGGTTCAATTAGTATCGGGGAGCCGATGAGTGAGC
ATACTTCGCTCAAGATCGGC

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MELGKTKCVHIVGIGGAGMSAIAELLLKSGFTVTGSDLSSGEVTDKLSELGAEVYKGHSEGNVGACDVVVYSSAVRPESN
VEILAAEKKGIPVIKRDEMLGELMRFRSGVCVAGTHGKTTTTAMIATMLIEAGESPTVMIGGISDYLKGSTVVGNGKYMV
IEADEYDRAFLKLTPSIAVINSLEAEHADTYATLDELRDAFIDFANSVPFYGKVICCVDWPEVRRIVSGFNRRYSTYGID
ETADLMARDIRIEKNETFFSVDYMRSHLADFRIAVPGRHNVHNALAAIAVGLEMGLPVERLVSGLAAFSGMRRRFQIRYT
SPDGPIIVDDYAHHPSEVKAAVKAAKAGWPEREVIAVFQPHLYSRTADFAGEFGWALSGADRVCIAGIYPAREDPRNFPG
ISGELVAEAARVAGASNVSFFEDGKELSAHLAGYCVPGMLMLFMGAGDITGISVSMADFCTKRS

Sequences:

>Translated_464_residues
MELGKTKCVHIVGIGGAGMSAIAELLLKSGFTVTGSDLSSGEVTDKLSELGAEVYKGHSEGNVGACDVVVYSSAVRPESN
VEILAAEKKGIPVIKRDEMLGELMRFRSGVCVAGTHGKTTTTAMIATMLIEAGESPTVMIGGISDYLKGSTVVGNGKYMV
IEADEYDRAFLKLTPSIAVINSLEAEHADTYATLDELRDAFIDFANSVPFYGKVICCVDWPEVRRIVSGFNRRYSTYGID
ETADLMARDIRIEKNETFFSVDYMRSHLADFRIAVPGRHNVHNALAAIAVGLEMGLPVERLVSGLAAFSGMRRRFQIRYT
SPDGPIIVDDYAHHPSEVKAAVKAAKAGWPEREVIAVFQPHLYSRTADFAGEFGWALSGADRVCIAGIYPAREDPRNFPG
ISGELVAEAARVAGASNVSFFEDGKELSAHLAGYCVPGMLMLFMGAGDITGISVSMADFCTKRS
>Mature_464_residues
MELGKTKCVHIVGIGGAGMSAIAELLLKSGFTVTGSDLSSGEVTDKLSELGAEVYKGHSEGNVGACDVVVYSSAVRPESN
VEILAAEKKGIPVIKRDEMLGELMRFRSGVCVAGTHGKTTTTAMIATMLIEAGESPTVMIGGISDYLKGSTVVGNGKYMV
IEADEYDRAFLKLTPSIAVINSLEAEHADTYATLDELRDAFIDFANSVPFYGKVICCVDWPEVRRIVSGFNRRYSTYGID
ETADLMARDIRIEKNETFFSVDYMRSHLADFRIAVPGRHNVHNALAAIAVGLEMGLPVERLVSGLAAFSGMRRRFQIRYT
SPDGPIIVDDYAHHPSEVKAAVKAAKAGWPEREVIAVFQPHLYSRTADFAGEFGWALSGADRVCIAGIYPAREDPRNFPG
ISGELVAEAARVAGASNVSFFEDGKELSAHLAGYCVPGMLMLFMGAGDITGISVSMADFCTKRS

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=472, Percent_Identity=39.8305084745763, Blast_Score=300, Evalue=1e-82,
Organism=Escherichia coli, GI1790680, Length=474, Percent_Identity=28.2700421940928, Blast_Score=147, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_PROA2 (B4S6Q8)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002016910.1
- ProteinModelPortal:   B4S6Q8
- SMR:   B4S6Q8
- GeneID:   6459579
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_2262
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 49942; Mature: 49942

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELGKTKCVHIVGIGGAGMSAIAELLLKSGFTVTGSDLSSGEVTDKLSELGAEVYKGHSE
CCCCCCEEEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCC
GNVGACDVVVYSSAVRPESNVEILAAEKKGIPVIKRDEMLGELMRFRSGVCVAGTHGKTT
CCCCEEEEEEEECCCCCCCCCEEEEECCCCCCEEEHHHHHHHHHHHHCCEEEECCCCCHH
TTAMIATMLIEAGESPTVMIGGISDYLKGSTVVGNGKYMVIEADEYDRAFLKLTPSIAVI
HHHHHHHHHHHCCCCCEEEEECCHHHHCCCEEEECCEEEEEECCCCCCEEEEECCCHHHH
NSLEAEHADTYATLDELRDAFIDFANSVPFYGKVICCVDWPEVRRIVSGFNRRYSTYGID
HCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCC
ETADLMARDIRIEKNETFFSVDYMRSHLADFRIAVPGRHNVHNALAAIAVGLEMGLPVER
HHHHHHHHHEEEECCCEEEEHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHCCCCHHH
LVSGLAAFSGMRRRFQIRYTSPDGPIIVDDYAHHPSEVKAAVKAAKAGWPEREVIAVFQP
HHHHHHHHHCCCEEEEEEEECCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEECC
HLYSRTADFAGEFGWALSGADRVCIAGIYPAREDPRNFPGISGELVAEAARVAGASNVSF
HHHHHHHHHHHCCCCEECCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCH
FEDGKELSAHLAGYCVPGMLMLFMGAGDITGISVSMADFCTKRS
HHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCC
>Mature Secondary Structure
MELGKTKCVHIVGIGGAGMSAIAELLLKSGFTVTGSDLSSGEVTDKLSELGAEVYKGHSE
CCCCCCEEEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCC
GNVGACDVVVYSSAVRPESNVEILAAEKKGIPVIKRDEMLGELMRFRSGVCVAGTHGKTT
CCCCEEEEEEEECCCCCCCCCEEEEECCCCCCEEEHHHHHHHHHHHHCCEEEECCCCCHH
TTAMIATMLIEAGESPTVMIGGISDYLKGSTVVGNGKYMVIEADEYDRAFLKLTPSIAVI
HHHHHHHHHHHCCCCCEEEEECCHHHHCCCEEEECCEEEEEECCCCCCEEEEECCCHHHH
NSLEAEHADTYATLDELRDAFIDFANSVPFYGKVICCVDWPEVRRIVSGFNRRYSTYGID
HCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCCCCC
ETADLMARDIRIEKNETFFSVDYMRSHLADFRIAVPGRHNVHNALAAIAVGLEMGLPVER
HHHHHHHHHEEEECCCEEEEHHHHHHHHCCEEEECCCCCCHHHHHHHHHHHHHCCCCHHH
LVSGLAAFSGMRRRFQIRYTSPDGPIIVDDYAHHPSEVKAAVKAAKAGWPEREVIAVFQP
HHHHHHHHHCCCEEEEEEEECCCCCEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEECC
HLYSRTADFAGEFGWALSGADRVCIAGIYPAREDPRNFPGISGELVAEAARVAGASNVSF
HHHHHHHHHHHCCCCEECCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCH
FEDGKELSAHLAGYCVPGMLMLFMGAGDITGISVSMADFCTKRS
HHCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA