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The map label for this gene is hrcA

Identifier: 194334389

GI number: 194334389

Start: 1725371

End: 1726438

Strand: Reverse

Name: hrcA

Synonym: Paes_1584

Alternate gene names: 194334389

Gene position: 1726438-1725371 (Counterclockwise)

Preceding gene: 194334390

Following gene: 194334388

Centisome position: 68.7

GC content: 48.97

Gene sequence:

>1068_bases
ATGAAAACTATTGATCTGACACCGCGGGAGCGGGAGGTGCTTGGTATCATCATACAGGCTTATGTTGTTTCAGCATCACC
TGTAAGTTCCCGTTTTATAGCAAAAAATTATAATCTTGGACTTTCCGATGCTACCATCAGAAATGTGATGGCCGATCTGG
AAGACGCAGGATTTATCAGTCAGCCCCATACCTCTGCCGGGAGGGTGCCGACTGATAAGGGCTATCGTTACTATGTGGAT
CTTATCATGATGGTTCAGGGGATCGATGATGATGAGAAACGCCATATCGACAGCAATCTCCGGCTTTTTACCATCGACAG
GAAGGATTCGTCGGAAGTGCTTTTTGCCGCAGCCAAGGTTCTGGGCAGTATTTCGCAGCAGCTCAGTGTGGTGATGTCTC
CGCGGCTTTCTCTTGGCGTTTTCGAGCGGCTCGACATGGTACTTTTGAGTTCTTCGAGAATTATGGTGATTTTGTCGATT
CAGTCTCTGTTTGTCAAGACTATTGTCATGGAGCTTGATCTCGATGTTTCCCGCCGGCAGATCGAGATGGTTGTCGATCT
GCTTAATCAGCGACTTTCCGGGCTGACGCTTGATGAGATCCGTACTTCCATTGCTGAGCGTCTTGCTGACTGTGATACCG
ATCAGGGCCTGCTGAACAGGATTGTTCGTTCAGCAGACGAACTCTTTGATGAGTCACCGGTGCTCGACAGGCTCTATATT
GCAGGAGCCGAATACATTGTCAGCCAGCCTGAGTTCGATCAGCCGCAGAAGGTCAGGGATCTTATCTGTATGATTGAAGA
CAAAACCCGCATTGCCCGGATCGTTGATCTCGATGGTGTTGTTGTACCGCAGGTTATGACTGAGCGGGACGTGAGCATAA
CTATCGGCAGGGAGAATCCTGCATCGACTGAAGGAGATTTTACCGTTGTGACAACACCTTATTTTGTCGGCAACACCATG
GGGCGTCTGGCTGTGCTCGGCCCGAAACGGATGGATTACGCTCGTGTTGTTCGGGTTGTCAATTATATGGCGGACCGTTT
GTCAACCACATTTTCAGATGTCAATTAA

Upstream 100 bases:

>100_bases
TGGTTCCCCACTGCTGCAACAGGTTCTTTTTTTGTAAATTGGCTCTATTTTGAGCGTTGGCGTGTGTTTGCAGCAACTCT
CTATCAGGGAAGAGCAATCG

Downstream 100 bases:

>100_bases
ATCGTATCAGCACAACTTATGAGTAAAAAAGCATCAATGCATAAAGAGGAAAAACATGAAAAGGGGCAGCATAAGCAGCC
TGCAGATGAACAGCCTCTCG

Product: heat-inducible transcription repressor HrcA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MKTIDLTPREREVLGIIIQAYVVSASPVSSRFIAKNYNLGLSDATIRNVMADLEDAGFISQPHTSAGRVPTDKGYRYYVD
LIMMVQGIDDDEKRHIDSNLRLFTIDRKDSSEVLFAAAKVLGSISQQLSVVMSPRLSLGVFERLDMVLLSSSRIMVILSI
QSLFVKTIVMELDLDVSRRQIEMVVDLLNQRLSGLTLDEIRTSIAERLADCDTDQGLLNRIVRSADELFDESPVLDRLYI
AGAEYIVSQPEFDQPQKVRDLICMIEDKTRIARIVDLDGVVVPQVMTERDVSITIGRENPASTEGDFTVVTTPYFVGNTM
GRLAVLGPKRMDYARVVRVVNYMADRLSTTFSDVN

Sequences:

>Translated_355_residues
MKTIDLTPREREVLGIIIQAYVVSASPVSSRFIAKNYNLGLSDATIRNVMADLEDAGFISQPHTSAGRVPTDKGYRYYVD
LIMMVQGIDDDEKRHIDSNLRLFTIDRKDSSEVLFAAAKVLGSISQQLSVVMSPRLSLGVFERLDMVLLSSSRIMVILSI
QSLFVKTIVMELDLDVSRRQIEMVVDLLNQRLSGLTLDEIRTSIAERLADCDTDQGLLNRIVRSADELFDESPVLDRLYI
AGAEYIVSQPEFDQPQKVRDLICMIEDKTRIARIVDLDGVVVPQVMTERDVSITIGRENPASTEGDFTVVTTPYFVGNTM
GRLAVLGPKRMDYARVVRVVNYMADRLSTTFSDVN
>Mature_355_residues
MKTIDLTPREREVLGIIIQAYVVSASPVSSRFIAKNYNLGLSDATIRNVMADLEDAGFISQPHTSAGRVPTDKGYRYYVD
LIMMVQGIDDDEKRHIDSNLRLFTIDRKDSSEVLFAAAKVLGSISQQLSVVMSPRLSLGVFERLDMVLLSSSRIMVILSI
QSLFVKTIVMELDLDVSRRQIEMVVDLLNQRLSGLTLDEIRTSIAERLADCDTDQGLLNRIVRSADELFDESPVLDRLYI
AGAEYIVSQPEFDQPQKVRDLICMIEDKTRIARIVDLDGVVVPQVMTERDVSITIGRENPASTEGDFTVVTTPYFVGNTM
GRLAVLGPKRMDYARVVRVVNYMADRLSTTFSDVN

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_PROA2 (B4S9D2)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002016249.1
- ProteinModelPortal:   B4S9D2
- SMR:   B4S9D2
- GeneID:   6459964
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_1584
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   CLSK637786
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR005104
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF03444 DUF293; PF01628 HrcA

EC number: NA

Molecular weight: Translated: 39782; Mature: 39782

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTIDLTPREREVLGIIIQAYVVSASPVSSRFIAKNYNLGLSDATIRNVMADLEDAGFIS
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCC
QPHTSAGRVPTDKGYRYYVDLIMMVQGIDDDEKRHIDSNLRLFTIDRKDSSEVLFAAAKV
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCEEEEECCCCCHHHHHHHHHH
LGSISQQLSVVMSPRLSLGVFERLDMVLLSSSRIMVILSIQSLFVKTIVMELDLDVSRRQ
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHCCCHHHHH
IEMVVDLLNQRLSGLTLDEIRTSIAERLADCDTDQGLLNRIVRSADELFDESPVLDRLYI
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
AGAEYIVSQPEFDQPQKVRDLICMIEDKTRIARIVDLDGVVVPQVMTERDVSITIGRENP
HCHHHHCCCCCCCCHHHHHHHHHHHCCCHHEEEEECCCCEECCHHHCCCCCEEEEECCCC
ASTEGDFTVVTTPYFVGNTMGRLAVLGPKRMDYARVVRVVNYMADRLSTTFSDVN
CCCCCCEEEEECCHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKTIDLTPREREVLGIIIQAYVVSASPVSSRFIAKNYNLGLSDATIRNVMADLEDAGFIS
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCC
QPHTSAGRVPTDKGYRYYVDLIMMVQGIDDDEKRHIDSNLRLFTIDRKDSSEVLFAAAKV
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCCEEEEECCCCCHHHHHHHHHH
LGSISQQLSVVMSPRLSLGVFERLDMVLLSSSRIMVILSIQSLFVKTIVMELDLDVSRRQ
HHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHCCCHHHHH
IEMVVDLLNQRLSGLTLDEIRTSIAERLADCDTDQGLLNRIVRSADELFDESPVLDRLYI
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHH
AGAEYIVSQPEFDQPQKVRDLICMIEDKTRIARIVDLDGVVVPQVMTERDVSITIGRENP
HCHHHHCCCCCCCCHHHHHHHHHHHCCCHHEEEEECCCCEECCHHHCCCCCEEEEECCCC
ASTEGDFTVVTTPYFVGNTMGRLAVLGPKRMDYARVVRVVNYMADRLSTTFSDVN
CCCCCCEEEEECCHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA