Click here to switch to the map view.

The map label for this gene is mutL

Identifier: 193214447

GI number: 193214447

Start: 857316

End: 859238

Strand: Direct

Name: mutL

Synonym: Ctha_0730

Alternate gene names: 193214447

Gene position: 857316-859238 (Clockwise)

Preceding gene: 193214439

Following gene: 193214448

Centisome position: 26.03

GC content: 46.91

Gene sequence:

>1923_bases
ATGTCGCTCATTAAGAAATTGCCCGATATTGTCGCCAATAAAATTTCCGCTGGTGAAGTGGTGCAACGGCCCGCTTCGGC
GGTCAAAGAACTGTTGGAAAATGCGATCGATGCAGGCGCCGACGAAATTACCCTTGCCATTAAAGCTGCTGGAAAAACGT
TAATTCAGGTTATCGATAATGGCTGCGGACTTTCCGAAGAGGATGCCACCCTTTGCTTCGAGCGATTTGCAACCAGCAAA
ATTAGTGATGTGGGAGATCTTGAAAATCTTCATACGCTTGGCTTTCGTGGTGAAGCGCTCGCCAGCATTGCGTCGGTTTC
TCAAGTTGAACTCAAAACCAAGCGCTACGACGATCGCACCGGCACTTTGGTAAAAATTTCCGGTGGCCGGTTTGAAGAAG
TGAGCCGCACGGAAACACCAAACGGCACCGCCTTCAGCATTCGCAACCTTTTTTACAATGTGCCCGCTCGCCGAAAATTT
CTAAAAACCAACGCCACCGAATACAAACATATTTTCGAAACAGTCCAAGCGCAAACGCTCGTTTATCCTGACATTAAATG
GCGGTTTTATAGCGACGATGAGGAAATTTTCTCGTTTTTAAACAACAATCTTTCCGAACGATTGGATTATTTCTTTGGGA
AGGATTTTTCCCAAAACCTAATAGAATTTACCGAAGAAAACGACTTCATGAAGCTTCGCGGCTACTTGGGCAAGCCCGCC
ATGATGAAACGGACGAAAAACCAGCAATTTCTTTTTATCAATAATCGCGTCACGCAAAGCAAGTTGCTTTCCAGCGCCAT
CATGACGGCTTACGGAGAACTTTTAGGCGAGCGAGAATATCCGTTTTTCCTTATCTACATGGACATTGCGCCGCATTATA
TCGATGTGAATGTCCATCCAACCAAGATGGAAGTGAAGTTCGACGATGAGCGAAATATTTATAACATGGTTCATTCCGTT
GTGAAACATCGGATTAAAACCCTTGATTTTTCGCCCAATGTTCAAGTTGAAGAAAAACCGGATTCGCCGCGGCCAACTGG
CGAAAGCTTTAATTTTCCCGGCGTAGCAAAGCGCCTAAGCTACAACGATCGAGATGCCGACATGCGTAGCTCAAACGCTT
TGTTTCGCGATTATAAAACTTATTACAAAGCGCAAGACGAACGCGCCGAACCAGGATTTTTTGCCAATCCGAAAAGAGAA
ATGGATTGGCGCTCGTCGCTGCCCGCTCATACCGAAGCATCTTTAACGCCGCCCAAACAGGCTGAGCCTGAAGGCAATCC
GACCTTTCACGATGGTAGTCGACAAATGGAAATATTTATCCAGTCGCGCGACGACGAGCCCGCCACAGCCGGCCAAGAGC
GTTTCGTTTGGCAACTTCACAACACCTATATTTTAACCCAAATCAAATCGGGGTTGCTCATCATCGACCAGCATGTGGCA
CACGAGCGCATTTTATACGAACGCGCCATTGCCGTCATGGAATCCAATGTGCCCAATTCGCAACAGCTTTTATTTCCACA
TTCAGCCAAGCTGAGCGCGTGGGAGTTCGATGTGTTGAAGGAAATTAAAACCGACTTGGTGCAATTGGGCTTTTCACTTC
GGATTTTAGACCAGCGAACGGTGCTTGTAGAAGGCATTCCGCCAGATGTGATGCCAGGAAGAGAGGAACGAATTTTGCAC
GAAATGCTCGAGCAATACCAAGACTATCAGCAAAACCTGAAGCTTGAGCAACGCGACAATGTGGCCAAATCCTATGCGTG
CCGCAGTTCCATTATGGCCGGCCAAAAACTCTCGCGCAATGAAATGACCAGCCTCATCGATCAGCTTTTCGCAACGTCTA
TGCCCTACGTATGCCCACATGGGCGGCCTATCATTATTAAATTATCCATTGAAGAACTCGATAAAATGTTTGGGCGTTCT
TAG

Upstream 100 bases:

>100_bases
ATTCAGTATTTTTTGGAAATATGTGTGAGGGGAAAGAACGGTCAACTCAGTGGCCACCTTTATAGTTGCATATTGCAAAC
CAAAGAAAGACTTCGCTTGT

Downstream 100 bases:

>100_bases
CAGGCAGGTGAAAAGTTTTTTATTTTCATTAATTTGATTTTATTGTAGAAGTTCTTCGTTTGTTGCCCTTGTAGCTCAGA
AGGATAGAGCAGCAGTTTCC

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 640; Mature: 639

Protein sequence:

>640_residues
MSLIKKLPDIVANKISAGEVVQRPASAVKELLENAIDAGADEITLAIKAAGKTLIQVIDNGCGLSEEDATLCFERFATSK
ISDVGDLENLHTLGFRGEALASIASVSQVELKTKRYDDRTGTLVKISGGRFEEVSRTETPNGTAFSIRNLFYNVPARRKF
LKTNATEYKHIFETVQAQTLVYPDIKWRFYSDDEEIFSFLNNNLSERLDYFFGKDFSQNLIEFTEENDFMKLRGYLGKPA
MMKRTKNQQFLFINNRVTQSKLLSSAIMTAYGELLGEREYPFFLIYMDIAPHYIDVNVHPTKMEVKFDDERNIYNMVHSV
VKHRIKTLDFSPNVQVEEKPDSPRPTGESFNFPGVAKRLSYNDRDADMRSSNALFRDYKTYYKAQDERAEPGFFANPKRE
MDWRSSLPAHTEASLTPPKQAEPEGNPTFHDGSRQMEIFIQSRDDEPATAGQERFVWQLHNTYILTQIKSGLLIIDQHVA
HERILYERAIAVMESNVPNSQQLLFPHSAKLSAWEFDVLKEIKTDLVQLGFSLRILDQRTVLVEGIPPDVMPGREERILH
EMLEQYQDYQQNLKLEQRDNVAKSYACRSSIMAGQKLSRNEMTSLIDQLFATSMPYVCPHGRPIIIKLSIEELDKMFGRS

Sequences:

>Translated_640_residues
MSLIKKLPDIVANKISAGEVVQRPASAVKELLENAIDAGADEITLAIKAAGKTLIQVIDNGCGLSEEDATLCFERFATSK
ISDVGDLENLHTLGFRGEALASIASVSQVELKTKRYDDRTGTLVKISGGRFEEVSRTETPNGTAFSIRNLFYNVPARRKF
LKTNATEYKHIFETVQAQTLVYPDIKWRFYSDDEEIFSFLNNNLSERLDYFFGKDFSQNLIEFTEENDFMKLRGYLGKPA
MMKRTKNQQFLFINNRVTQSKLLSSAIMTAYGELLGEREYPFFLIYMDIAPHYIDVNVHPTKMEVKFDDERNIYNMVHSV
VKHRIKTLDFSPNVQVEEKPDSPRPTGESFNFPGVAKRLSYNDRDADMRSSNALFRDYKTYYKAQDERAEPGFFANPKRE
MDWRSSLPAHTEASLTPPKQAEPEGNPTFHDGSRQMEIFIQSRDDEPATAGQERFVWQLHNTYILTQIKSGLLIIDQHVA
HERILYERAIAVMESNVPNSQQLLFPHSAKLSAWEFDVLKEIKTDLVQLGFSLRILDQRTVLVEGIPPDVMPGREERILH
EMLEQYQDYQQNLKLEQRDNVAKSYACRSSIMAGQKLSRNEMTSLIDQLFATSMPYVCPHGRPIIIKLSIEELDKMFGRS
>Mature_639_residues
SLIKKLPDIVANKISAGEVVQRPASAVKELLENAIDAGADEITLAIKAAGKTLIQVIDNGCGLSEEDATLCFERFATSKI
SDVGDLENLHTLGFRGEALASIASVSQVELKTKRYDDRTGTLVKISGGRFEEVSRTETPNGTAFSIRNLFYNVPARRKFL
KTNATEYKHIFETVQAQTLVYPDIKWRFYSDDEEIFSFLNNNLSERLDYFFGKDFSQNLIEFTEENDFMKLRGYLGKPAM
MKRTKNQQFLFINNRVTQSKLLSSAIMTAYGELLGEREYPFFLIYMDIAPHYIDVNVHPTKMEVKFDDERNIYNMVHSVV
KHRIKTLDFSPNVQVEEKPDSPRPTGESFNFPGVAKRLSYNDRDADMRSSNALFRDYKTYYKAQDERAEPGFFANPKREM
DWRSSLPAHTEASLTPPKQAEPEGNPTFHDGSRQMEIFIQSRDDEPATAGQERFVWQLHNTYILTQIKSGLLIIDQHVAH
ERILYERAIAVMESNVPNSQQLLFPHSAKLSAWEFDVLKEIKTDLVQLGFSLRILDQRTVLVEGIPPDVMPGREERILHE
MLEQYQDYQQNLKLEQRDNVAKSYACRSSIMAGQKLSRNEMTSLIDQLFATSMPYVCPHGRPIIIKLSIEELDKMFGRS

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=329, Percent_Identity=36.4741641337386, Blast_Score=209, Evalue=7e-54,
Organism=Homo sapiens, GI4505913, Length=336, Percent_Identity=27.6785714285714, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI310128478, Length=336, Percent_Identity=27.6785714285714, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI4505911, Length=327, Percent_Identity=29.3577981651376, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI189458898, Length=327, Percent_Identity=29.3577981651376, Blast_Score=124, Evalue=4e-28,
Organism=Homo sapiens, GI189458896, Length=317, Percent_Identity=28.7066246056782, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI91992162, Length=271, Percent_Identity=34.3173431734317, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI91992160, Length=271, Percent_Identity=34.3173431734317, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI263191589, Length=234, Percent_Identity=32.0512820512821, Blast_Score=114, Evalue=4e-25,
Organism=Homo sapiens, GI310128480, Length=294, Percent_Identity=25.1700680272109, Blast_Score=103, Evalue=4e-22,
Organism=Escherichia coli, GI1790612, Length=573, Percent_Identity=31.413612565445, Blast_Score=231, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI71991825, Length=322, Percent_Identity=34.472049689441, Blast_Score=177, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17562796, Length=352, Percent_Identity=27.2727272727273, Blast_Score=132, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6323819, Length=363, Percent_Identity=31.9559228650138, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6324247, Length=353, Percent_Identity=24.929178470255, Blast_Score=120, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6325093, Length=293, Percent_Identity=24.9146757679181, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323063, Length=359, Percent_Identity=26.7409470752089, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17136968, Length=348, Percent_Identity=33.0459770114943, Blast_Score=205, Evalue=9e-53,
Organism=Drosophila melanogaster, GI17136970, Length=357, Percent_Identity=26.6106442577031, Blast_Score=116, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_CHLT3 (B3QW86)

Other databases:

- EMBL:   CP001100
- RefSeq:   YP_001995646.1
- GeneID:   6421775
- GenomeReviews:   CP001100_GR
- KEGG:   cts:Ctha_0730
- HOGENOM:   HBG520262
- OMA:   FLFINNR
- ProtClustDB:   CLSK638049
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 73297; Mature: 73166

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLIKKLPDIVANKISAGEVVQRPASAVKELLENAIDAGADEITLAIKAAGKTLIQVIDN
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHC
GCGLSEEDATLCFERFATSKISDVGDLENLHTLGFRGEALASIASVSQVELKTKRYDDRT
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCC
GTLVKISGGRFEEVSRTETPNGTAFSIRNLFYNVPARRKFLKTNATEYKHIFETVQAQTL
CCEEEECCCCCHHHHCCCCCCCCEEEHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHCEE
VYPDIKWRFYSDDEEIFSFLNNNLSERLDYFFGKDFSQNLIEFTEENDFMKLRGYLGKPA
ECCCEEEEEECCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHCCCCCEEEHHHCCCCH
MMKRTKNQQFLFINNRVTQSKLLSSAIMTAYGELLGEREYPFFLIYMDIAPHYIDVNVHP
HHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEECC
TKMEVKFDDERNIYNMVHSVVKHRIKTLDFSPNVQVEEKPDSPRPTGESFNFPGVAKRLS
CEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHCC
YNDRDADMRSSNALFRDYKTYYKAQDERAEPGFFANPKREMDWRSSLPAHTEASLTPPKQ
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCC
AEPEGNPTFHDGSRQMEIFIQSRDDEPATAGQERFVWQLHNTYILTQIKSGLLIIDQHVA
CCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHEEEEECCEEEEEECCCCEEEEEHHHH
HERILYERAIAVMESNVPNSQQLLFPHSAKLSAWEFDVLKEIKTDLVQLGFSLRILDQRT
HHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCE
VLVEGIPPDVMPGREERILHEMLEQYQDYQQNLKLEQRDNVAKSYACRSSIMAGQKLSRN
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHH
EMTSLIDQLFATSMPYVCPHGRPIIIKLSIEELDKMFGRS
HHHHHHHHHHHCCCCCCCCCCCEEEEEEEHHHHHHHHCCC
>Mature Secondary Structure 
SLIKKLPDIVANKISAGEVVQRPASAVKELLENAIDAGADEITLAIKAAGKTLIQVIDN
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHC
GCGLSEEDATLCFERFATSKISDVGDLENLHTLGFRGEALASIASVSQVELKTKRYDDRT
CCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCC
GTLVKISGGRFEEVSRTETPNGTAFSIRNLFYNVPARRKFLKTNATEYKHIFETVQAQTL
CCEEEECCCCCHHHHCCCCCCCCEEEHHHHHHCCCHHHHHHHCCCHHHHHHHHHHHHCEE
VYPDIKWRFYSDDEEIFSFLNNNLSERLDYFFGKDFSQNLIEFTEENDFMKLRGYLGKPA
ECCCEEEEEECCHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHCCCCCEEEHHHCCCCH
MMKRTKNQQFLFINNRVTQSKLLSSAIMTAYGELLGEREYPFFLIYMDIAPHYIDVNVHP
HHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEEECC
TKMEVKFDDERNIYNMVHSVVKHRIKTLDFSPNVQVEEKPDSPRPTGESFNFPGVAKRLS
CEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHCC
YNDRDADMRSSNALFRDYKTYYKAQDERAEPGFFANPKREMDWRSSLPAHTEASLTPPKQ
CCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCC
AEPEGNPTFHDGSRQMEIFIQSRDDEPATAGQERFVWQLHNTYILTQIKSGLLIIDQHVA
CCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHEEEEECCEEEEEECCCCEEEEEHHHH
HERILYERAIAVMESNVPNSQQLLFPHSAKLSAWEFDVLKEIKTDLVQLGFSLRILDQRT
HHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHCCEEEEECCCE
VLVEGIPPDVMPGREERILHEMLEQYQDYQQNLKLEQRDNVAKSYACRSSIMAGQKLSRN
EEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHH
EMTSLIDQLFATSMPYVCPHGRPIIIKLSIEELDKMFGRS
HHHHHHHHHHHCCCCCCCCCCCEEEEEEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA