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The map label for this gene is atoC [H]

Identifier: 193214448

GI number: 193214448

Start: 859421

End: 860914

Strand: Direct

Name: atoC [H]

Synonym: Ctha_0731

Alternate gene names: 193214448

Gene position: 859421-860914 (Clockwise)

Preceding gene: 193214447

Following gene: 193214449

Centisome position: 26.09

GC content: 46.45

Gene sequence:

>1494_bases
ATGAGCACCATATTAGTTGTTGATGACGAACCCGTTGTTACGGATTACATCAAAGAAGCGCTTTCTGAAGAAGGCTACGC
AGTTGAAGTTGCCTATACAGGCAATGACGGCATCGTGCAAGCCAAAAAGGTTTCCCCTGATGTAATCATTTTGGATTTTA
TGCTTCCTGACCTCAACGGCATTGAGGTGCTCAAAAAACTTCGCCAGCTTGATGAAAGCTTACAAGTGATTATGCTCACC
GCCTATAATTCCGTTCCAACTGCCCTTGAGGCAGTTCGAAACGGTGCAGCTGACTACATTCTCAAACCGTTCGACCTCGA
CGCGTTTAAAATCACCGTTGCTAAAATTTGTGAAAAAGCACATCTGACCAACCAGCTCCGCTTTTTGCGTGAAGACAACG
CGAAAAAACTTGCGGGCAATGAGTTCCTACTTTGCCCTTCAGTGCAAATGGCAAAGGTGTATGATTTGGTGTTTCAGGTG
GCGCAAACCAACGATACCACCGTGCTGATTTTGGGCGAAAGCGGCGCAGGAAAAGAACATATTGCTAAACTCATTCATCA
AAATTCCTCGCGTGCGGCAAAGCCATTTGTTGAAATGAACTGCGCCGCCATTCCCGAAAATCTACTTGAATCGGAGCTAT
TCGGGCATGAACCGGGCGCATTTACAGACGCGCGCAGCAAAAAGCTTGGCTTATTCGAGTATGCCGATGGCGGCACCATT
TTCCTTGATGAAATTGGCGACATGCCTTTGGCCACGCAAGCCAAAATTCTGAAAGTTTTGGAAACGAAAGAGTTTCGGCG
AGTGGGTGGATTGAGAGATATTAAAAGCGATGTTCGTGTGGTAGCCGCTACAAACAAAGACTTGTCGTTTGAAATTGACA
GAGGAAACTTCCGAGAAGATCTCTACTATCGCTTGCAAGTTGTCCCAATAGACATTCCGCCGCTCAGAGAACGCAAGGAG
GACATTTTGCATCTTGCCAATTTCTTTCTTGAAATGACCGGGCGATCGATGCGAAAGCGCTTAGAACTTTCCGGTGATGC
CGCGTCTGCGCTGCTTTCTTATACCTGGAAAGGAAATGTTCGCGAGCTGAAAAATGTGATTGAACGCGCAGTGATTGTCA
CCCCAAACGGTTCGCGAATTCTGCCTGAACACTTGGCATTTAAACCGATGTCTGTGGCTGAACTCGCGAAAAAATCAGAA
GAATTTTTGATTCCCAAGCCGGATTATGAAGCACGGCAAGCTGAGCAACAGCGGCAAGCTGAACAGCGTAGCAACGGCCT
GTCCTTTTCTTTGTCAAAGTTTTATGATGGATTTTCGCTCAAAGCTCATCTTGAACAGATCGAGCGCCAGTATTTGCTCG
ACGCGCTTGAAAAAACAGGTGGAAACCAGCTTCAAGCGGCAAAGTTGCTCGGCATTGAACGCCACGTGCTGCGCTATCAA
ATGAAAAAATACGAAATAGACGATCCGCGCAATTCAAAAAATTCTGACGATTAA

Upstream 100 bases:

>100_bases
GATAGAGCAGCAGTTTCCTAAACTGCGTGCCGGCAGTTCGAATCTGCCCAAGGGCACCAACCAACTTGTAGACTCTTTTC
GTGAGAAGACCAATACCAGC

Downstream 100 bases:

>100_bases
TCCCTTTTGCCTAAAAATATCCCCCACTTTAACACATTTTACTTTTTCGGCATTAGCTGCATTTTAAATCCACAACCAAC
TAACCTTGCAAACGCAAAAA

Product: Fis family two component sigma-54 specific transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MSTILVVDDEPVVTDYIKEALSEEGYAVEVAYTGNDGIVQAKKVSPDVIILDFMLPDLNGIEVLKKLRQLDESLQVIMLT
AYNSVPTALEAVRNGAADYILKPFDLDAFKITVAKICEKAHLTNQLRFLREDNAKKLAGNEFLLCPSVQMAKVYDLVFQV
AQTNDTTVLILGESGAGKEHIAKLIHQNSSRAAKPFVEMNCAAIPENLLESELFGHEPGAFTDARSKKLGLFEYADGGTI
FLDEIGDMPLATQAKILKVLETKEFRRVGGLRDIKSDVRVVAATNKDLSFEIDRGNFREDLYYRLQVVPIDIPPLRERKE
DILHLANFFLEMTGRSMRKRLELSGDAASALLSYTWKGNVRELKNVIERAVIVTPNGSRILPEHLAFKPMSVAELAKKSE
EFLIPKPDYEARQAEQQRQAEQRSNGLSFSLSKFYDGFSLKAHLEQIERQYLLDALEKTGGNQLQAAKLLGIERHVLRYQ
MKKYEIDDPRNSKNSDD

Sequences:

>Translated_497_residues
MSTILVVDDEPVVTDYIKEALSEEGYAVEVAYTGNDGIVQAKKVSPDVIILDFMLPDLNGIEVLKKLRQLDESLQVIMLT
AYNSVPTALEAVRNGAADYILKPFDLDAFKITVAKICEKAHLTNQLRFLREDNAKKLAGNEFLLCPSVQMAKVYDLVFQV
AQTNDTTVLILGESGAGKEHIAKLIHQNSSRAAKPFVEMNCAAIPENLLESELFGHEPGAFTDARSKKLGLFEYADGGTI
FLDEIGDMPLATQAKILKVLETKEFRRVGGLRDIKSDVRVVAATNKDLSFEIDRGNFREDLYYRLQVVPIDIPPLRERKE
DILHLANFFLEMTGRSMRKRLELSGDAASALLSYTWKGNVRELKNVIERAVIVTPNGSRILPEHLAFKPMSVAELAKKSE
EFLIPKPDYEARQAEQQRQAEQRSNGLSFSLSKFYDGFSLKAHLEQIERQYLLDALEKTGGNQLQAAKLLGIERHVLRYQ
MKKYEIDDPRNSKNSDD
>Mature_496_residues
STILVVDDEPVVTDYIKEALSEEGYAVEVAYTGNDGIVQAKKVSPDVIILDFMLPDLNGIEVLKKLRQLDESLQVIMLTA
YNSVPTALEAVRNGAADYILKPFDLDAFKITVAKICEKAHLTNQLRFLREDNAKKLAGNEFLLCPSVQMAKVYDLVFQVA
QTNDTTVLILGESGAGKEHIAKLIHQNSSRAAKPFVEMNCAAIPENLLESELFGHEPGAFTDARSKKLGLFEYADGGTIF
LDEIGDMPLATQAKILKVLETKEFRRVGGLRDIKSDVRVVAATNKDLSFEIDRGNFREDLYYRLQVVPIDIPPLRERKED
ILHLANFFLEMTGRSMRKRLELSGDAASALLSYTWKGNVRELKNVIERAVIVTPNGSRILPEHLAFKPMSVAELAKKSEE
FLIPKPDYEARQAEQQRQAEQRSNGLSFSLSKFYDGFSLKAHLEQIERQYLLDALEKTGGNQLQAAKLLGIERHVLRYQM
KKYEIDDPRNSKNSDD

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=488, Percent_Identity=38.9344262295082, Blast_Score=350, Evalue=2e-97,
Organism=Escherichia coli, GI1790437, Length=485, Percent_Identity=36.701030927835, Blast_Score=305, Evalue=6e-84,
Organism=Escherichia coli, GI1790299, Length=492, Percent_Identity=34.7560975609756, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI1788905, Length=485, Percent_Identity=35.4639175257732, Blast_Score=281, Evalue=9e-77,
Organism=Escherichia coli, GI87082117, Length=281, Percent_Identity=48.7544483985765, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1789087, Length=229, Percent_Identity=51.9650655021834, Blast_Score=228, Evalue=8e-61,
Organism=Escherichia coli, GI87082152, Length=241, Percent_Identity=48.5477178423236, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1789233, Length=339, Percent_Identity=39.2330383480826, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI87081872, Length=326, Percent_Identity=38.9570552147239, Blast_Score=211, Evalue=1e-55,
Organism=Escherichia coli, GI1786524, Length=286, Percent_Identity=41.958041958042, Blast_Score=204, Evalue=1e-53,
Organism=Escherichia coli, GI1787583, Length=230, Percent_Identity=42.6086956521739, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI87081858, Length=324, Percent_Identity=32.4074074074074, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1789828, Length=239, Percent_Identity=35.9832635983264, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1786784, Length=113, Percent_Identity=34.5132743362832, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI87082012, Length=121, Percent_Identity=33.8842975206612, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790860, Length=102, Percent_Identity=40.1960784313725, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786911, Length=106, Percent_Identity=37.7358490566038, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789402, Length=103, Percent_Identity=33.9805825242718, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1787229, Length=136, Percent_Identity=29.4117647058824, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI2367329, Length=186, Percent_Identity=30.1075268817204, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1787375, Length=104, Percent_Identity=30.7692307692308, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1786599, Length=103, Percent_Identity=33.9805825242718, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 55885; Mature: 55754

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTILVVDDEPVVTDYIKEALSEEGYAVEVAYTGNDGIVQAKKVSPDVIILDFMLPDLNG
CCEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCEEEEEEECCCCCH
IEVLKKLRQLDESLQVIMLTAYNSVPTALEAVRNGAADYILKPFDLDAFKITVAKICEKA
HHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHCCCHHHEECCCCCCHHHHHHHHHHHHH
HLTNQLRFLREDNAKKLAGNEFLLCPSVQMAKVYDLVFQVAQTNDTTVLILGESGAGKEH
HHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHH
IAKLIHQNSSRAAKPFVEMNCAAIPENLLESELFGHEPGAFTDARSKKLGLFEYADGGTI
HHHHHHCCCCCCCCCHHHCCHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCEE
FLDEIGDMPLATQAKILKVLETKEFRRVGGLRDIKSDVRVVAATNKDLSFEIDRGNFRED
EEECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEEEECCCCEEEEECCCCCCCC
LYYRLQVVPIDIPPLRERKEDILHLANFFLEMTGRSMRKRLELSGDAASALLSYTWKGNV
EEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHCCCCCH
RELKNVIERAVIVTPNGSRILPEHLAFKPMSVAELAKKSEEFLIPKPDYEARQAEQQRQA
HHHHHHHHCEEEECCCCCEECHHHHCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
EQRSNGLSFSLSKFYDGFSLKAHLEQIERQYLLDALEKTGGNQLQAAKLLGIERHVLRYQ
HHHHCCCEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
MKKYEIDDPRNSKNSDD
HHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
STILVVDDEPVVTDYIKEALSEEGYAVEVAYTGNDGIVQAKKVSPDVIILDFMLPDLNG
CEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCCEEEEEEECCCCCH
IEVLKKLRQLDESLQVIMLTAYNSVPTALEAVRNGAADYILKPFDLDAFKITVAKICEKA
HHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHCCCHHHEECCCCCCHHHHHHHHHHHHH
HLTNQLRFLREDNAKKLAGNEFLLCPSVQMAKVYDLVFQVAQTNDTTVLILGESGAGKEH
HHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHH
IAKLIHQNSSRAAKPFVEMNCAAIPENLLESELFGHEPGAFTDARSKKLGLFEYADGGTI
HHHHHHCCCCCCCCCHHHCCHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCEE
FLDEIGDMPLATQAKILKVLETKEFRRVGGLRDIKSDVRVVAATNKDLSFEIDRGNFRED
EEECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEEEECCCCEEEEECCCCCCCC
LYYRLQVVPIDIPPLRERKEDILHLANFFLEMTGRSMRKRLELSGDAASALLSYTWKGNV
EEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHCCCCCH
RELKNVIERAVIVTPNGSRILPEHLAFKPMSVAELAKKSEEFLIPKPDYEARQAEQQRQA
HHHHHHHHCEEEECCCCCEECHHHHCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
EQRSNGLSFSLSKFYDGFSLKAHLEQIERQYLLDALEKTGGNQLQAAKLLGIERHVLRYQ
HHHHCCCEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
MKKYEIDDPRNSKNSDD
HHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]