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The map label for this gene is folK [H]

Identifier: 193213977

GI number: 193213977

Start: 303276

End: 303833

Strand: Direct

Name: folK [H]

Synonym: Ctha_0258

Alternate gene names: 193213977

Gene position: 303276-303833 (Clockwise)

Preceding gene: 193213976

Following gene: 193213982

Centisome position: 9.21

GC content: 45.52

Gene sequence:

>558_bases
ATGGAATTACATTCATCCTCAGAGCACTTTCCCACCAAAAGAGTTTCAAGTCCTCATGAAATTGCTGTTGTAACGCCTGT
TTTCATTGGGCTTGGCACAAACATCGGCAATCGGTTTCAAAACATTCACGACGCAATAGACGAGCTTCGTGCGCTTCCAG
AAAGCCAACTTGCCGCCATTTCAAATCTTTATGAAACCCCGCCGCTTGGAATTTTGGATCAACCGTCCTTTTTGAATGCT
GTTTGCAAAATCGATACGTCGCTTGAACCGGAAGAGTTGCTTGCTCAACTAAAAAGCATCGAGCGTCGACTTGGCCGTCC
AGAAACCTACATTAAATGGGGCCCACGCGTGATTGACCTGGACATCTTATTTTATGGCGATTTGACTTTAGAGACCGCTC
ACCTGAGCATTCCACATCCTGAAATCGCCAATCGGAAGTTTGTGATGGTGCCACTTTTAGATCTTCAAAATCCGCACCAT
CCGATTTTGGGCAAAACGATCAAAGAGTTGCTTGCAGAAACCCGCGATAGTTCGAGCATTATCCAACTTTGCATCTGA

Upstream 100 bases:

>100_bases
AAAACACCATCGCAAACGCATTGATTTTATTTTTTGAGGAAACGATTTCGCAAGCAATTCAGATTTGTTCATCACACGCA
TTAGACATCTATTAGAATAC

Downstream 100 bases:

>100_bases
TCCGGGCGAATCACGCTTCTACCTGCCCGTATAACCGCCCGCGAAGTTTGAGATTTTTTTTCACGAAGTTTGAGAACTCT
CTCCCCGATTCCGCCATGAG

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MELHSSSEHFPTKRVSSPHEIAVVTPVFIGLGTNIGNRFQNIHDAIDELRALPESQLAAISNLYETPPLGILDQPSFLNA
VCKIDTSLEPEELLAQLKSIERRLGRPETYIKWGPRVIDLDILFYGDLTLETAHLSIPHPEIANRKFVMVPLLDLQNPHH
PILGKTIKELLAETRDSSSIIQLCI

Sequences:

>Translated_185_residues
MELHSSSEHFPTKRVSSPHEIAVVTPVFIGLGTNIGNRFQNIHDAIDELRALPESQLAAISNLYETPPLGILDQPSFLNA
VCKIDTSLEPEELLAQLKSIERRLGRPETYIKWGPRVIDLDILFYGDLTLETAHLSIPHPEIANRKFVMVPLLDLQNPHH
PILGKTIKELLAETRDSSSIIQLCI
>Mature_185_residues
MELHSSSEHFPTKRVSSPHEIAVVTPVFIGLGTNIGNRFQNIHDAIDELRALPESQLAAISNLYETPPLGILDQPSFLNA
VCKIDTSLEPEELLAQLKSIERRLGRPETYIKWGPRVIDLDILFYGDLTLETAHLSIPHPEIANRKFVMVPLLDLQNPHH
PILGKTIKELLAETRDSSSIIQLCI

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=132, Percent_Identity=39.3939393939394, Blast_Score=118, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6324073, Length=167, Percent_Identity=33.5329341317365, Blast_Score=91, Evalue=9e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 20725; Mature: 20725

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELHSSSEHFPTKRVSSPHEIAVVTPVFIGLGTNIGNRFQNIHDAIDELRALPESQLAAI
CCCCCCCCCCCHHHCCCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHH
SNLYETPPLGILDQPSFLNAVCKIDTSLEPEELLAQLKSIERRLGRPETYIKWGPRVIDL
HHHHCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCEEEEE
DILFYGDLTLETAHLSIPHPEIANRKFVMVPLLDLQNPHHPILGKTIKELLAETRDSSSI
EEEEECCEEEEEEEEECCCCHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHH
IQLCI
HEECC
>Mature Secondary Structure
MELHSSSEHFPTKRVSSPHEIAVVTPVFIGLGTNIGNRFQNIHDAIDELRALPESQLAAI
CCCCCCCCCCCHHHCCCCCCEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHH
SNLYETPPLGILDQPSFLNAVCKIDTSLEPEELLAQLKSIERRLGRPETYIKWGPRVIDL
HHHHCCCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCEEEEE
DILFYGDLTLETAHLSIPHPEIANRKFVMVPLLDLQNPHHPILGKTIKELLAETRDSSSI
EEEEECCEEEEEEEEECCCCHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCHH
IQLCI
HEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]