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The map label for this gene is paaH [H]

Identifier: 193213807

GI number: 193213807

Start: 101963

End: 103159

Strand: Direct

Name: paaH [H]

Synonym: Ctha_0088

Alternate gene names: 193213807

Gene position: 101963-103159 (Clockwise)

Preceding gene: 193213806

Following gene: 193213810

Centisome position: 3.1

GC content: 45.78

Gene sequence:

>1197_bases
ATGAACAGCAAAATTATTGGAATTGTCGGCGCAAAAAGTAGTGGCGTCAATATGGCCATTACAGTCGCAAAGGCAAACCA
CAGCGTGCTAATTTACGACCCGAACCCTGTTCTTTTGCAGCAAGTGACTTCAAGAGTGCGGAAAGTGATGGAAAAATGGC
AGCAGAGAAACCTGCTCACGCCAAAGGAAGCCAATTTGTTAGTTGAACGGATTTGTCCGGTTTCGACTATCAAAAGCTTG
TCTTCTGCGGATGCCATTTTTGAGACGGGCTCCGAAAGCTTGGAGAAGAAAAAAGAGCTCTTCAAATCACTCGATGAATT
TTCTCCCGAGTCGATCATTTTGGTATCAACCAGCGCCTTCATTTCTGTCACAACACTGGCCTCTGTCTGCTTTTTCAAGA
AAAGAGTGATTGGCATGCAAATTCATCATCAATCTTCGATGGCCTCGTTAATTGAGCTATCGCAAGGCATGGACACTTCG
CGCGAGGTGCTGAAACAGTCTATCGAGCTTGGCCGATCACTGGCAAAAGAAGTGGTAATCTGCTACGACATGCCCGGACT
CATTGTCCATCGGGTTTCTCGAAACTTTTTTGGAGAAGCGTTGCGAATCTTTGAAGAAGGCACGGCCTCGATGCTCGAAA
TTGATGCGTTTATGCGGCAAGCCGGCGGCTTTCATCTTGGACCTTTTGAACTGCTCGACTGCCTCGGCATAGACAAAACC
TACATCAGCGATTTGGAGCTCTATAACGCATTTTTTCAAGAACCGCGTTTTCGTCCCACCCATTTGATGAAAACACTTTT
TGAATCCGGCTATTACGGAAAAAAGTCGGGCAGAGGCTTTTATGATTACTCGATTAATGAGGCTGCGCCCAGAATGGCCA
TTCAACAAAGTGAACAAGAAGCGGCCAGAAAATTTTTTCAAAACCACTACATCAGCTTGTTTATGGTTAAGCAAGCGGTT
TTTGCAAGAATCATCGCGATGCTCGTGAATGAGGCGCTTTTTTGCGTCCAGGAAAATGTGTCTTCCGAAGGCGACGTCGA
CCTTGCAATGAAGTATGGCATGAGCTTCCCAAAAGGGCCAATTGAATGGGGGCGCGAAATCGGCTTTGATAAAATCGCTT
CGGTCTTAAATGCGCTCTACAATGAATTTCGCGACGATCGCTATCGGCCTGCGCCACTTTTAAAAATTTATCAATAA

Upstream 100 bases:

>100_bases
CATTTTAAAAAAAAATGGTTTTGAACAGATCCGTTTTGTTCAAGATTATGCTGGTTTTTCGAGAATTGCAATTGCCAGTA
ATTCTTAATACACCCAGATA

Downstream 100 bases:

>100_bases
CGCAGTCACCCTCGCAAATAGGCTTTGCAATTGACTGCAACAAAAAAGGCGACCTTGGTGGTCGCCCTTACAAAACAGCC
TGAGCTTCTGTAAAAAACCT

Product: NAD-binding 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MNSKIIGIVGAKSSGVNMAITVAKANHSVLIYDPNPVLLQQVTSRVRKVMEKWQQRNLLTPKEANLLVERICPVSTIKSL
SSADAIFETGSESLEKKKELFKSLDEFSPESIILVSTSAFISVTTLASVCFFKKRVIGMQIHHQSSMASLIELSQGMDTS
REVLKQSIELGRSLAKEVVICYDMPGLIVHRVSRNFFGEALRIFEEGTASMLEIDAFMRQAGGFHLGPFELLDCLGIDKT
YISDLELYNAFFQEPRFRPTHLMKTLFESGYYGKKSGRGFYDYSINEAAPRMAIQQSEQEAARKFFQNHYISLFMVKQAV
FARIIAMLVNEALFCVQENVSSEGDVDLAMKYGMSFPKGPIEWGREIGFDKIASVLNALYNEFRDDRYRPAPLLKIYQ

Sequences:

>Translated_398_residues
MNSKIIGIVGAKSSGVNMAITVAKANHSVLIYDPNPVLLQQVTSRVRKVMEKWQQRNLLTPKEANLLVERICPVSTIKSL
SSADAIFETGSESLEKKKELFKSLDEFSPESIILVSTSAFISVTTLASVCFFKKRVIGMQIHHQSSMASLIELSQGMDTS
REVLKQSIELGRSLAKEVVICYDMPGLIVHRVSRNFFGEALRIFEEGTASMLEIDAFMRQAGGFHLGPFELLDCLGIDKT
YISDLELYNAFFQEPRFRPTHLMKTLFESGYYGKKSGRGFYDYSINEAAPRMAIQQSEQEAARKFFQNHYISLFMVKQAV
FARIIAMLVNEALFCVQENVSSEGDVDLAMKYGMSFPKGPIEWGREIGFDKIASVLNALYNEFRDDRYRPAPLLKIYQ
>Mature_398_residues
MNSKIIGIVGAKSSGVNMAITVAKANHSVLIYDPNPVLLQQVTSRVRKVMEKWQQRNLLTPKEANLLVERICPVSTIKSL
SSADAIFETGSESLEKKKELFKSLDEFSPESIILVSTSAFISVTTLASVCFFKKRVIGMQIHHQSSMASLIELSQGMDTS
REVLKQSIELGRSLAKEVVICYDMPGLIVHRVSRNFFGEALRIFEEGTASMLEIDAFMRQAGGFHLGPFELLDCLGIDKT
YISDLELYNAFFQEPRFRPTHLMKTLFESGYYGKKSGRGFYDYSINEAAPRMAIQQSEQEAARKFFQNHYISLFMVKQAV
FARIIAMLVNEALFCVQENVSSEGDVDLAMKYGMSFPKGPIEWGREIGFDKIASVLNALYNEFRDDRYRPAPLLKIYQ

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=292, Percent_Identity=30.4794520547945, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI296179427, Length=309, Percent_Identity=28.8025889967638, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI20127408, Length=397, Percent_Identity=22.6700251889169, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI261878539, Length=400, Percent_Identity=22.75, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI68989263, Length=400, Percent_Identity=22.75, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1787661, Length=283, Percent_Identity=34.6289752650177, Blast_Score=188, Evalue=6e-49,
Organism=Escherichia coli, GI1788682, Length=381, Percent_Identity=23.3595800524934, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790281, Length=349, Percent_Identity=22.3495702005731, Blast_Score=102, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17549919, Length=285, Percent_Identity=27.719298245614, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17553560, Length=289, Percent_Identity=29.0657439446367, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17508953, Length=396, Percent_Identity=25, Blast_Score=121, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17508951, Length=396, Percent_Identity=25, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17558304, Length=397, Percent_Identity=24.4332493702771, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71985930, Length=376, Percent_Identity=23.4042553191489, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI71985923, Length=399, Percent_Identity=21.3032581453634, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI25144276, Length=280, Percent_Identity=25, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17563036, Length=289, Percent_Identity=23.8754325259516, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19921000, Length=405, Percent_Identity=24.4444444444444, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24583077, Length=405, Percent_Identity=24.4444444444444, Blast_Score=125, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24583079, Length=405, Percent_Identity=24.4444444444444, Blast_Score=125, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 44924; Mature: 44924

Theoretical pI: Translated: 7.90; Mature: 7.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSKIIGIVGAKSSGVNMAITVAKANHSVLIYDPNPVLLQQVTSRVRKVMEKWQQRNLLT
CCCCEEEEEECCCCCCEEEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCC
PKEANLLVERICPVSTIKSLSSADAIFETGSESLEKKKELFKSLDEFSPESIILVSTSAF
CHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEECHHH
ISVTTLASVCFFKKRVIGMQIHHQSSMASLIELSQGMDTSREVLKQSIELGRSLAKEVVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEE
CYDMPGLIVHRVSRNFFGEALRIFEEGTASMLEIDAFMRQAGGFHLGPFELLDCLGIDKT
EECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHH
YISDLELYNAFFQEPRFRPTHLMKTLFESGYYGKKSGRGFYDYSINEAAPRMAIQQSEQE
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHH
AARKFFQNHYISLFMVKQAVFARIIAMLVNEALFCVQENVSSEGDVDLAMKYGMSFPKGP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCH
IEWGREIGFDKIASVLNALYNEFRDDRYRPAPLLKIYQ
HHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MNSKIIGIVGAKSSGVNMAITVAKANHSVLIYDPNPVLLQQVTSRVRKVMEKWQQRNLLT
CCCCEEEEEECCCCCCEEEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCC
PKEANLLVERICPVSTIKSLSSADAIFETGSESLEKKKELFKSLDEFSPESIILVSTSAF
CHHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEECHHH
ISVTTLASVCFFKKRVIGMQIHHQSSMASLIELSQGMDTSREVLKQSIELGRSLAKEVVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHEEE
CYDMPGLIVHRVSRNFFGEALRIFEEGTASMLEIDAFMRQAGGFHLGPFELLDCLGIDKT
EECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCHH
YISDLELYNAFFQEPRFRPTHLMKTLFESGYYGKKSGRGFYDYSINEAAPRMAIQQSEQE
HHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHH
AARKFFQNHYISLFMVKQAVFARIIAMLVNEALFCVQENVSSEGDVDLAMKYGMSFPKGP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCH
IEWGREIGFDKIASVLNALYNEFRDDRYRPAPLLKIYQ
HHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]