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The map label for this gene is uvrC [C]

Identifier: 193213751

GI number: 193213751

Start: 42575

End: 44311

Strand: Direct

Name: uvrC [C]

Synonym: Ctha_0031

Alternate gene names: 193213751

Gene position: 42575-44311 (Clockwise)

Preceding gene: 193213750

Following gene: 193213752

Centisome position: 1.29

GC content: 43.98

Gene sequence:

>1737_bases
ATGGTTGCTGACCTATCAAATCGTGGTAAGGGAAAAGATGAACTTCCCGCAAAGATAACGGACGCTACTTTTGCGGTTGT
TGATTTGGAAACAACTGGTGGCTTAAAACCGGAAAATCGAATTATTGAGATTTGCGCGATCAAGTGCCGTAATGGCCAAG
AGGTTGGCATGTTGGAATCGCTGGTTAATCCAGAGCAACAAATCTCGTATTTCATTTCGCAATATACCGGCATTACGAAC
AGCATGGTCGACAATGCGCCGGTGATTCAAAGCCTCTTGACGAAAGTCTCTGAATTTTTTCAGGAAACCATTTTTGTTGC
GCACAATGTCCCGTTTGATATGGGATTTATCAACATGGAGCTCGAGCGCAACGGCTATGCGAAACTGACGAACCGCTGGC
TTTGCACATTTCGTTTGGCGCGGCGACTGCTGCCAACGCAGCAAAAGAAAAATCTTGGCGACCTGGCCAAATATTTCGGC
ATCATAGTTGAAAATCGACACCGAGCTCGCGGCGATTGCGAAGCCACCATCAAGTTGCTCGCCGAATTGATCATTCTTGC
TCAAGAGCAACACGGTGTTGAAACCGCCGAGGAGTTGCTTTCCCTACAATTCAAAGCGATCCGCAATTTTAAGCGCGAAC
CCCGACACTTTTCCAAAATTCGCAATACCGTTCTAAACAAATTCCCGACAAAGTCTGGCGTGTATTTGATGAAATCAGCC
AAAGACGAAGTGCTTTACATCGGCAAATCGAAAAATTTGAAATCGCGCGTGTCGTCGTATTTCAATCAAAATATCGATCG
TTCGGAAAAGGTTGTGGAGCTCACCCATCATGTTCGCAAAATTGATTACACGCTGACAGGCTCGGAGCTTGAAGCGCTGC
TTTTGGAATCAAAATTGATTAAGCAATACAAACCGCGCTTCAACACGCTGCTAAAACGCTATCGTTCATATCCTTTTTTG
ACTTTTTCGGAGCATGAATTTCCAAAGTTAGAAATTGCGCTGGATGTTGAGGATGGCGATAAAGAATATTTTGGCCCTTT
TCCATCGTTAGAATTGCTTCAGCATGTTGTAGAAATTTTGGAGCGCTATTTCAAAGTTCGCAAATGCTCCGATCACGATT
TTTCGCGGGCGCGTTTTTGCATATACTTCGATCTGGATCGCTGCTTTGCGCCGTGCAAACATCCCAAGCATTATAAAGAG
GCCTACATCAAAGAGTTGGATCAGATTCGAGCGTTTCTTTCCGGCAAAAATCCTGAAATTATCAATGTGATGATTCGGGA
AATGAAAGCGCTGGCCAGCGAAAACCTGTTCGAAGAAGCCGCCGACTTGAAACAAAAAATTCATAGTTTGCAGAAAGTTT
TCTTTCGCCAGTCCGATATCGTGAATTCGGTTAATGAAAACAATGTGATTGCAATTTTGCCTTCCGAAAATTTTTCCGAC
TGCTGCAAAGAATATGTGCTGCTCTTTGTTCGGTTTGGAAGATTAATCGATCAGAAAAAAGTTTTTGAGGACGAAACGGA
AAGCCTGGTGCCGGTTATTGCGTCGGTTTATCACAATGGCCACAGCTCGCCAACGCCATGCCGAAAGGAGGAAATTGACG
AGATGCAAATTCTATCCAATTGGATTTATCAGAATAAAGACTCGCTTCATTGCTTTTACGTGAAAGACGCTTTGACAACC
GAACAAATTCACGAAACGCTGCAAAAACGCCTGAAAAGTCTTTCGGAAACACGTTGA

Upstream 100 bases:

>100_bases
CAAAGCTTTTCTCAGTAAATTGATGGTTGATGTTCTTCTCATGTGAGTCTGTTGTCTATGTGTTAATGAATTTGTTTTGT
GTAATGAAAAATAAACGGAA

Downstream 100 bases:

>100_bases
GGAAAAGGGATTCAGAACTCAAAAGCTGATTTGCTCTGTCCTGTTTTGCGTCGTAACTTGCATTTTTATAGCAAGTCCAT
TGCATTTTCAAATTGCGATT

Product: hypothetical protein

Products: diphosphate; DNAn+1

Alternate protein names: NA

Number of amino acids: Translated: 578; Mature: 578

Protein sequence:

>578_residues
MVADLSNRGKGKDELPAKITDATFAVVDLETTGGLKPENRIIEICAIKCRNGQEVGMLESLVNPEQQISYFISQYTGITN
SMVDNAPVIQSLLTKVSEFFQETIFVAHNVPFDMGFINMELERNGYAKLTNRWLCTFRLARRLLPTQQKKNLGDLAKYFG
IIVENRHRARGDCEATIKLLAELIILAQEQHGVETAEELLSLQFKAIRNFKREPRHFSKIRNTVLNKFPTKSGVYLMKSA
KDEVLYIGKSKNLKSRVSSYFNQNIDRSEKVVELTHHVRKIDYTLTGSELEALLLESKLIKQYKPRFNTLLKRYRSYPFL
TFSEHEFPKLEIALDVEDGDKEYFGPFPSLELLQHVVEILERYFKVRKCSDHDFSRARFCIYFDLDRCFAPCKHPKHYKE
AYIKELDQIRAFLSGKNPEIINVMIREMKALASENLFEEAADLKQKIHSLQKVFFRQSDIVNSVNENNVIAILPSENFSD
CCKEYVLLFVRFGRLIDQKKVFEDETESLVPVIASVYHNGHSSPTPCRKEEIDEMQILSNWIYQNKDSLHCFYVKDALTT
EQIHETLQKRLKSLSETR

Sequences:

>Translated_578_residues
MVADLSNRGKGKDELPAKITDATFAVVDLETTGGLKPENRIIEICAIKCRNGQEVGMLESLVNPEQQISYFISQYTGITN
SMVDNAPVIQSLLTKVSEFFQETIFVAHNVPFDMGFINMELERNGYAKLTNRWLCTFRLARRLLPTQQKKNLGDLAKYFG
IIVENRHRARGDCEATIKLLAELIILAQEQHGVETAEELLSLQFKAIRNFKREPRHFSKIRNTVLNKFPTKSGVYLMKSA
KDEVLYIGKSKNLKSRVSSYFNQNIDRSEKVVELTHHVRKIDYTLTGSELEALLLESKLIKQYKPRFNTLLKRYRSYPFL
TFSEHEFPKLEIALDVEDGDKEYFGPFPSLELLQHVVEILERYFKVRKCSDHDFSRARFCIYFDLDRCFAPCKHPKHYKE
AYIKELDQIRAFLSGKNPEIINVMIREMKALASENLFEEAADLKQKIHSLQKVFFRQSDIVNSVNENNVIAILPSENFSD
CCKEYVLLFVRFGRLIDQKKVFEDETESLVPVIASVYHNGHSSPTPCRKEEIDEMQILSNWIYQNKDSLHCFYVKDALTT
EQIHETLQKRLKSLSETR
>Mature_578_residues
MVADLSNRGKGKDELPAKITDATFAVVDLETTGGLKPENRIIEICAIKCRNGQEVGMLESLVNPEQQISYFISQYTGITN
SMVDNAPVIQSLLTKVSEFFQETIFVAHNVPFDMGFINMELERNGYAKLTNRWLCTFRLARRLLPTQQKKNLGDLAKYFG
IIVENRHRARGDCEATIKLLAELIILAQEQHGVETAEELLSLQFKAIRNFKREPRHFSKIRNTVLNKFPTKSGVYLMKSA
KDEVLYIGKSKNLKSRVSSYFNQNIDRSEKVVELTHHVRKIDYTLTGSELEALLLESKLIKQYKPRFNTLLKRYRSYPFL
TFSEHEFPKLEIALDVEDGDKEYFGPFPSLELLQHVVEILERYFKVRKCSDHDFSRARFCIYFDLDRCFAPCKHPKHYKE
AYIKELDQIRAFLSGKNPEIINVMIREMKALASENLFEEAADLKQKIHSLQKVFFRQSDIVNSVNENNVIAILPSENFSD
CCKEYVLLFVRFGRLIDQKKVFEDETESLVPVIASVYHNGHSSPTPCRKEEIDEMQILSNWIYQNKDSLHCFYVKDALTT
EQIHETLQKRLKSLSETR

Specific function: The Uvrabc Repair System Catalyzes The Recognition And Processing Of DNA Lesions. Uvrc Both Incises The 5' And 3' Sides Of The Lesion. The N-Terminal Half Is Responsible For The 3' Incision And The C-Terminal Half Is Responsible For The 5' Incision. [C]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87081999, Length=280, Percent_Identity=34.6428571428571, Blast_Score=178, Evalue=8e-46,
Organism=Escherichia coli, GI1788037, Length=249, Percent_Identity=29.3172690763052, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1788149, Length=164, Percent_Identity=29.2682926829268, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR012337
- InterPro:   IPR000305 [H]

Pfam domain/function: PF00929 Exonuc_X-T; PF01541 GIY-YIG [H]

EC number: 2.7.7.7

Molecular weight: Translated: 67035; Mature: 67035

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS50164 UVRC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVADLSNRGKGKDELPAKITDATFAVVDLETTGGLKPENRIIEICAIKCRNGQEVGMLES
CCCCCCCCCCCCCCCCCEECCCEEEEEEEECCCCCCCCCCEEEEEEEECCCCCCHHHHHH
LVNPEQQISYFISQYTGITNSMVDNAPVIQSLLTKVSEFFQETIFVAHNVPFDMGFINME
HCCHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
LERNGYAKLTNRWLCTFRLARRLLPTQQKKNLGDLAKYFGIIVENRHRARGDCEATIKLL
ECCCCCHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
AELIILAQEQHGVETAEELLSLQFKAIRNFKREPRHFSKIRNTVLNKFPTKSGVYLMKSA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEECC
KDEVLYIGKSKNLKSRVSSYFNQNIDRSEKVVELTHHVRKIDYTLTGSELEALLLESKLI
CCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCEEECCHHHHHHHHHHHHH
KQYKPRFNTLLKRYRSYPFLTFSEHEFPKLEIALDVEDGDKEYFGPFPSLELLQHVVEIL
HHHCHHHHHHHHHHHCCCCEEECCCCCCEEEEEEECCCCCHHHCCCCCCHHHHHHHHHHH
ERYFKVRKCSDHDFSRARFCIYFDLDRCFAPCKHPKHYKEAYIKELDQIRAFLSGKNPEI
HHHHHHHCCCCCCCCCCEEEEEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHH
INVMIREMKALASENLFEEAADLKQKIHSLQKVFFRQSDIVNSVNENNVIAILPSENFSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHH
CCKEYVLLFVRFGRLIDQKKVFEDETESLVPVIASVYHNGHSSPTPCRKEEIDEMQILSN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
WIYQNKDSLHCFYVKDALTTEQIHETLQKRLKSLSETR
HHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVADLSNRGKGKDELPAKITDATFAVVDLETTGGLKPENRIIEICAIKCRNGQEVGMLES
CCCCCCCCCCCCCCCCCEECCCEEEEEEEECCCCCCCCCCEEEEEEEECCCCCCHHHHHH
LVNPEQQISYFISQYTGITNSMVDNAPVIQSLLTKVSEFFQETIFVAHNVPFDMGFINME
HCCHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
LERNGYAKLTNRWLCTFRLARRLLPTQQKKNLGDLAKYFGIIVENRHRARGDCEATIKLL
ECCCCCHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
AELIILAQEQHGVETAEELLSLQFKAIRNFKREPRHFSKIRNTVLNKFPTKSGVYLMKSA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEECC
KDEVLYIGKSKNLKSRVSSYFNQNIDRSEKVVELTHHVRKIDYTLTGSELEALLLESKLI
CCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCEEECCHHHHHHHHHHHHH
KQYKPRFNTLLKRYRSYPFLTFSEHEFPKLEIALDVEDGDKEYFGPFPSLELLQHVVEIL
HHHCHHHHHHHHHHHCCCCEEECCCCCCEEEEEEECCCCCHHHCCCCCCHHHHHHHHHHH
ERYFKVRKCSDHDFSRARFCIYFDLDRCFAPCKHPKHYKEAYIKELDQIRAFLSGKNPEI
HHHHHHHCCCCCCCCCCEEEEEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHH
INVMIREMKALASENLFEEAADLKQKIHSLQKVFFRQSDIVNSVNENNVIAILPSENFSD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHH
CCKEYVLLFVRFGRLIDQKKVFEDETESLVPVIASVYHNGHSSPTPCRKEEIDEMQILSN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
WIYQNKDSLHCFYVKDALTTEQIHETLQKRLKSLSETR
HHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxynucleoside triphosphate; DNAn

Specific reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]