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The map label for this gene is yvaE [H]

Identifier: 193213197

GI number: 193213197

Start: 1698354

End: 1698680

Strand: Direct

Name: yvaE [H]

Synonym: Cpar_1552

Alternate gene names: 193213197

Gene position: 1698354-1698680 (Clockwise)

Preceding gene: 193213196

Following gene: 193213198

Centisome position: 74.19

GC content: 55.66

Gene sequence:

>327_bases
ATGCCCTGGCTCTACCTCATCCTCGCCATCGTCGCCGAAGTCTCCGGCACCACCAGCATGAAGCTCTCGGAGGGCTTCAC
CAAACCGCTGCCATCAGCAATGATTTTCGTTTTTTACGCCCTGAGTCTTACTTTCCTCACGCTGACGCTCAGGACGATGC
CCATCGGCTTCGCCTACGCTATCTGGTCGGCGCTCGGCACGGCACTCATCACGGCGATTGGCGTACTCTGGTTCGGCGAG
GGAATGAACACGCTCAAGGTAGTCTCGCTGATTCTGGTGATCGTCGGCATTGCAGGTTTGCATTTCAGTCAGGAAATCAT
GAAGTAA

Upstream 100 bases:

>100_bases
AGCTTCAGCCTGCAGCTCTTCGGCGAGTGCATTGACAAGGAGGCCTGCGTCCGGAGGGTCGACGAGAAACACAACGAGAA
CGCCTGAACTCACGGACACC

Downstream 100 bases:

>100_bases
GGCATGAGTCACCACCACCCGGTTTATAAACGAATCGTCGTCAAGGTCGGCACGAACGTCATCACAGGCCGCGACGGCAG
GCTCGACCCGGCCATCCTCG

Product: small multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MPWLYLILAIVAEVSGTTSMKLSEGFTKPLPSAMIFVFYALSLTFLTLTLRTMPIGFAYAIWSALGTALITAIGVLWFGE
GMNTLKVVSLILVIVGIAGLHFSQEIMK

Sequences:

>Translated_108_residues
MPWLYLILAIVAEVSGTTSMKLSEGFTKPLPSAMIFVFYALSLTFLTLTLRTMPIGFAYAIWSALGTALITAIGVLWFGE
GMNTLKVVSLILVIVGIAGLHFSQEIMK
>Mature_107_residues
PWLYLILAIVAEVSGTTSMKLSEGFTKPLPSAMIFVFYALSLTFLTLTLRTMPIGFAYAIWSALGTALITAIGVLWFGEG
MNTLKVVSLILVIVGIAGLHFSQEIMK

Specific function: Multidrug Transporter. Confers Resistance To A Wide Range Of Toxic Compounds By Removing Them For The Cells. The Efflux Is Coupled To An Influx Of Protons. Probably Prevents The Incorporation Of Methyl VIologen Into Cells. Involved In Ethidium Bromide Ef

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=96, Percent_Identity=41.6666666666667, Blast_Score=72, Evalue=5e-15,
Organism=Escherichia coli, GI87082378, Length=105, Percent_Identity=30.4761904761905, Blast_Score=65, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11730; Mature: 11599

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPWLYLILAIVAEVSGTTSMKLSEGFTKPLPSAMIFVFYALSLTFLTLTLRTMPIGFAYA
CHHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IWSALGTALITAIGVLWFGEGMNTLKVVSLILVIVGIAGLHFSQEIMK
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
PWLYLILAIVAEVSGTTSMKLSEGFTKPLPSAMIFVFYALSLTFLTLTLRTMPIGFAYA
HHHHHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IWSALGTALITAIGVLWFGEGMNTLKVVSLILVIVGIAGLHFSQEIMK
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]