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The map label for this gene is pyrD [H]

Identifier: 193213171

GI number: 193213171

Start: 1670682

End: 1671623

Strand: Direct

Name: pyrD [H]

Synonym: Cpar_1526

Alternate gene names: 193213171

Gene position: 1670682-1671623 (Clockwise)

Preceding gene: 193213170

Following gene: 193213173

Centisome position: 72.98

GC content: 58.49

Gene sequence:

>942_bases
ATGACCTCATCAGCTTCAACAGTTACCAACTCCCCTGCCGCCATCAATCTCGGCAGGGGTCTCGACCTCCGCTCGCCGGT
CATGCTCGCCTCGGGCACCGTGTCTTACGGCGAAGAGCTTTCAAAACTCTGCGACCTGTCGAAAATCGGCGGACTGGTCA
CCAAAGCCATTTCGCCTGAGCCCCGCACGGGCAACCAGCCGCAGCGCATTGCTGAAACCTCGTGCGGCATAATCAACGCT
ATCGGACTGGCCAACGTCGGCCTCGACAAGTTTGTGTCGGACAAGGTTCCGTTTTTGCAGACAATCGGCACGCAGGTGAT
CGTCAACATCGCAGGCAAGTCGATTGATGACTACTGTCAGGTGGTCGAACGGCTCGACCAGGTTGAAGGCATCGCCGCCT
ACGAGCTGAACCTGTCCTGCCCGAACGTGAAAGGTGAGTGCATGATCATGGGCGTCAGCCCGGACGCGACCCGCGAGATC
GTCTCGACGTTGCGCAAGCTGACCGACCGTCACCTGATGGTCAAGCTCACGCCGAATGTCACCTCGATCAGCGCCATCGC
ACTGGCTGCTGAAGAGAGCGGAGCGGACTCGGTATCGCTCATCAACACCGTGGTCGGCATGGCGATCGATTACCGCACCC
GCAAGCCGCTTCTGAAGAATGTGACCGGCGGGCTGTCCGGCCCGGCTATCAAGCCGATTGCGCTGGCCAAGGTCTGGGAG
GTATCGAATGCCGTCAAAATTCCGATCGTAGGCATGGGCGGTATCGCCTCGTTCGCCGATGCGATGGAGTTCCTGCTGGC
AGGAGCCAGCGCCATCCAGATCGGCACGATGAATTTCGTCTATCCCGACATTGGCGAAAAAATTGCTATCGAGATCGACA
ACTTCTTCTCGCAACCGGATGCGCCGTCGTTCCAGGAATATGTCGGCAGTCTGATCGTTTAA

Upstream 100 bases:

>100_bases
CCTCCATCGCTCCGGTCTATAACACCGACCGCATGGTCAAGGAGTACACCATGCGCTACTACCTCAATGACCAGCGTCCC
TGAGCCATTAACAGAGTACC

Downstream 100 bases:

>100_bases
GCTACCTGCTGCGCCGATAGCCGGAGAATTTTTTCCGACGGCCGGCAGGAGACCTGAACACCGGTCGGGAATATTGGCGT
TCCGTACGGCTACGATCAAG

Product: dihydroorotate dehydrogenase family protein

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MTSSASTVTNSPAAINLGRGLDLRSPVMLASGTVSYGEELSKLCDLSKIGGLVTKAISPEPRTGNQPQRIAETSCGIINA
IGLANVGLDKFVSDKVPFLQTIGTQVIVNIAGKSIDDYCQVVERLDQVEGIAAYELNLSCPNVKGECMIMGVSPDATREI
VSTLRKLTDRHLMVKLTPNVTSISAIALAAEESGADSVSLINTVVGMAIDYRTRKPLLKNVTGGLSGPAIKPIALAKVWE
VSNAVKIPIVGMGGIASFADAMEFLLAGASAIQIGTMNFVYPDIGEKIAIEIDNFFSQPDAPSFQEYVGSLIV

Sequences:

>Translated_313_residues
MTSSASTVTNSPAAINLGRGLDLRSPVMLASGTVSYGEELSKLCDLSKIGGLVTKAISPEPRTGNQPQRIAETSCGIINA
IGLANVGLDKFVSDKVPFLQTIGTQVIVNIAGKSIDDYCQVVERLDQVEGIAAYELNLSCPNVKGECMIMGVSPDATREI
VSTLRKLTDRHLMVKLTPNVTSISAIALAAEESGADSVSLINTVVGMAIDYRTRKPLLKNVTGGLSGPAIKPIALAKVWE
VSNAVKIPIVGMGGIASFADAMEFLLAGASAIQIGTMNFVYPDIGEKIAIEIDNFFSQPDAPSFQEYVGSLIV
>Mature_312_residues
TSSASTVTNSPAAINLGRGLDLRSPVMLASGTVSYGEELSKLCDLSKIGGLVTKAISPEPRTGNQPQRIAETSCGIINAI
GLANVGLDKFVSDKVPFLQTIGTQVIVNIAGKSIDDYCQVVERLDQVEGIAAYELNLSCPNVKGECMIMGVSPDATREIV
STLRKLTDRHLMVKLTPNVTSISAIALAAEESGADSVSLINTVVGMAIDYRTRKPLLKNVTGGLSGPAIKPIALAKVWEV
SNAVKIPIVGMGGIASFADAMEFLLAGASAIQIGTMNFVYPDIGEKIAIEIDNFFSQPDAPSFQEYVGSLIV

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=169, Percent_Identity=36.6863905325444, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI45006951, Length=310, Percent_Identity=26.7741935483871, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI87082059, Length=216, Percent_Identity=31.4814814814815, Blast_Score=99, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI71984108, Length=168, Percent_Identity=34.5238095238095, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322633, Length=265, Percent_Identity=33.5849056603774, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24640763, Length=170, Percent_Identity=38.2352941176471, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI18858217, Length=170, Percent_Identity=38.2352941176471, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281361352, Length=316, Percent_Identity=28.1645569620253, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17137316, Length=316, Percent_Identity=28.1645569620253, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.3.1 [H]

Molecular weight: Translated: 32932; Mature: 32801

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSASTVTNSPAAINLGRGLDLRSPVMLASGTVSYGEELSKLCDLSKIGGLVTKAISPE
CCCCCCCCCCCCCEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
PRTGNQPQRIAETSCGIINAIGLANVGLDKFVSDKVPFLQTIGTQVIVNIAGKSIDDYCQ
CCCCCCHHHHHHHHCCHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHEEECCCCCHHHHHH
VVERLDQVEGIAAYELNLSCPNVKGECMIMGVSPDATREIVSTLRKLTDRHLMVKLTPNV
HHHHHHHHCCEEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCC
TSISAIALAAEESGADSVSLINTVVGMAIDYRTRKPLLKNVTGGLSGPAIKPIALAKVWE
CHHHHEEEEECCCCCCHHHHHHHHHHHHHCCHHCCCHHHHHCCCCCCCCCCHHHHHHHHH
VSNAVKIPIVGMGGIASFADAMEFLLAGASAIQIGTMNFVYPDIGEKIAIEIDNFFSQPD
CCCCEEEEEEECCHHHHHHHHHHHHHCCCCEEEECCCEEECCCCCCEEEEEEHHHCCCCC
APSFQEYVGSLIV
CCCHHHHHHHHCC
>Mature Secondary Structure 
TSSASTVTNSPAAINLGRGLDLRSPVMLASGTVSYGEELSKLCDLSKIGGLVTKAISPE
CCCCCCCCCCCCEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
PRTGNQPQRIAETSCGIINAIGLANVGLDKFVSDKVPFLQTIGTQVIVNIAGKSIDDYCQ
CCCCCCHHHHHHHHCCHHHHHHHHHCCHHHHHHCCCHHHHHHHHHHEEECCCCCHHHHHH
VVERLDQVEGIAAYELNLSCPNVKGECMIMGVSPDATREIVSTLRKLTDRHLMVKLTPNV
HHHHHHHHCCEEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEEECCCC
TSISAIALAAEESGADSVSLINTVVGMAIDYRTRKPLLKNVTGGLSGPAIKPIALAKVWE
CHHHHEEEEECCCCCCHHHHHHHHHHHHHCCHHCCCHHHHHCCCCCCCCCCHHHHHHHHH
VSNAVKIPIVGMGGIASFADAMEFLLAGASAIQIGTMNFVYPDIGEKIAIEIDNFFSQPD
CCCCEEEEEEECCHHHHHHHHHHHHHCCCCEEEECCCEEECCCCCCEEEEEEHHHCCCCC
APSFQEYVGSLIV
CCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA