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The map label for this gene is mscM [H]

Identifier: 193212326

GI number: 193212326

Start: 707184

End: 708431

Strand: Direct

Name: mscM [H]

Synonym: Cpar_0659

Alternate gene names: 193212326

Gene position: 707184-708431 (Clockwise)

Preceding gene: 193212325

Following gene: 193212328

Centisome position: 30.89

GC content: 53.85

Gene sequence:

>1248_bases
ATGCTTGACTCTCTCTTGCTTTTTATCGAGTCCTTCAAAATCGACCCGTCCGTTGCCAAGCCGCTTGCCACCCTGATTGC
AATCCTGGTCTCATTTTTACTGATCTGGATTGTTGAGGTCATTCTGAAAAATGTGCTTTTGCGTTTCATCCACCGGTTTG
CGTCCAAAACGGCGACCCGTTTCGATGATCTGCTTGTCAAGCACAACGTCTTTGTCTGGGTAGCCCGCATGGTGCCGCCG
GTGCTCGCTTATCGCATGGCCAAGCCCGTTTTGCAATTCTACCCCGATGCTGTGCCGCTGGTGCATGATGTGCTGGTTAT
TCTGTTCGCGTTCGTCGTCATTATGCTGCTGCTCTCGGCGCTCGATGTGGTGTACGAGTTCTTCGGGAGTCATCCGATCG
GCAAGAAGCTACCGATAAAAAGCATCGTGCAGGTCTTCAAGACCATCGGCGTGTTTGTTGGCCTGATCATCGTCATCTCC
CGGCTGATGGGCCAGTCGCCGGTTGTGTTTTTCAGCGGTATCGGCGCGTTTACGGCGGTGCTGCTGCTGATTTTCAAGGA
TTCCATCCTCGGTCTGGTGGCGGGTGTGCAGCTTTCGACCAACGATCTGGTGCGCATCGGCGACTGGATCACGATGCCGA
AATACGGCGCGGATGGTGACGTGATCGATATTTCGCTGGTGACTGTGTCGGTGCAGAACTTCGACAAGACCATTGTGGTG
CTGCCGGCCTATACGCTCATCTCCGAAGGATTTAAAAACTGGCGGGGAATGCAGGAGTCGGACGGACGACGCATCAAGCG
TTCCTTCAACATCGATATGCAGAGCATCAGGTTTCTCGACGATGACCTTGCCAAAAAGATCGAGAACGTCCAGCTTTTGA
AGTCTTACCTGCAAGAGCGGCGTCAGGAGATCGAGAACTATAACCGGGCGGTCATGGTTGACGAAAACTCACCGGTCAAT
GGCCGCCGGATGACCAATCTTGGCACGTTCAGGGCCTATCTGGAGGCCTATGTGCGCAGCATGACCAAGATCAATTCCGA
TATGATGATTATGATCCGGTACCTCCAGCCGGATGCGTTCGGCTTGCCGTGCGAGGTCTATTGCTTCACCAGAACGAAAG
ACTGGGCGGCCTATGAGGCGATTCAGGCCGACATCATGGATCATATTTTCGCCGTGCTGCCGTTCTTCGAGCTGAGAGCT
TATCAGCTCGAAGGCGCGGTGGTTCCGCCGTCAGCCGTCAAAGAGTAA

Upstream 100 bases:

>100_bases
CAGGCTTCGGTTAGTTCCGGATTTTTTGTATTAATAAGCACCGAACAGCTTTCGTCAGATTTGCTGTCGCTTGACCCTTT
GAATACGAATTGTTGTTGTC

Downstream 100 bases:

>100_bases
GCGACAGGTCGCGTTCCGGCCACCGGCTCGCCTCGATGATGTGCGCGTGTAATGGAATGCGCACATTCGGCAGGTTGTCG
GGGCTGTAAAATCCAGCCTC

Product: mechanosensitive ion channel MscS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MLDSLLLFIESFKIDPSVAKPLATLIAILVSFLLIWIVEVILKNVLLRFIHRFASKTATRFDDLLVKHNVFVWVARMVPP
VLAYRMAKPVLQFYPDAVPLVHDVLVILFAFVVIMLLLSALDVVYEFFGSHPIGKKLPIKSIVQVFKTIGVFVGLIIVIS
RLMGQSPVVFFSGIGAFTAVLLLIFKDSILGLVAGVQLSTNDLVRIGDWITMPKYGADGDVIDISLVTVSVQNFDKTIVV
LPAYTLISEGFKNWRGMQESDGRRIKRSFNIDMQSIRFLDDDLAKKIENVQLLKSYLQERRQEIENYNRAVMVDENSPVN
GRRMTNLGTFRAYLEAYVRSMTKINSDMMIMIRYLQPDAFGLPCEVYCFTRTKDWAAYEAIQADIMDHIFAVLPFFELRA
YQLEGAVVPPSAVKE

Sequences:

>Translated_415_residues
MLDSLLLFIESFKIDPSVAKPLATLIAILVSFLLIWIVEVILKNVLLRFIHRFASKTATRFDDLLVKHNVFVWVARMVPP
VLAYRMAKPVLQFYPDAVPLVHDVLVILFAFVVIMLLLSALDVVYEFFGSHPIGKKLPIKSIVQVFKTIGVFVGLIIVIS
RLMGQSPVVFFSGIGAFTAVLLLIFKDSILGLVAGVQLSTNDLVRIGDWITMPKYGADGDVIDISLVTVSVQNFDKTIVV
LPAYTLISEGFKNWRGMQESDGRRIKRSFNIDMQSIRFLDDDLAKKIENVQLLKSYLQERRQEIENYNRAVMVDENSPVN
GRRMTNLGTFRAYLEAYVRSMTKINSDMMIMIRYLQPDAFGLPCEVYCFTRTKDWAAYEAIQADIMDHIFAVLPFFELRA
YQLEGAVVPPSAVKE
>Mature_415_residues
MLDSLLLFIESFKIDPSVAKPLATLIAILVSFLLIWIVEVILKNVLLRFIHRFASKTATRFDDLLVKHNVFVWVARMVPP
VLAYRMAKPVLQFYPDAVPLVHDVLVILFAFVVIMLLLSALDVVYEFFGSHPIGKKLPIKSIVQVFKTIGVFVGLIIVIS
RLMGQSPVVFFSGIGAFTAVLLLIFKDSILGLVAGVQLSTNDLVRIGDWITMPKYGADGDVIDISLVTVSVQNFDKTIVV
LPAYTLISEGFKNWRGMQESDGRRIKRSFNIDMQSIRFLDDDLAKKIENVQLLKSYLQERRQEIENYNRAVMVDENSPVN
GRRMTNLGTFRAYLEAYVRSMTKINSDMMIMIRYLQPDAFGLPCEVYCFTRTKDWAAYEAIQADIMDHIFAVLPFFELRA
YQLEGAVVPPSAVKE

Specific function: Mechanosensitive channel of miniconductance that confers protection against mild hypoosmotic shock. Overexpression confers protection against severe shocks [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1786791, Length=371, Percent_Identity=45.2830188679245, Blast_Score=325, Evalue=2e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685 [H]

Pfam domain/function: PF00924 MS_channel [H]

EC number: NA

Molecular weight: Translated: 47049; Mature: 47049

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDSLLLFIESFKIDPSVAKPLATLIAILVSFLLIWIVEVILKNVLLRFIHRFASKTATR
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDDLLVKHNVFVWVARMVPPVLAYRMAKPVLQFYPDAVPLVHDVLVILFAFVVIMLLLSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LDVVYEFFGSHPIGKKLPIKSIVQVFKTIGVFVGLIIVISRLMGQSPVVFFSGIGAFTAV
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHH
LLLIFKDSILGLVAGVQLSTNDLVRIGDWITMPKYGADGDVIDISLVTVSVQNFDKTIVV
HHHHHHHHHHHHHHCCEECCCCHHEECCEEECCCCCCCCCEEEEEEEEEEECCCCCEEEE
LPAYTLISEGFKNWRGMQESDGRRIKRSFNIDMQSIRFLDDDLAKKIENVQLLKSYLQER
EHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQEIENYNRAVMVDENSPVNGRRMTNLGTFRAYLEAYVRSMTKINSDMMIMIRYLQPDAF
HHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCC
GLPCEVYCFTRTKDWAAYEAIQADIMDHIFAVLPFFELRAYQLEGAVVPPSAVKE
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCC
>Mature Secondary Structure
MLDSLLLFIESFKIDPSVAKPLATLIAILVSFLLIWIVEVILKNVLLRFIHRFASKTATR
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDDLLVKHNVFVWVARMVPPVLAYRMAKPVLQFYPDAVPLVHDVLVILFAFVVIMLLLSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LDVVYEFFGSHPIGKKLPIKSIVQVFKTIGVFVGLIIVISRLMGQSPVVFFSGIGAFTAV
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHH
LLLIFKDSILGLVAGVQLSTNDLVRIGDWITMPKYGADGDVIDISLVTVSVQNFDKTIVV
HHHHHHHHHHHHHHCCEECCCCHHEECCEEECCCCCCCCCEEEEEEEEEEECCCCCEEEE
LPAYTLISEGFKNWRGMQESDGRRIKRSFNIDMQSIRFLDDDLAKKIENVQLLKSYLQER
EHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQEIENYNRAVMVDENSPVNGRRMTNLGTFRAYLEAYVRSMTKINSDMMIMIRYLQPDAF
HHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCC
GLPCEVYCFTRTKDWAAYEAIQADIMDHIFAVLPFFELRAYQLEGAVVPPSAVKE
CCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 7813889 [H]