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The map label for this gene is fabF [H]

Identifier: 192290621

GI number: 192290621

Start: 2420189

End: 2421469

Strand: Reverse

Name: fabF [H]

Synonym: Rpal_2230

Alternate gene names: 192290621

Gene position: 2421469-2420189 (Counterclockwise)

Preceding gene: 192290622

Following gene: 192290620

Centisome position: 42.16

GC content: 66.74

Gene sequence:

>1281_bases
ATGACCGTGACGCGGGACAAATTCGGCAGACCGATCGTGGTCGTCACCGGCATGGGCGTGGTTACCTCGCTCGGTGCCGG
CAAGAACGACAATTGGGCCAAGCTCACCGCCGGGGAATCCGGCATACGCACCATCACCCGCTTTCCGATCGACGGGCTGA
AGAGCACGATGGCCGGCACGGTGGACTTCGTCCCGGTCGAGCCGTTCTCCTCGGTCGTGCTCGGTGAAAAGCTCGCCGAC
CTCGCCACCGAAGAGGCGATCGCGCAGTCGGGCATCGGCCGTAAGGGCGACTTCCCCGGCCCGCTATTTCTCGCGGTCGC
GCCGGTGGAGCTGGAATGGCTGCCGCGCCAGGAGCTGGCGCGCGCCACCGGCGCGAACACCGCGATCGACTACGATGCCC
TGCTCCGCGTCAGCGGCGGCGGCGCCTTCACGCAGTATCATCGTCGCTTCCTGTTCGGCTCGGTCGCCGATCATCTCGCC
GACACCTTCGGCACCAAGGGTTCGCCGATCTCGCTGTCGACCGCCTGCGCCTCCGGCGCGAGCGCGATCCAGCTTGGTGT
CGAAGCGATCCGGCGCGGTGAAGCGGATGCCGCGCTGTGCGTCGCGACCGACGGCTCGGTCAACGCCGAAGCGCTGATCA
GATTCTCGCTGCTATCGGCGCTGTCGACCCAGAACGATCCTCCGCAGGCGTCCTCGAAGCCGTTCGCCAAGAACCGCGAC
GGCTTCGTGATGGCCGAAGGCGCCGGCGCGCTAGTGCTGGAGAGCTACGAGTCGGCGGTGGCGCGCGGCGCCTCAATCCT
CGGCGTGATCGCCGGCTGCGGCGAACTCGCCGACAACTTCCACCGCACCCGCTCGAGCCCGGACGGCAAGCCGATCATCG
GCTGCATCAACAAGACGCTGGCCGACGCCGGCATGAGCGTCGATCGGATCGACTACATCAACGCTCACGGCACCGGAACG
CCCGAGAACGACAAGATGGAGTATCTCGGTATCTCCAGCGTGTTTGGCGAACGCGCCTCATCCCTCCCAGTGTCGTCGAA
CAAATCGATGGTCGGCCACACGTTGTCCGCCGCCGGCGCGGTCGAAGCGATCTTCTCGCTGCTGACGCTGGAGCATCAGC
GGATTCCGCCGACCATTAACTACGACGTGCCGGACCCGGCGATCCCGCTGGATGTGGTGCCCAATCAGGCCCGCGACGCC
CGCGTCACCGCGGTGATGTCGAACTCGTTCGGGTTCGGCGGCCAGAACGCCTCGCTGATCCTGACCCGCGAACCGGCCTA
A

Upstream 100 bases:

>100_bases
GAAATGAGCAAGACCCCCGACCAGATTGTCGTGATCGGGGCGGGCCACTGGCGCGGCGAAGGCATGGCGCTGGTCGAGGC
CGTTCGGTAAGGGGGACGCA

Downstream 100 bases:

>100_bases
TTGCCCGTGAATCGCAGCTCCGGCCGCCGCGGTTGACGCAGCGGCCTCCAGCGGCGATACGCAGGGCGCAAGCCTCCAAC
CGTTCGGACGATACCCATGC

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MTVTRDKFGRPIVVVTGMGVVTSLGAGKNDNWAKLTAGESGIRTITRFPIDGLKSTMAGTVDFVPVEPFSSVVLGEKLAD
LATEEAIAQSGIGRKGDFPGPLFLAVAPVELEWLPRQELARATGANTAIDYDALLRVSGGGAFTQYHRRFLFGSVADHLA
DTFGTKGSPISLSTACASGASAIQLGVEAIRRGEADAALCVATDGSVNAEALIRFSLLSALSTQNDPPQASSKPFAKNRD
GFVMAEGAGALVLESYESAVARGASILGVIAGCGELADNFHRTRSSPDGKPIIGCINKTLADAGMSVDRIDYINAHGTGT
PENDKMEYLGISSVFGERASSLPVSSNKSMVGHTLSAAGAVEAIFSLLTLEHQRIPPTINYDVPDPAIPLDVVPNQARDA
RVTAVMSNSFGFGGQNASLILTREPA

Sequences:

>Translated_426_residues
MTVTRDKFGRPIVVVTGMGVVTSLGAGKNDNWAKLTAGESGIRTITRFPIDGLKSTMAGTVDFVPVEPFSSVVLGEKLAD
LATEEAIAQSGIGRKGDFPGPLFLAVAPVELEWLPRQELARATGANTAIDYDALLRVSGGGAFTQYHRRFLFGSVADHLA
DTFGTKGSPISLSTACASGASAIQLGVEAIRRGEADAALCVATDGSVNAEALIRFSLLSALSTQNDPPQASSKPFAKNRD
GFVMAEGAGALVLESYESAVARGASILGVIAGCGELADNFHRTRSSPDGKPIIGCINKTLADAGMSVDRIDYINAHGTGT
PENDKMEYLGISSVFGERASSLPVSSNKSMVGHTLSAAGAVEAIFSLLTLEHQRIPPTINYDVPDPAIPLDVVPNQARDA
RVTAVMSNSFGFGGQNASLILTREPA
>Mature_425_residues
TVTRDKFGRPIVVVTGMGVVTSLGAGKNDNWAKLTAGESGIRTITRFPIDGLKSTMAGTVDFVPVEPFSSVVLGEKLADL
ATEEAIAQSGIGRKGDFPGPLFLAVAPVELEWLPRQELARATGANTAIDYDALLRVSGGGAFTQYHRRFLFGSVADHLAD
TFGTKGSPISLSTACASGASAIQLGVEAIRRGEADAALCVATDGSVNAEALIRFSLLSALSTQNDPPQASSKPFAKNRDG
FVMAEGAGALVLESYESAVARGASILGVIAGCGELADNFHRTRSSPDGKPIIGCINKTLADAGMSVDRIDYINAHGTGTP
ENDKMEYLGISSVFGERASSLPVSSNKSMVGHTLSAAGAVEAIFSLLTLEHQRIPPTINYDVPDPAIPLDVVPNQARDAR
VTAVMSNSFGFGGQNASLILTREPA

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=428, Percent_Identity=35.2803738317757, Blast_Score=218, Evalue=9e-57,
Organism=Homo sapiens, GI223972627, Length=147, Percent_Identity=42.1768707482993, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI41872631, Length=275, Percent_Identity=31.6363636363636, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI1787337, Length=270, Percent_Identity=45.1851851851852, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI1788663, Length=423, Percent_Identity=34.0425531914894, Blast_Score=185, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI71983541, Length=280, Percent_Identity=35.3571428571429, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71983535, Length=263, Percent_Identity=36.1216730038023, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI212642053, Length=280, Percent_Identity=29.2857142857143, Blast_Score=118, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17550940, Length=266, Percent_Identity=27.0676691729323, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320904, Length=450, Percent_Identity=29.1111111111111, Blast_Score=144, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24644341, Length=439, Percent_Identity=35.0797266514806, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI19920632, Length=279, Percent_Identity=30.8243727598566, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI221330659, Length=279, Percent_Identity=30.8243727598566, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24581345, Length=274, Percent_Identity=28.4671532846715, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44397; Mature: 44265

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTRDKFGRPIVVVTGMGVVTSLGAGKNDNWAKLTAGESGIRTITRFPIDGLKSTMAGT
CCCCCHHCCCCEEEEECCHHHHHCCCCCCCCEEEEECCCCCCCCHHHCCCHHHHHHHCCC
VDFVPVEPFSSVVLGEKLADLATEEAIAQSGIGRKGDFPGPLFLAVAPVELEWLPRQELA
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECEEEEECCHHHHH
RATGANTAIDYDALLRVSGGGAFTQYHRRFLFGSVADHLADTFGTKGSPISLSTACASGA
HHCCCCCEECHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHCCCH
SAIQLGVEAIRRGEADAALCVATDGSVNAEALIRFSLLSALSTQNDPPQASSKPFAKNRD
HHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GFVMAEGAGALVLESYESAVARGASILGVIAGCGELADNFHRTRSSPDGKPIIGCINKTL
CEEEECCCCEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
ADAGMSVDRIDYINAHGTGTPENDKMEYLGISSVFGERASSLPVSSNKSMVGHTLSAAGA
HHCCCCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
VEAIFSLLTLEHQRIPPTINYDVPDPAIPLDVVPNQARDARVTAVMSNSFGFGGQNASLI
HHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEE
LTREPA
EEECCC
>Mature Secondary Structure 
TVTRDKFGRPIVVVTGMGVVTSLGAGKNDNWAKLTAGESGIRTITRFPIDGLKSTMAGT
CCCCHHCCCCEEEEECCHHHHHCCCCCCCCEEEEECCCCCCCCHHHCCCHHHHHHHCCC
VDFVPVEPFSSVVLGEKLADLATEEAIAQSGIGRKGDFPGPLFLAVAPVELEWLPRQELA
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECEEEEECCHHHHH
RATGANTAIDYDALLRVSGGGAFTQYHRRFLFGSVADHLADTFGTKGSPISLSTACASGA
HHCCCCCEECHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHCCCH
SAIQLGVEAIRRGEADAALCVATDGSVNAEALIRFSLLSALSTQNDPPQASSKPFAKNRD
HHHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
GFVMAEGAGALVLESYESAVARGASILGVIAGCGELADNFHRTRSSPDGKPIIGCINKTL
CEEEECCCCEEEHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
ADAGMSVDRIDYINAHGTGTPENDKMEYLGISSVFGERASSLPVSSNKSMVGHTLSAAGA
HHCCCCCCCEEEEECCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
VEAIFSLLTLEHQRIPPTINYDVPDPAIPLDVVPNQARDARVTAVMSNSFGFGGQNASLI
HHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEE
LTREPA
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]