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The map label for this gene is fabF [C]

Identifier: 192290622

GI number: 192290622

Start: 2421480

End: 2422688

Strand: Reverse

Name: fabF [C]

Synonym: Rpal_2231

Alternate gene names: 192290622

Gene position: 2422688-2421480 (Counterclockwise)

Preceding gene: 192290623

Following gene: 192290621

Centisome position: 42.18

GC content: 68.16

Gene sequence:

>1209_bases
ATGGCTGACACCACCACGTCCCGCGCCGAACCGATCGAAGCCTGGATTACCGGCATCGGCCTCGCCACCTCGCTGGCCGA
GGGGCTCGACGCGCATTGGGATGCGCTGACCGAACGCCGGGTGAGCGTCGATACCGCGGCCTTCGCCCCCTACGTGGTGC
ACCCGCTGGCGCCGCTCAGCTTCGACAAGCAGATCCCCAAGAAGGGCGATCAGCGCCAGATGGAAGCCTGGCAGCGGATC
GGCACCTATGCGGCCGGTCTCGCGCTCGAGTCCGCCGGGATCAAAGGCAACACCGAGATCCTGTCGCGGATGGACATGAT
CGTCGCGGCGGGTGGCGGTGAGCGCGACCTTGCGGTCGATTCCGCCGTGCTCAACGCCGAAGGTTATGGCACCGTGCCGC
CCAGTGCGCTCAACGAGCGCCTCATGAACGACCTGCGCCCCACCCTCTTCCTCGCACAACTGTCCAATCTGCTCGCCGGC
AACATCGCGATCGTGCACGGCGTCACCGGCTCGTCGCGCACCTTCATGGGCGAAGAGGAAGCCGGCGTCGACGCCGCGCG
GATCGCGCTGGCGCGGATCGCAGCGGGCCAGAGCGACATCGCGCTGATCGGCGCCGCCCAGAACGGCGAGCGCAAAGATC
TGCTGATGCTTTACGAGTTCGGCGACTTCAATCTGAAGGACAACTACGCGCCGGTGTTCGCGCGCGGTCCCAAGGGCGGC
TTCGCGCTCGGCTCGGGCTCAGCGTTCCTTGTGATCGAGTCGAAGGCGCATGCCGAAGCGCGCGGCGCCAAGCCGTATGC
GCGGCTGAAGAACGTCGTCGCCGACCAGTCGCGCCGCCGCAACGCCGGCGACGTGACCGCGTCGCTAGAGAAGCTATGGT
CGAAGCTCGGCCCGCGCGACGGTGCCACCGCGATCATCACCGGTGCGACCGGCGCCGAGCCCGTGACCGCCGAGGAAACC
GCGTTCCTGCGCAATCACGCCAATGCGCCGGTGCGCGGCACCGCGACGCCGTTCGGCCACGTGATGGAAGCGCAATTCCC
GCTCGGCATCGCGCTCGCAGCGCTGTCGCTGTCGCGCGGCGCGCTGTATCCGCCGAACGATCCAGCCGGGCTCGAAGTTG
AAATGAGCAAGACCCCCGACCAGATTGTCGTGATCGGGGCGGGCCACTGGCGCGGCGAAGGCATGGCGCTGGTCGAGGCC
GTTCGGTAA

Upstream 100 bases:

>100_bases
GCCACGCTGACGTTCCGCCACGTCCCGTTTCCGCATCCCGATCTGCGCGGGCATATGGAAGCGATGGCGAAGCAAATCGG
ATTTCCGGAGCAGATGATCC

Downstream 100 bases:

>100_bases
GGGGGACGCAATGACCGTGACGCGGGACAAATTCGGCAGACCGATCGTGGTCGTCACCGGCATGGGCGTGGTTACCTCGC
TCGGTGCCGGCAAGAACGAC

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: 3-oxoacyl-[acyl-carrier protein]; CO2; [acyl-carrier protein]

Alternate protein names: Beta-Ketoacyl Synthase; 3-Oxoacyl-(Acyl-Carrier-Protein) Synthase II; 3-Oxoacyl-[Acyl-Carrier-Protein] Synthase II Protein; 3-Oxoacyl-(Acyl-Acp) Synthase II Protein; 3-Oxoacyl-[Acyl-Carrier-Protein] Synthase II

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MADTTTSRAEPIEAWITGIGLATSLAEGLDAHWDALTERRVSVDTAAFAPYVVHPLAPLSFDKQIPKKGDQRQMEAWQRI
GTYAAGLALESAGIKGNTEILSRMDMIVAAGGGERDLAVDSAVLNAEGYGTVPPSALNERLMNDLRPTLFLAQLSNLLAG
NIAIVHGVTGSSRTFMGEEEAGVDAARIALARIAAGQSDIALIGAAQNGERKDLLMLYEFGDFNLKDNYAPVFARGPKGG
FALGSGSAFLVIESKAHAEARGAKPYARLKNVVADQSRRRNAGDVTASLEKLWSKLGPRDGATAIITGATGAEPVTAEET
AFLRNHANAPVRGTATPFGHVMEAQFPLGIALAALSLSRGALYPPNDPAGLEVEMSKTPDQIVVIGAGHWRGEGMALVEA
VR

Sequences:

>Translated_402_residues
MADTTTSRAEPIEAWITGIGLATSLAEGLDAHWDALTERRVSVDTAAFAPYVVHPLAPLSFDKQIPKKGDQRQMEAWQRI
GTYAAGLALESAGIKGNTEILSRMDMIVAAGGGERDLAVDSAVLNAEGYGTVPPSALNERLMNDLRPTLFLAQLSNLLAG
NIAIVHGVTGSSRTFMGEEEAGVDAARIALARIAAGQSDIALIGAAQNGERKDLLMLYEFGDFNLKDNYAPVFARGPKGG
FALGSGSAFLVIESKAHAEARGAKPYARLKNVVADQSRRRNAGDVTASLEKLWSKLGPRDGATAIITGATGAEPVTAEET
AFLRNHANAPVRGTATPFGHVMEAQFPLGIALAALSLSRGALYPPNDPAGLEVEMSKTPDQIVVIGAGHWRGEGMALVEA
VR
>Mature_401_residues
ADTTTSRAEPIEAWITGIGLATSLAEGLDAHWDALTERRVSVDTAAFAPYVVHPLAPLSFDKQIPKKGDQRQMEAWQRIG
TYAAGLALESAGIKGNTEILSRMDMIVAAGGGERDLAVDSAVLNAEGYGTVPPSALNERLMNDLRPTLFLAQLSNLLAGN
IAIVHGVTGSSRTFMGEEEAGVDAARIALARIAAGQSDIALIGAAQNGERKDLLMLYEFGDFNLKDNYAPVFARGPKGGF
ALGSGSAFLVIESKAHAEARGAKPYARLKNVVADQSRRRNAGDVTASLEKLWSKLGPRDGATAIITGATGAEPVTAEETA
FLRNHANAPVRGTATPFGHVMEAQFPLGIALAALSLSRGALYPPNDPAGLEVEMSKTPDQIVVIGAGHWRGEGMALVEAV
R

Specific function: Catalyzes The Condensation Reaction Of Fatty Acid Synthesis By The Addition To An Acyl Acceptor Of Two Carbons From Malonyl-Acp. Has A Preference For Short Chain Acid Substrates And May Function To Supply The Octanoic Substrates For Lipoic Acid Biosynthe

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.3.1.41

Molecular weight: Translated: 42305; Mature: 42174

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTTTSRAEPIEAWITGIGLATSLAEGLDAHWDALTERRVSVDTAAFAPYVVHPLAPLS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHCCCCCCC
FDKQIPKKGDQRQMEAWQRIGTYAAGLALESAGIKGNTEILSRMDMIVAAGGGERDLAVD
CCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHEEEECCCCCCCHHHH
SAVLNAEGYGTVPPSALNERLMNDLRPTLFLAQLSNLLAGNIAIVHGVTGSSRTFMGEEE
HEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEECCCHH
AGVDAARIALARIAAGQSDIALIGAAQNGERKDLLMLYEFGDFNLKDNYAPVFARGPKGG
CCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCEEEECCCCC
FALGSGSAFLVIESKAHAEARGAKPYARLKNVVADQSRRRNAGDVTASLEKLWSKLGPRD
EEECCCCEEEEEECCCCCHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
GATAIITGATGAEPVTAEETAFLRNHANAPVRGTATPFGHVMEAQFPLGIALAALSLSRG
CCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHCCC
ALYPPNDPAGLEVEMSKTPDQIVVIGAGHWRGEGMALVEAVR
CCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCEEEHEECC
>Mature Secondary Structure 
ADTTTSRAEPIEAWITGIGLATSLAEGLDAHWDALTERRVSVDTAAFAPYVVHPLAPLS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHCCCCCCC
FDKQIPKKGDQRQMEAWQRIGTYAAGLALESAGIKGNTEILSRMDMIVAAGGGERDLAVD
CCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHEEEECCCCCCCHHHH
SAVLNAEGYGTVPPSALNERLMNDLRPTLFLAQLSNLLAGNIAIVHGVTGSSRTFMGEEE
HEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCEECCCHH
AGVDAARIALARIAAGQSDIALIGAAQNGERKDLLMLYEFGDFNLKDNYAPVFARGPKGG
CCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCEEEECCCCC
FALGSGSAFLVIESKAHAEARGAKPYARLKNVVADQSRRRNAGDVTASLEKLWSKLGPRD
EEECCCCEEEEEECCCCCHHCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
GATAIITGATGAEPVTAEETAFLRNHANAPVRGTATPFGHVMEAQFPLGIALAALSLSRG
CCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHCCC
ALYPPNDPAGLEVEMSKTPDQIVVIGAGHWRGEGMALVEAVR
CCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCEEEHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: None [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.138 {cis-9-hexadecenoyl-ACP}} 0.017 {cis-9-hexadecenoyl-ACP}} 0.012 {cis-3-decenoyl-ACP}} 0.04 {acetyl-ACP}} 0.031 {acetyl-ACP}} [C]

Substrates: acyl-[acyl-carrier protein]; malonyl-[acyl-carrier protein]

Specific reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]

General reaction: Acyl group transfer [C]

Inhibitor: Acetyl-CoA; Acyl-CoA; Iodoacetamide; N-Ethyl maleimide acyl -ACP-derivatives protect, malonyl-ACP-decarboxylation, Cerulenin [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA