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The map label for this gene is mepA [H]

Identifier: 192290284

GI number: 192290284

Start: 2035520

End: 2036893

Strand: Reverse

Name: mepA [H]

Synonym: Rpal_1888

Alternate gene names: 192290284

Gene position: 2036893-2035520 (Counterclockwise)

Preceding gene: 192290288

Following gene: 192290283

Centisome position: 35.46

GC content: 68.49

Gene sequence:

>1374_bases
ATGACCATCGAGGCACCCGCCGACACGCCGCTGCCCGCTCCGCCGCCGAACCGGCTGCTGACCGCCCCGATCCTGCCGAC
GCTGGTGCGGCTGGCGATCCCCAACACCATCGCGATGCTCGGCACTGCTTTGGTGGCGGTGGCCGAGACGTCGTATATCG
GCCGGCTCGGCACCGAGCCGTTGGCGGCGATCGCTCTGGTGTTTCCGTTCGCGATGCTGACGCAGATGATGTCGGCCGGC
GCCATGGGCGGGGGCGTATCATCGGCAATCAGCCGCGCCCTCGGCGCCGGTGATACACACCGGGCGGGCGTTCTGGCGCT
CCATGCGATTCTGATCGGGATCGGCGGCGGGCTGCTGTTCACGCTGGTGATGCTGGTGTTCGGCCGGTCCCTGTTTGCTC
TGTTGGGCGGGCGCGGCGACGTGCTGGAGCAGGCCTGCAGCTACTCGGTCGTCCTGTTCTCGGGTGCCGTGTCGATCTGG
CTGGTGAACACCCTCGCCTCGATCTTGCGCGGCACTGGCGACATGATCCTGCCGGCCGGCGCCCTGCTCGGTGTCGCGGC
TTTGCAGGTGGTGATCGGCGGCGCGCTCGGACTCGGCCTGTTCGGAATGCCGCGGCTCGGCATGCCTGGCGTCGCCTCCG
GTCAAGCGATCGCCTTCACCATCGGCGCGCTGTTCCTGCTGATCTATCTCGGCAGCGGCCGCAGCCGGCTGCGGCTGCAA
CTGCGGTCGTTTCGTCTGCAGCGTCCGATCTTCATCGACATCCTCAAGGTCGGTGCGCTCGCCTGTCTTGCTCCGCTGCA
GTCGGTGCTGACGATCCTGATCTTCACCAAGGTGCTGGCAAGCTACGGCACTACCACGCTCGCCGGCTACGGCATCGGCT
CACGCTTGGAATTCCTGTTGATCCCGATCGCGTTCGCAGTCGGTGTCGCCTCGATCCCGATGGTCGGGATGGCGATCGGC
GCCGGTGATATCGCCCGGGCGCGGCGGGTCGCATGGACGGCCGGCGTAGTATCCGCGGTGATCGTCGGACTGGTCGGCGC
CGTGCTGGCGATCTGGCCGGCGCTCTGGGTGTCGTTGTTCACCGCCGATCCGGCCGTCACCGCCGCCGCGCATACGTACT
TCCACCTCGCCGGCCCCGGCTTCGGATTCTTCGGCCTCGGCGTGACGCTGTATTTCGCCAGCCAGGGCGCCGCCAAGGTT
GGCGGGCCGGTGCTCGCCGCGACCGGACGGCTTGTGCTGGTGGCCCTCGGCGGATGGGCGCTGGTCGCCTTCGGAGCACC
GGCGTCGGCGATGTTCGCGATGGTGGCGGTGGCGATGGTGGTGTACGGCCTCGGCAGCGCCGCGGCGATCTATCTGACAC
GCTGGGTCAAATGA

Upstream 100 bases:

>100_bases
CCCCGCCGCTTGTGCCGGATAACGCCTTGCGCTTATTGTATGTTAATCATCATATAAAAGAGCGCCTTAGATCGCGAGGC
GGCATCCGGGGAGCGACCAC

Downstream 100 bases:

>100_bases
ATCGGAATTATCCCCAGCGTGCGGCAAGGGTCATACGATTGCACGAATCGGCCGCTCTGCTATCCAACCGCCCGCCGCAC
TGCTTCTGAATGCTGTTCGA

Product: MATE efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MTIEAPADTPLPAPPPNRLLTAPILPTLVRLAIPNTIAMLGTALVAVAETSYIGRLGTEPLAAIALVFPFAMLTQMMSAG
AMGGGVSSAISRALGAGDTHRAGVLALHAILIGIGGGLLFTLVMLVFGRSLFALLGGRGDVLEQACSYSVVLFSGAVSIW
LVNTLASILRGTGDMILPAGALLGVAALQVVIGGALGLGLFGMPRLGMPGVASGQAIAFTIGALFLLIYLGSGRSRLRLQ
LRSFRLQRPIFIDILKVGALACLAPLQSVLTILIFTKVLASYGTTTLAGYGIGSRLEFLLIPIAFAVGVASIPMVGMAIG
AGDIARARRVAWTAGVVSAVIVGLVGAVLAIWPALWVSLFTADPAVTAAAHTYFHLAGPGFGFFGLGVTLYFASQGAAKV
GGPVLAATGRLVLVALGGWALVAFGAPASAMFAMVAVAMVVYGLGSAAAIYLTRWVK

Sequences:

>Translated_457_residues
MTIEAPADTPLPAPPPNRLLTAPILPTLVRLAIPNTIAMLGTALVAVAETSYIGRLGTEPLAAIALVFPFAMLTQMMSAG
AMGGGVSSAISRALGAGDTHRAGVLALHAILIGIGGGLLFTLVMLVFGRSLFALLGGRGDVLEQACSYSVVLFSGAVSIW
LVNTLASILRGTGDMILPAGALLGVAALQVVIGGALGLGLFGMPRLGMPGVASGQAIAFTIGALFLLIYLGSGRSRLRLQ
LRSFRLQRPIFIDILKVGALACLAPLQSVLTILIFTKVLASYGTTTLAGYGIGSRLEFLLIPIAFAVGVASIPMVGMAIG
AGDIARARRVAWTAGVVSAVIVGLVGAVLAIWPALWVSLFTADPAVTAAAHTYFHLAGPGFGFFGLGVTLYFASQGAAKV
GGPVLAATGRLVLVALGGWALVAFGAPASAMFAMVAVAMVVYGLGSAAAIYLTRWVK
>Mature_456_residues
TIEAPADTPLPAPPPNRLLTAPILPTLVRLAIPNTIAMLGTALVAVAETSYIGRLGTEPLAAIALVFPFAMLTQMMSAGA
MGGGVSSAISRALGAGDTHRAGVLALHAILIGIGGGLLFTLVMLVFGRSLFALLGGRGDVLEQACSYSVVLFSGAVSIWL
VNTLASILRGTGDMILPAGALLGVAALQVVIGGALGLGLFGMPRLGMPGVASGQAIAFTIGALFLLIYLGSGRSRLRLQL
RSFRLQRPIFIDILKVGALACLAPLQSVLTILIFTKVLASYGTTTLAGYGIGSRLEFLLIPIAFAVGVASIPMVGMAIGA
GDIARARRVAWTAGVVSAVIVGLVGAVLAIWPALWVSLFTADPAVTAAAHTYFHLAGPGFGFFGLGVTLYFASQGAAKVG
GPVLAATGRLVLVALGGWALVAFGAPASAMFAMVAVAMVVYGLGSAAAIYLTRWVK

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=353, Percent_Identity=28.328611898017, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 46461; Mature: 46330

Theoretical pI: Translated: 10.82; Mature: 10.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIEAPADTPLPAPPPNRLLTAPILPTLVRLAIPNTIAMLGTALVAVAETSYIGRLGTEP
CCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHH
LAAIALVFPFAMLTQMMSAGAMGGGVSSAISRALGAGDTHRAGVLALHAILIGIGGGLLF
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHH
TLVMLVFGRSLFALLGGRGDVLEQACSYSVVLFSGAVSIWLVNTLASILRGTGDMILPAG
HHHHHHHHHHHHHHHCCCCHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHHCCCCEEEHHH
ALLGVAALQVVIGGALGLGLFGMPRLGMPGVASGQAIAFTIGALFLLIYLGSGRSRLRLQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
LRSFRLQRPIFIDILKVGALACLAPLQSVLTILIFTKVLASYGTTTLAGYGIGSRLEFLL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHH
IPIAFAVGVASIPMVGMAIGAGDIARARRVAWTAGVVSAVIVGLVGAVLAIWPALWVSLF
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TADPAVTAAAHTYFHLAGPGFGFFGLGVTLYFASQGAAKVGGPVLAATGRLVLVALGGWA
CCCCHHHHHHHHEEEECCCCCHHHHHHHHHHEECCCCCHHCCCCEEECCCEEEEEECCCE
LVAFGAPASAMFAMVAVAMVVYGLGSAAAIYLTRWVK
EEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TIEAPADTPLPAPPPNRLLTAPILPTLVRLAIPNTIAMLGTALVAVAETSYIGRLGTEP
CCCCCCCCCCCCCCCCCEEECHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHH
LAAIALVFPFAMLTQMMSAGAMGGGVSSAISRALGAGDTHRAGVLALHAILIGIGGGLLF
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHH
TLVMLVFGRSLFALLGGRGDVLEQACSYSVVLFSGAVSIWLVNTLASILRGTGDMILPAG
HHHHHHHHHHHHHHHCCCCHHHHHHHCCEEHHHHHHHHHHHHHHHHHHHHCCCCEEEHHH
ALLGVAALQVVIGGALGLGLFGMPRLGMPGVASGQAIAFTIGALFLLIYLGSGRSRLRLQ
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
LRSFRLQRPIFIDILKVGALACLAPLQSVLTILIFTKVLASYGTTTLAGYGIGSRLEFLL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHH
IPIAFAVGVASIPMVGMAIGAGDIARARRVAWTAGVVSAVIVGLVGAVLAIWPALWVSLF
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TADPAVTAAAHTYFHLAGPGFGFFGLGVTLYFASQGAAKVGGPVLAATGRLVLVALGGWA
CCCCHHHHHHHHEEEECCCCCHHHHHHHHHHEECCCCCHHCCCCEEECCCEEEEEECCCE
LVAFGAPASAMFAMVAVAMVVYGLGSAAAIYLTRWVK
EEEECCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA