Click here to switch to the map view.

The map label for this gene is divL [H]

Identifier: 192288515

GI number: 192288515

Start: 89441

End: 91954

Strand: Reverse

Name: divL [H]

Synonym: Rpal_0082

Alternate gene names: 192288515

Gene position: 91954-89441 (Counterclockwise)

Preceding gene: 192288516

Following gene: 192288514

Centisome position: 1.6

GC content: 66.27

Gene sequence:

>2514_bases
ATGTCAGGCGTATTGGGGTCCATACGTCGGACCAGTCTGTCGTGCACCTCCCTGGTGCATGGTTTGGCTGGGACGGCCGT
GATGGTCGCGTCGTCGCCGGCGCGAGCCGCGGACGATCACCTGGCCGCCATCACGTCGTCGCTGCTGCTGGATCTCAACC
GCCACGAGATGATGACGTTGATCATCGCGCTCGCGGCGCTGGGCTTTTCGGTGATGTCTGCGATCATGCTGGTGCGGACG
CGGCAGCGCGCGGTTGCGCGCGAAGCGGGGCTGCGCGCCGACCTGCAGGGGCTGCAGGCGGAGTCTGATCGTTTCCAGGC
GCTGCTGTTCGCCGAGCCGCAAGTGCTGATCTCTTGGGCGGCTGGTGACAGCCGGCCGCAGGTCAGCGGCGACACCGCGC
TGTTCCTGCCGCTGGAGACGCAGAGTCGCCAACCGCAACGAGTGCTGGCGTTCGGAACCTGGTTGCCGCCCGAGCCGGCG
CTGCAAATGGATCACGCAGTCGATGCGCTGCTCGACAAGGGCGAAGGCTTTCTGCTGCAGCTCGTCACCTCGAACGGCCG
GTCGATCGAGGCGATGGGGCGCGCCGTCGGCGGGCAGGCTGTCGTCCGCATCCGAGAACTGAGCGGCGTGCGCCGCGAGC
TCGCCGACATGACCCGGCGCTTCAAGGCGCTGCAGGAAGAAACCGAGATGCTGCGCGGCTTCGCCACCGCCGCGCCGTGG
CCGATCTGGACCCGCCGCTCCGACGGCACACTCAGCTTCGCCAACGCCGCCTATGCGCGGGCGACCGATGCCAGCGACGC
CGCGGACGCGATCGGCCGCAATCTCGAACTGCTCGATTCCGGCGATCGCGCCGCGTTGGCACGTGCGCTCGGCGACGGCT
ACGAATATTCCGGCCGGCTGCCGATCGTGGTCGGCGGCGAGCGCCGCTACTACGACGTCCGCGCCCTGAAGGTGAGCGGC
GGCAGCGCCGGCATCGCAGTCGACGCCACGGAAACGGCCGCGCTCGGCGCCGCACTAGAGCGGATGGCCGATGCGCATCG
GCGCACGCTTGATCAGCTTTCTTCCGGCGTTGCGGTGTTCGACGCTCAGCGCCGGCTGTCGTTTTACAACGACTCCTATC
GCAAGCTGTGGGACCTCGACCGCATCTTCCTCGATAGCCATCCCGACGATTCCACCGTGCTCGACCGGCTGCGAGCCGAG
CGCAAGCTGCCGGAGGAGCGCGACTTCAAGGCGTGGAAGAACAAGCTGCACGAAGCCTATCGGGCGGTCGAGGCCGAGAA
GGACGTCTGGTATCTGCCGGACGGCCGCGCCGTCAGCATCGTCACCACGCCCAATCCTGAAGGCGGCGTCACCTATCTGT
TTGACGACGTCACCGAGAGTCTCGACCTCAAGCGTCGCTATGGCGGCCTGATCGATGTTCAGCGCGAAACGCTCGACAAT
CTGTCGGAAGCCGTTGCGGTGTTCGGCTCCAATGGCTGCGCGCAGTTGTTCAACCCGCCGTTCGCGCGGATGTGGAACCT
GTCGGCCGAGGCGCTGCAGAGCCAGCCGCACATCGAGGCGATCGAGGAGTGGTGCCGGCCGTTGTTCGACGACGACGTGT
TCTGGCAGGCGCTACGCGGCGCCATCACCGGCATCGACGATCGCCGCCACGTCCTGCTCAAGATCGAGCGCAAGGACGGC
AGCGTGCTGGCCTGCAAGACCATGCCGCTGCCCGACGGCGCCACGATGCTGACGTTCCAGGACATCACCGACACCGAGAA
CGTCGAGCGGGCGCTGCGCGAGCGCAATGAGGCGCTCGAGACCGCCGATCGCATCAAGATCGATTTCGTCCACCATGTCT
CGTATGAGCTGCGGTCGCCACTGACCACCATCATCGGCTTCGCACACTTCCTCAGCGATTCTTCGACCGGGCCGCTCACC
GAGAAGCAGGCCGAGTACGTGAACTACATCACGACCTCGACCAACGCGCTGATGGCGATCATCAACAACATCCTCGATCT
GGCCAGCATCGACGCCGGGGCGATGACGCTCAATCTCGGCCCGATCGACATCCGCAAGGCGATCGATGCGGCGGCCGAGG
GCATTCAGGACCGGCTTGCGCGCGATCAAATCGCGCTGCAGATCGACGTCGATCCGGCGATCGAGAGCTTTGTCGGCGAC
GAGCGGCGCGTCGTGCAGGTGCTGTACAATCTGCTCGCCAATGCGATCGATTTCTCGCCCTCGCAGGGGACGGTGCGGCT
GACGGTGCGCCGGGGCGAAACCCGGGTGGCGTTCACTGTCACCGATTCTGGTCCCGGCATCGCGCCGGCGTTCAAAGAGA
AAATGTTCGATCTGTTCGAGAGCGATCCGCAGGGCTCGCGCCATCGTGGCGCCGGCCTTGGCCTGTCACTGGTGCGTTCG
TTCGTCGAGCTGCACGGCGGTAAAGTCCTGGTCGAGTCGGCGGTCGGTCGCGGCACATCGGTGACCTGCGAGTTTCCGAT
CGAGCCGGCCGCCCAACGCCACGCGGCCGAATGA

Upstream 100 bases:

>100_bases
ACGGTCTGGACTCTTACCCCCCGAGTCGCGATGGCGATAATGTCCTCCGATTCGGCTATGGCGCGGCTTGTCAGTTGCGC
CGTGCGGTTTGGGGCAATCG

Downstream 100 bases:

>100_bases
GTGCGGTTGCGACATTCTCGGTGGCGCTTGCCAACGAGGTGGCGACCGTGCGGCTGATGGCCGAGGTCGCGCTGCTGATC
GGTCCAGGCGATGTCGTGAC

Product: PAS/PAC sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 837; Mature: 836

Protein sequence:

>837_residues
MSGVLGSIRRTSLSCTSLVHGLAGTAVMVASSPARAADDHLAAITSSLLLDLNRHEMMTLIIALAALGFSVMSAIMLVRT
RQRAVAREAGLRADLQGLQAESDRFQALLFAEPQVLISWAAGDSRPQVSGDTALFLPLETQSRQPQRVLAFGTWLPPEPA
LQMDHAVDALLDKGEGFLLQLVTSNGRSIEAMGRAVGGQAVVRIRELSGVRRELADMTRRFKALQEETEMLRGFATAAPW
PIWTRRSDGTLSFANAAYARATDASDAADAIGRNLELLDSGDRAALARALGDGYEYSGRLPIVVGGERRYYDVRALKVSG
GSAGIAVDATETAALGAALERMADAHRRTLDQLSSGVAVFDAQRRLSFYNDSYRKLWDLDRIFLDSHPDDSTVLDRLRAE
RKLPEERDFKAWKNKLHEAYRAVEAEKDVWYLPDGRAVSIVTTPNPEGGVTYLFDDVTESLDLKRRYGGLIDVQRETLDN
LSEAVAVFGSNGCAQLFNPPFARMWNLSAEALQSQPHIEAIEEWCRPLFDDDVFWQALRGAITGIDDRRHVLLKIERKDG
SVLACKTMPLPDGATMLTFQDITDTENVERALRERNEALETADRIKIDFVHHVSYELRSPLTTIIGFAHFLSDSSTGPLT
EKQAEYVNYITTSTNALMAIINNILDLASIDAGAMTLNLGPIDIRKAIDAAAEGIQDRLARDQIALQIDVDPAIESFVGD
ERRVVQVLYNLLANAIDFSPSQGTVRLTVRRGETRVAFTVTDSGPGIAPAFKEKMFDLFESDPQGSRHRGAGLGLSLVRS
FVELHGGKVLVESAVGRGTSVTCEFPIEPAAQRHAAE

Sequences:

>Translated_837_residues
MSGVLGSIRRTSLSCTSLVHGLAGTAVMVASSPARAADDHLAAITSSLLLDLNRHEMMTLIIALAALGFSVMSAIMLVRT
RQRAVAREAGLRADLQGLQAESDRFQALLFAEPQVLISWAAGDSRPQVSGDTALFLPLETQSRQPQRVLAFGTWLPPEPA
LQMDHAVDALLDKGEGFLLQLVTSNGRSIEAMGRAVGGQAVVRIRELSGVRRELADMTRRFKALQEETEMLRGFATAAPW
PIWTRRSDGTLSFANAAYARATDASDAADAIGRNLELLDSGDRAALARALGDGYEYSGRLPIVVGGERRYYDVRALKVSG
GSAGIAVDATETAALGAALERMADAHRRTLDQLSSGVAVFDAQRRLSFYNDSYRKLWDLDRIFLDSHPDDSTVLDRLRAE
RKLPEERDFKAWKNKLHEAYRAVEAEKDVWYLPDGRAVSIVTTPNPEGGVTYLFDDVTESLDLKRRYGGLIDVQRETLDN
LSEAVAVFGSNGCAQLFNPPFARMWNLSAEALQSQPHIEAIEEWCRPLFDDDVFWQALRGAITGIDDRRHVLLKIERKDG
SVLACKTMPLPDGATMLTFQDITDTENVERALRERNEALETADRIKIDFVHHVSYELRSPLTTIIGFAHFLSDSSTGPLT
EKQAEYVNYITTSTNALMAIINNILDLASIDAGAMTLNLGPIDIRKAIDAAAEGIQDRLARDQIALQIDVDPAIESFVGD
ERRVVQVLYNLLANAIDFSPSQGTVRLTVRRGETRVAFTVTDSGPGIAPAFKEKMFDLFESDPQGSRHRGAGLGLSLVRS
FVELHGGKVLVESAVGRGTSVTCEFPIEPAAQRHAAE
>Mature_836_residues
SGVLGSIRRTSLSCTSLVHGLAGTAVMVASSPARAADDHLAAITSSLLLDLNRHEMMTLIIALAALGFSVMSAIMLVRTR
QRAVAREAGLRADLQGLQAESDRFQALLFAEPQVLISWAAGDSRPQVSGDTALFLPLETQSRQPQRVLAFGTWLPPEPAL
QMDHAVDALLDKGEGFLLQLVTSNGRSIEAMGRAVGGQAVVRIRELSGVRRELADMTRRFKALQEETEMLRGFATAAPWP
IWTRRSDGTLSFANAAYARATDASDAADAIGRNLELLDSGDRAALARALGDGYEYSGRLPIVVGGERRYYDVRALKVSGG
SAGIAVDATETAALGAALERMADAHRRTLDQLSSGVAVFDAQRRLSFYNDSYRKLWDLDRIFLDSHPDDSTVLDRLRAER
KLPEERDFKAWKNKLHEAYRAVEAEKDVWYLPDGRAVSIVTTPNPEGGVTYLFDDVTESLDLKRRYGGLIDVQRETLDNL
SEAVAVFGSNGCAQLFNPPFARMWNLSAEALQSQPHIEAIEEWCRPLFDDDVFWQALRGAITGIDDRRHVLLKIERKDGS
VLACKTMPLPDGATMLTFQDITDTENVERALRERNEALETADRIKIDFVHHVSYELRSPLTTIIGFAHFLSDSSTGPLTE
KQAEYVNYITTSTNALMAIINNILDLASIDAGAMTLNLGPIDIRKAIDAAAEGIQDRLARDQIALQIDVDPAIESFVGDE
RRVVQVLYNLLANAIDFSPSQGTVRLTVRRGETRVAFTVTDSGPGIAPAFKEKMFDLFESDPQGSRHRGAGLGLSLVRSF
VELHGGKVLVESAVGRGTSVTCEFPIEPAAQRHAAE

Specific function: Required for cell division and growth. It catalyzes the phosphorylation of CtrA and activates transcription in vitro of the cell cycle-regulated fliF promoter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=238, Percent_Identity=28.5714285714286, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI1788713, Length=301, Percent_Identity=28.2392026578073, Blast_Score=111, Evalue=2e-25,
Organism=Escherichia coli, GI1789149, Length=245, Percent_Identity=29.3877551020408, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI48994928, Length=244, Percent_Identity=31.9672131147541, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI145693157, Length=259, Percent_Identity=28.1853281853282, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI87081816, Length=240, Percent_Identity=31.6666666666667, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1790861, Length=256, Percent_Identity=28.125, Blast_Score=93, Evalue=8e-20,
Organism=Escherichia coli, GI1786600, Length=270, Percent_Identity=24.8148148148148, Blast_Score=92, Evalue=2e-19,
Organism=Escherichia coli, GI1790436, Length=215, Percent_Identity=26.5116279069767, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1788549, Length=402, Percent_Identity=22.1393034825871, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1786912, Length=245, Percent_Identity=24.8979591836735, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI87082128, Length=240, Percent_Identity=26.6666666666667, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1790300, Length=376, Percent_Identity=23.936170212766, Blast_Score=76, Evalue=1e-14,
Organism=Escherichia coli, GI1788279, Length=202, Percent_Identity=26.7326732673267, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1786783, Length=233, Percent_Identity=28.755364806867, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 91661; Mature: 91530

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGVLGSIRRTSLSCTSLVHGLAGTAVMVASSPARAADDHLAAITSSLLLDLNRHEMMTL
CCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHH
IIALAALGFSVMSAIMLVRTRQRAVAREAGLRADLQGLQAESDRFQALLFAEPQVLISWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHEEEEEECCEEEEEEE
AGDSRPQVSGDTALFLPLETQSRQPQRVLAFGTWLPPEPALQMDHAVDALLDKGEGFLLQ
CCCCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEE
LVTSNGRSIEAMGRAVGGQAVVRIRELSGVRRELADMTRRFKALQEETEMLRGFATAAPW
EEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PIWTRRSDGTLSFANAAYARATDASDAADAIGRNLELLDSGDRAALARALGDGYEYSGRL
CCEECCCCCCEEECCCHHHCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHCCCCCCCCEE
PIVVGGERRYYDVRALKVSGGSAGIAVDATETAALGAALERMADAHRRTLDQLSSGVAVF
EEEECCCCEEEEEEEEEECCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEE
DAQRRLSFYNDSYRKLWDLDRIFLDSHPDDSTVLDRLRAERKLPEERDFKAWKNKLHEAY
EHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
RAVEAEKDVWYLPDGRAVSIVTTPNPEGGVTYLFDDVTESLDLKRRYGGLIDVQRETLDN
HHHHCCCCEEECCCCCEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHCCEEEEHHHHHHH
LSEAVAVFGSNGCAQLFNPPFARMWNLSAEALQSQPHIEAIEEWCRPLFDDDVFWQALRG
HHHHHHHHCCCCCHHHCCCCHHHHHCCCHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHH
AITGIDDRRHVLLKIERKDGSVLACKTMPLPDGATMLTFQDITDTENVERALRERNEALE
HHCCCCCCCEEEEEEEECCCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
TADRIKIDFVHHVSYELRSPLTTIIGFAHFLSDSSTGPLTEKQAEYVNYITTSTNALMAI
HHHHEEEEEHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHH
INNILDLASIDAGAMTLNLGPIDIRKAIDAAAEGIQDRLARDQIALQIDVDPAIESFVGD
HHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHCCC
ERRVVQVLYNLLANAIDFSPSQGTVRLTVRRGETRVAFTVTDSGPGIAPAFKEKMFDLFE
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCEEEEEEEECCCCCCCHHHHHHHHHHHC
SDPQGSRHRGAGLGLSLVRSFVELHGGKVLVESAVGRGTSVTCEFPIEPAAQRHAAE
CCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEHHCCCCCEEEEECCCCCHHHHCCCC
>Mature Secondary Structure 
SGVLGSIRRTSLSCTSLVHGLAGTAVMVASSPARAADDHLAAITSSLLLDLNRHEMMTL
CCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHH
IIALAALGFSVMSAIMLVRTRQRAVAREAGLRADLQGLQAESDRFQALLFAEPQVLISWA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHEEEEEECCEEEEEEE
AGDSRPQVSGDTALFLPLETQSRQPQRVLAFGTWLPPEPALQMDHAVDALLDKGEGFLLQ
CCCCCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEEE
LVTSNGRSIEAMGRAVGGQAVVRIRELSGVRRELADMTRRFKALQEETEMLRGFATAAPW
EEECCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PIWTRRSDGTLSFANAAYARATDASDAADAIGRNLELLDSGDRAALARALGDGYEYSGRL
CCEECCCCCCEEECCCHHHCCCCCCHHHHHHCCCEEEECCCCHHHHHHHHCCCCCCCCEE
PIVVGGERRYYDVRALKVSGGSAGIAVDATETAALGAALERMADAHRRTLDQLSSGVAVF
EEEECCCCEEEEEEEEEECCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEE
DAQRRLSFYNDSYRKLWDLDRIFLDSHPDDSTVLDRLRAERKLPEERDFKAWKNKLHEAY
EHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
RAVEAEKDVWYLPDGRAVSIVTTPNPEGGVTYLFDDVTESLDLKRRYGGLIDVQRETLDN
HHHHCCCCEEECCCCCEEEEEECCCCCCCEEEEEHHHHHHHHHHHHHCCEEEEHHHHHHH
LSEAVAVFGSNGCAQLFNPPFARMWNLSAEALQSQPHIEAIEEWCRPLFDDDVFWQALRG
HHHHHHHHCCCCCHHHCCCCHHHHHCCCHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHH
AITGIDDRRHVLLKIERKDGSVLACKTMPLPDGATMLTFQDITDTENVERALRERNEALE
HHCCCCCCCEEEEEEEECCCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHH
TADRIKIDFVHHVSYELRSPLTTIIGFAHFLSDSSTGPLTEKQAEYVNYITTSTNALMAI
HHHHEEEEEHHHHHHHHHCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHH
INNILDLASIDAGAMTLNLGPIDIRKAIDAAAEGIQDRLARDQIALQIDVDPAIESFVGD
HHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHCCC
ERRVVQVLYNLLANAIDFSPSQGTVRLTVRRGETRVAFTVTDSGPGIAPAFKEKMFDLFE
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCEEEEEEEECCCCCCCHHHHHHHHHHHC
SDPQGSRHRGAGLGLSLVRSFVELHGGKVLVESAVGRGTSVTCEFPIEPAAQRHAAE
CCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEHHCCCCCEEEEECCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10557274; 11259647 [H]