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The map label for this gene is cya [H]

Identifier: 190895181

GI number: 190895181

Start: 936891

End: 937940

Strand: Reverse

Name: cya [H]

Synonym: RHECIAT_PC0000854

Alternate gene names: 190895181

Gene position: 937940-936891 (Counterclockwise)

Preceding gene: 190895182

Following gene: 190895180

Centisome position: 85.93

GC content: 52.86

Gene sequence:

>1050_bases
ATGGCTACAGTTAATCTTTTGCCGGGCCAGGACAGTGATTTTTCTGATCAGGCAGGTCCGGTCAACGTTTACGGCACCGA
TGGGAACGATAATATTGTTGGTACTGACGCCAATGATAACCTGCGCGGCGGGATCGGGAACGACATCTTGGTCGGCGGCG
CTGGCGACGATTTCCTCGATGGTGGCGAGGGTAACGATAGGATGTACGGTGGCGTTGGTAACGACACTTATGTCGTGCAA
AGCGCGCAGGACGTTGTCGTAGAACTCGCTGGCGAGGGTATTGACCACGTGAAGGCCTACATCAGCTATACTCTCCGTCC
AAATGTCGAAAATCTGACGCTGATGGGCGAAGATAACCTTAATGGCTCGGGCAATGAGCTTAACAACACCATCAAGGGCA
ACATCGGAAACAACACGCTCTTCGGCGGCGACGGCGACGACAGCTTATTGGGTCTCGCGGGCAACGATATCATCCGCGGC
GGCAACGGTAATGACTTTATGGATGGTGGCACCGGTGTTGACCTGGTTTCTTACAAAGACGCACTCAATGGAGTGACGGT
CGATCTTTCGATAAACACCAAATCCCAGGATACAATTGGTGCTGGCCGTGACACGTTGAAAAACTTCGAGAACCTTGAAG
GCTCAATTTTTGCTGACAAGCTGTCTGGTGATGCCGGGGACAACAAGATCGCAGGCTTGGACGGCAACGATGTCATTCGC
GGCGGCGCCGGCAATGATGATATCACTGGTGGAGCAGGGGCGGATACTATCGTGTTTGAGGCCGCGGGCGCTACCAACGG
CGTCGACCGAATTCGCGATTTCCAATCCACCATTGACTCGCTGCAATTCAGTAAAGCCGATTATGACGTCAACGCCCTAT
TCACGTCGAGCGATAAGAGTGAAGCGGAGGGCGCTGGCGCACAATTCGTCTTTAACACTAAAACATTTGCACTTTACTAC
GATGCAGACGGAGAGGGCGGAAACGCCGCAATCCATATTGCAGATTTCACGCCAGTGACCGTGCACGCAGAAGATATCCA
CATCGTTTAA

Upstream 100 bases:

>100_bases
GCCAAATTAAACAGTGATAACAGCGTCCCATGTGGTTAGAAGTTAATCGTAAGAGTTTGATTTGGCTTATATGAGCAATC
AATTAAACAGGGAGTAAAAA

Downstream 100 bases:

>100_bases
GGCTGATTTGAACGCGCCGCTAACCAGCGGCGCGTTCAATCGGAAGTATTTAAATAATGTAGCTCGCCATTAACACTTAA
GACACCAATGCACTGTACTA

Product: hypothetical protein

Products: NA

Alternate protein names: AC-HLY; ACT; Cyclolysin; ATP pyrophosphate-lyase; Adenylyl cyclase [H]

Number of amino acids: Translated: 349; Mature: 348

Protein sequence:

>349_residues
MATVNLLPGQDSDFSDQAGPVNVYGTDGNDNIVGTDANDNLRGGIGNDILVGGAGDDFLDGGEGNDRMYGGVGNDTYVVQ
SAQDVVVELAGEGIDHVKAYISYTLRPNVENLTLMGEDNLNGSGNELNNTIKGNIGNNTLFGGDGDDSLLGLAGNDIIRG
GNGNDFMDGGTGVDLVSYKDALNGVTVDLSINTKSQDTIGAGRDTLKNFENLEGSIFADKLSGDAGDNKIAGLDGNDVIR
GGAGNDDITGGAGADTIVFEAAGATNGVDRIRDFQSTIDSLQFSKADYDVNALFTSSDKSEAEGAGAQFVFNTKTFALYY
DADGEGGNAAIHIADFTPVTVHAEDIHIV

Sequences:

>Translated_349_residues
MATVNLLPGQDSDFSDQAGPVNVYGTDGNDNIVGTDANDNLRGGIGNDILVGGAGDDFLDGGEGNDRMYGGVGNDTYVVQ
SAQDVVVELAGEGIDHVKAYISYTLRPNVENLTLMGEDNLNGSGNELNNTIKGNIGNNTLFGGDGDDSLLGLAGNDIIRG
GNGNDFMDGGTGVDLVSYKDALNGVTVDLSINTKSQDTIGAGRDTLKNFENLEGSIFADKLSGDAGDNKIAGLDGNDVIR
GGAGNDDITGGAGADTIVFEAAGATNGVDRIRDFQSTIDSLQFSKADYDVNALFTSSDKSEAEGAGAQFVFNTKTFALYY
DADGEGGNAAIHIADFTPVTVHAEDIHIV
>Mature_348_residues
ATVNLLPGQDSDFSDQAGPVNVYGTDGNDNIVGTDANDNLRGGIGNDILVGGAGDDFLDGGEGNDRMYGGVGNDTYVVQS
AQDVVVELAGEGIDHVKAYISYTLRPNVENLTLMGEDNLNGSGNELNNTIKGNIGNNTLFGGDGDDSLLGLAGNDIIRGG
NGNDFMDGGTGVDLVSYKDALNGVTVDLSINTKSQDTIGAGRDTLKNFENLEGSIFADKLSGDAGDNKIAGLDGNDVIRG
GAGNDDITGGAGADTIVFEAAGATNGVDRIRDFQSTIDSLQFSKADYDVNALFTSSDKSEAEGAGAQFVFNTKTFALYYD
ADGEGGNAAIHIADFTPVTVHAEDIHIV

Specific function: This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 17 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005165
- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF03497 Anthrax_toxA; PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 36017; Mature: 35886

Theoretical pI: Translated: 3.74; Mature: 3.74

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATVNLLPGQDSDFSDQAGPVNVYGTDGNDNIVGTDANDNLRGGIGNDILVGGAGDDFLD
CCEEEECCCCCCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCEEEECCCCCCCC
GGEGNDRMYGGVGNDTYVVQSAQDVVVELAGEGIDHVKAYISYTLRPNVENLTLMGEDNL
CCCCCCEEECCCCCCEEEEECHHHHHHHHHCCCHHHEEEEEEEEECCCCCEEEEEECCCC
NGSGNELNNTIKGNIGNNTLFGGDGDDSLLGLAGNDIIRGGNGNDFMDGGTGVDLVSYKD
CCCCCCCCCEEECCCCCCEEECCCCCCCEEEECCCCEEECCCCCCCCCCCCCEEEEEHHH
ALNGVTVDLSINTKSQDTIGAGRDTLKNFENLEGSIFADKLSGDAGDNKIAGLDGNDVIR
HHCCEEEEEEECCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCEEECCCCCCEEE
GGAGNDDITGGAGADTIVFEAAGATNGVDRIRDFQSTIDSLQFSKADYDVNALFTSSDKS
CCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHEECCCCCCEEEEEECCCCC
EAEGAGAQFVFNTKTFALYYDADGEGGNAAIHIADFTPVTVHAEDIHIV
CCCCCCEEEEEECEEEEEEECCCCCCCCEEEEEECCCEEEEEECEEEEC
>Mature Secondary Structure 
ATVNLLPGQDSDFSDQAGPVNVYGTDGNDNIVGTDANDNLRGGIGNDILVGGAGDDFLD
CEEEECCCCCCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCCCCCCEEEECCCCCCCC
GGEGNDRMYGGVGNDTYVVQSAQDVVVELAGEGIDHVKAYISYTLRPNVENLTLMGEDNL
CCCCCCEEECCCCCCEEEEECHHHHHHHHHCCCHHHEEEEEEEEECCCCCEEEEEECCCC
NGSGNELNNTIKGNIGNNTLFGGDGDDSLLGLAGNDIIRGGNGNDFMDGGTGVDLVSYKD
CCCCCCCCCEEECCCCCCEEECCCCCCCEEEECCCCEEECCCCCCCCCCCCCEEEEEHHH
ALNGVTVDLSINTKSQDTIGAGRDTLKNFENLEGSIFADKLSGDAGDNKIAGLDGNDVIR
HHCCEEEEEEECCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCEEECCCCCCEEE
GGAGNDDITGGAGADTIVFEAAGATNGVDRIRDFQSTIDSLQFSKADYDVNALFTSSDKS
CCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHEECCCCCCEEEEEECCCCC
EAEGAGAQFVFNTKTFALYYDADGEGGNAAIHIADFTPVTVHAEDIHIV
CCCCCCEEEEEECEEEEEEECCCCCCCCEEEEEECCCEEEEEECEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7557410; 12910271 [H]