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The map label for this gene is 190894907

Identifier: 190894907

GI number: 190894907

Start: 625601

End: 626599

Strand: Reverse

Name: 190894907

Synonym: RHECIAT_PC0000572

Alternate gene names: NA

Gene position: 626599-625601 (Counterclockwise)

Preceding gene: 190894908

Following gene: 190894906

Centisome position: 57.41

GC content: 61.86

Gene sequence:

>999_bases
ATGAGAAACAGCTTCTTCTGCATCGACGCCCATACCTGCGGCAACCCGGTCCGTCTCGTCGCCGGCGGCGGTCCGCTGCT
TCCGCATCTGCCGATGGGCGAGCGCCGGGAAATCTTTGTCCGCGACCATGACTGGGTTCGCAAGGCGCTGATGTTCGAGC
CGAGGGGGCATGACATTATGTCGGGCTCGATCATCTATCCGGCCTATCGGGAAGATTGTGATTTCGCCGTTCTTTTCATC
GAGGTAAGCGGCTGTCTGCCGATGTGCGGCGCCGGCACGATCGGCACCGTCACCGCCGCGATCGAAGAGGGCTTGGTCAA
GCCGCGTGAAGCCGGAAGGGTCGCTATCGAAACGCCGGCCGGCAGGGTCGACGTCACCTATGAGGAGAAGGGCGGCTATG
TCGATTCCGTTCGCCTCCACAATGTGGCGAGCTATCTCCACCAGGCGGATGTCGAGGTCGATGTGCCTGATATGGGCCGG
CTGCGTGTCGATATTTCCTATGGGGGCAACTATTATGCGGTCGTCGAGCCGCAGGAGAACTGGAGCGGGCTCGACGGCAT
GAGCGCCTCCGACATCGTCGGATGCAGCCAAAAGCTCCGGGCAGCGCTTGCCCATGTCGTCGATCCCGTTCATCCCGATG
ATCCGAGGATTCGCGGCGTCCATCACGCGATCTGGTGCGACCGCCCGGTGAATGATGTCTCGGACGGGCGCTGCGCCGTC
TTCTACGGAGAAAAGGCGATCGACCGGTCGCCCGGCGGCACCGGCACGTCCGCACGCATGGCGCAGCTTTACGGAAAGGG
CCGGCTTGCCGTCGGTTCGAGATACCGCCATGAAAGCCTGATCGGAACGATTTTCGAGGGCAGGGTCGAAGCCGAGGCGA
AAATCGGACCTTATGCCGGCATTCTTCCGAGTATCGGAGGCTGGGCGCGGGTGATCGGGCACAATACGATTTTCGTCGAC
GATCGCGATCCGCTGGCGCACGGTTTTCAAATTCGATGA

Upstream 100 bases:

>100_bases
CTGGCAATCGTTGCCGTCGCCCTGCTGCTCGACCGGTTGACCCGCGGCCTGTTCGACCGCGGCCGGCTGGCGAAGGCGCG
GTGAGCGGGGATATGAAAAA

Downstream 100 bases:

>100_bases
GGGGCGTTCGAAGGGGCAGGAGATGAACATGCGACCTGAACAGCATCGATTGGTAGACGATAGCGCAAAACAGCCGGCCC
GACTGAAGGTGGGGTTCGTT

Product: hydroxyproline-2-epimerase

Products: NA

Alternate protein names: Hydroxyproline-2-epimerase; HyPRE [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MRNSFFCIDAHTCGNPVRLVAGGGPLLPHLPMGERREIFVRDHDWVRKALMFEPRGHDIMSGSIIYPAYREDCDFAVLFI
EVSGCLPMCGAGTIGTVTAAIEEGLVKPREAGRVAIETPAGRVDVTYEEKGGYVDSVRLHNVASYLHQADVEVDVPDMGR
LRVDISYGGNYYAVVEPQENWSGLDGMSASDIVGCSQKLRAALAHVVDPVHPDDPRIRGVHHAIWCDRPVNDVSDGRCAV
FYGEKAIDRSPGGTGTSARMAQLYGKGRLAVGSRYRHESLIGTIFEGRVEAEAKIGPYAGILPSIGGWARVIGHNTIFVD
DRDPLAHGFQIR

Sequences:

>Translated_332_residues
MRNSFFCIDAHTCGNPVRLVAGGGPLLPHLPMGERREIFVRDHDWVRKALMFEPRGHDIMSGSIIYPAYREDCDFAVLFI
EVSGCLPMCGAGTIGTVTAAIEEGLVKPREAGRVAIETPAGRVDVTYEEKGGYVDSVRLHNVASYLHQADVEVDVPDMGR
LRVDISYGGNYYAVVEPQENWSGLDGMSASDIVGCSQKLRAALAHVVDPVHPDDPRIRGVHHAIWCDRPVNDVSDGRCAV
FYGEKAIDRSPGGTGTSARMAQLYGKGRLAVGSRYRHESLIGTIFEGRVEAEAKIGPYAGILPSIGGWARVIGHNTIFVD
DRDPLAHGFQIR
>Mature_332_residues
MRNSFFCIDAHTCGNPVRLVAGGGPLLPHLPMGERREIFVRDHDWVRKALMFEPRGHDIMSGSIIYPAYREDCDFAVLFI
EVSGCLPMCGAGTIGTVTAAIEEGLVKPREAGRVAIETPAGRVDVTYEEKGGYVDSVRLHNVASYLHQADVEVDVPDMGR
LRVDISYGGNYYAVVEPQENWSGLDGMSASDIVGCSQKLRAALAHVVDPVHPDDPRIRGVHHAIWCDRPVNDVSDGRCAV
FYGEKAIDRSPGGTGTSARMAQLYGKGRLAVGSRYRHESLIGTIFEGRVEAEAKIGPYAGILPSIGGWARVIGHNTIFVD
DRDPLAHGFQIR

Specific function: Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting 4- hydroxy-L-proline to 4-hydroxy-D-proline, which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases. Strong B-cell

COG id: COG3938

COG function: function code E; Proline racemase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the proline racemase family. 4- hydroxyproline epimerase subfamily [H]

Homologues:

Organism=Homo sapiens, GI21389361, Length=343, Percent_Identity=33.5276967930029, Blast_Score=162, Evalue=6e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008794 [H]

Pfam domain/function: PF05544 Pro_racemase [H]

EC number: =5.1.1.8 [H]

Molecular weight: Translated: 36211; Mature: 36211

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNSFFCIDAHTCGNPVRLVAGGGPLLPHLPMGERREIFVRDHDWVRKALMFEPRGHDIM
CCCCEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCEEEEECHHHHHHHHEECCCCCCCC
SGSIIYPAYREDCDFAVLFIEVSGCLPMCGAGTIGTVTAAIEEGLVKPREAGRVAIETPA
CCCEECCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCHHCCEEEEECCC
GRVDVTYEEKGGYVDSVRLHNVASYLHQADVEVDVPDMGRLRVDISYGGNYYAVVEPQEN
CEEEEEECCCCCEEEHHHHHHHHHHHHHCCCEECCCCCCEEEEEEEECCCEEEEECCCCC
WSGLDGMSASDIVGCSQKLRAALAHVVDPVHPDDPRIRGVHHAIWCDRPVNDVSDGRCAV
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEE
FYGEKAIDRSPGGTGTSARMAQLYGKGRLAVGSRYRHESLIGTIFEGRVEAEAKIGPYAG
EECCHHHCCCCCCCCCHHHHHHHHCCCEEEECCCHHHHHHHHHHHCCEEEECCCCCCCCC
ILPSIGGWARVIGHNTIFVDDRDPLAHGFQIR
CCCCCCCHHHEECCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MRNSFFCIDAHTCGNPVRLVAGGGPLLPHLPMGERREIFVRDHDWVRKALMFEPRGHDIM
CCCCEEEEECCCCCCCEEEEECCCCCCCCCCCCCCCEEEEECHHHHHHHHEECCCCCCCC
SGSIIYPAYREDCDFAVLFIEVSGCLPMCGAGTIGTVTAAIEEGLVKPREAGRVAIETPA
CCCEECCCCCCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCHHCCEEEEECCC
GRVDVTYEEKGGYVDSVRLHNVASYLHQADVEVDVPDMGRLRVDISYGGNYYAVVEPQEN
CEEEEEECCCCCEEEHHHHHHHHHHHHHCCCEECCCCCCEEEEEEEECCCEEEEECCCCC
WSGLDGMSASDIVGCSQKLRAALAHVVDPVHPDDPRIRGVHHAIWCDRPVNDVSDGRCAV
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEE
FYGEKAIDRSPGGTGTSARMAQLYGKGRLAVGSRYRHESLIGTIFEGRVEAEAKIGPYAG
EECCHHHCCCCCCCCCHHHHHHHHCCCEEEECCCHHHHHHHHHHHCCEEEECCCCCCCCC
ILPSIGGWARVIGHNTIFVDDRDPLAHGFQIR
CCCCCCCHHHEECCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA