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The map label for this gene is zraS [C]

Identifier: 190894792

GI number: 190894792

Start: 484783

End: 486456

Strand: Reverse

Name: zraS [C]

Synonym: RHECIAT_PC0000457

Alternate gene names: 190894792

Gene position: 486456-484783 (Counterclockwise)

Preceding gene: 190894793

Following gene: 190894791

Centisome position: 44.57

GC content: 64.81

Gene sequence:

>1674_bases
ATGAACCCCGTCAACATCCTCCTCGTCGACGACCAGCCCGCCAAACTCCTGAGCTACGAGGTCATTCTCGAAGAGCTTGA
GGAGAACCTCATCAAGGCGCAGTCGGCCCGCGAAGCCTTCGAGCACCTGCTGCGCACTGAAATCGCCGTCATCCTGGTAG
ATGTCTGCATGCCGGAACAGGATGGTTTCGAGCTCGTTAGCATGATCCGGCAACACCCGCGCTATCAGAACACGCCGATC
ATCTTCGTCTCGGCCGTCATGCTGGCCGAACCGGACCGGCTGCGCGGCTATGCGGTCGGTGCCGTCGACTACGTCTCCGT
CCCGATCGTGCCCGAGGTGCTGAGGGCCAAGGTCCGGGTCTTTGCCGATCTCTACAGAAAGACGCGGGAGCTCGAGCGGC
TGAACGCCGATCTGGAAGCTAGGGTGCACCAGCGCACCGCCGAGCTCGAGGCTTCTGCCATCCAGTTGCGTCAACTGAAC
GAGGAGCTCGAGCAGCGGATCGACCAGCGGACGCGCGAGCGTGAGGAGGCGCTGGCGCAGCTTTTCGAAGCGCAGAAGCT
CGACACGATCGGTCACCTCACCGGCGGCGTGGCGCACGATTTCAACAATCTTCTCATGGCAGTGCTCGGCAGCCTCAGCC
TGCTGAAGAAGCGGCTGCCGGCGGACGAGCGCAGCGAACGCCTGGTGACGAATGCCATCCAGGCGGCCGAGCGCGGCACG
GCGCTCACCCAGCGCCTGCTCGCCTTCGCGCGGCGCCAGGAACTGAAGCCGCAGGCAGTCGACTTCCTCAGGCTGTTTGA
AAATATCGAGGATCTGCTCGCCAAGGCGGTGGGACCGCGCGTCGAGATCCGAAAGTGCATCCCGGCGGATCTGCCGCCGC
TCTTGGTCGACAGCAATCAGCTGGAGCTGGCGCTGCTCAACCTCTTCGTCAATGCACGCGATGCGCTCGAAAGCGGCGGT
GCGGTGACGGTCGCGGCGGCTGCGGAGGAGGCACGGCCGACCGGCCTTGCGGGCGGAAATTACATCAAGATATCGGTCTC
GGACGATGGCGAAGGGATGGACGAGGCGACGGTCCTGCGTGCCGCCGAGCCATTTTTCACCACCAAGGGGATCGGCAAGG
GCACCGGCCTCGGCCTGTCGATGGTGCACGGCCTGGCAGCGCAATCGGGCGGCTCGATCCAGATTTCGAGCACGAGAGGC
AAGGGCACCACCGTCTCACTCTGGCTGCCCGTCGCCGAGAGCTTCACCAGGGCGCAGGCGGCGGACGTGCCGACAGCGGC
GGAACCGGTGAAGCCGGTGTCGCGATCGCTCGCCATTCTTGTCGTCGACGACGATGCGCTCGTCAGGACTGGAACTGTGG
CGATGCTGGAGGATCTCGGACATTTGCCGCGGGAGGCGTCTTCCGCCTCCCAGGCTCTGGAATTCTTCGCCGGCGGGCAG
GAGTGCGATCTGGTTATCACCGATCACGCCATGCCGGGCATGACCGGCGCCGAGCTTGCGCGCCACCTTCGTGCAGCCTT
TCCCAACCTGCCCGTGATCCTCGCTTCCGGCTATGTCGAGCTTGCCGAGGACCAGGGGCTCGGCCGGTTGCTCAGAATGA
CGAAGCCGTTCACCCAAGAGCAGCTTCAGGCCGCCATGGACGAAGCGCTCCGGGACAAGGTCGCTGCGGCGTGA

Upstream 100 bases:

>100_bases
TGCCTCGAGGCGGGTGCGTCGGATTACCTGGCGAAGCCCGTCAACACCGAGCAGCTGCTGTCAGCGCTGCGCATGTGGCT
GCACCGTTGAGGATCCGGCC

Downstream 100 bases:

>100_bases
TCGACGAAGCGAGCGGCTGGCCCTTCACTTTGATAGGCAGGCAGCTTGCGATTGTGATGAGTTTAGGAAATCCCACTCCC
TCTCGGCCTGCACGCTGCTG

Product: putative two-component sensor histidine kinase/response regulator hybrid protein

Products: NA

Alternate protein names: Blue-light-activated histidine kinase; Response regulator [H]

Number of amino acids: Translated: 557; Mature: 557

Protein sequence:

>557_residues
MNPVNILLVDDQPAKLLSYEVILEELEENLIKAQSAREAFEHLLRTEIAVILVDVCMPEQDGFELVSMIRQHPRYQNTPI
IFVSAVMLAEPDRLRGYAVGAVDYVSVPIVPEVLRAKVRVFADLYRKTRELERLNADLEARVHQRTAELEASAIQLRQLN
EELEQRIDQRTREREEALAQLFEAQKLDTIGHLTGGVAHDFNNLLMAVLGSLSLLKKRLPADERSERLVTNAIQAAERGT
ALTQRLLAFARRQELKPQAVDFLRLFENIEDLLAKAVGPRVEIRKCIPADLPPLLVDSNQLELALLNLFVNARDALESGG
AVTVAAAAEEARPTGLAGGNYIKISVSDDGEGMDEATVLRAAEPFFTTKGIGKGTGLGLSMVHGLAAQSGGSIQISSTRG
KGTTVSLWLPVAESFTRAQAADVPTAAEPVKPVSRSLAILVVDDDALVRTGTVAMLEDLGHLPREASSASQALEFFAGGQ
ECDLVITDHAMPGMTGAELARHLRAAFPNLPVILASGYVELAEDQGLGRLLRMTKPFTQEQLQAAMDEALRDKVAAA

Sequences:

>Translated_557_residues
MNPVNILLVDDQPAKLLSYEVILEELEENLIKAQSAREAFEHLLRTEIAVILVDVCMPEQDGFELVSMIRQHPRYQNTPI
IFVSAVMLAEPDRLRGYAVGAVDYVSVPIVPEVLRAKVRVFADLYRKTRELERLNADLEARVHQRTAELEASAIQLRQLN
EELEQRIDQRTREREEALAQLFEAQKLDTIGHLTGGVAHDFNNLLMAVLGSLSLLKKRLPADERSERLVTNAIQAAERGT
ALTQRLLAFARRQELKPQAVDFLRLFENIEDLLAKAVGPRVEIRKCIPADLPPLLVDSNQLELALLNLFVNARDALESGG
AVTVAAAAEEARPTGLAGGNYIKISVSDDGEGMDEATVLRAAEPFFTTKGIGKGTGLGLSMVHGLAAQSGGSIQISSTRG
KGTTVSLWLPVAESFTRAQAADVPTAAEPVKPVSRSLAILVVDDDALVRTGTVAMLEDLGHLPREASSASQALEFFAGGQ
ECDLVITDHAMPGMTGAELARHLRAAFPNLPVILASGYVELAEDQGLGRLLRMTKPFTQEQLQAAMDEALRDKVAAA
>Mature_557_residues
MNPVNILLVDDQPAKLLSYEVILEELEENLIKAQSAREAFEHLLRTEIAVILVDVCMPEQDGFELVSMIRQHPRYQNTPI
IFVSAVMLAEPDRLRGYAVGAVDYVSVPIVPEVLRAKVRVFADLYRKTRELERLNADLEARVHQRTAELEASAIQLRQLN
EELEQRIDQRTREREEALAQLFEAQKLDTIGHLTGGVAHDFNNLLMAVLGSLSLLKKRLPADERSERLVTNAIQAAERGT
ALTQRLLAFARRQELKPQAVDFLRLFENIEDLLAKAVGPRVEIRKCIPADLPPLLVDSNQLELALLNLFVNARDALESGG
AVTVAAAAEEARPTGLAGGNYIKISVSDDGEGMDEATVLRAAEPFFTTKGIGKGTGLGLSMVHGLAAQSGGSIQISSTRG
KGTTVSLWLPVAESFTRAQAADVPTAAEPVKPVSRSLAILVVDDDALVRTGTVAMLEDLGHLPREASSASQALEFFAGGQ
ECDLVITDHAMPGMTGAELARHLRAAFPNLPVILASGYVELAEDQGLGRLLRMTKPFTQEQLQAAMDEALRDKVAAA

Specific function: Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=241, Percent_Identity=33.6099585062241, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI1788549, Length=239, Percent_Identity=29.2887029288703, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI48994928, Length=373, Percent_Identity=29.4906166219839, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788713, Length=367, Percent_Identity=26.4305177111717, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87081816, Length=408, Percent_Identity=24.2647058823529, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 60657; Mature: 60657

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPVNILLVDDQPAKLLSYEVILEELEENLIKAQSAREAFEHLLRTEIAVILVDVCMPEQ
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DGFELVSMIRQHPRYQNTPIIFVSAVMLAEPDRLRGYAVGAVDYVSVPIVPEVLRAKVRV
CCHHHHHHHHHCCCCCCCCEEEEEHHHHCCCHHHCCEEECCHHHEECCCHHHHHHHHHHH
FADLYRKTRELERLNADLEARVHQRTAELEASAIQLRQLNEELEQRIDQRTREREEALAQ
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFEAQKLDTIGHLTGGVAHDFNNLLMAVLGSLSLLKKRLPADERSERLVTNAIQAAERGT
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
ALTQRLLAFARRQELKPQAVDFLRLFENIEDLLAKAVGPRVEIRKCIPADLPPLLVDSNQ
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCEEECCCC
LELALLNLFVNARDALESGGAVTVAAAAEEARPTGLAGGNYIKISVSDDGEGMDEATVLR
HHHHHHHHHHHHHHHHHCCCCEEEEECHHHCCCCCCCCCCEEEEEECCCCCCCCHHHHHH
AAEPFFTTKGIGKGTGLGLSMVHGLAAQSGGSIQISSTRGKGTTVSLWLPVAESFTRAQA
HCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEECHHHHHHHHHH
ADVPTAAEPVKPVSRSLAILVVDDDALVRTGTVAMLEDLGHLPREASSASQALEFFAGGQ
CCCCCCCCCCHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
ECDLVITDHAMPGMTGAELARHLRAAFPNLPVILASGYVELAEDQGLGRLLRMTKPFTQE
CEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEECCCHHHHCCCCHHHHHHHCCCCCHH
QLQAAMDEALRDKVAAA
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNPVNILLVDDQPAKLLSYEVILEELEENLIKAQSAREAFEHLLRTEIAVILVDVCMPEQ
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DGFELVSMIRQHPRYQNTPIIFVSAVMLAEPDRLRGYAVGAVDYVSVPIVPEVLRAKVRV
CCHHHHHHHHHCCCCCCCCEEEEEHHHHCCCHHHCCEEECCHHHEECCCHHHHHHHHHHH
FADLYRKTRELERLNADLEARVHQRTAELEASAIQLRQLNEELEQRIDQRTREREEALAQ
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFEAQKLDTIGHLTGGVAHDFNNLLMAVLGSLSLLKKRLPADERSERLVTNAIQAAERGT
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
ALTQRLLAFARRQELKPQAVDFLRLFENIEDLLAKAVGPRVEIRKCIPADLPPLLVDSNQ
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCEEECCCC
LELALLNLFVNARDALESGGAVTVAAAAEEARPTGLAGGNYIKISVSDDGEGMDEATVLR
HHHHHHHHHHHHHHHHHCCCCEEEEECHHHCCCCCCCCCCEEEEEECCCCCCCCHHHHHH
AAEPFFTTKGIGKGTGLGLSMVHGLAAQSGGSIQISSTRGKGTTVSLWLPVAESFTRAQA
HCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEECHHHHHHHHHH
ADVPTAAEPVKPVSRSLAILVVDDDALVRTGTVAMLEDLGHLPREASSASQALEFFAGGQ
CCCCCCCCCCHHHCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCC
ECDLVITDHAMPGMTGAELARHLRAAFPNLPVILASGYVELAEDQGLGRLLRMTKPFTQE
CEEEEEECCCCCCCCHHHHHHHHHHHCCCCCEEEECCCHHHHCCCCHHHHHHHCCCCCHH
QLQAAMDEALRDKVAAA
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA