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The map label for this gene is eIF1A [H]

Identifier: 18977954

GI number: 18977954

Start: 1478198

End: 1478539

Strand: Reverse

Name: eIF1A [H]

Synonym: PF1582

Alternate gene names: 18977954

Gene position: 1478539-1478198 (Counterclockwise)

Preceding gene: 18977958

Following gene: 18977953

Centisome position: 77.48

GC content: 43.57

Gene sequence:

>342_bases
ATGCCTAAGAAAGAGAGGAAAGTTGAGGGAGAAGAGGTTATTAGAGTTCCTCTACCAGAAGGAAACCAGTTATTTGGGGT
AGTAGAACAAGCCTTAGGGGCAGGATGGATGGACGTTAGATGTGAGGATGGGAAAGTTAGAAGATGCAGAATCCCAGGTA
GACTAAGGAGAAGAGTGTGGATTAAAGTTGGTGACCTTGTAATTGTTGAACCATGGCCTGTGCAGAGTGACAAAAGAGGT
GACATAGTTTACAGATATACCCAAACACAAGTGGAATGGTTACTTAGAAAAGGAAAGATCAGTCAGGAATTTCTCACAGG
TGGCTCTCTGCTGCTAGAGTGA

Upstream 100 bases:

>100_bases
AGGTGTTGGTCATGTAATTGTGTGTCCTATGCAAAAATTTTTAAACACTCATGTGAAGAGAGAGACAGAAAAATTTTTGC
AAAATTAGGAGGTGATGCTC

Downstream 100 bases:

>100_bases
TGGGACATGGAATGGCTAGATAAAGAAATTGCAGAAGTTCTTGGGTTAACTGAGAGGAGAGAGAAGGATAGTGAGCTCTT
TAAAGTATTTAGTGAAGTAT

Product: translation initiation factor IF-1A

Products: NA

Alternate protein names: aIF-1A [H]

Number of amino acids: Translated: 113; Mature: 112

Protein sequence:

>113_residues
MPKKERKVEGEEVIRVPLPEGNQLFGVVEQALGAGWMDVRCEDGKVRRCRIPGRLRRRVWIKVGDLVIVEPWPVQSDKRG
DIVYRYTQTQVEWLLRKGKISQEFLTGGSLLLE

Sequences:

>Translated_113_residues
MPKKERKVEGEEVIRVPLPEGNQLFGVVEQALGAGWMDVRCEDGKVRRCRIPGRLRRRVWIKVGDLVIVEPWPVQSDKRG
DIVYRYTQTQVEWLLRKGKISQEFLTGGSLLLE
>Mature_112_residues
PKKERKVEGEEVIRVPLPEGNQLFGVVEQALGAGWMDVRCEDGKVRRCRIPGRLRRRVWIKVGDLVIVEPWPVQSDKRGD
IVYRYTQTQVEWLLRKGKISQEFLTGGSLLLE

Specific function: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits [H]

COG id: COG0361

COG function: function code J; Translation initiation factor 1 (IF-1)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1-like domain [H]

Homologues:

Organism=Caenorhabditis elegans, GI17540984, Length=85, Percent_Identity=42.3529411764706, Blast_Score=66, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR006196
- InterPro:   IPR001253
- InterPro:   IPR018104
- ProDom:   PD005579 [H]

Pfam domain/function: PF01176 eIF-1a [H]

EC number: NA

Molecular weight: Translated: 13072; Mature: 12941

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: PS50832 S1_IF1_TYPE ; PS01262 IF1A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKKERKVEGEEVIRVPLPEGNQLFGVVEQALGAGWMDVRCEDGKVRRCRIPGRLRRRVW
CCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCEEEEECCHHHCEEEE
IKVGDLVIVEPWPVQSDKRGDIVYRYTQTQVEWLLRKGKISQEFLTGGSLLLE
EEECCEEEECCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCHHHHCCCEEEEC
>Mature Secondary Structure 
PKKERKVEGEEVIRVPLPEGNQLFGVVEQALGAGWMDVRCEDGKVRRCRIPGRLRRRVW
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCEEEEECCHHHCEEEE
IKVGDLVIVEPWPVQSDKRGDIVYRYTQTQVEWLLRKGKISQEFLTGGSLLLE
EEECCEEEECCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCHHHHCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]