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The map label for this gene is rio1 [H]

Identifier: 18977953

GI number: 18977953

Start: 1477391

End: 1478191

Strand: Reverse

Name: rio1 [H]

Synonym: PF1581

Alternate gene names: 18977953

Gene position: 1478191-1477391 (Counterclockwise)

Preceding gene: 18977954

Following gene: 18977952

Centisome position: 77.46

GC content: 39.2

Gene sequence:

>801_bases
ATGGAATGGCTAGATAAAGAAATTGCAGAAGTTCTTGGGTTAACTGAGAGGAGAGAGAAGGATAGTGAGCTCTTTAAAGT
ATTTAGTGAAGTATTTGACAGAACTACAGTAGAGACCATTAGCTATTTTTACAGAAGGGGGAAGATAGAACGTCTCTATG
GAGTTCTAAGTACGGGAAAAGAAGCTAATGTGTTTGCTGGATTCGACTCAAAAGGAAACAGAATTGCCGTTAAAATATAT
CGGACTTACACTACCGAATTTAGAAGGATCTGGGAGTATTTGGCAGCAGATCCAAGAGTGGGCTACCTACCTAAAGACAT
TAGAAAGTTGGTGTTTGTTTGGACAAGAAGAGAGTTTAAAAATCTGCAAAGAGCCATGAAGTATGCAGTAAGAGCACCAG
AGCCAATAGCGTTTAGAAATAATGTTCTTATAATGGAATACATTGGAGATGATCGACCAGCTCCCAGGTTAAAGGACATT
GAGAAAGATTTGGAGCTTAAAGACTTTGAAGAGCTCTACGATTTTGCTATGGGGAGTATAGAGAAATTGTGGAAAAGAGG
GGATATGGTTCATGGAGATCTGAGTGAATACAACATCCTTATCTGGAACGAACCTGTAATTATAGATTGGTCCCAAGCAA
CTGTAAAGAGAAATAGAATGAGCTTGACCCTCCTTTACAGAGATATTAGAAATATCACTAATTACTTCGGTAGAAAGGGT
GTTAGCGTGGAAAATCCTGAGGAGAAATTCAGAGAGTTGGCGGGTGATGAGTTATGGGAGAGGACTTTGAGAAACTTATG
A

Upstream 100 bases:

>100_bases
TTACAGATATACCCAAACACAAGTGGAATGGTTACTTAGAAAAGGAAAGATCAGTCAGGAATTTCTCACAGGTGGCTCTC
TGCTGCTAGAGTGATGGGAC

Downstream 100 bases:

>100_bases
AAAAATTTGAGAAGGTTAGTAAAGATGGTGAGATTATTAAAGAGGAAGAGGATGAAGAGTGGGAAGAATTCTTCAAGCAA
GAAGAATATGTTAAGATTCC

Product: rio1 protein, putative

Products: NA

Alternate protein names: AfRio1 [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MEWLDKEIAEVLGLTERREKDSELFKVFSEVFDRTTVETISYFYRRGKIERLYGVLSTGKEANVFAGFDSKGNRIAVKIY
RTYTTEFRRIWEYLAADPRVGYLPKDIRKLVFVWTRREFKNLQRAMKYAVRAPEPIAFRNNVLIMEYIGDDRPAPRLKDI
EKDLELKDFEELYDFAMGSIEKLWKRGDMVHGDLSEYNILIWNEPVIIDWSQATVKRNRMSLTLLYRDIRNITNYFGRKG
VSVENPEEKFRELAGDELWERTLRNL

Sequences:

>Translated_266_residues
MEWLDKEIAEVLGLTERREKDSELFKVFSEVFDRTTVETISYFYRRGKIERLYGVLSTGKEANVFAGFDSKGNRIAVKIY
RTYTTEFRRIWEYLAADPRVGYLPKDIRKLVFVWTRREFKNLQRAMKYAVRAPEPIAFRNNVLIMEYIGDDRPAPRLKDI
EKDLELKDFEELYDFAMGSIEKLWKRGDMVHGDLSEYNILIWNEPVIIDWSQATVKRNRMSLTLLYRDIRNITNYFGRKG
VSVENPEEKFRELAGDELWERTLRNL
>Mature_266_residues
MEWLDKEIAEVLGLTERREKDSELFKVFSEVFDRTTVETISYFYRRGKIERLYGVLSTGKEANVFAGFDSKGNRIAVKIY
RTYTTEFRRIWEYLAADPRVGYLPKDIRKLVFVWTRREFKNLQRAMKYAVRAPEPIAFRNNVLIMEYIGDDRPAPRLKDI
EKDLELKDFEELYDFAMGSIEKLWKRGDMVHGDLSEYNILIWNEPVIIDWSQATVKRNRMSLTLLYRDIRNITNYFGRKG
VSVENPEEKFRELAGDELWERTLRNL

Specific function: Autophosphorylation of the rio1 protein is not necessary for maintenance of kinase activity. Prefers ATP over GTP. The yeast ortholog is involved in ribosome biogenesis [H]

COG id: COG1718

COG function: function code TD; Serine/threonine protein kinase involved in cell cycle control

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI23510356, Length=251, Percent_Identity=33.8645418326693, Blast_Score=131, Evalue=5e-31,
Organism=Homo sapiens, GI22325377, Length=214, Percent_Identity=30.8411214953271, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI23510358, Length=136, Percent_Identity=36.0294117647059, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17556977, Length=228, Percent_Identity=33.7719298245614, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI115532073, Length=231, Percent_Identity=32.4675324675325, Blast_Score=121, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71989043, Length=146, Percent_Identity=33.5616438356164, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324693, Length=246, Percent_Identity=32.1138211382114, Blast_Score=113, Evalue=4e-26,
Organism=Drosophila melanogaster, GI24662811, Length=226, Percent_Identity=34.9557522123894, Blast_Score=127, Evalue=8e-30,
Organism=Drosophila melanogaster, GI21356879, Length=226, Percent_Identity=34.9557522123894, Blast_Score=127, Evalue=8e-30,
Organism=Drosophila melanogaster, GI19920700, Length=219, Percent_Identity=29.6803652968037, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24649986, Length=239, Percent_Identity=23.0125523012552, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR018934
- InterPro:   IPR000687
- InterPro:   IPR018935 [H]

Pfam domain/function: PF01163 RIO1 [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 31741; Mature: 31741

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: PS00109 PROTEIN_KINASE_TYR ; PS01245 RIO1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEWLDKEIAEVLGLTERREKDSELFKVFSEVFDRTTVETISYFYRRGKIERLYGVLSTGK
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
EANVFAGFDSKGNRIAVKIYRTYTTEFRRIWEYLAADPRVGYLPKDIRKLVFVWTRREFK
CCCEEECCCCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
NLQRAMKYAVRAPEPIAFRNNVLIMEYIGDDRPAPRLKDIEKDLELKDFEELYDFAMGSI
HHHHHHHHHHCCCCCEEECCCEEEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHH
EKLWKRGDMVHGDLSEYNILIWNEPVIIDWSQATVKRNRMSLTLLYRDIRNITNYFGRKG
HHHHHCCCCCCCCCCCCEEEEECCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VSVENPEEKFRELAGDELWERTLRNL
CCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEWLDKEIAEVLGLTERREKDSELFKVFSEVFDRTTVETISYFYRRGKIERLYGVLSTGK
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
EANVFAGFDSKGNRIAVKIYRTYTTEFRRIWEYLAADPRVGYLPKDIRKLVFVWTRREFK
CCCEEECCCCCCCEEEEEEEHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
NLQRAMKYAVRAPEPIAFRNNVLIMEYIGDDRPAPRLKDIEKDLELKDFEELYDFAMGSI
HHHHHHHHHHCCCCCEEECCCEEEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHH
EKLWKRGDMVHGDLSEYNILIWNEPVIIDWSQATVKRNRMSLTLLYRDIRNITNYFGRKG
HHHHHCCCCCCCCCCCCEEEEECCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VSVENPEEKFRELAGDELWERTLRNL
CCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9389475 [H]