| Definition | Pyrococcus furiosus DSM 3638, complete genome. |
|---|---|
| Accession | NC_003413 |
| Length | 1,908,256 |
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The map label for this gene is coaBC [H]
Identifier: 18977812
GI number: 18977812
Start: 1349191
End: 1350399
Strand: Direct
Name: coaBC [H]
Synonym: PF1440
Alternate gene names: 18977812
Gene position: 1349191-1350399 (Clockwise)
Preceding gene: 18977809
Following gene: 18977826
Centisome position: 70.7
GC content: 39.95
Gene sequence:
>1209_bases ATGCTTCACCACGTCAAGCTAATCTACGCCACAAAAAGTCGAAAGCTAGTTGGAAAAAAGATAGTTCTCGCAATCCCAGG GAGTATTGCAGCTGTGGAATGTGTAAAGCTTGCTAGGGAACTAATTAGGCATGGGGCCGAAGTTCATGCAGTGATGAGTG AGGCAGCCACCAAGATAATTCATCCTTATGCAATGGAATTTGCCACGGGAAATCCAGTCATAACTGAGATCACTGGATTT ATCGAGCATGTTGAGTTAGCAGGGGAACATGAGAATAAAGCAGATTTAATTTTGGTTTGTCCTGCCACTGCCAACACAAT TAGTAAGATTGCATGTGGAATAGATGATACTCCAGTAACTACAGTCGTGACCACAGCATTTCCCCACATTCCAATTATGA TAGCCCCAGCAATGCATGAGACAATGTACAGGCATCCCATAGTAAGGGAGAACATTGAAAGGTTAAAGAAGCTTGGCGTT GAGTTTATAGGACCAAGAATTGAGGAGGGAAAGGCAAAAGTTGCAAGCATTGATGAAATAGTTTACAGAGTTATTAAAAA GCTCCACAAAAAAACATTGGAAGGGAAGAGAGTCCTAGTAACGGCGGGAGCAACAAGAGAGTACATAGATCCAATAAGAT TCATAACAAATGCCAGCAGTGGAAAAATGGGAGTAGCGTTGGCTGAAGAAGCAGATTTTAGAGGAGCTGAGGTTACCCTC ATAAGAACAAAGGGAAGTGTAAAGAGCTTTGTAGAAAATCAAATTGAAGTTGAGACAGTGGAAGAAATGCTTTCAGCGAT TGAAAATGAGTTGAGGAGTAAAAAGTATGACGTAGTTATTATGGCAGCTGCTGTAAGCGATTTTAGGCCAAAAATTAAAG CAGAGGGAAAAATTAAAAGCGATAGATCAATAACGATAGAGCTCGTTCCAAATCCCAAAATCATTGATAGAATAAAGGAA ATTCAACCAAATGTCTTTCTTGTTGGATTTAAAGCAGAAACTTCAAAAGAAAAGCTTATAGAAGAAGGTAAAAGGCAGAT TGAGAGGGCCAAGGCTGACTTAGTCGTTGGTAACACATTGGAAGCCTTTGGAAGCGAGGAAAACCAAGTAGTATTAATTG GCAGAGATTTCACAAAAGAACTTCCAAAAATGAAAAAGAGAGAGTTAGCAGAGAGAATTTGGGATGAGATAGAGAAATTA CTGTCCTGA
Upstream 100 bases:
>100_bases GCCAAGAGATGTATTTCCGCTTTCCATTATTTCCACCTCTTTCTAGAATAAAAGCAAAGGTTAATTAAACTTTCGACAAT TAATCTTTGAGGGAAGAAAA
Downstream 100 bases:
>100_bases TTCCTTCTTTTCTTCCTCTTGCTGTTTTGTTGTGGGCTGGGGTTTTACTGGAGGCTTAAGTCCATAACCAAGTATTTTGA ATTTGAATGTGGTGCCATCT
Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase
Products: NA
Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]
Number of amino acids: Translated: 402; Mature: 402
Protein sequence:
>402_residues MLHHVKLIYATKSRKLVGKKIVLAIPGSIAAVECVKLARELIRHGAEVHAVMSEAATKIIHPYAMEFATGNPVITEITGF IEHVELAGEHENKADLILVCPATANTISKIACGIDDTPVTTVVTTAFPHIPIMIAPAMHETMYRHPIVRENIERLKKLGV EFIGPRIEEGKAKVASIDEIVYRVIKKLHKKTLEGKRVLVTAGATREYIDPIRFITNASSGKMGVALAEEADFRGAEVTL IRTKGSVKSFVENQIEVETVEEMLSAIENELRSKKYDVVIMAAAVSDFRPKIKAEGKIKSDRSITIELVPNPKIIDRIKE IQPNVFLVGFKAETSKEKLIEEGKRQIERAKADLVVGNTLEAFGSEENQVVLIGRDFTKELPKMKKRELAERIWDEIEKL LS
Sequences:
>Translated_402_residues MLHHVKLIYATKSRKLVGKKIVLAIPGSIAAVECVKLARELIRHGAEVHAVMSEAATKIIHPYAMEFATGNPVITEITGF IEHVELAGEHENKADLILVCPATANTISKIACGIDDTPVTTVVTTAFPHIPIMIAPAMHETMYRHPIVRENIERLKKLGV EFIGPRIEEGKAKVASIDEIVYRVIKKLHKKTLEGKRVLVTAGATREYIDPIRFITNASSGKMGVALAEEADFRGAEVTL IRTKGSVKSFVENQIEVETVEEMLSAIENELRSKKYDVVIMAAAVSDFRPKIKAEGKIKSDRSITIELVPNPKIIDRIKE IQPNVFLVGFKAETSKEKLIEEGKRQIERAKADLVVGNTLEAFGSEENQVVLIGRDFTKELPKMKKRELAERIWDEIEKL LS >Mature_402_residues MLHHVKLIYATKSRKLVGKKIVLAIPGSIAAVECVKLARELIRHGAEVHAVMSEAATKIIHPYAMEFATGNPVITEITGF IEHVELAGEHENKADLILVCPATANTISKIACGIDDTPVTTVVTTAFPHIPIMIAPAMHETMYRHPIVRENIERLKKLGV EFIGPRIEEGKAKVASIDEIVYRVIKKLHKKTLEGKRVLVTAGATREYIDPIRFITNASSGKMGVALAEEADFRGAEVTL IRTKGSVKSFVENQIEVETVEEMLSAIENELRSKKYDVVIMAAAVSDFRPKIKAEGKIKSDRSITIELVPNPKIIDRIKE IQPNVFLVGFKAETSKEKLIEEGKRQIERAKADLVVGNTLEAFGSEENQVVLIGRDFTKELPKMKKRELAERIWDEIEKL LS
Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]
COG id: COG0452
COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]
Homologues:
Organism=Escherichia coli, GI87082301, Length=409, Percent_Identity=33.7408312958435, Blast_Score=173, Evalue=2e-44, Organism=Drosophila melanogaster, GI24657262, Length=160, Percent_Identity=30.625, Blast_Score=67, Evalue=2e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005252 - InterPro: IPR007085 - InterPro: IPR003382 [H]
Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]
EC number: =4.1.1.36; =6.3.2.5 [H]
Molecular weight: Translated: 44722; Mature: 44722
Theoretical pI: Translated: 8.74; Mature: 8.74
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 2.5 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 2.5 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLHHVKLIYATKSRKLVGKKIVLAIPGSIAAVECVKLARELIRHGAEVHAVMSEAATKII CCCEEEEEEEECCCHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH HPYAMEFATGNPVITEITGFIEHVELAGEHENKADLILVCPATANTISKIACGIDDTPVT CHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCHH TVVTTAFPHIPIMIAPAMHETMYRHPIVRENIERLKKLGVEFIGPRIEEGKAKVASIDEI HHHHHCCCCCCEEEECHHHHHHHHCCHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHH VYRVIKKLHKKTLEGKRVLVTAGATREYIDPIRFITNASSGKMGVALAEEADFRGAEVTL HHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEE IRTKGSVKSFVENQIEVETVEEMLSAIENELRSKKYDVVIMAAAVSDFRPKIKAEGKIKS EECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCCCCCCCCCC DRSITIELVPNPKIIDRIKEIQPNVFLVGFKAETSKEKLIEEGKRQIERAKADLVVGNTL CCEEEEEECCCCHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCEEECCCH EAFGSEENQVVLIGRDFTKELPKMKKRELAERIWDEIEKLLS HHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHC >Mature Secondary Structure MLHHVKLIYATKSRKLVGKKIVLAIPGSIAAVECVKLARELIRHGAEVHAVMSEAATKII CCCEEEEEEEECCCHHCCCEEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH HPYAMEFATGNPVITEITGFIEHVELAGEHENKADLILVCPATANTISKIACGIDDTPVT CHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCHH TVVTTAFPHIPIMIAPAMHETMYRHPIVRENIERLKKLGVEFIGPRIEEGKAKVASIDEI HHHHHCCCCCCEEEECHHHHHHHHCCHHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHH VYRVIKKLHKKTLEGKRVLVTAGATREYIDPIRFITNASSGKMGVALAEEADFRGAEVTL HHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEE IRTKGSVKSFVENQIEVETVEEMLSAIENELRSKKYDVVIMAAAVSDFRPKIKAEGKIKS EECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCCCCCCCCCC DRSITIELVPNPKIIDRIKEIQPNVFLVGFKAETSKEKLIEEGKRQIERAKADLVVGNTL CCEEEEEECCCCHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHCEEECCCH EAFGSEENQVVLIGRDFTKELPKMKKRELAERIWDEIEKLLS HHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8688087 [H]