Click here to switch to the map view.

The map label for this gene is upp

Identifier: 18977613

GI number: 18977613

Start: 1175104

End: 1175802

Strand: Direct

Name: upp

Synonym: PF1241

Alternate gene names: 18977613

Gene position: 1175104-1175802 (Clockwise)

Preceding gene: 18977612

Following gene: 18977617

Centisome position: 61.58

GC content: 40.49

Gene sequence:

>699_bases
ATGATTGAGGATAAGAGATGGGGTGGAGTTTATTCCTTTGAGGATTCTCCCTATATTATGGAAATACTAACGGAACTTAG
AGACAAAGACACCGACAGTATAAAGTTCAGAAAAGGCCTTGTCAAGCTTGGAAGATACATGGGGTATGAGATCACAAAGA
CAATGGACGTAGAAAAGGTTAAGGTTGAGACTCCATTGGAAGAAACCGAGGGAATAATAGTCAAAGATAGAAGGAATGTG
GTAATAATAACAGTTCTGAGGGCGGCCATACCATTTATGGAAGGACTAATAAAAGTTTTTGAGCATGCAAGAGTTGGAAT
AGTCTCAGCTGCTAGAGGAAAACCTCCAAAGTTCGAAATCGAGATGAACTACATTAAGATTCCCCAGATAACTCCTGAGG
ATACCGTTATAGTGGCTGATCCGATGATAGCAACTGGCTCAACTTTACTAAGAGTTCTTGAGGAAGTTAAGAAATACGGA
ACTCCAAAGAGGACATTAGTTGTTGGAGTATTAGCTGCTCCAGAGGGAATTACAAGAATAAAAGAAAAATTCCCGGAGGT
TGAAATTTTCGTCGCCAAGATAGACAGGGAATTAAATGATAAAGGTTATATTCTCCCAGGATTGGGGGATGCTGGAGACA
GGGCTTTTGGAGAGCCAGTGAAAATCACTACCCTTCCTCAGGTTCACTATATAGAGTAA

Upstream 100 bases:

>100_bases
TTGGAACACTTCCCACAAATAATTGCAAGCATATTGGAGTCTGGAATGGCCGTTGGAGCTATAACGGCTATTGTGTTAGA
GCAGGTGTTGAGGTGATAAT

Downstream 100 bases:

>100_bases
CATCAACCCATGTTGAGTGGAAAGCTGAGGCCTTTCCATACTCTTCTACTTTTTTGTCTGTTGTTAGGAAGTTAACGTTC
CAGCCAAGGAGTGAAGGCCA

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MIEDKRWGGVYSFEDSPYIMEILTELRDKDTDSIKFRKGLVKLGRYMGYEITKTMDVEKVKVETPLEETEGIIVKDRRNV
VIITVLRAAIPFMEGLIKVFEHARVGIVSAARGKPPKFEIEMNYIKIPQITPEDTVIVADPMIATGSTLLRVLEEVKKYG
TPKRTLVVGVLAAPEGITRIKEKFPEVEIFVAKIDRELNDKGYILPGLGDAGDRAFGEPVKITTLPQVHYIE

Sequences:

>Translated_232_residues
MIEDKRWGGVYSFEDSPYIMEILTELRDKDTDSIKFRKGLVKLGRYMGYEITKTMDVEKVKVETPLEETEGIIVKDRRNV
VIITVLRAAIPFMEGLIKVFEHARVGIVSAARGKPPKFEIEMNYIKIPQITPEDTVIVADPMIATGSTLLRVLEEVKKYG
TPKRTLVVGVLAAPEGITRIKEKFPEVEIFVAKIDRELNDKGYILPGLGDAGDRAFGEPVKITTLPQVHYIE
>Mature_232_residues
MIEDKRWGGVYSFEDSPYIMEILTELRDKDTDSIKFRKGLVKLGRYMGYEITKTMDVEKVKVETPLEETEGIIVKDRRNV
VIITVLRAAIPFMEGLIKVFEHARVGIVSAARGKPPKFEIEMNYIKIPQITPEDTVIVADPMIATGSTLLRVLEEVKKYG
TPKRTLVVGVLAAPEGITRIKEKFPEVEIFVAKIDRELNDKGYILPGLGDAGDRAFGEPVKITTLPQVHYIE

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=210, Percent_Identity=23.8095238095238, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI57863312, Length=210, Percent_Identity=23.8095238095238, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI87082118, Length=206, Percent_Identity=32.0388349514563, Blast_Score=114, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6321920, Length=212, Percent_Identity=28.3018867924528, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28573516, Length=221, Percent_Identity=25.3393665158371, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28573514, Length=221, Percent_Identity=25.3393665158371, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28573512, Length=221, Percent_Identity=25.3393665158371, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI45550449, Length=221, Percent_Identity=25.3393665158371, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_PYRFU (Q8U1G7)

Other databases:

- EMBL:   AE009950
- RefSeq:   NP_578970.1
- ProteinModelPortal:   Q8U1G7
- SMR:   Q8U1G7
- EnsemblBacteria:   EBPYRT00000005076
- GeneID:   1469113
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF1241
- GeneTree:   EBGT00050000023049
- HOGENOM:   HBG326432
- ProtClustDB:   PRK00129
- BRENDA:   2.4.2.9
- HAMAP:   MF_01218_A
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 26164; Mature: 26164

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: NA

Important sites: BINDING 87-87 BINDING 112-112 BINDING 204-204 BINDING 210-210

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEDKRWGGVYSFEDSPYIMEILTELRDKDTDSIKFRKGLVKLGRYMGYEITKTMDVEKV
CCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEEECCCEEE
KVETPLEETEGIIVKDRRNVVIITVLRAAIPFMEGLIKVFEHARVGIVSAARGKPPKFEI
EECCCHHHHCCEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEE
EMNYIKIPQITPEDTVIVADPMIATGSTLLRVLEEVKKYGTPKRTLVVGVLAAPEGITRI
EEEEEECCCCCCCCEEEEECCCHHCHHHHHHHHHHHHHHCCCCHHEEEEEEECCHHHHHH
KEKFPEVEIFVAKIDRELNDKGYILPGLGDAGDRAFGEPVKITTLPQVHYIE
HHHCCCEEEEEEECCCCCCCCCEEECCCCCCCCCCCCCCEEEEECCCEEECC
>Mature Secondary Structure
MIEDKRWGGVYSFEDSPYIMEILTELRDKDTDSIKFRKGLVKLGRYMGYEITKTMDVEKV
CCCCCCCCCEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCEEEEEECCCEEE
KVETPLEETEGIIVKDRRNVVIITVLRAAIPFMEGLIKVFEHARVGIVSAARGKPPKFEI
EECCCHHHHCCEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCEEEE
EMNYIKIPQITPEDTVIVADPMIATGSTLLRVLEEVKKYGTPKRTLVVGVLAAPEGITRI
EEEEEECCCCCCCCEEEEECCCHHCHHHHHHHHHHHHHHCCCCHHEEEEEEECCHHHHHH
KEKFPEVEIFVAKIDRELNDKGYILPGLGDAGDRAFGEPVKITTLPQVHYIE
HHHCCCEEEEEEECCCCCCCCCEEECCCCCCCCCCCCCCEEEEECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA