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The map label for this gene is cpx [H]

Identifier: 18977612

GI number: 18977612

Start: 1173816

End: 1175099

Strand: Direct

Name: cpx [H]

Synonym: PF1240

Alternate gene names: 18977612

Gene position: 1173816-1175099 (Clockwise)

Preceding gene: 18977610

Following gene: 18977613

Centisome position: 61.51

GC content: 43.77

Gene sequence:

>1284_bases
ATGGGTCCTGACATTAAGGTTAAAATAGATGAGAAAGTTGAACCAAAAAGAGCTATTCTCTTTGGGCTTCAGCACGTCCT
TGCAATGTTTGGAGCAACAGTTACAGTTCCACTAGTAGTTGGAACCACAGTAGGGCTTTCGACAAGAGAGATAGCAACCA
TGATCCAGGCCGTTTTGTTGGCAATGGGAATTGCAACGATTCTCCAAACCACAATTGGTTCGAGGTATCCAATAGTCCAA
GGTTCAAGCTTTGCATTTATCCCAGGTTTGATAAGCATAGGGAAGAGCCTTGGAATGGCCGCTACCCAGGGAGCCCTAAT
AGTTGGCGGAATAATAGAGGCTCTAGTTGGTGGGCTGGGAATAGTAGGGAAAATCAAAAAGCTCTTTACGCCCGTAGTTA
CAGGAGTTACAATAATGCTTATAGGATTCTCTCTGGCTCACGTATCGGTAAAGTATTTCTTTAACTACTTCGCCGACCCA
TCTGGAGCGAGCATTCCAAGAGCAACAATCGTTGCTCTTATAACCTTTGGAACAACTGTGTACGTTGCTCTAAAAAGCAG
AGGTACATTAAGGGCAATGCCCGTTATAGTTGGAGCATTTGTGGGATATTTAGTCAGCATCCCCCTGGGATTAGCAGATT
TTCAGCTAGTAAAAGAGCTTCCAGTTGTCAGTGTTCCAAAGATATTCCCGTGGGGAACTCCAGTATTTGATGTGGGGGCA
ATTATAACTCTGCTCTTTGCATTCATGGTCAGCATTATAGAGAGCGTTGGAGATTATCATGCAATCTCAGCTATTGCAGA
GGCTCCCATAACTAATAAGCACATAAATAGGGGAATAATGAGTGAAGGAATTGCATGTTCAATTGCTGGAGTATTGGGAG
CATGTGGAACAACAAGCTATTCAGAGAACATAGGACTAGTGGCTCTTACAAAAGTTGCGAGTAGATACGTTGTCCAGGTT
GGTGGGATTATACTCATTGTAATCTCTCTGTTCCCAAAATTTGCGGGATTGTTAGCTGCAATGCCTGCCCCAGTGCTTGG
AGGTCTTACCCTTGCCCTTTATGGAATGATTAGCGTTACAGGGCTAAGGTTAATTAAGGAGAAAGTAGAACTAAATGACA
GGAACACAATAATAATAGCAACGGCCTTAATTGCAGGACTTGGTGCTCCACAGCTTCCACCAGAGTTCTTGGAACACTTC
CCACAAATAATTGCAAGCATATTGGAGTCTGGAATGGCCGTTGGAGCTATAACGGCTATTGTGTTAGAGCAGGTGTTGAG
GTGA

Upstream 100 bases:

>100_bases
TTACTTTCAATGCTTTCTTCATACTCCATTTGTACTTCCCCTATAAAGCACTAAAAGAAAGTTTTTTAAAGGTTTTCTAA
CACACTTTGAGCGGGCTTTA

Downstream 100 bases:

>100_bases
TAATATGATTGAGGATAAGAGATGGGGTGGAGTTTATTCCTTTGAGGATTCTCCCTATATTATGGAAATACTAACGGAAC
TTAGAGACAAAGACACCGAC

Product: putative purine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MGPDIKVKIDEKVEPKRAILFGLQHVLAMFGATVTVPLVVGTTVGLSTREIATMIQAVLLAMGIATILQTTIGSRYPIVQ
GSSFAFIPGLISIGKSLGMAATQGALIVGGIIEALVGGLGIVGKIKKLFTPVVTGVTIMLIGFSLAHVSVKYFFNYFADP
SGASIPRATIVALITFGTTVYVALKSRGTLRAMPVIVGAFVGYLVSIPLGLADFQLVKELPVVSVPKIFPWGTPVFDVGA
IITLLFAFMVSIIESVGDYHAISAIAEAPITNKHINRGIMSEGIACSIAGVLGACGTTSYSENIGLVALTKVASRYVVQV
GGIILIVISLFPKFAGLLAAMPAPVLGGLTLALYGMISVTGLRLIKEKVELNDRNTIIIATALIAGLGAPQLPPEFLEHF
PQIIASILESGMAVGAITAIVLEQVLR

Sequences:

>Translated_427_residues
MGPDIKVKIDEKVEPKRAILFGLQHVLAMFGATVTVPLVVGTTVGLSTREIATMIQAVLLAMGIATILQTTIGSRYPIVQ
GSSFAFIPGLISIGKSLGMAATQGALIVGGIIEALVGGLGIVGKIKKLFTPVVTGVTIMLIGFSLAHVSVKYFFNYFADP
SGASIPRATIVALITFGTTVYVALKSRGTLRAMPVIVGAFVGYLVSIPLGLADFQLVKELPVVSVPKIFPWGTPVFDVGA
IITLLFAFMVSIIESVGDYHAISAIAEAPITNKHINRGIMSEGIACSIAGVLGACGTTSYSENIGLVALTKVASRYVVQV
GGIILIVISLFPKFAGLLAAMPAPVLGGLTLALYGMISVTGLRLIKEKVELNDRNTIIIATALIAGLGAPQLPPEFLEHF
PQIIASILESGMAVGAITAIVLEQVLR
>Mature_426_residues
GPDIKVKIDEKVEPKRAILFGLQHVLAMFGATVTVPLVVGTTVGLSTREIATMIQAVLLAMGIATILQTTIGSRYPIVQG
SSFAFIPGLISIGKSLGMAATQGALIVGGIIEALVGGLGIVGKIKKLFTPVVTGVTIMLIGFSLAHVSVKYFFNYFADPS
GASIPRATIVALITFGTTVYVALKSRGTLRAMPVIVGAFVGYLVSIPLGLADFQLVKELPVVSVPKIFPWGTPVFDVGAI
ITLLFAFMVSIIESVGDYHAISAIAEAPITNKHINRGIMSEGIACSIAGVLGACGTTSYSENIGLVALTKVASRYVVQVG
GIILIVISLFPKFAGLLAAMPAPVLGGLTLALYGMISVTGLRLIKEKVELNDRNTIIIATALIAGLGAPQLPPEFLEHFP
QIIASILESGMAVGAITAIVLEQVLR

Specific function: Unknown

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680145, Length=497, Percent_Identity=30.3822937625755, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI44680143, Length=501, Percent_Identity=30.1397205588822, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI44680148, Length=490, Percent_Identity=29.1836734693878, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI40316845, Length=490, Percent_Identity=29.1836734693878, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI222080105, Length=392, Percent_Identity=24.4897959183673, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI222080107, Length=400, Percent_Identity=24, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI87082181, Length=427, Percent_Identity=31.3817330210773, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI1790087, Length=442, Percent_Identity=29.185520361991, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI87082178, Length=442, Percent_Identity=28.5067873303167, Blast_Score=166, Evalue=2e-42,
Organism=Escherichia coli, GI1788843, Length=390, Percent_Identity=31.7948717948718, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI87081818, Length=400, Percent_Identity=29.75, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI87081750, Length=435, Percent_Identity=23.2183908045977, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17558856, Length=501, Percent_Identity=27.7445109780439, Blast_Score=165, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17541904, Length=419, Percent_Identity=27.9236276849642, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17542262, Length=479, Percent_Identity=27.7661795407098, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI71993493, Length=469, Percent_Identity=26.0127931769723, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI193206893, Length=430, Percent_Identity=23.7209302325581, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17542260, Length=255, Percent_Identity=26.6666666666667, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21356175, Length=445, Percent_Identity=25.1685393258427, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44520; Mature: 44389

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGPDIKVKIDEKVEPKRAILFGLQHVLAMFGATVTVPLVVGTTVGLSTREIATMIQAVLL
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCHHEEHHHHHCCCCCCHHHHHHHHHHHHH
AMGIATILQTTIGSRYPIVQGSSFAFIPGLISIGKSLGMAATQGALIVGGIIEALVGGLG
HHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHCCCC
IVGKIKKLFTPVVTGVTIMLIGFSLAHVSVKYFFNYFADPSGASIPRATIVALITFGTTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCEE
YVALKSRGTLRAMPVIVGAFVGYLVSIPLGLADFQLVKELPVVSVPKIFPWGTPVFDVGA
EEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
IITLLFAFMVSIIESVGDYHAISAIAEAPITNKHINRGIMSEGIACSIAGVLGACGTTSY
HHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
SENIGLVALTKVASRYVVQVGGIILIVISLFPKFAGLLAAMPAPVLGGLTLALYGMISVT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
GLRLIKEKVELNDRNTIIIATALIAGLGAPQLPPEFLEHFPQIIASILESGMAVGAITAI
HHHHHHHHHHCCCCCEEEEHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
VLEQVLR
HHHHHHC
>Mature Secondary Structure 
GPDIKVKIDEKVEPKRAILFGLQHVLAMFGATVTVPLVVGTTVGLSTREIATMIQAVLL
CCCEEEEECCCCCHHHHHHHHHHHHHHHHCCHHEEHHHHHCCCCCCHHHHHHHHHHHHH
AMGIATILQTTIGSRYPIVQGSSFAFIPGLISIGKSLGMAATQGALIVGGIIEALVGGLG
HHHHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHCCCC
IVGKIKKLFTPVVTGVTIMLIGFSLAHVSVKYFFNYFADPSGASIPRATIVALITFGTTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCEE
YVALKSRGTLRAMPVIVGAFVGYLVSIPLGLADFQLVKELPVVSVPKIFPWGTPVFDVGA
EEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHH
IITLLFAFMVSIIESVGDYHAISAIAEAPITNKHINRGIMSEGIACSIAGVLGACGTTSY
HHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
SENIGLVALTKVASRYVVQVGGIILIVISLFPKFAGLLAAMPAPVLGGLTLALYGMISVT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
GLRLIKEKVELNDRNTIIIATALIAGLGAPQLPPEFLEHFPQIIASILESGMAVGAITAI
HHHHHHHHHHCCCCCEEEEHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHH
VLEQVLR
HHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11792842; 8162194 [H]