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The map label for this gene is hom [H]

Identifier: 18977476

GI number: 18977476

Start: 1051467

End: 1052429

Strand: Reverse

Name: hom [H]

Synonym: PF1104

Alternate gene names: 18977476

Gene position: 1052429-1051467 (Counterclockwise)

Preceding gene: 18977478

Following gene: 33359540

Centisome position: 55.15

GC content: 43.2

Gene sequence:

>963_bases
ATGAAGGAGGTCAAAATTTCTATTTTCGGTTTTGGAACAGTTGGCAGGGCTTTGGCTGAAATAGTTGCCGAAAACTCAGA
AGTTTACGGGATTAAGTTGAAGGTAGTCTCAATAACTGACAGGAGCGGGACTCTCTGGGGGGACTTTGACCTACTTGAGG
CCAAGGAAGTTAAGGAAGCAACTGGGAAGATAAGTAACATAGGAGATTACGAAGTCTATTATCTTAAGCCAGAAGAGATA
ATTGAGGAGATAAGACCAGATATCTTTGTTGATGTCAGTAGTTGGGATGATGCGGCGAGGGTTTATGAGTTCGCATTAAA
GGAGGGGGTAAGCGTAGTAACAAGCAATAAGCCACCTATTGCCGAAAGTTATGATAAGTTGCTAAAAGCTTCCCAAGAGG
GGAATGCTGGATTATTCTTCGAAGCTACCGTGATGGCAGGAACGCCGATTATAGGACTTTTGAGGGAGAACCTGCTCGGA
GAGAAGATAGAGGAGATCAAGGCAGTTGTTAATGCAAGTACAACTTTTATTCTCACAAGAATGGAGCAAGGAAAGACATT
TGAAGAAGCTTTTAATGAAGCTAAATCCCTGGGAGTGTTAGAGGAGGATCCTTCTAAGGACATAGATGGAATTGATGCCT
TCTATAAGGCAAAGATTCTTCACTGGGTGTCATATGGAGCTCCTCCAGAGTTTGAGGAAAGAGTTGGGATTCGAGAAGTT
AAGGATGCAAGAAATGTTAGATTGGTGGCTCAAGTCTCTGAAGGAAGAATAAGTGTGAAGCCCATCAAACTCCCGGAGAA
TAGCCCATTATTGGTTGAAGGAGTACAAAATGCTGCAATAATAAAGACGGACAATTTGGGGGAAGTTGTTCTTAAAGGCC
CAGGGGGAGGAGGAAGAGTTACTGCGAGCGGAGTTTTCACAGATATAATCAAAGCTGCCCTAAGGTTTCCAAAGGCTAGG
TAA

Upstream 100 bases:

>100_bases
ACCTCATATGCATTTACCTTTTGTTCTATTTTTAGTTTATGGTCACGGCATCCAAATTATTCCCTAAACATTTTTATTTT
TGCTTTGCCACTCTCCATTC

Downstream 100 bases:

>100_bases
TTAATGCCTCTCCTTTATTTTCATCGTGTACTTAGGGTATATCTCTTTTGTAAACCTAACGAACTTTGTTTTCCTGGGGC
TTTTTACTACCGTTATCTCA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
MKEVKISIFGFGTVGRALAEIVAENSEVYGIKLKVVSITDRSGTLWGDFDLLEAKEVKEATGKISNIGDYEVYYLKPEEI
IEEIRPDIFVDVSSWDDAARVYEFALKEGVSVVTSNKPPIAESYDKLLKASQEGNAGLFFEATVMAGTPIIGLLRENLLG
EKIEEIKAVVNASTTFILTRMEQGKTFEEAFNEAKSLGVLEEDPSKDIDGIDAFYKAKILHWVSYGAPPEFEERVGIREV
KDARNVRLVAQVSEGRISVKPIKLPENSPLLVEGVQNAAIIKTDNLGEVVLKGPGGGGRVTASGVFTDIIKAALRFPKAR

Sequences:

>Translated_320_residues
MKEVKISIFGFGTVGRALAEIVAENSEVYGIKLKVVSITDRSGTLWGDFDLLEAKEVKEATGKISNIGDYEVYYLKPEEI
IEEIRPDIFVDVSSWDDAARVYEFALKEGVSVVTSNKPPIAESYDKLLKASQEGNAGLFFEATVMAGTPIIGLLRENLLG
EKIEEIKAVVNASTTFILTRMEQGKTFEEAFNEAKSLGVLEEDPSKDIDGIDAFYKAKILHWVSYGAPPEFEERVGIREV
KDARNVRLVAQVSEGRISVKPIKLPENSPLLVEGVQNAAIIKTDNLGEVVLKGPGGGGRVTASGVFTDIIKAALRFPKAR
>Mature_320_residues
MKEVKISIFGFGTVGRALAEIVAENSEVYGIKLKVVSITDRSGTLWGDFDLLEAKEVKEATGKISNIGDYEVYYLKPEEI
IEEIRPDIFVDVSSWDDAARVYEFALKEGVSVVTSNKPPIAESYDKLLKASQEGNAGLFFEATVMAGTPIIGLLRENLLG
EKIEEIKAVVNASTTFILTRMEQGKTFEEAFNEAKSLGVLEEDPSKDIDGIDAFYKAKILHWVSYGAPPEFEERVGIREV
KDARNVRLVAQVSEGRISVKPIKLPENSPLLVEGVQNAAIIKTDNLGEVVLKGPGGGGRVTASGVFTDIIKAALRFPKAR

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homoserine dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=264, Percent_Identity=27.2727272727273, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322599, Length=235, Percent_Identity=26.8085106382979, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005106
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR022697
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 34998; Mature: 34998

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEVKISIFGFGTVGRALAEIVAENSEVYGIKLKVVSITDRSGTLWGDFDLLEAKEVKEA
CCEEEEEEEECCHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCEECCCCHHHHHHHHHH
TGKISNIGDYEVYYLKPEEIIEEIRPDIFVDVSSWDDAARVYEFALKEGVSVVTSNKPPI
HCCCCCCCCEEEEEECHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCC
AESYDKLLKASQEGNAGLFFEATVMAGTPIIGLLRENLLGEKIEEIKAVVNASTTFILTR
HHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
MEQGKTFEEAFNEAKSLGVLEEDPSKDIDGIDAFYKAKILHWVSYGAPPEFEERVGIREV
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHH
KDARNVRLVAQVSEGRISVKPIKLPENSPLLVEGVQNAAIIKTDNLGEVVLKGPGGGGRV
HHCCCEEEEEEECCCEEEEEEEECCCCCCEEEECCCCEEEEEECCCCEEEEECCCCCCEE
TASGVFTDIIKAALRFPKAR
EHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKEVKISIFGFGTVGRALAEIVAENSEVYGIKLKVVSITDRSGTLWGDFDLLEAKEVKEA
CCEEEEEEEECCHHHHHHHHHHHCCCEEEEEEEEEEEEECCCCCEECCCCHHHHHHHHHH
TGKISNIGDYEVYYLKPEEIIEEIRPDIFVDVSSWDDAARVYEFALKEGVSVVTSNKPPI
HCCCCCCCCEEEEEECHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCC
AESYDKLLKASQEGNAGLFFEATVMAGTPIIGLLRENLLGEKIEEIKAVVNASTTFILTR
HHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
MEQGKTFEEAFNEAKSLGVLEEDPSKDIDGIDAFYKAKILHWVSYGAPPEFEERVGIREV
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHCCHHHH
KDARNVRLVAQVSEGRISVKPIKLPENSPLLVEGVQNAAIIKTDNLGEVVLKGPGGGGRV
HHCCCEEEEEEECCCEEEEEEEECCCCCCEEEECCCCEEEEEECCCCEEEEECCCCCCEE
TASGVFTDIIKAALRFPKAR
EHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]