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The map label for this gene is cdc6

Identifier: 18976389

GI number: 18976389

Start: 16236

End: 17498

Strand: Direct

Name: cdc6

Synonym: PF0017

Alternate gene names: 18976389

Gene position: 16236-17498 (Clockwise)

Preceding gene: 18976388

Following gene: 18976390

Centisome position: 0.85

GC content: 39.51

Gene sequence:

>1263_bases
ATGAACGAAGGTGAACATCAAATAAAGCTTGACGAGCTATTCGAAAAGTTGCTCCGAGCTAGGAAGATATTCAAAAACAA
AGATGTCCTTAGGCATAGCTATACTCCCAAGGATCTACCTCACAGACATGAGCAAATAGAAACTCTCGCCCAAATTTTAG
TACCAGTTCTCAGAGGAGAAACTCCATCAAACATATTCGTTTATGGGAAGACTGGAACTGGAAAGACTGTAACTGTAAAA
TTTGTAACTGAAGAGCTGAAAAGAATATCTGAAAAATACAACATTCCAGTTGATGTGATCTACATTAATTGTGAGATTGT
CGATACTCACTATAGAGTTCTTGCTAACATAGTTAACTACTTCAAAGATGAGACTGGGATTGAAGTTCCAATGGTAGGTT
GGCCTACCGATGAAGTTTACGCAAAGCTTAAGCAGGTTATAGATATGAAGGAGAGGTTTGTGATAATTGTGTTGGATGAA
ATTGACAAGTTGGTAAAGAAGAGTGGTGATGAGGTTCTCTATTCATTAACAAGAATAAATACTGAACTTAAAAGGGCTAA
AGTGAGTGTAATTGGTATATCAAACGACCTTAAATTTAAAGAGTATCTAGATCCAAGAGTTCTCTCAAGTTTGAGTGAGG
AAGAGGTGGTATTCCCACCCTATGATGCAAATCAGCTTAGGGATATACTGACCCAAAGAGCTGAAGAGGCCTTTTATCCT
GGGGTTTTAGACGAAGGTGTGATTCCCCTCTGTGCAGCATTAGCTGCTAGAGAGCATGGAGATGCAAGAAAGGCACTTGA
CCTTCTAAGAGTTGCAGGGGAAATAGCGGAAAGAGAAGGGGCAAGTAAAGTAACTGAAAAGCATGTTTGGAAAGCCCAGG
AAAAGATTGAACAGGACATGATGGAGGAGGTAATAAAAACTCTACCCCTTCAGTCAAAAGTTCTCCTCTATGCCATAGTT
CTTTTGGACGAAAACGGCGATTTACCAGCAAATACTGGGGATGTTTACGCTGTTTATAGGGAATTGTGCGAGTACATTGA
CTTGGAACCTCTCACCCAAAGAAGGATAAGTGATCTAATTAATGAGCTTGACATGCTTGGAATAATAAATGCAAAAGTTG
TTAGTAAGGGGAGATATGGGAGGACAAAGGAAATAAGGCTTAACGTTACCTCATATAAGATAAGAAATGTGCTGAGATAT
GATTACTCTATTCAGCCCCTCCTCACAATTTCCCTTAAGAGTGAGCAGAGGAGGTTGATCTAA

Upstream 100 bases:

>100_bases
GTTATATGGATGGGGGAAAAATTAACAACATGTGTTATGTTTCCTCTGGAAAATTGATCTATAATAATCTAGGAGCACAA
TTTCCAATGGAGGGTCATCA

Downstream 100 bases:

>100_bases
TGGATGAATTTGTAAAATCACTTCTAAAAGCTAACTATCTAATAACTCCCTCTGCCTACTATCTCTTGAGAGAATACTAT
GAAAAAGGTGAATTCTCAAT

Product: cell division control protein 6

Products: NA

Alternate protein names: CDC6 homolog

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MNEGEHQIKLDELFEKLLRARKIFKNKDVLRHSYTPKDLPHRHEQIETLAQILVPVLRGETPSNIFVYGKTGTGKTVTVK
FVTEELKRISEKYNIPVDVIYINCEIVDTHYRVLANIVNYFKDETGIEVPMVGWPTDEVYAKLKQVIDMKERFVIIVLDE
IDKLVKKSGDEVLYSLTRINTELKRAKVSVIGISNDLKFKEYLDPRVLSSLSEEEVVFPPYDANQLRDILTQRAEEAFYP
GVLDEGVIPLCAALAAREHGDARKALDLLRVAGEIAEREGASKVTEKHVWKAQEKIEQDMMEEVIKTLPLQSKVLLYAIV
LLDENGDLPANTGDVYAVYRELCEYIDLEPLTQRRISDLINELDMLGIINAKVVSKGRYGRTKEIRLNVTSYKIRNVLRY
DYSIQPLLTISLKSEQRRLI

Sequences:

>Translated_420_residues
MNEGEHQIKLDELFEKLLRARKIFKNKDVLRHSYTPKDLPHRHEQIETLAQILVPVLRGETPSNIFVYGKTGTGKTVTVK
FVTEELKRISEKYNIPVDVIYINCEIVDTHYRVLANIVNYFKDETGIEVPMVGWPTDEVYAKLKQVIDMKERFVIIVLDE
IDKLVKKSGDEVLYSLTRINTELKRAKVSVIGISNDLKFKEYLDPRVLSSLSEEEVVFPPYDANQLRDILTQRAEEAFYP
GVLDEGVIPLCAALAAREHGDARKALDLLRVAGEIAEREGASKVTEKHVWKAQEKIEQDMMEEVIKTLPLQSKVLLYAIV
LLDENGDLPANTGDVYAVYRELCEYIDLEPLTQRRISDLINELDMLGIINAKVVSKGRYGRTKEIRLNVTSYKIRNVLRY
DYSIQPLLTISLKSEQRRLI
>Mature_420_residues
MNEGEHQIKLDELFEKLLRARKIFKNKDVLRHSYTPKDLPHRHEQIETLAQILVPVLRGETPSNIFVYGKTGTGKTVTVK
FVTEELKRISEKYNIPVDVIYINCEIVDTHYRVLANIVNYFKDETGIEVPMVGWPTDEVYAKLKQVIDMKERFVIIVLDE
IDKLVKKSGDEVLYSLTRINTELKRAKVSVIGISNDLKFKEYLDPRVLSSLSEEEVVFPPYDANQLRDILTQRAEEAFYP
GVLDEGVIPLCAALAAREHGDARKALDLLRVAGEIAEREGASKVTEKHVWKAQEKIEQDMMEEVIKTLPLQSKVLLYAIV
LLDENGDLPANTGDVYAVYRELCEYIDLEPLTQRRISDLINELDMLGIINAKVVSKGRYGRTKEIRLNVTSYKIRNVLRY
DYSIQPLLTISLKSEQRRLI

Specific function: Might be involved in the initiation of DNA replication

COG id: COG1474

COG function: function code LO; Cdc6-related protein, AAA superfamily ATPase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDC6/cdc18 family

Homologues:

Organism=Homo sapiens, GI4502703, Length=401, Percent_Identity=25.6857855361596, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17555708, Length=375, Percent_Identity=27.4666666666667, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17506005, Length=322, Percent_Identity=25.1552795031056, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355681, Length=413, Percent_Identity=25.181598062954, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI17137456, Length=301, Percent_Identity=29.9003322259136, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CDC6_PYRFU (P81413)

Other databases:

- EMBL:   D84670
- EMBL:   AE009950
- PIR:   T43932
- RefSeq:   NP_577746.1
- ProteinModelPortal:   P81413
- SMR:   P81413
- EnsemblBacteria:   EBPYRT00000004114
- GeneID:   1467845
- GenomeReviews:   AE009950_GR
- KEGG:   pfu:PF0017
- NMPDR:   fig|186497.1.peg.17
- GeneTree:   EBGT00050000022172
- HOGENOM:   HBG553472
- OMA:   ATISFPK
- ProtClustDB:   PRK00411
- HAMAP:   MF_01407
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR015163
- InterPro:   IPR014277
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PANTHER:   PTHR10763:SF8
- SMART:   SM00382
- TIGRFAMs:   TIGR02928

Pfam domain/function: PF00004 AAA; PF09079 Cdc6_C

EC number: NA

Molecular weight: Translated: 48247; Mature: 48247

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEGEHQIKLDELFEKLLRARKIFKNKDVLRHSYTPKDLPHRHEQIETLAQILVPVLRGE
CCCCCCEEEHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
TPSNIFVYGKTGTGKTVTVKFVTEELKRISEKYNIPVDVIYINCEIVDTHYRVLANIVNY
CCCCEEEEECCCCCCEEEEEHHHHHHHHHHHHCCCCEEEEEEEEEEECHHHHHHHHHHHH
FKDETGIEVPMVGWPTDEVYAKLKQVIDMKERFVIIVLDEIDKLVKKSGDEVLYSLTRIN
HCCCCCCEEEEECCCCHHHHHHHHHHHCHHHCEEEEEHHHHHHHHHCCCHHHHHHHHHHH
TELKRAKVSVIGISNDLKFKEYLDPRVLSSLSEEEVVFPPYDANQLRDILTQRAEEAFYP
HHHHHHEEEEEECCCCCCHHHHCCHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHCCC
GVLDEGVIPLCAALAAREHGDARKALDLLRVAGEIAEREGASKVTEKHVWKAQEKIEQDM
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
MEEVIKTLPLQSKVLLYAIVLLDENGDLPANTGDVYAVYRELCEYIDLEPLTQRRISDLI
HHHHHHHCCCCHHHEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
NELDMLGIINAKVVSKGRYGRTKEIRLNVTSYKIRNVLRYDYSIQPLLTISLKSEQRRLI
HHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHHHCCCCCCEEEEEEECCCCCCCC
>Mature Secondary Structure
MNEGEHQIKLDELFEKLLRARKIFKNKDVLRHSYTPKDLPHRHEQIETLAQILVPVLRGE
CCCCCCEEEHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
TPSNIFVYGKTGTGKTVTVKFVTEELKRISEKYNIPVDVIYINCEIVDTHYRVLANIVNY
CCCCEEEEECCCCCCEEEEEHHHHHHHHHHHHCCCCEEEEEEEEEEECHHHHHHHHHHHH
FKDETGIEVPMVGWPTDEVYAKLKQVIDMKERFVIIVLDEIDKLVKKSGDEVLYSLTRIN
HCCCCCCEEEEECCCCHHHHHHHHHHHCHHHCEEEEEHHHHHHHHHCCCHHHHHHHHHHH
TELKRAKVSVIGISNDLKFKEYLDPRVLSSLSEEEVVFPPYDANQLRDILTQRAEEAFYP
HHHHHHEEEEEECCCCCCHHHHCCHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHCCC
GVLDEGVIPLCAALAAREHGDARKALDLLRVAGEIAEREGASKVTEKHVWKAQEKIEQDM
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
MEEVIKTLPLQSKVLLYAIVLLDENGDLPANTGDVYAVYRELCEYIDLEPLTQRRISDLI
HHHHHHHCCCCHHHEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHH
NELDMLGIINAKVVSKGRYGRTKEIRLNVTSYKIRNVLRYDYSIQPLLTISLKSEQRRLI
HHHHHHHHHHHHHHCCCCCCCCEEEEEEEHHHHHHHHHHCCCCCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9348040