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The map label for this gene is xapA [C]

Identifier: 18976388

GI number: 18976388

Start: 14581

End: 15354

Strand: Direct

Name: xapA [C]

Synonym: PF0016

Alternate gene names: 18976388

Gene position: 14581-15354 (Clockwise)

Preceding gene: 18976384

Following gene: 18976389

Centisome position: 0.76

GC content: 44.32

Gene sequence:

>774_bases
ATGCCCAAGATAGGGATAATCGGTGGTTCTGGAGTTTATGGAATTTTTGAACCGAAGGAAACAGTTAAAGTACACACACC
CTATGGAAGACCCTCAGCTCCAGTGGAAATAGGGGAAATAGAGGGAGTCGAAGTTGCATTTATACCCAGGCACGGAAAGT
ACCATGAGTTCCCACCCCATGAAGTCCCCTACAGGGCCAATATATGGGCTCTTCACGAGCTTGGAGTTGAGAGGGTCATA
GCGGTAAACGCCGTGGGTTCTCTAAAGGAGGAATACAAACCTGGAGACATAGTTATAATCGACCAATTCATTGACTTCAC
AAAGAAGAGGGAATACACATTCTACAATGGACCAAGAGTTGCTCACATCAGTATGGCCGATCCATTCTGTCCAGAGCTAA
GAAGAATTTTCATCGAGACTGCAAAGGAGCTCAACCTGCCCGTTCATGAAAAGGGAACGTACATCTGTATAGAAGGACCG
AGGTTCTCAACTAGGGCCGAGTCAAGAATGTTCAGACAGTTTGCAGATGTTATAGGAATGACTCTAGTTCCAGAGGTCAA
CTTGGCTAGAGAGTTGGGAATGTGTTACGTAAACATTTCAACGGTAACTGACTACGATGTTTGGGCCGAAAAGCCAGTTG
ATGCTCAAGAAGTTCTTAGAGTCATGAAGGAGAACGAAGAGAAAGTCCAAAAGCTTTTAAAAAGAGCAATTCCAAAGATT
CCAGAAGAGAGAAAATGTGGTTGTGCAGATGTTCTCAAGACGATGTTTGTGTGA

Upstream 100 bases:

>100_bases
CCGCCCACCATTGTTAATTTAGTTCCAAAAGGTTATTAAAGTTTTGGACTTTAAAGTAACCCTTATATTCTCCTAAATAC
CAATTAAGACGGTGATAACT

Downstream 100 bases:

>100_bases
ACTTTTTTATCTCCTATTTACTTTGTAACTTTGTAGCTGCAAACCACCTGGGATGCTAAATTTTTCAGCAAAATATAGAA
ACGTTTCTATGTTGATCTTA

Product: 5'-methylthioadenosine phosphorylase II

Products: ribose-1-phosphate; xanthine [C]

Alternate protein names: NA

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MPKIGIIGGSGVYGIFEPKETVKVHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPHEVPYRANIWALHELGVERVI
AVNAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPRVAHISMADPFCPELRRIFIETAKELNLPVHEKGTYICIEGP
RFSTRAESRMFRQFADVIGMTLVPEVNLARELGMCYVNISTVTDYDVWAEKPVDAQEVLRVMKENEEKVQKLLKRAIPKI
PEERKCGCADVLKTMFV

Sequences:

>Translated_257_residues
MPKIGIIGGSGVYGIFEPKETVKVHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPHEVPYRANIWALHELGVERVI
AVNAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPRVAHISMADPFCPELRRIFIETAKELNLPVHEKGTYICIEGP
RFSTRAESRMFRQFADVIGMTLVPEVNLARELGMCYVNISTVTDYDVWAEKPVDAQEVLRVMKENEEKVQKLLKRAIPKI
PEERKCGCADVLKTMFV
>Mature_256_residues
PKIGIIGGSGVYGIFEPKETVKVHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPHEVPYRANIWALHELGVERVIA
VNAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPRVAHISMADPFCPELRRIFIETAKELNLPVHEKGTYICIEGPR
FSTRAESRMFRQFADVIGMTLVPEVNLARELGMCYVNISTVTDYDVWAEKPVDAQEVLRVMKENEEKVQKLLKRAIPKIP
EERKCGCADVLKTMFV

Specific function: The Nucleoside Phosphorylases Catalyze The Phosphorolytic Breakdown Of The N-Glycosidic Bond In The Nucleoside Molecule, With The Formation Of The Corresponding Free Bases And Pentose-1-Phosphate. This Protein Can Degrade All Purine Nucleosides Except Ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=248, Percent_Identity=52.0161290322581, Blast_Score=249, Evalue=1e-66,
Organism=Homo sapiens, GI157168362, Length=262, Percent_Identity=25.9541984732824, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1788746, Length=216, Percent_Identity=28.7037037037037, Blast_Score=78, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71980569, Length=249, Percent_Identity=43.3734939759036, Blast_Score=199, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17541190, Length=266, Percent_Identity=24.4360902255639, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6323045, Length=261, Percent_Identity=37.5478927203065, Blast_Score=159, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6323238, Length=245, Percent_Identity=29.3877551020408, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI20130079, Length=270, Percent_Identity=45.1851851851852, Blast_Score=223, Evalue=7e-59,
Organism=Drosophila melanogaster, GI221459247, Length=251, Percent_Identity=37.0517928286853, Blast_Score=183, Evalue=1e-46,
Organism=Drosophila melanogaster, GI45552887, Length=262, Percent_Identity=26.7175572519084, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI45552885, Length=262, Percent_Identity=26.7175572519084, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24656090, Length=262, Percent_Identity=26.7175572519084, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24656093, Length=262, Percent_Identity=26.7175572519084, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 29220; Mature: 29089

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKIGIIGGSGVYGIFEPKETVKVHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPH
CCCEEEEECCCEEEEECCCCEEEEECCCCCCCCCEEECCCCCEEEEEECCCCCCCCCCCC
EVPYRANIWALHELGVERVIAVNAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPRV
CCCCCCCEEEHHHHCHHHEEEEHHHHHHHHHCCCCCEEEEHHHHHHHHCCCEEEECCCEE
AHISMADPFCPELRRIFIETAKELNLPVHEKGTYICIEGPRFSTRAESRMFRQFADVIGM
EEEECCCCCCHHHHHHHHHHHHHCCCCEECCCCEEEEECCCCCHHHHHHHHHHHHHHHCC
TLVPEVNLARELGMCYVNISTVTDYDVWAEKPVDAQEVLRVMKENEEKVQKLLKRAIPKI
HHCCCCHHHHHCCEEEEEEEEEECCHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCC
PEERKCGCADVLKTMFV
CCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
PKIGIIGGSGVYGIFEPKETVKVHTPYGRPSAPVEIGEIEGVEVAFIPRHGKYHEFPPH
CCEEEEECCCEEEEECCCCEEEEECCCCCCCCCEEECCCCCEEEEEECCCCCCCCCCCC
EVPYRANIWALHELGVERVIAVNAVGSLKEEYKPGDIVIIDQFIDFTKKREYTFYNGPRV
CCCCCCCEEEHHHHCHHHEEEEHHHHHHHHHCCCCCEEEEHHHHHHHHCCCEEEECCCEE
AHISMADPFCPELRRIFIETAKELNLPVHEKGTYICIEGPRFSTRAESRMFRQFADVIGM
EEEECCCCCCHHHHHHHHHHHHHCCCCEECCCCEEEEECCCCCHHHHHHHHHHHHHHHCC
TLVPEVNLARELGMCYVNISTVTDYDVWAEKPVDAQEVLRVMKENEEKVQKLLKRAIPKI
HHCCCCHHHHHCCEEEEEEEEEECCHHHCCCCCCHHHHHHHHHCCHHHHHHHHHHHCCCC
PEERKCGCADVLKTMFV
CCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthosine; phosphate [C]

Specific reaction: xanthosine + phosphate = ribose-1-phosphate + xanthine [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]