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The map label for this gene is purE [H]

Identifier: 189423627

GI number: 189423627

Start: 525104

End: 525607

Strand: Reverse

Name: purE [H]

Synonym: Glov_0556

Alternate gene names: 189423627

Gene position: 525607-525104 (Counterclockwise)

Preceding gene: 189423640

Following gene: 189423626

Centisome position: 13.42

GC content: 61.31

Gene sequence:

>504_bases
ATGAGCAAACCGTTGGTTGGCATTTTAATGGGCAGTGATAGCGATCTGCCGGTAATGGAGAAGGCAGCCGAGGTCCTGAC
ACAACTGGGAATTGGCTGGGAGATGGATATCAGTTCGGCCCACCGTCTGCCGGACAAGACTGCTGTCTACGCCCGCACCG
CCCGTGAACGGGGCATTGAAGTCCTGATCTGCGGGGCAGGCATGGCTGCCCACCTGGCCGGCGTTGTTGCCTCCCACACA
ACCCTGCCGGTAATCGGTGTCCCGCTGAAATCCGGTGCCCTGGCCGGTGTGGATGCGCTCTATGCCACGGTGCAGATGCC
TCCCGGCATTCCGGTCGCTACGGTGGCCGTTGACGGCGGCAAGAATGCCGGCTACCTGGCTGCTTCAATCCTTTCCATCA
AACGACCTGAGCTGGCAGACAGGCTGGAGCAGTTCCGTGCTGCCACCCGGCAGGAGCTGGAGGAAAAATCCAGCGAGCTG
CAGACCCGCCTGAAGCAGGCTTGA

Upstream 100 bases:

>100_bases
ATCGGCATCAATGCCCTTAAAACCAGTTGACAGGGATGCAATGATTCGGTAGGACTCCCCCCTGCACGTAACTCAACAGA
TGCGTAAGGAGCACCCCACT

Downstream 100 bases:

>100_bases
GGGAGAAGCAGCAATGCAGGAGATCCAGAAATTTATCCACGGCTTCCGTAACTTCCAGGAGGAGTACTTCCACGAAGACC
GGGAACTGTTTGATTGCCTG

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 167; Mature: 166

Protein sequence:

>167_residues
MSKPLVGILMGSDSDLPVMEKAAEVLTQLGIGWEMDISSAHRLPDKTAVYARTARERGIEVLICGAGMAAHLAGVVASHT
TLPVIGVPLKSGALAGVDALYATVQMPPGIPVATVAVDGGKNAGYLAASILSIKRPELADRLEQFRAATRQELEEKSSEL
QTRLKQA

Sequences:

>Translated_167_residues
MSKPLVGILMGSDSDLPVMEKAAEVLTQLGIGWEMDISSAHRLPDKTAVYARTARERGIEVLICGAGMAAHLAGVVASHT
TLPVIGVPLKSGALAGVDALYATVQMPPGIPVATVAVDGGKNAGYLAASILSIKRPELADRLEQFRAATRQELEEKSSEL
QTRLKQA
>Mature_166_residues
SKPLVGILMGSDSDLPVMEKAAEVLTQLGIGWEMDISSAHRLPDKTAVYARTARERGIEVLICGAGMAAHLAGVVASHTT
LPVIGVPLKSGALAGVDALYATVQMPPGIPVATVAVDGGKNAGYLAASILSIKRPELADRLEQFRAATRQELEEKSSELQ
TRLKQA

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=153, Percent_Identity=47.7124183006536, Blast_Score=118, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6324702, Length=162, Percent_Identity=50.6172839506173, Blast_Score=160, Evalue=8e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17543; Mature: 17411

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPLVGILMGSDSDLPVMEKAAEVLTQLGIGWEMDISSAHRLPDKTAVYARTARERGIE
CCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEECCCHHHCCCCHHHHHHHHHHHCCCE
VLICGAGMAAHLAGVVASHTTLPVIGVPLKSGALAGVDALYATVQMPPGIPVATVAVDGG
EEEECCCHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHEEECCCCCCEEEEEEECC
KNAGYLAASILSIKRPELADRLEQFRAATRQELEEKSSELQTRLKQA
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKPLVGILMGSDSDLPVMEKAAEVLTQLGIGWEMDISSAHRLPDKTAVYARTARERGIE
CCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEECCCHHHCCCCHHHHHHHHHHHCCCE
VLICGAGMAAHLAGVVASHTTLPVIGVPLKSGALAGVDALYATVQMPPGIPVATVAVDGG
EEEECCCHHHHHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHEEECCCCCCEEEEEEECC
KNAGYLAASILSIKRPELADRLEQFRAATRQELEEKSSELQTRLKQA
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]